Hepatitis B Virus Molecular Mechanisms In Disease And Novel Strategies For Therapy

Author : Wolfgang Helmut Caselmann
Publisher : World Scientific
ISBN 13 : 1783262737
Total Pages : 342 pages
Book Rating : 4.31/5 ( download)

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Download or read book Hepatitis B Virus: Molecular Mechanisms In Disease And Novel Strategies For Therapy written by Wolfgang Helmut Caselmann and published by World Scientific. This book was released on 1998-06-30 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book covers both the molecular aspects of hepatitis B virus replication and gene expression in vivo and in model systems, and the clinical impact of genetic variants or immunological response in chronic infection. Major emphasis is laid on the molecular mechanisms underlying hepatitis B virus-associated liver carcinogenesis and their possible relevance to therapy and to the prevention of infection. Rational approaches to design novel vaccines or cytokine treatments, as well as strategies to develop vectors for liver-directed gene therapy, are discussed.

Author : Jia-Horng Kao
Publisher : Springer
ISBN 13 : 9811048436
Total Pages : 360 pages
Book Rating : 4.32/5 ( download)

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Download or read book Hepatitis B Virus and Liver Disease written by Jia-Horng Kao and published by Springer. This book was released on 2018-01-12 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive, state-of-the art review of HBV infection and liver disease. It discusses new data on basic and translational medicine, including the viral life cycle, the immunopathogenesis of virus-induced chronic hepatitis, viral and host genetic factors affecting disease progression, and the mechanism of virus-induced hepatocarcinogenesis, as well as their potential applications in daily clinical practice. The clinical aspects of chronic HBV infection are examined in chapters on the global epidemiology, efficacy of HBV vaccination, natural history, co-infections with HCV, HDV or HIV, and management of special populations including children, pregnant women and patients undergoing immunosuppressive therapy. Further, it describes the advances and perspectives in the development of novel antiviral treatments as possible cures for HBV infection. The book is a valuable resource for medical students, physicians, and researchers who are interested in managem ent of patients with chronic HBV infection and investigation of HBV infection.

Author : Klaus Dembowsky
Publisher : John Wiley & Sons
ISBN 13 : 352761303X
Total Pages : 382 pages
Book Rating : 4.38/5 ( download)

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Download or read book Novel Therapeutic Proteins written by Klaus Dembowsky and published by John Wiley & Sons. This book was released on 2008-07-11 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes medical applications of recombinant proteins and monoclonal antibodies, some of which have already been on the market for several years while others have only recently been launched. It also highlights the manufacturing processes for individual products, the strategies that were taken by companies in the clinical development, and the hurdles that were encountered in clinical trials and had to be overcome before approval by regulatory authorities. Finally, this book illustrates strategies to modify and improve the pharmacodynamic and pharmacokinetic properties of naturally occurring proteins thus paving the way for a new era in biotechnology. Foreword written by Jürgen Drews.

Author : Peter Perlman
Publisher : Springer Science & Business Media
ISBN 13 : 3642599559
Total Pages : 553 pages
Book Rating : 4.52/5 ( download)

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Download or read book Vaccines written by Peter Perlman and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 553 pages. Available in PDF, EPUB and Kindle. Book excerpt: The immune system is the only organ system in the body besides the central nervous systems endowed with memory. Both types of memories are specific and long-lasting, sometimes life long. This memory capacity of the immune system provides the basis for the most cost-efficient of all medical interventions, successful vaccinations against many common infectious diseases. Such a success requires the isolation of the infectious agent or toxic substance, methods to grow and/or purify the relevant antigen and change it into something innocuous whilst maintaining its immunogenicity. Whereas the early vaccines could only use the enhanced resistance against infectious disease as a measure of vaccine efficacy, most modern vaccines rely upon standardized laboratory tests accepted to parallel the in vivo protective capacity to confirm the quality and potency of the respective vaccine. We are presently experiencing an explosion in the development of new and/or improved vaccines. This is largely due to a parallel rapid expansion in our knowledge of the immune system and of the detailed molecular structure and function of microorganisms. Using this knowledge it is now possible to compose vaccines of new types where only certain molecules (or parts of molecules) derived from a pathogen are included, excluding other potentially harmful ones. Whereas earlier attenuated live vaccines were created by em pirical means such vaccines can now be created by molecularly defined inter ventions in the genome of the microorganism.

Author : Joseph M. Colacino
Publisher : Birkhäuser
ISBN 13 : 3034879032
Total Pages : 250 pages
Book Rating : 4.33/5 ( download)

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Download or read book Hepatitis Prevention and Treatment written by Joseph M. Colacino and published by Birkhäuser. This book was released on 2012-12-06 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic viral hepatitis has emerged as one of the most common causes of disease and death worldwide. Because of their unique modes of replication and intimate association with the host immune system, hepatitis B virus (HBV) and hepatitis C virus (HCV) pose challenging problems to scientists in basic and applied research as well as to clinicians engaged in disease management. Although approved antiviral therapy is available for chronic HBV, the emergence of viral resistance provides a rationale for the development of novel chemotherapeutic agents. The lack of a robust cell culture system for HCV replication and a readily accessible small-animal model of HCV infection have hampered the development of antiviral agents for HCV. Neverthe-less, new antiviral agents targeting HCV are now in preclinical and clinical development. This monograph, providing an up-to-date overview of the field of Hepatitis Prevention and Treatment, includes contributions from internationally recognized experts in the field of viral hepatitis, and covers the current state of knowledge and practice regarding the molecular biology, immunology, biochemistry, pharmacology and clinical aspects of chronic HBV and HCV infection. The volume includes salient topics such as: the history and epidemiology of HBV and HCV; recent insights into the molecular mechanisms of viral replication; the host immune response to infection and a discussion of the use (HBV) or potential development (HCV) of vaccines; the current standard of care for chronically-infected patients; and emerging therapies and issues associated with current antiviral treatments. The latest information to researchers and clinicians actively engaged in viral hepatitis research is provided, but also sufficient background and discussion of the literature to benefit the newcomer to the field.

Author : R. Pochet
Publisher : Springer Science & Business Media
ISBN 13 : 9401006881
Total Pages : 746 pages
Book Rating : 4.80/5 ( download)

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Download or read book Calcium: The molecular basis of calcium action in biology and medicine written by R. Pochet and published by Springer Science & Business Media. This book was released on 2011-06-28 with total page 746 pages. Available in PDF, EPUB and Kindle. Book excerpt: The enormous and varied role of calcium in living systems is now widely appreciated by both cell biologists and clinicians. The identification and characterisation of new calcium binding proteins and regulatory pathways is matched by the recognition of the involvement of calcium binding proteins in a growing number of disease states. This book is intended to introduce clinicians to fundamental biological research, whilst at the same time attracting researchers to the clinical world. The publication of the book coincides with the elucidation of the complete Human Genomic Sequence. As a result of this, scientists now have access to an unprecedented array of data, from which new calcium binding proteins and hence new regulatory pathways will undoubtedly be discovered. It is a further aim of this book to provide a `key' to open the door to the new postgenomic era. The book is in three parts. The first section introduces the reader to the role of calcium in cell biology, providing an appreciation of how this small, simple, non-metabolisable agent can move rapidly and silently through the different cellular compartments, thereby influencing and controlling the fate of the cell. This section also illustrates and dissects the often-complex interplay between calcium and numerous agents in muscle and endocrine cells, neurons, hepatocytes, and platelets. In the second section the reader will discover the role of calcium and its partners in common diseases such as migraine and drug dependence. New classes of diseases such as annexinopathies, channelopathies, calcium-sensing disorders, and citrullinemia are discussed, and the authors give many new insights into the molecular mechanisms of the diseases, thereby explaining how and why they occur. Such information is clearly of primary importance for the pharmaceutical industry. New ideas and concepts of neurodegenerative diseases are introduced, which should stimulate new approaches. Clinicians will also have access, in a comprehensive and authoritative yet highly readable chapter, to data from recent large-scale clinical studies on the numerous and widely prescribed calcium antagonists. The final section gives information on new methods and devices for calcium imaging, and illustrates how calcium movement and change can be monitored and ingeniously utilised as a fast, cheap, and accurate drug screening instrument.

Author : Roger J. A. Grand
Publisher : Gulf Professional Publishing
ISBN 13 : 9780444504968
Total Pages : 540 pages
Book Rating : 4.66/5 ( download)

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Download or read book Viruses, Cell Transformation, and Cancer written by Roger J. A. Grand and published by Gulf Professional Publishing. This book was released on 2001-04-20 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: Viruses are the agent responsible for perhaps up to one million cases of cancer worldwide each year. Significantly, the study of viruses has also provided important clues to the causes and development of the most common human cancers. This volume presents an account of those viruses which have been directly associated with common human malignancies such as human papillomavirus (HPV), cervical carcinoma, Epstein-Barr virus (EBV) and Burkitt's lymphoma. In addition, the biology and biochemistry of those viruses which have been shown to be capable of transforming cells in culture are described in detail. Thus adenovirus are discussed, as are the other small DNA tumour viruses - Simian virus 40 (SV40) and polyoma virus. Consideration has also been given to human T-cell leukaemia virus (HTLV), hepatitis B virus (HBV) and human herpes virus 8 (HHV8), amongst others. General themes such as the host's immune response to viral infection, virally-induced apoptosis and the use of viruses as a delivery system in gene therapy have been discussed. Individual chapters have been written by an international group of experts in their own field of research.

Author : Devarajan Thangadurai
Publisher : CRC Press
ISBN 13 : 1771880015
Total Pages : 526 pages
Book Rating : 4.15/5 ( download)

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Download or read book Biotechnology and Bioinformatics written by Devarajan Thangadurai and published by CRC Press. This book was released on 2014-07-01 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reflecting the interdisciplinary nature of biotechnology, this book covers the role of targeted delivery of polymeric nanodrugs to cancer cells, microbial detoxifying enzymes in bioremediation and bacterial plasmids in antimicrobial resistance. It addresses modern trends such as pharmacogenomics, evaluation of gene expression, recombinant proteins from methylotrophic yeast, identification of novel fermentation inhibitors of bioethanol production, and polyhydroxyalkanoate based biomaterials. The book highlights the practical utility of biotechnology and bioinformatics for bioenergy, production of high value biochemicals, modeling molecular interactions, drug discovery, and personalized medicine.

Author : F. Berr
Publisher : Springer Science & Business Media
ISBN 13 : 9780792387794
Total Pages : 242 pages
Book Rating : 4.91/5 ( download)

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Download or read book Malignant Liver Tumours: Basic Concepts and Clinical Management written by F. Berr and published by Springer Science & Business Media. This book was released on 2002-11-30 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC), both increasing in incidence, have become a major topic of basic and clinical research as well as clinical practice in hepatology. Experts in the field update the current concepts on the carcinogenesis of HCC and CC such as genetic alterations in the pathways of cell cylce and apoptosis regulation, the hypothesis of dedifferentiation of hepatocytes to the malignant phenotype vs that of activation of hepatic progenitor cells incapable of maturation (maturation arrest hypothesis). In spite of an increasing number of genetic alterations described in human HCC as well as cell regulatory pathways tested in experimental HCC models, the key hits causing progression of the cell cycle in imbalance with apoptosis, tissue invasive growth and metastatic potential of cell clones still remain elusive. Very powerful genomic and proteomic techniques are promising insights into the carcinogenesis of liver malignancies that will allow more efficient therapeutic strategies. The current concepts on risk profiling, surveillance of risk groups and therapeutic strategies are evidence-based for HCC and less detailed for CC. Surveillance of risk groups improves detection of liver tumours in curable stages. Best strategies for curative treatment of HCC use neoadjuvant antitumour therapies before liver transplantation and a role is emerging for living donor-related liver transplantation. New palliative therapies for HCC are in the experimental stage with biological response modifiers, including angiogenesis inhibitors, and entering phase II clinical trials with the alpha-fetoprotein derived vaccines.

Author : Hong Tang
Publisher : Springer Nature
ISBN 13 : 9811391513
Total Pages : 190 pages
Book Rating : 4.14/5 ( download)

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Download or read book Hepatitis B Virus Infection written by Hong Tang and published by Springer Nature. This book was released on 2019-11-18 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a state-of-the-art review of the key aspects of HBV. It covers our current understanding of the HBV genome and lifecycle, liver-enriched factors in the regulation of HBV transcription and translation, HBV protein structures and biological functions, and the immunology and pathogenesis of HBV. It also provides an update on cell and animal models, as well as molecular approaches. The respective chapters also cover the clinical management of hepatitis B and discuss future research directions, in particular, the identification of molecular targets for pharmacological intervention. Given its scope, the book offers a valuable resource for students, researchers, clinicians, and health practitioners in the fields of virology, infectious disease, public health etc. Dr Hong Tang is a Professor and Director of the Center of Infectious Diseases, West China Hospital of Sichuan University.