Biomedical Frontiers Of Fluorine Chemistry

Author : Iwao Ojima
Publisher :
ISBN 13 :
Total Pages : 376 pages
Book Rating : 4.58/5 ( download)

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Download or read book Biomedical Frontiers of Fluorine Chemistry written by Iwao Ojima and published by . This book was released on 1996 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: Developed from symposia sponsored by the Division of Fluorine Chemistry and the Division of Medicinal Chemistry.

Author :
Publisher :
ISBN 13 :
Total Pages : 356 pages
Book Rating : 4.31/5 ( download)

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Download or read book Biomedical Frontiers of Fluorine Chemistry written by and published by . This book was released on 1996 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Iwao Ojima
Publisher : John Wiley & Sons
ISBN 13 : 9780470744086
Total Pages : 640 pages
Book Rating : 4.81/5 ( download)

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Download or read book Fluorine in Medicinal Chemistry and Chemical Biology written by Iwao Ojima and published by John Wiley & Sons. This book was released on 2009-03-23 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt: The extraordinary potential of fluorine-containing molecules in medicinal chemistry and chemical biology has been recognized by researchers outside of the traditional fluorine chemistry field, and thus a new wave of fluorine chemistry is rapidly expanding its biomedical frontiers. With several of the best selling drugs in the world crucially containing fluorine atoms, the incorporation of fluorine to drug leads has become an essential practice in biomedical research, especially for drug design and discovery as well as development. Focusing on the unique and significant roles that fluorine plays in medicinal chemistry and chemical biology, this book reviews recent advances and future prospects in this rapidly developing field. Topics covered include: Discovery and development of fluorine containing drugs and drug candidates. New and efficient synthetic methods for medicinal chemistry and the optimisation of fluorine-containing drug candidates. Structural and chemical biology of fluorinated amino acids and peptides. Fluorine labels as probes in metabolic study, protein engineering and clinical diagnosis. Applications of 19F NMR spectroscopy in biomedical research. An appendix presents an invaluable index of all fluorine-containing drugs that have been approved by the US Food and Drug Administration, including information on structure and pharmaceutical action. Fluorine in Medicinal Chemistry and Chemical Biology will serve as an excellent reference source for graduate students as well as academic and industrial researchers who want to take advantage of fluorine in biomedical research.

Author : Iwao Ojima
Publisher : World Scientific
ISBN 13 : 1786347342
Total Pages : 842 pages
Book Rating : 4.43/5 ( download)

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Download or read book Frontiers Of Organofluorine Chemistry written by Iwao Ojima and published by World Scientific. This book was released on 2019-12-24 with total page 842 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the new frontiers of organofluorine chemistry in synthetic, organometallic, bioorganic, medicinal, agricultural, and materials chemistry as well as chemical physics and their applications to biomedical and material sciences. The extraordinary potential of fluorine-containing molecules in biology, pharmaceuticals, agrochemical, materials and their wide range of applications has been recognized by researchers who are not in the traditional fluorine chemistry field, and thus the new wave of organofluorine chemistry is rapidly expanding its frontiers.Featuring major leading researchers from all over the world and their cutting-edge research projects, this title reviews the recent advances and envision the new exciting developments in the future. Frontiers of Organofluorine Chemistry is an excellent reference book for professional researchers, and graduate students, in both industry and academia to get inspirations and new ideas for their projects.

Author : Alain Tressaud
Publisher : Elsevier
ISBN 13 : 0080558119
Total Pages : 821 pages
Book Rating : 4.10/5 ( download)

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Download or read book Fluorine and Health written by Alain Tressaud and published by Elsevier. This book was released on 2008-06-06 with total page 821 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fluorine and Health presents a critical multidisciplinary overview on the contribution of fluorinated compounds to resolve the important global issue of medicinal monitoring and health care. The involved subjects are organized in three thematic parts devoted to Molecular Imaging, Biomedical Materials and Pharmaceuticals. Initially the key-position of partially fluorinated low molecular weight compounds labelled either with the natural 19F-isotope for Magnetic Resonance Imaging (MRI) or labelled with the radioactive [18F]-isotope for Positron Emission Tomography (PET) is highlighted. Both non-invasive methods belong to the most challenging in vivo imaging techniques in oncology, neurology and in cardiology for the diagnosis of diseases having the highest mortality in the industrialized countries. The manifold facets of fluorinated biomaterials range from inorganic ceramics to perfluorinated organic molecules. Liquid perfluorocarbons are suitable for oxygen transport and as potential respiratory gas carriers, while fluorinated polymers are connected to the pathology of blood vessels. Another important issue concerns the application of highly fluorinated liquids in ophthalmology. Moreover, fluorine is an essential trace element in bone mineral, dentine and tooth enamel and is applied for the prophylaxis and treatment of dental caries. The various origins of human exposure to fluoride species is detailed to promote a better understanding of the effect of fluoride species on living organisms.Medicinally relevant fluorinated molecules and their interactions with native proteins are the main focus of the third part. New molecules fluorinated in strategic position are crucial for the development of pharmaceuticals with desired action and optimal pharmacological profile. Among the hundreds of marketed active drug components there are more than 150 fluorinated compounds. The chapters will illustrate how the presence of fluorine atoms alters properties of bioactive compounds at various biochemical steps, and possibly facilitate its emergence as pharmaceuticals. Finally the synthetic potential of a fluorinase, the first C-F bond forming enzyme, is summarized. New approach of topics involving chemistry, biology and medicinal techniques Transdisciplinar papers on fluoride products Importance of fluoride products in health Updated data on specific topics

Author : Paul F. Torrence
Publisher : John Wiley & Sons
ISBN 13 : 9780471326335
Total Pages : 438 pages
Book Rating : 4.3X/5 ( download)

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Download or read book Biomedical Chemistry written by Paul F. Torrence and published by John Wiley & Sons. This book was released on 2000-01-24 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: How basic chemical ideas help advance the understanding and treatment of disease Biomedical Chemistry presents clear, concise coverage of the application of chemistry to drug discovery and determination of disease etiology, highlighting its role in the explosive growth of biotechnology and molecular biology. Through expert contributions from leading researchers in diverse fields, the book provides readers with an understanding of how fundamental chemical concepts are used in the development of novel approaches to the major problems in medicine today. The authors explain both the science and reasoning underlying each experimental approach, exploring cutting-edge developments in AIDS, cancer, alcoholism, Parkinson's disease, trypanosomiasis, emphysema, and malaria. Contemporary research problems discussed include: * Mechanism-based drug discovery * Design of new antitumor and antiviral agents * Targeting tumors using magnetic drug delivery * Antisense and antigene agents Easily accessible to anyone with a solid undergraduate background in chemistry, Biomedical Chemistry is an excellent resource for researchers in health-related fields as well as anyone seeking an overview of frontier topics in medicinal chemistry, organic chemistry, and biochemistry.

Author : Gouverneur Veronique
Publisher : World Scientific
ISBN 13 : 1908977892
Total Pages : 572 pages
Book Rating : 4.92/5 ( download)

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Download or read book Fluorine In Pharmaceutical And Medicinal Chemistry: From Biophysical Aspects To Clinical Applications written by Gouverneur Veronique and published by World Scientific. This book was released on 2012-04-26 with total page 572 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fluorine chemistry is an expanding area of research that is attracting international interest, due to the impact of fluorine in drug discovery and in clinical and molecular imaging (e.g. PET, MRI). Many researchers and academics are entering this area of research, while scientists in industrial and clinical environments are also indirectly exposed to fluorine chemistry through the use of fluorinated compounds for imaging.This book provides an overview of the impact that fluorine has made in the life sciences. In the first section, the emphasis is on how fluorine substitution of amino acids, peptides, nucleobases and carbohydrates can provide invaluable information at a molecular level. The following chapters provide answers to the key questions posed on the importance of fluorine in drug discovery and clinical applications. For examples, the reader will discover how fluorine has found its place as a key element improving drug efficacy, with reference to some of the best-selling drugs on the market. Finally, a thorough review on the design, synthesis and use of 18F-radiotracers for positron emission tomography is provided, and this is complemented with a discussion on how 19F NMR has advanced molecular and clinical imaging./a

Author : Tamejiro Hiyama
Publisher : Springer Science & Business Media
ISBN 13 : 3662041642
Total Pages : 281 pages
Book Rating : 4.42/5 ( download)

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Download or read book Organofluorine Compounds written by Tamejiro Hiyama and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: In view of increasing interest in organofluorine compounds, this book was undertaken to describe biological and physical properties of organofluorine compounds, synthetic methods of these, their roles in pharmaceutical, agrochemical and material sciences. In particular, the book will emphasize on the usefulness of fluorination reaction, availability of fluorination agents, so that even graduate students who are unfamiliar to this field can understand and participate in this fascinating heteroatom chemistry.

Author : Jean-Pierre Bégué
Publisher : John Wiley & Sons
ISBN 13 : 0470281871
Total Pages : 385 pages
Book Rating : 4.71/5 ( download)

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Download or read book Bioorganic and Medicinal Chemistry of Fluorine written by Jean-Pierre Bégué and published by John Wiley & Sons. This book was released on 2008-06-02 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a thorough overview of the role of fluorine in pharmaceutical science and development Includes chapters on fluorinated analogues of natural products, fluorinated amino acids and peptides, and derivatives of sugars Classifies marketed and in-development fluorinated pharmaceuticals according to their therapeutic classes

Author : R.E. Banks
Publisher : Elsevier
ISBN 13 : 9780080531793
Total Pages : 660 pages
Book Rating : 4.92/5 ( download)

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Download or read book Fluorine Chemistry at the Millennium written by R.E. Banks and published by Elsevier. This book was released on 2000-12-04 with total page 660 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume brings together contributions by leading researchers covering a wide scope so characteristic of fluorine chemistry. It is a monograph of historical character comprising personalized accounts of progress and events in areas of particular interest. There is also much to interest and instruct chemists from other disciplines as a good proportion of the chapters contain a considerable amount of 'hard' referenced information relating to modern organic, organoelemental and inorganic chemistry. Historians of chemistry and technology will no doubt be tempted to dip into this book, and surely whoever addresses the task of commemorating Moissan's achievement at the 150-years stage will bless us all in some measure for its existence.