Thyroid Hormone Metabolismmolecular Biology And Alternate Pathways

Author : Sing-Yung Wu
Publisher : CRC Press
ISBN 13 : 9780849347740
Total Pages : 274 pages
Book Rating : 4.42/5 ( download)

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Download or read book Thyroid Hormone MetabolismMolecular Biology and Alternate Pathways written by Sing-Yung Wu and published by CRC Press. This book was released on 1994-07-13 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gathers some of the most talented and well-informed experts in the field, who not only summarize the recent breakthroughs and new findings, but also shed light on future research. Special emphasis is placed on the exciting new understanding of the molecular structure of one of the major enzymes (type 1 iodothyronine deiodinase) involved in the activation of the thyroid hormone. This breakthrough culminates the major effort in this field around the world. As a result, we can study the regulation of thyroid hormone activation mechanism at the molecular level. Two other important deiodinase enzymes (types II and III) are also reviewed. Alternate pathways of thyroid hormone metabolism represent another major advance. These pathways are associated with a variety of physiological and disease states, including fasting, glucocorticoid excess, fetal development, and inflammatory and non-thyroidal illnesses. The understanding of these pathways assists us to better understand the physiological and biological basis of the disease process and thus to improve clinical management of patients with thyroidal and non-thyroidal illnesses.

Author : Jack Oppenheimer
Publisher : Elsevier
ISBN 13 : 0323147453
Total Pages : 515 pages
Book Rating : 4.53/5 ( download)

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Download or read book Molecular Basis of Thyroid Hormone Action written by Jack Oppenheimer and published by Elsevier. This book was released on 2012-12-02 with total page 515 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Basis of Thyroid Hormone Action focuses on the actions of thyroid hormones in eukaryotic cells. This book discusses the profound effects of thyroid hormones on the growth, development, and metabolism of practically all tissues of higher organisms. Organized into 15 chapters, this volume starts with an overview of the kinetic interrelationships of hormone bound to specific receptors and hormone associated with other tissue and plasma pools in living animals. This book then discusses the thyroid hormone receptor, a chromatin-associated protein that appears to mediate the actions of the thyroid hormones in mammalian cells. Other chapters consider the localization of the receptors in chromatin. This book further discusses how thyroid hormones stimulate the accumulation of specific mRNA molecules in cell culture as well as in tissues in vivo. This book is intended for readers who are interested in cell and molecular biology. Endocrinologists will also find this book extremely useful.

Author :
Publisher : Academic Press
ISBN 13 : 0128141174
Total Pages : 564 pages
Book Rating : 4.75/5 ( download)

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Download or read book Thyroid Hormone written by and published by Academic Press. This book was released on 2018-01-18 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thyroid hormone, Volume 106, the latest release in the Vitamins and Hormones series first published in 1943 provides up-to-date information on crystal structures and basic structural studies on neurotrophins and their receptors, neurotrophin functions and the biological actions of neurotrophins related to clinical conditions and disease. This new release focuses on timely topics, including the Nuclear Import and Export of the Thyroid Hormone Receptor, the Thyroid hormone and the white matter of the central nervous system: from development to repair, Thyroid hormone and astrocyte differentiation, and the Molecular Basis of Nongenomic Actions of Thyroid Hormone, amongst other topics. Presents the latest information on thyroid hormone Provides a long-running series that focuses on updates and advances in vitamins and hormones Covers single molecules or diseases that are related to vitamins or hormones, with the topic broadly interpreted to include related substances

Author : Rosalind Pitt-Rivers
Publisher : Elsevier
ISBN 13 : 1483279227
Total Pages : 270 pages
Book Rating : 4.20/5 ( download)

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Download or read book The Thyroid Hormones written by Rosalind Pitt-Rivers and published by Elsevier. This book was released on 2013-10-22 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: International Series of Monographs on Pure and Applied Biology, Volume 1: The Thyroid Hormones focuses on the reactions, characteristics, and chemistry of thyroid hormones. The selection first offers information on the chemistry of thyroxine, iodinated compounds of the thyroid glands, and biosynthesis of the thyroid hormones. Discussions focus on the constitution of desiodothyroxine, diiodotyrosine, biological significance of the iodothyronines, rate of secretion of the thyroid hormone into the circulation, and formation of thyroxine from diiodotyrosine in vitro. The manuscript then takes a look at the transport and physiological actions of the thyroid hormones. Topics include thyroxine-binding by other serum proteins, extravascular fluids, and tissue proteins, effect on nitrogen and lipid metabolism, growth, maturation, and differentiation, and effect on the cardiovascular system and blood. The book examines the mechanism of action of thyroid hormones, extrathyroidal distribution and metabolism of iodine, and biochemical pathways of thyroid hormone metabolism. The text is a dependable reference for readers interested in the reactions, characteristics, and chemistry of thyroid hormones.

Author : Ulrich Loos
Publisher :
ISBN 13 :
Total Pages : 108 pages
Book Rating : 4.39/5 ( download)

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Download or read book Molecular Biological Approaches to Thyroid Research written by Ulrich Loos and published by . This book was released on 1987 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Michelina Plateroti
Publisher : Humana
ISBN 13 : 9781493993208
Total Pages : 300 pages
Book Rating : 4.08/5 ( download)

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Download or read book Thyroid Hormone Nuclear Receptor written by Michelina Plateroti and published by Humana. This book was released on 2019-06-26 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume aims to detail the advances in the field of Thyroid hormones (THs), namely T3 and T4, and their nuclear receptor TRs from a conceptual and methodological point of view. Chapters guide readers through a general introduction, TR's engineered mice, human genetics of TRs, control of the hypothalamus-pituitary-thyroid (HPT) axis, the relevance of the local THs production and metabolism and pathological consequences of TH/TR alterations. Non-mammalian models are also presented and discussed. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Thyroid Hormone Nuclear Receptor: Methods and Protocols aims to ensure successful results in the further study of this vital field.

Author : Antonino Belfiore
Publisher : Springer
ISBN 13 : 9783319446745
Total Pages : 0 pages
Book Rating : 4.46/5 ( download)

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Download or read book Principles of Endocrinology and Hormone Action written by Antonino Belfiore and published by Springer. This book was released on 2018-02-08 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides comprehensive coverage of the current knowledge of the physiology of the endocrine system and hormone synthesis and release, transport, and action at the molecular and cellular levels. It presents essential as well as in-depth information of value to both medical students and specialists in Endocrinology, Gynecology, Pediatrics, and Internal Medicine. Although it is well established that the endocrine system regulates essential functions involved in growth, reproduction, and homeostasis, it is increasingly being recognized that this complex regulatory system comprises not only hormones secreted by the classic endocrine glands but also hormones and regulatory factors produced by many organs, and involves extensive crosstalk with the neural and immune system. At the same time, our knowledge of the molecular basis of hormone action has greatly improved. Understanding this complexity of endocrine physiology is crucial to prevent endocrine disorders, to improve the sensitivity of our diagnostic tools, and to provide the rationale for pharmacological, immunological, or genetic interventions. It is such understanding that this book is designed to foster.

Author : John A.H. Wass
Publisher : Oxford University Press, USA
ISBN 13 : 0199235295
Total Pages : 2158 pages
Book Rating : 4.92/5 ( download)

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Download or read book Oxford Textbook of Endocrinology and Diabetes written by John A.H. Wass and published by Oxford University Press, USA. This book was released on 2011-07-28 with total page 2158 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in its second edition, the Oxford Textbook of Endocrinology and Diabetes is a fully comprehensive, evidence-based, and highly-valued reference work combining basic science with clinical guidance, and providing first rate advice on diagnosis and treatment.

Author : A.P. Weetman
Publisher : Springer Science & Business Media
ISBN 13 : 3642607098
Total Pages : 384 pages
Book Rating : 4.97/5 ( download)

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Download or read book Pharmacotherapeutics of the Thyroid Gland written by A.P. Weetman and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: All the important pharmacological interactions affecting thyroid function are described in this book. The first section is devoted to the physiology and biochemistry of thyroid disease, putting the pharmacological interactions into perspective. The second section reviews all the important pharmacological effects on thyroid function and also deals with the impact of other environmental agents. The chapters are written by internationally recognised experts and extensively referenced to provide an up-to-date review of the pharmacological interactions important to the thyroid and its diseases.

Author : Jen-Chywan Wang
Publisher : Springer
ISBN 13 : 1493928953
Total Pages : 385 pages
Book Rating : 4.58/5 ( download)

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Download or read book Glucocorticoid Signaling written by Jen-Chywan Wang and published by Springer. This book was released on 2015-07-27 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: This timely volume provides a comprehensive overview of glucocorticoids and their role in regulating many aspects of physiology and their use in the treatment of disease. The book is broken into four sections that begin by giving a general introduction to glucocorticoids and a brief history of the field. The second section will discuss the effects of glucocorticoids on metabolism, while the third section will cover the effects of glucocorticoids on key tissues. The final section will discuss general topics, such as animal models in glucocorticoid research and clinical implications of glucocorticoid research. Featuring chapters from leaders in the field, this volume will be of interest to both researchers and clinicians.