The Role Of Glycosylation In Health And Disease

Author : Gordan Lauc
Publisher : Springer Nature
ISBN 13 : 3030701158
Total Pages : 392 pages
Book Rating : 4.54/5 ( download)

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Download or read book The Role of Glycosylation in Health and Disease written by Gordan Lauc and published by Springer Nature. This book was released on 2021-09-08 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glycobiology is an emerging field of studying glycans (sugars) and glycoconjugates that are essentially involved in almost all biological processes, from fine-tuning glycoprotein function to protein-protein interactions, signaling, immune response, host-pathogen interactions, etc. However, due to structural complexity of glycans and analytical challenges this exciting field was lagging behind other areas of biology. With technological advancements growing number of glycans’ functions are being discovered and the study of glycans is becoming a cutting-edge discipline in basic and clinical research. Despite recent developments in glycobiology field, many aspects of glycosylation process still remain unknown, both in a healthy human organism and in pathological states. Human glycome is dynamic and changes with physiological triggers, immune challenges and disease. Atypical glycosylation is consequently a subject of disease biomarker research, and a target for therapeutic interventions. On the other hand, properties of glycosylated biotherapeutics are predominantly determined by their glycans. The Role of Glycosylation in Health and Disease provides a comprehensive overview of types and functions of glycans in a healthy human organism as well as their role in pathophysiology of different diseases and efficiency of glycosylated biotherapeutics. Written by the experts in the field, this book aims to bring glycobiology field closer to students, researchers in life sciences and professionals in biopharmaceutical industry.

Author : Ajit Varki
Publisher : CSHL Press
ISBN 13 : 9780879696818
Total Pages : 694 pages
Book Rating : 4.18/5 ( download)

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Download or read book Essentials of Glycobiology written by Ajit Varki and published by CSHL Press. This book was released on 1999 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.

Author : Marija Pezer
Publisher : Springer Nature
ISBN 13 : 3030769127
Total Pages : 588 pages
Book Rating : 4.23/5 ( download)

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Download or read book Antibody Glycosylation written by Marija Pezer and published by Springer Nature. This book was released on 2021-10-22 with total page 588 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes recent advances in antibody glycosylation research. Covering major topics relevant for immunoglobulin glycosylation - analytical methods, biosynthesis and regulation, modulation of effector functions - it provides new perspectives for research and development in the field of therapeutic antibodies, biomarkers, vaccinations, and immunotherapy. Glycans attached to both variable and constant regions of antibodies are known to affect the antibody conformation, stability, and effector functions. Although it focuses on immunoglobulin G (IgG), the most explored antibody in this context, and unravels the natural phenomena resulting from the mixture of IgG glycovariants present in the human body, the book also discusses other classes of human immunoglobulins, as well as immunoglobulins produced in other species and production systems. Further, it reviews the glycoanalytical methods applied to antibodies and addresses a range of less commonly explored topics, such as automatization and bioinformatics aspects of high-throughput antibody glycosylation analysis. Lastly, the book highlights application areas ranging from the ones already benefitting from antibody glycoengineering (such as monoclonal antibody production), to those still in the research stages (such as exploration of antibody glycosylation as a clinical or biological age biomarker), and the potential use of antibody glycosylation in the optimization of vaccine production and immunization protocols. Summarizing the current knowledge on the broad topic of antibody glycosylation and its therapeutic and biomarker potential, this book will appeal to a wide biomedical readership in academia and industry alike. Chapter 4 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309260868
Total Pages : 171 pages
Book Rating : 4.62/5 ( download)

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Download or read book Transforming Glycoscience written by National Research Council and published by National Academies Press. This book was released on 2012-10-23 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: A new focus on glycoscience, a field that explores the structures and functions of sugars, promises great advances in areas as diverse as medicine, energy generation, and materials science, this report finds. Glycans-also known as carbohydrates, saccharides, or simply as sugars-play central roles in many biological processes and have properties useful in an array of applications. However, glycans have received little attention from the research community due to a lack of tools to probe their often complex structures and properties. Transforming Glycoscience: A Roadmap for the Future presents a roadmap for transforming glycoscience from a field dominated by specialists to a widely studied and integrated discipline, which could lead to a more complete understanding of glycans and help solve key challenges in diverse fields.

Author : Gherman Wiederschain
Publisher : CRC Press
ISBN 13 : 1498709192
Total Pages : 334 pages
Book Rating : 4.94/5 ( download)

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Download or read book Glycobiology and Human Diseases written by Gherman Wiederschain and published by CRC Press. This book was released on 2016-02-22 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses glycobiology and various forms of human diseases. Topics covered include immunoglobulins, inflammation and glycosylation, the role and therapeutic significance of natural anti-glycan antibodies in malignancies and in normal and aberrant pregnancy, identifying urinary glycans as a possible method for the diagnosis of lysosomal storage diseases, glycobiology of human milk (biological roles and diseases) and pectins as biological modulators of human physiological reactions. The book includes analysis of comprehensive data and some productive conclusions and perspectives.

Author : Shyamasree Ghosh
Publisher : Academic Press
ISBN 13 : 0128161272
Total Pages : 386 pages
Book Rating : 4.72/5 ( download)

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Download or read book Sialic Acids and Sialoglycoconjugates in the Biology of Life, Health and Disease written by Shyamasree Ghosh and published by Academic Press. This book was released on 2020-01-08 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sialic Acids and Sialoglycoconjugates in the Biology of Life, Health and Disease enables the reader to understand the role of sialylation as a post translational modification. The book provides insights on the latest knowledge in the field of sialoglycobiology. Sialic acids as terminal residues of oligosaccharide chains play crucial roles in several cellular recognition events. Synthesized post translationally, they play an important role in recognition, signaling, immunological response and cell-cell interaction. Improper sialylations have been associated with several diseases including cancer. In the post genomics and proteomics era, sialoglybiology has become more and more important in deciphering health and disease conditions. Discusses the sialic acids and their role in different diseases (other than cancer) Provides an understanding of sialylations as post translational modifications (PTM) Demonstrates the impact sialylation has on infectious diseases, the autoimmune system and health Gives insights on the importance of sialic acid biology through animal models

Author : Michelle Kilcoyne
Publisher : Academic Press
ISBN 13 : 0128220023
Total Pages : 464 pages
Book Rating : 4.23/5 ( download)

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Download or read book Translational Glycobiology in Human Health and Disease written by Michelle Kilcoyne and published by Academic Press. This book was released on 2023-11-29 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: Along with nucleic acids, proteins, and lipids, carbohydrates stand as one of four main components of cellular architecture. However, glycobiology (or carbohydrate bioscience) is little understood by non-experts, partly because carbohydrates are a complex, diverse class of molecules structurally and functionally. In recent years, advances in computational analytics (glycomics) have allowed us to better interpret and realize the importance of glycobiology in human health and disease, and glycans and their associated processes have been shown to play a significant role across a variety of disease types. As the biomedical sciences continue to adopt multi-omic and precision medicine approaches, a greater understanding of glycobiology is essential for maintaining healthy physiology and advancing disease treatment.Translational Glycobiology in Human Health and Disease offers a deep examination of glycobiology for experts and non-experts alike in areas ranging from the role of glycobiology in chronic and infectious diseases to advances in technologies for higher throughput analysis and diagnosis. While keeping human health in the forefront, this book integrates a thorough discussion of glycobiology fundamentals with its growing areas of application and societal impact. With emphasis throughout on the interdisciplinary nature of glycosciences, this book also features perspectives from the health, computational (glycoanalytics), materials, biopharmaceutical, and diagnostic sciences.Disease and speciality areas addressed include gycoimmunology, neuroglycobiology, commensal glycobiology, gut health, regenerative medicine and glycobiology, glycobiology and cancer, congenital disorders of glycosylation, infectious disease glycobiology, and parasite glycobiology. Computational approaches discussed, supporting the advance of new research, include advanced glycoanalytics, glycomics microarrays, glycoengineering, and glycol systems biology. Additionally, authors consider impact areas for society and public health, such as glycobiology and entrepreneurship, policy and regulatory requirements for glycosylation, future research, and translation to new diagnostics and drug discovery. Provides a deep, foundational overview of glycoscience and its translational potential, highlighting glycobiology’s growing role in human health and disease study Examines a broad range of relevant disease areas and applications of glycobiology in policy and public health Features chapter contributions from leading, international experts in the field, fully integrating perspectives from the health, computational, materials, biopharmaceutical, and diagnostic sciences

Author : John S. Axford
Publisher : Springer Science & Business Media
ISBN 13 : 038725515X
Total Pages : 153 pages
Book Rating : 4.56/5 ( download)

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Download or read book Glycobiology and Medicine written by John S. Axford and published by Springer Science & Business Media. This book was released on 2006-01-27 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt: The potential for glycobiology to improve the practice of medicine has been well recognised, which is why biannual meetings concerning the association have been taking place for the last 14 years. The science of glycobiology has matured rapidly, and with it the far reaching clinical implications are becoming understood. The next decade is going to see this final frontier of science conquered. The impact this understanding of glycobiology will have upon our practice of medicine is going to be exciting. The 7th Jenner Glycobiology and Medicine Symposium was designed to reflect these advances. All the major clinical areas were involved, with contributions from pivotal players in science and medicine.

Author : Alexandra Castilho
Publisher : Humana
ISBN 13 : 9781493927593
Total Pages : 0 pages
Book Rating : 4.90/5 ( download)

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Download or read book Glyco-Engineering written by Alexandra Castilho and published by Humana. This book was released on 2015-06-17 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Conceived with the intention of providing an array of strategies and technologies currently in use for glyco-engineering distinct living organisms, this book contains a wide range of methods being developed to control the composition of carbohydrates and the properties of proteins through manipulations on the production host rather than in the protein itself. The first five sections deal with host-specific glyco-engineering and contain chapters that provide protocols for modifications of the glycosylation pathway in bacteria, yeast, insect, plants and mammalian cells, while the last two sections explore alternative approaches to host glyco-engineering and selected protocols for the analysis of the N-glycans and glyco-profiling by mass spectrometry. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls. Authoritative and extensive, Glyco-Engineering: Methods and Protocols offers vast options to help researchers to choose the expression system and approach that best suits their intended protein research or applications.

Author : National Organization for Rare Disorders
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 9780781730631
Total Pages : 982 pages
Book Rating : 4.35/5 ( download)

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Download or read book NORD Guide to Rare Disorders written by National Organization for Rare Disorders and published by Lippincott Williams & Wilkins. This book was released on 2003 with total page 982 pages. Available in PDF, EPUB and Kindle. Book excerpt: NORD Guide to Rare Disorders is a comprehensive, practical, authoritative guide to the diagnosis and management of more than 800 rare diseases. The diseases are discussed in a uniform, easy-to-follow format--a brief description, signs and symptoms, etiology, related disorders, epidemiology, standard treatment, investigational treatment, resources, and references.The book includes a complete directory of orphan drugs, a full-color atlas of visual diagnostic signs, and a Master Resource List of support groups and helpful organizations. An index of symptoms and key words offers physicians valuable assistance in finding the information they need quickly.