The First Miracle Drugs

Author : John E. Lesch
Publisher : Oxford University Press, USA
ISBN 13 : 019518775X
Total Pages : 377 pages
Book Rating : 4.55/5 ( download)

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Download or read book The First Miracle Drugs written by John E. Lesch and published by Oxford University Press, USA. This book was released on 2007 with total page 377 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the decade from 1935-1945, while the Second World War raged in Europe, a new class of medicines capable of controlling bacterial infections launched a therapeutic revolution that continues today. The new medicines were not penicillin and antibiotics, but sulfonamides, or sulfa drugs. The sulfa drugs preceded penicillin by almost a decade, and during World War II they carried the main therapeutic burden in both military and civilian medicine. Their success stimulated a rapid expansion of research and production in the international pharmaceutical industry, raised expectations of medicine, and accelerated the appearance of new and powerful medicines based on research. The latter development created new regulatory dilemmas and unanticipated therapeutic problems. The sulfa drugs also proved extraordinarily fruitful as starting points for new drugs or classes of drugs, both for bacterial infections and for a number of important non-infectious diseases. This book examines this breakthrough in medicine, pharmacy, and science in three parts. Part I shows that an industrial research setting was crucial to the success of the revolution in therapeutics that emerged from medicinal chemistry. Part II shows how national differences shaped the reception of the sulfa drugs in Germany, France, Britain, and the United States. The author uses press coverage of the day to explore popular perceptions of the dramatic changes taking place in medicine. Part III documents the impact of the sulfa drugs on the American effort in World War II. It also shows how researchers came to an understanding of how the sulfa drugs worked, adding a new theoretical dimension to the science of pharmacology and at the same time providing a basis for the discovery of new medicinal drugs in the 1940s, 1950s, and 1960s. A concluding chapter summarizes the transforming impact of the sulfa drugs on twentieth-century medicine, tracing the therapeutic revolution from the initial breakthrough in the 1930s to the current search for effective treatments for AIDS and the new horizons opened up by the human genome project and stem cell research.

Author : Thomas Hager
Publisher : Crown
ISBN 13 : 0307352285
Total Pages : 354 pages
Book Rating : 4.86/5 ( download)

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Download or read book The Demon Under the Microscope written by Thomas Hager and published by Crown. This book was released on 2006-09-19 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: In The Demon Under the Microscope, Thomas Hager chronicles the dramatic history of sulfa, the first antibiotic and the drug that shaped modern medicine. The Nazis discovered it. The Allies won the war with it. It conquered diseases, changed laws, and single-handedly launched the era of antibiotics. Sulfa saved millions of lives—among them those of Winston Churchill and Franklin Delano Roosevelt Jr.—but its real effects are even more far reaching. Sulfa changed the way new drugs were developed, approved, and sold; transformed the way doctors treated patients; and ushered in the era of modern medicine. The very concept that chemicals created in a lab could cure disease revolutionized medicine, taking it from the treatment of symptoms and discomfort to the eradication of the root cause of illness. A strange and colorful story, The Demon Under the Microscope illuminates the vivid characters, corporate strategy, individual idealism, careful planning, lucky breaks, cynicism, heroism, greed, hard work, and the central (though mistaken) idea that brought sulfa to the world. This is a fascinating scientific tale with all the excitement and intrigue of a great suspense novel.

Author : William Rosen
Publisher : Penguin
ISBN 13 : 0525428100
Total Pages : 370 pages
Book Rating : 4.07/5 ( download)

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Download or read book Miracle Cure written by William Rosen and published by Penguin. This book was released on 2017-05-09 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: The epic history of how antibiotics were born, saving millions of lives and creating a vast new industry known as Big Pharma. As late as the 1930s, virtually no drug intended for sickness did any good; doctors could set bones, deliver babies, and offer palliative care. That all changed in less than a generation with the discovery and development of a new category of medicine known as antibiotics. By 1955, the age-old evolutionary relationship between humans and microbes had been transformed, trivializing once-deadly infections. William Rosen captures this revolution with all its false starts, lucky surprises, and eccentric characters. He explains why, given the complex nature of bacteria—and their ability to rapidly evolve into new forms—the only way to locate and test potential antibiotic strains is by large-scale, systematic, trial-and-error experimentation. Organizing that research needs large, well-funded organizations and businesses, and so our entire scientific-industrial complex, built around the pharmaceutical company, was born. Timely, engrossing, and eye-opening, Miracle Cure is a must-read science narrative—a drama of enormous range, combining science, technology, politics, and economics to illuminate the reasons behind one of the most dramatic changes in humanity’s relationship with nature since the invention of agriculture ten thousand years ago.

Author : Robert L. Shook
Publisher : Penguin
ISBN 13 : 1440696071
Total Pages : 400 pages
Book Rating : 4.77/5 ( download)

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Download or read book Miracle Medicines written by Robert L. Shook and published by Penguin. This book was released on 2007-03-01 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: It’s the business of saving lives. Miracle Medicines goes behind the scenes of the pharmaceutical industry and into the high-security laboratories to tell the stories of the men and women---chemists, physiologists, medical and clinical researchers, engineers---who have chosen to toil for years in the lab in order to transform scientific theories into new lifesaving medicines. You’ll witness the day-to-day labors, victories and defeats of the dedicated professionals who are waging a war against the diseases that still plague mankind. From the confines of their laboratories, these pharmaceutical adventurers explore unknown territories in health and science. Miracle Medicines reveals what really happens during the long and uncertain journey that each new drug and its creators must endure from theory, to research, to testing and, finally, FDA approval and delivery to the public. It’s a very human story within the context of fascinating scientific innovation. Through first hand interviews you’ll also meet the patients who benefit from these manmade miracles and learn how, within their bloodstreams, an ongoing battle is raging. The drugs profiled are: Advair: GlaxoSmithKline’s revolutionary asthma medication, the first packaged as both a control and emergency drug. Gleevec: The Novartis’ chronic myeloid leukemia treatment born from decades of medical research in a field of study that was once considered hopeless. Humalog: Eli Lilly’s reinvention of insulin to control diabetes has been described as being better than nature Lipitor: Pfizer’s miracle antidote for high cholesterol that was nearly lost to the pharmaceutical vaults and has since become the world’s top-selling medicine. Norvir: Abbott’s contribution to the fight against HIV that nearly erases all traces of the disease from the bloodstream and prolongs the life of patients. Remicade: Created for the treatment of Crohn’s disease, rheumatoid arthritis and other Immune Mediated Inflammatory Diseases, Johnson & Johnson’s revolutionary biomedicine was developed from technology that once was only found in science fiction. Seroquel: AstraZeneca’s treatment for both schizophrenia and bipolar mania that has given millions of psychiatrics a new lease on life. This compelling and truth-revealing book will forever change the way you view the medicines in your medicine cabinet, and the people who create them.

Author : Diarmuid Jeffreys
Publisher : Chemical Heritage Foundation
ISBN 13 : 1596918160
Total Pages : 352 pages
Book Rating : 4.60/5 ( download)

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Download or read book Aspirin written by Diarmuid Jeffreys and published by Chemical Heritage Foundation. This book was released on 2008-12 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: A fast-paced, medical-historical mystery, filled with twists and turns.-Chicago Tribune

Author : Thomas Hager
Publisher : Abrams
ISBN 13 : 1683355318
Total Pages : 342 pages
Book Rating : 4.11/5 ( download)

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Download or read book Ten Drugs written by Thomas Hager and published by Abrams. This book was released on 2019-03-05 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: “The stories are skillfully told and entirely entertaining . . . An expert, mostly feel-good book about modern medicine” from the award-winning author (Kirkus Reviews, starred review). Behind every landmark drug is a story. It could be an oddball researcher’s genius insight, a catalyzing moment in geopolitical history, a new breakthrough technology, or an unexpected but welcome side effect discovered during clinical trials. Piece together these stories, as Thomas Hager does in this remarkable, century-spanning history, and you can trace the evolution of our culture and the practice of medicine. Beginning with opium, the “joy plant,” which has been used for 10,000 years, Hager tells a captivating story of medicine. His subjects include the largely forgotten female pioneer who introduced smallpox inoculation to Britain, the infamous knockout drops, the first antibiotic, which saved countless lives, the first antipsychotic, which helped empty public mental hospitals, Viagra, statins, and the new frontier of monoclonal antibodies. This is a deep, wide-ranging, and wildly entertaining book. “[An] absorbing new book.” —The New York Times Book Review “[A] well-written and engaging chronicle.” —The Wall Street Journal “Lucidly informative and compulsively readable.” —Publishers Weekly “Entertaining [and] insightful.” —Booklist “Well-written, well-researched and fascinating to read Ten Drugs provides an insightful look at how drugs have shaped modern medical practices. Towards the end of the book Hager writes that he ‘came away surprised by some of the things he had learned.’ I had the very same reaction.” —Penny Le Couteur, coauthor of Napoleon’s Buttons: How 17 Molecules Changed History

Author : Stuart B. Levy
Publisher : Springer
ISBN 13 : 1489960422
Total Pages : 284 pages
Book Rating : 4.29/5 ( download)

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Download or read book The Antibiotic Paradox written by Stuart B. Levy and published by Springer. This book was released on 2013-11-11 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discovery of antibiotics heralded medicine's triumph over previously fatal diseases that once destroyed entire civilizations - thus earning their reputation as miracle drugs. But today, the terrifying reality of antibiotic-resistant bacteria resulting from our widespread misuse of antibiotics forewarns us that the miracle may be coming to an end. The seemingly innocent consumer who demands antibiotics to treat nonbacterial diseases such as the common cold or plays doctor by saving old prescriptions for later use is paving the way for a future of antibiotic failure. "What harm can it do?" is a popular refrain of people worldwide as they pop another antibiotic pill. Dr. Stuart Levy - the leading international expert on hazards of antibiotic misuse - reveals how this cavalier and naive attitude about the power of antibiotics can have deadly consequences. He explains that we are presently witnessing a massive evolutionary change in bacteria. This build-up of new antibiotic-resistant bacteria in individuals and the environment worldwide is an insidious and silent process. Thus, unwittingly consumers encounter resistant bacteria in their meat, poultry, fish, and vegetables. Unregulated dispensing of antibiotics in poorer countries breeds countless more resistant strains. Since bacteria recognize no geographical boundaries, resistant forms can travel the globe. If this trend continues to grow unchecked, we may someday find that all of our antibiotics are obsolete. Today doctors can no longer expect that their first choice of antibiotic for women's urinary tract infections or children's ear infections will work. Similarly, cancer therapy is rendered useless if patients are unable to fight infections that are sometimes resistant to eight to ten different drugs. In developing countries, people are now dying of previously treatable diseases that are no longer responsive to traditional antibiotics. These problems are just a harbinger of what will come if we do not act now. Dr. Levy, recognized by The New Yorker for his superb contributions to this field, is sending out an urgent message that the world cannot afford to ignore any longer. The goal of this unprecedented investigation into the dangers of antibiotic misuse is to protect the world community from resistant infections and ensure the success of antibiotics for generations to come

Author : Eric Lax
Publisher : Henry Holt and Company
ISBN 13 : 1627796444
Total Pages : 320 pages
Book Rating : 4.46/5 ( download)

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Download or read book The Mold in Dr. Florey's Coat written by Eric Lax and published by Henry Holt and Company. This book was released on 2015-06-02 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: The untold story of the discovery of the first wonder drug, the men who led the way, and how it changed the modern world The discovery of penicillin in 1928 ushered in a new age in medicine. But it took a team of Oxford scientists headed by Howard Florey and Ernst Chain four more years to develop it as the first antibiotic, and the most important family of drugs in the twentieth century. At once the world was transformed-major bacterial scourges such as blood poisoning and pneumonia, scarlet fever and diphtheria, gonorrhea and syphilis were defeated as penicillin helped to foster not only a medical revolution but a sexual one as well. In his wonderfully engaging book, acclaimed author Eric Lax tells the real story behind the discovery and why it took so long to develop the drug. He reveals the reasons why credit for penicillin was misplaced, and why this astonishing achievement garnered a Nobel Prize but no financial rewards for Alexander Fleming, Florey, and his team. The Mold in Dr. Florey's Coat is the compelling story of the passage of medicine from one era to the next and of the eccentric individuals whose participation in this extraordinary accomplishment has, until now, remained largely unknown.

Author : Jordan Metzl
Publisher : Rodale Books
ISBN 13 : 1623364329
Total Pages : 306 pages
Book Rating : 4.28/5 ( download)

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Download or read book The Exercise Cure written by Jordan Metzl and published by Rodale Books. This book was released on 2014-12-23 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: A simple approach to weight loss and better health, with an exhaustive (and exhausting) collection of fun, fat-torching, life-changing workouts that can be tailored to any fitness level “This is a must read for everyone who wants to live a long and active life.”—Robert Sallis, MD, former president, American College of Sports Medicine What if there were a drug to treat every illness, across all body systems, proven potent against heart disease, depression, arthritis, PMS and erectile dysfunction—even in chronic diseases such as asthma, dementia, and certain types of cancer? What if it had no side effects, was completely free, readily available, and worked for everyone? Every single person who took it decreased her risk of premature death and raised his quality of life. Would you want it? In a healthcare system that spends 17% of GDP, roughly $2.7 trillion, mostly on disease treatment, how do we save money and prevent illness? By increasing the use of the world's most effective preventive medicine: exercise. In The Exercise Cure, Dr. Jordan Metzl—nationally renowned sports medicine physician—offers malady-specific and well-researched exercise prescriptions to help readers stay healthy, heal disease, drop pounds, increase longevity, and transform their lives. Dr. Metzl knows that exercise is inexpensive, powerful medicine that has benefits in prevention and treatment of disease without disturbing side effects. Even in older adults, daily exercise has been found to prevent dementia by generating neuron development in the hippocampus, the memory center of the brain. Combining the latest data and his proven motivational skills, Dr. Metzl addresses the common maladies troubling millions. He discusses our cardiovascular, pulmonary, metabolic, musculoskeletal, neurologic, reproductive, and endocrinologic body systems, with special sections on sleep problems and cancer prevention, presenting the science behind the role of exercise as medicine. Then, he details workouts that can be tailored easily to any fitness level, beginner to advanced, and provides nutritional information, including meal plans for healthy eating and disease prevention.

Author : Robert Bud
Publisher : OUP Oxford
ISBN 13 : 0199254060
Total Pages : 342 pages
Book Rating : 4.64/5 ( download)

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Download or read book Penicillin written by Robert Bud and published by OUP Oxford. This book was released on 2007 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: The author sets the discovery and use of penicillin in the broader context of social and cultural changes across the world. He examines the drug's contributions to medicine and agriculture, and investigates the global spread of resistant bacteria as antibiotic use continues to rise.