Single Molecule Cellular Biophysics

Author : Mark C. Leake
Publisher : Cambridge University Press
ISBN 13 : 1107005833
Total Pages : 291 pages
Book Rating : 4.39/5 ( download)

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Download or read book Single-Molecule Cellular Biophysics written by Mark C. Leake and published by Cambridge University Press. This book was released on 2013-01-31 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: Indispensable textbook for undergraduate students in the physical and life sciences, unravelling the inner workings of the cell.

Author : Yuri L. Lyubchenko
Publisher : CRC Press
ISBN 13 : 1351333127
Total Pages : 240 pages
Book Rating : 4.22/5 ( download)

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Download or read book An Introduction to Single Molecule Biophysics written by Yuri L. Lyubchenko and published by CRC Press. This book was released on 2017-11-22 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gives an accessible, detailed overview on techniques of single molecule biophysics (SMB), showing how they are applied to numerous biological problems associated with understanding the molecular mechanisms of DNA replication, transcription, and translation, as well as functioning of molecular machines. It covers major single molecule imaging and probing techniques, highlighting key strengths and limitations of each method using recent examples. The chapters begin with a discussion of single molecule fluorescence techniques followed by an overview of the atomic force microscope and its use for direct time-lapse visualization of dynamics of molecular complexes at the nanoscale, as well as applications in measurements of interactions between molecules and mechanical properties of isolated molecules and their complexes. The next chapters address magnetic tweezers and optical tweezers, including instrumentation, fundamentals of operation, and applications. A final chapter turns to nanopore transport and nanopore-based DNA sequencing technology that will play a major role in next-generation genomics and healthcare applications.

Author : Royal Society (Great Britain)
Publisher :
ISBN 13 : 9780854039906
Total Pages : pages
Book Rating : 4.02/5 ( download)

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Download or read book Single Molecule Cellular Biophysics written by Royal Society (Great Britain) and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Peter Hinterdorfer
Publisher : Springer Science & Business Media
ISBN 13 : 0387764976
Total Pages : 634 pages
Book Rating : 4.79/5 ( download)

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Download or read book Handbook of Single-Molecule Biophysics written by Peter Hinterdorfer and published by Springer Science & Business Media. This book was released on 2009-12-24 with total page 634 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook describes experimental techniques to monitor and manipulate individual biomolecules, including fluorescence detection, atomic force microscopy, and optical and magnetic trapping. It includes single-molecule studies of physical properties of biomolecules such as folding, polymer physics of protein and DNA, enzymology and biochemistry, single molecules in the membrane, and single-molecule techniques in living cells.

Author : Tamiki Komatsuzaki
Publisher : John Wiley & Sons
ISBN 13 : 111813138X
Total Pages : 403 pages
Book Rating : 4.81/5 ( download)

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Download or read book Single-Molecule Biophysics written by Tamiki Komatsuzaki and published by John Wiley & Sons. This book was released on 2011-11-16 with total page 403 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discover the experimental and theoretical developments in optical single-molecule spectroscopy that are changing the ways we think about molecules and atoms The Advances in Chemical Physics series provides the chemical physics field with a forum for critical, authoritative evaluations of advances in every area of the discipline. This latest volume explores the advent of optical single-molecule spectroscopy, and how atomic force microscopy has empowered novel experiments on individual biomolecules, opening up new frontiers in molecular and cell biology and leading to new theoretical approaches and insights. Organized into two parts—one experimental, the other theoretical—this volume explores advances across the field of single-molecule biophysics, presenting new perspectives on the theoretical properties of atoms and molecules. Single-molecule experiments have provided fresh perspectives on questions such as how proteins fold to specific conformations from highly heterogeneous structures, how signal transductions take place on the molecular level, and how proteins behave in membranes and living cells.This volume is designed to further contribute to the rapid development of single-molecule biophysics research. Filled with cutting-edge research reported in a cohesive manner not found elsewhere in the literature, each volume of the Advances in Chemical Physics series serves as the perfect supplement to any advanced graduate class devoted to the study of chemical physics.

Author : Meyer B. Jackson
Publisher : Cambridge University Press
ISBN 13 : 1139447246
Total Pages : 590 pages
Book Rating : 4.49/5 ( download)

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Download or read book Molecular and Cellular Biophysics written by Meyer B. Jackson and published by Cambridge University Press. This book was released on 2006-01-12 with total page 590 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular and Cellular Biophysics provides advanced undergraduate and graduate students with a foundation in the basic concepts of biophysics. Students who have taken physical chemistry and calculus courses will find this book an accessible and valuable aid in learning how these concepts can be used in biological research. The text provides a rigorous treatment of the fundamental theories in biophysics and illustrates their application with examples. Conformational transitions of proteins are studied first using thermodynamics, and subsequently with kinetics. Allosteric theory is developed as the synthesis of conformational transitions and association reactions. Basic ideas of thermodynamics and kinetics are applied to topics such as protein folding, enzyme catalysis and ion channel permeation. These concepts are then used as the building blocks in a treatment of membrane excitability. Through these examples, students will gain an understanding of the general importance and broad applicability of biophysical principles to biological problems.

Author : Susanta K Sarkar
Publisher : Morgan & Claypool Publishers
ISBN 13 : 1681741164
Total Pages : 74 pages
Book Rating : 4.61/5 ( download)

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Download or read book Single Molecule Biophysics and Poisson Process Approach to Statistical Mechanics written by Susanta K Sarkar and published by Morgan & Claypool Publishers. This book was released on 2016-04-01 with total page 74 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is an overview of single molecule physics, the study of both equilibrium and non-equilibrium properties at the single molecule level. It begins with an introduction to this fascinating science and includes a chapter on how to build the most popular instrument for single molecule biophysics, the total internal reflection fluorescence (TIRF) microscope. It concludes with the Poisson process approach to statistical mechanics, explaining how to relate the process to diverse areas and see how data analysis and error bars are integral parts of science.

Author : Nathan R. Zaccai
Publisher : Cambridge University Press
ISBN 13 : 1108508804
Total Pages : 710 pages
Book Rating : 4.03/5 ( download)

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Download or read book Methods in Molecular Biophysics written by Nathan R. Zaccai and published by Cambridge University Press. This book was released on 2017-05-18 with total page 710 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current techniques for studying biological macromolecules and their interactions are based on the application of physical methods, ranging from classical thermodynamics to more recently developed techniques for the detection and manipulation of single molecules. Reflecting the advances made in biophysics research over the past decade, and now including a new section on medical imaging, this new edition describes the physical methods used in modern biology. All key techniques are covered, including mass spectrometry, hydrodynamics, microscopy and imaging, diffraction and spectroscopy, electron microscopy, molecular dynamics simulations and nuclear magnetic resonance. Each method is explained in detail using examples of real-world applications. Short asides are provided throughout to ensure that explanations are accessible to life scientists, physicists and those with medical backgrounds. The book remains an unparalleled and comprehensive resource for graduate students of biophysics and medical physics in science and medical schools, as well as for research scientists looking for an introduction to techniques from across this interdisciplinary field.

Author : Erwin J. G. Peterman
Publisher : Humana Press
ISBN 13 : 9781493958290
Total Pages : 317 pages
Book Rating : 4.91/5 ( download)

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Download or read book Single Molecule Analysis written by Erwin J. G. Peterman and published by Humana Press. This book was released on 2016-08-23 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: Life scientists believe that life is driven, directed, and shaped by biomolecules working on their own or in concert. It is only in the last few decades that technological breakthroughs in sensitive fluorescence microscopy and single-molecule manipulation techniques have made it possible to observe and manipulate single biomolecules and measure their individual properties. The methodologies presented in Single Molecule Techniques: Methods and Protocols are being applied more and more to the study of biologically relevant molecules, such as DNA, DNA-binding proteins, and motor proteins, and are becoming commonplace in molecular biophysics, biochemistry, and molecular and cell biology. The aim of Single Molecule Techniques: Methods and Protocols is to provide a broad overview of single-molecule approaches applied to biomolecules on the basis of clear and concise protocols, including a solid introduction to the most widely used single-molecule techniques, such as optical tweezers, single-molecule fluorescence tools, atomic force microscopy, magnetic tweezers, and tethered particle motion. Written in the highly successful Methods in Molecular BiologyTM series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Single Molecule Techniques: Methods and Protocols serves as an ideal guide to scientists of all backgrounds and provides a broad and thorough overview of the exciting and still-emerging field of single-molecule biology.

Author : S.H. Leuba
Publisher : Elsevier
ISBN 13 : 008056061X
Total Pages : 263 pages
Book Rating : 4.18/5 ( download)

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Download or read book Biology at the Single Molecule Level written by S.H. Leuba and published by Elsevier. This book was released on 2001-12-17 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first book solely devoted to single-molecule biochemistry and molecular biology. Authors were selected on the basis of their contribution to this new and exciting field, and were asked to focus more on the biological problems that can be approached using single-molecule techniques rather than on the techniques per se. It is thought that such techniques will eventually dominate the physical characterization of biologically important macromolecules.