Signaling Networks And Cell Cycle Control

Author : J. Silvio Gutkind
Publisher : Springer Science & Business Media
ISBN 13 : 159259218X
Total Pages : 579 pages
Book Rating : 4.80/5 ( download)

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Download or read book Signaling Networks and Cell Cycle Control written by J. Silvio Gutkind and published by Springer Science & Business Media. This book was released on 2000-04-14 with total page 579 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leading scientists summarize the latest findings on signal transduction and cell cycle regulation and describe the effort to design and synthesize inhibiting molecules, as well as to evaluate their biochemical and biological activities. They review the relevant cell surface receptors, their ligands, and their downstream pathways. Also examined are the latest findings on the components of novel signaling networks controlling the activity of nuclear transcription factors and cell cycle regulatory molecules. Cutting-edge and highly suggestive, Signaling Networks and Cell Cycle Control: The Molecular Basis of Cancer and Other Diseases presents a wealth of information on the emerging principles of the field, as well as an invaluable guide for all experimental and clinical investigators of cell regulation and its rapidly emerging pharmacological opportunities today.

Author : James Turkson
Publisher :
ISBN 13 : 9781603272827
Total Pages : 450 pages
Book Rating : 4.28/5 ( download)

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Download or read book Signaling Networks, Cell Cycle Control, and Human Cancer written by James Turkson and published by . This book was released on 2008-07-01 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: The past few decades have witnessed scientists gaining a considerable understanding of the molecular pathogenesis of human diseases, especially of cancer. Studies of the molecular basis of carcinogenesis have led to the realization that cancer is fundamentally a disease of genetic alterations. The multiple genetic changes in cancer are predominantly the result of accumulating mutations that have occurred in the genome over time. These genetic changes lead to the production of gene products with upreguated, repressed, or loss of function, which in turn produce aberrant signal transduction pathways and dysregulated cellular functions. The bulk of evidence demonstrates that dysregulated signal transduction pathways promote malignant transformation and support the formation, maintenance and progression of tumors.

Author : Sangdun Choi
Publisher : Springer Science & Business Media
ISBN 13 : 1441957979
Total Pages : 900 pages
Book Rating : 4.79/5 ( download)

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Download or read book Systems Biology for Signaling Networks written by Sangdun Choi and published by Springer Science & Business Media. This book was released on 2010-08-09 with total page 900 pages. Available in PDF, EPUB and Kindle. Book excerpt: System Biology encompasses the knowledge from diverse fields such as Molecular Biology, Immunology, Genetics, Computational Biology, Mathematical Biology, etc. not only to address key questions that are not answerable by individual fields alone, but also to help in our understanding of the complexities of biological systems. Whole genome expression studies have provided us the means of studying the expression of thousands of genes under a particular condition and this technique had been widely used to find out the role of key macromolecules that are involved in biological signaling pathways. However, making sense of the underlying complexity is only possible if we interconnect various signaling pathways into human and computer readable network maps. These maps can then be used to classify and study individual components involved in a particular phenomenon. Apart from transcriptomics, several individual gene studies have resulted in adding to our knowledge of key components that are involved in a signaling pathway. It therefore becomes imperative to take into account of these studies also, while constructing our network maps to highlight the interconnectedness of the entire signaling pathways and the role of that particular individual protein in the pathway. This collection of articles will contain a collection of pioneering work done by scientists working in regulatory signaling networks and the use of large scale gene expression and omics data. The distinctive features of this book would be: Act a single source of information to understand the various components of different signaling network (roadmap of biochemical pathways, the nature of a molecule of interest in a particular pathway, etc.), Serve as a platform to highlight the key findings in this highly volatile and evolving field, and Provide answers to various techniques both related to microarray and cell signaling to the readers.

Author : Miguel A. Aon
Publisher : Springer Science & Business Media
ISBN 13 : 3642385052
Total Pages : 375 pages
Book Rating : 4.56/5 ( download)

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Download or read book Systems Biology of Metabolic and Signaling Networks written by Miguel A. Aon and published by Springer Science & Business Media. This book was released on 2013-10-22 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systems Biology represents a new paradigm aiming at a whole-organism-level understanding of biological phenomena, emphasizing interconnections and functional interrelationships rather than component parts. The study of network properties, and how they control and regulate behavior from the cellular to organism level, constitutes a main focus of Systems Biology. This book addresses from a novel perspective a major unsolved biological problem: understanding how a cell works and what goes wrong in pathology. The task undertaken by the authors is in equal parts conceptual and methodological, integrative and analytical, experimental and theoretical, qualitative and quantitative, didactic and comprehensive. Essentially, they unravel the spatio-temporal unfolding of interacting mass-energy and information networks at the cellular and organ levels, as well as its modulation through activation or repression by signaling networks to produce a certain phenotype or (patho)physiological response. Starting with the historical roots, in thirteen chapters this work explores the Systems Biology of signaling networks, cellular structures and fluxes, organ and microorganism functions. In doing so, it establishes the basis of a 21st century approach to biological complexity.

Author : Ralph A. Bradshaw
Publisher : Academic Press
ISBN 13 : 0123822149
Total Pages : 550 pages
Book Rating : 4.47/5 ( download)

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Download or read book Regulation of Organelle and Cell Compartment Signaling written by Ralph A. Bradshaw and published by Academic Press. This book was released on 2011-04-05 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt: This must-have cell signaling title will appeal to researchers across molecular biology, biochemistry, cell biology and genetics. The articles are written and edited by experts in the field and emphasize signaling to and from intracellular compartments including transcriptional responses to cytoplasmic and nuclear signaling events, chromatin remodeling and stress responses, the regulation of endoplasmic reticulum function, control of cell cycle progression and apoptosis and the modulation of the activities of mitochondria and other organelles. Articles written and edited by experts in the field Thematic volume covering regulation of endoplasmic reticulum function, regulation of cell cycle progression, and quality control and assurance in mitochondrion events Up-to-date research on events in membrane proteins and proteins of intracellular matrix

Author : Zhenbiao Yang
Publisher : John Wiley & Sons
ISBN 13 : 1444302396
Total Pages : 448 pages
Book Rating : 4.94/5 ( download)

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Download or read book Annual Plant Reviews, Intracellular Signaling in Plants written by Zhenbiao Yang and published by John Wiley & Sons. This book was released on 2009-01-22 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: Annual Plant Reviews, Volume 33 Intracellular Signaling in Plants An intriguing and important question in our understanding of plantdevelopmental programming and responses to the environment is whatkinds of strategies and mechanisms plant cells use for thetransmission and the integration of various developmental andenvironmental signals. This book provides insight into thisfundamental question in plant biology. Intracellular Signaling in Plants is an excellent new addition tothe increasingly well-known and respected Annual Plant Reviews andoffers the reader: * Chapters prepared by an esteemed team of internationalauthors * A consistent and well-illustrated approach to the subjectmatter * An invaluable resource for all researchers and professionals inplant biochemistry and biology This important volume also deals with major known signalingmechanisms and several representative intracellular signalingnetworks in plants, integrating comprehensive reviews and insightsfrom leading experts in the field. Libraries in all universities and research establishments wherebiological sciences are studied and taught should have copies ofthis essential work on their shelves. Also Available from Wiley-Blackwell Annual Plant Reviews, Volume 32 Cell Cycle Control and Plant Development Edited by Dirk Inzé Print: 9781405150439 Online: 9780470988923 DOI: 10.1002/9780470988923 Annual Plant Reviews, Volume 31 Plant Mitochondria Edited by David Logan Print: 9781405149396 Online: 9780470986592 DOI: 10.1002/9780470986592

Author : James E. Ferrell
Publisher : Garland Science
ISBN 13 : 1000430782
Total Pages : 391 pages
Book Rating : 4.83/5 ( download)

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Download or read book Systems Biology of Cell Signaling written by James E. Ferrell and published by Garland Science. This book was released on 2021-09-28 with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt: How can we understand the complexity of genes, RNAs, and proteins and the associated regulatory networks? One approach is to look for recurring types of dynamical behavior. Mathematical models prove to be useful, especially models coming from theories of biochemical reactions such as ordinary differential equation models. Clever, careful experiments test these models and their basis in specific theories. This textbook aims to provide advanced students with the tools and insights needed to carry out studies of signal transduction drawing on modeling, theory, and experimentation. Early chapters summarize the basic building blocks of signaling systems: binding/dissociation, synthesis/destruction, and activation/inactivation. Subsequent chapters introduce various basic circuit devices: amplifiers, stabilizers, pulse generators, switches, stochastic spike generators, and oscillators. All chapters consistently use approaches and concepts from chemical kinetics and nonlinear dynamics, including rate-balance analysis, phase plane analysis, nullclines, linear stability analysis, stable nodes, saddles, unstable nodes, stable and unstable spirals, and bifurcations. This textbook seeks to provide quantitatively inclined biologists and biologically inclined physicists with the tools and insights needed to apply modeling and theory to interesting biological processes. Key Features: · Full-color illustration program with diagrams to help illuminate the concepts · Enables the reader to apply modeling and theory to the biological processes · Further Reading for each chapter · High-quality figures available for instructors to download

Author : David Owen Morgan
Publisher : New Science Press
ISBN 13 : 0199206104
Total Pages : 328 pages
Book Rating : 4.00/5 ( download)

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Download or read book The Cell Cycle written by David Owen Morgan and published by New Science Press. This book was released on 2007 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell division is a central biological process: it yields the cells required for development and growth, and supplies the replacement cells to repair and maintain old or damaged tissue. This book gives the students a complete overview of the process of cell division - from chromosome division, through mitosis, cytokinesis, and meiosis.

Author : Elahe Radmaneshfar
Publisher : Springer Science & Business Media
ISBN 13 : 3319007440
Total Pages : 122 pages
Book Rating : 4.41/5 ( download)

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Download or read book Mathematical Modelling of the Cell Cycle Stress Response written by Elahe Radmaneshfar and published by Springer Science & Business Media. This book was released on 2013-10-08 with total page 122 pages. Available in PDF, EPUB and Kindle. Book excerpt: The cell cycle is a sequence of biochemical events that are controlled by complex but robust molecular machinery. This enables cells to achieve accurate self-reproduction under a broad range of conditions. Environmental changes are transmitted by molecular signaling networks, which coordinate their actions with the cell cycle. This work presents the first description of two complementary computational models describing the influence of osmotic stress on the entire cell cycle of S. cerevisiae. Our models condense a vast amount of experimental evidence on the interaction of the cell cycle network components with the osmotic stress pathway. Importantly, it is only by considering the entire cell cycle that we are able to make a series of novel predictions which emerge from the coupling between the molecular components of different cell cycle phases. The model-based predictions are supported by experiments in S. cerevisiae and, moreover, have recently been observed in other eukaryotes. Furthermore our models reveal the mechanisms that emerge as a result of the interaction between the cell cycle and stress response networks.

Author : David A. Frank
Publisher : Springer Science & Business Media
ISBN 13 : 1402073402
Total Pages : 358 pages
Book Rating : 4.03/5 ( download)

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Download or read book Signal Transduction in Cancer written by David A. Frank and published by Springer Science & Business Media. This book was released on 2002-12-31 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the most exciting areas of cancer research now is the development of agents which can target signal transduction pathways that are activated inappropriately in malignant cells. The understanding of the molecular abnormalities which distinguish malignant cells from their normal counterparts has grown tremendously. This volume summarizes the current research on the role that signal transduction pathways play in the pathogenesis of cancer and how this knowledge may be used to develop the next generation of more effective and less toxic anticancer agents. Series Editor comments: "The biologic behavior of both normal and cancer cells is determined by critical signal transduction pathways. This text provides a comprehensive review of the field. Leading investigators discuss key molecules that may prove to be important diagnostic and/or therapeutic targets."