Radiolabeled Monoclonal Antibodies For Imaging And Therapy

Author : Suresh C. Srivastava
Publisher : Springer Science & Business Media
ISBN 13 : 1468455389
Total Pages : 851 pages
Book Rating : 4.80/5 ( download)

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Download or read book Radiolabeled Monoclonal Antibodies for Imaging and Therapy written by Suresh C. Srivastava and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 851 pages. Available in PDF, EPUB and Kindle. Book excerpt: The advent of hybridoma technology leading to the successful produc tion of monoclonal antibodies against a variety of tumor-associated antigens has, during the last decade, provided a very powerful tool for research and clinical investigations. These highly specific reagents have essentially replaced the polysera of the earlier days. The successful demonstration of the many wide ranging capabilities of the monoclonal antibody technique has already begun to exert an enormous impact on diverse areas of research in basic science and medicine. In particular, the potential of monoclonal antibodies to serve as carriers for selective targeting of radionuclides to tumors for diagnosis or therapy, has stimulated an intense surge of research interest and even revived hopes of realizing Ehrlich's concept of the "magic bullet". Indeed, the technology appears to be on the threshold of a revolution in diagnosing and treating malignant disease. Much work remains to be done, however, and even though the progress has been impressive, results to date have shown only moderate success. There is no question that the limited success we have achieved thus far is merely a prelude to the many more exciting developments yet to come.

Author : David M. Goldenberg
Publisher : Springer Science & Business Media
ISBN 13 : 1461314976
Total Pages : 469 pages
Book Rating : 4.74/5 ( download)

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Download or read book Cancer Imaging with Radiolabeled Antibodies written by David M. Goldenberg and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 469 pages. Available in PDF, EPUB and Kindle. Book excerpt: Where do you begin to look for a recent, authoritative article on the diagnosis or management of a particular malignancy? The few general oncology text books are generally out of date. Single papers in specialized journals are informative but seldom comprehensive; these are more often preliminary reports on a very limited number of patients. Certain general journals frequently publish good in-depth reviews of cancer topics, and published symposium lectures are often the best overviews available. Unfortunately, these reviews and supplements appear sporadically, and the reader can never be sure when a topic of special interest will be covered. Cancer Treatment and Research is a series of authoritative volumes that aim to meet this need. It is an attempt to establish a critical mass of oncology literature covering virtually all oncology topics, revised frequently to keep the coverage up to date, and easily available on a single library shelf or by a single personal subscription. We have approached the problem in the following fashion: first, by dividing the oncology literature into specific subdivisions such as lung cancer, genitourinary cancer, pediatric oncology, etc.; and second, by asking eminent authorities in each of these areas to edit a volume on the specific topic on an annual or biannual basis. Each topic and tumor type is covered in a volume appearing frequently and predictably, discussing current diagnosis, staging, markers, all forms of treatment modalities, basic biology, and more.

Author : David M. Goldenberg
Publisher : CRC Press
ISBN 13 : 1351087304
Total Pages : 574 pages
Book Rating : 4.08/5 ( download)

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Download or read book Cancer Therapy with Radiolabeled Antibodies written by David M. Goldenberg and published by CRC Press. This book was released on 2018-01-18 with total page 574 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer Therapy with Radiolabeled Antibodies explores the most current experimental and clinical advances in the newly emerging field of cancer radioimmunotherapy (RAIT). Providing a multidisciplinary and international context, some of the world's leading experts examine the problems and prospects of RAIT from radiation, immunological, chemical, physical, physiological, and clinical perspectives with both overviews and original research. Discussions cover the up-to-date clinical results in the RAIT of ovarian, breast, colorectal, and brain cancers, as well as the current status of RAIT in the management of B cell lymphomas. Radiobiology, dosimetry, radiochemistry, targeting biology in experimental models, clinical experiences in hematopoietic and solid tumors, and new approaches to improve cancer radioimmunotherapy are also discussed. In addition, new dosimetry concepts, new labeling methods, new concepts of antibody pharmacokinetics, and new methods to enhance selective cancer radioimmunotherapy are included.

Author : Marie-Luise Sautter-Bihl
Publisher : Springer Science & Business Media
ISBN 13 : 3642799523
Total Pages : 200 pages
Book Rating : 4.25/5 ( download)

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Download or read book Systemic Radiotherapy with Monoclonal Antibodies written by Marie-Luise Sautter-Bihl and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: Almost a century ago Paul Ehrlich introduced the "magic bullet" concept of targeting therapeutic agents to specific tissues in order to reduce systemic toxicity. Due to the advances in hybridoma technology in the 1980s, monoclonal antibodies (MAbs) with their exquisite affinity to tumor antigens have become powerful tools in the treatment of cancer, especially when linked to therapeutic agents such as radionuclides, drugs, toxins, or enzymes. It can now be expected that such agents will lead to new cancer treatments with high therapeutic success rates. However, there are major problems in developing this therapeutic concept to a routine treatment modality. This is partly due to factors such as heterogenous distribution of tumor antigens, insufficient blood supply of tumors, high interstitial pressure, and the large interstitial space that antibodies have to traverse. This book is focused on the development in radio immunotherapy (RIT) using radio labeled monoclonal antibodies as tumoritoxic agents. This area of research has attracted the interest of clinicians and scientists from many different disciplines. It is now clear that the full potential of RIT can only be realized through the concerted efforts of laboratory scientists (molecular biologists, cell physiologists, chemists, radiation physicists, and biologists) and cancer clinicians in nuclear medicine, radiooncology, and internal oncology.

Author : Jerome M. Vaeth
Publisher :
ISBN 13 :
Total Pages : 286 pages
Book Rating : 4.37/5 ( download)

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Download or read book The Present and Future Role of Monoclonal Antibodies in the Management of Cancer written by Jerome M. Vaeth and published by . This book was released on 1990 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Nima Rezaei
Publisher :
ISBN 13 : 9783030308476
Total Pages : 802 pages
Book Rating : 4.72/5 ( download)

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Download or read book Cancer Immunology written by Nima Rezaei and published by . This book was released on 2020 with total page 802 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This book focusing on the immunopathology of cancers is published as part of the three-volume Springer series Cancer Immunology, which aims to provide an up-to-date, clinically relevant review of cancer immunology and immunotherapy. Readers will find detailed descriptions of the interactions between cancerous cells and various components of the innate and adaptive immune system. The principal focus, however, is very much on clinical aspects, the aim being to educate clinicians in the clinical implications of the latest research and novel developments in the field. In the new edition of this very well received book, first published in 2015, the original chapters have been significantly updated and additional chapters included on, for example, current knowledge on the roles of T-helper cells and NK cells in tumor immunity, the part played by oncoviruses in the development of various cancers, and the applications of fluorescent in situ hybridization, bioluminescence, and cancer molecular and functional imaging"--Publisher's description.

Author : Raymond M. Reilly
Publisher : John Wiley & Sons
ISBN 13 : 1118035151
Total Pages : 849 pages
Book Rating : 4.53/5 ( download)

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Download or read book Monoclonal Antibody and Peptide-Targeted Radiotherapy of Cancer written by Raymond M. Reilly and published by John Wiley & Sons. This book was released on 2010-12-28 with total page 849 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oncology Book of 2011, British Medical Association's Medical Book Awards Awarded first prize in the Oncology category at the 2011 BMA Medical Book Awards, Monoclonal Antibody and Peptide-Targeted Radiotherapy of Cancer helps readers understand this hot pharmaceutical field with up-to-date developments. Expert discussion covers a range of diverse topics associated with this field, including the optimization of design of biomolecules and radiochemistry, cell and animal models for preclinical evaluation, discoveries from key clinical trials, radiation biology and dosimetry, and considerations in regulatory approval. With chapters authored by internationally renowned experts, this book delivers a wealth of information to push future discovery.

Author : Kenneth A. Foon
Publisher : Springer Science & Business Media
ISBN 13 : 1461326273
Total Pages : 171 pages
Book Rating : 4.74/5 ( download)

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Download or read book Monoclonal Antibody Therapy of Human Cancer written by Kenneth A. Foon and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: KENNETH A. FOON and ALTON C. MORGAN, JR. Passive immunotherapy using heteroantisera for the treatment of cancer in animals and humans has been studied for over 50 years. Attempts have been made to treat animal tumors with sera from immunized syngeneic, allogeneic, or xenogeneic animals. A number of studies of passive immunotherapy using heterologous antisera in humans have also been performed. These studies have generally been attempted in patients with large tumor burdens, and as would be expected, results have been transient at best. A wide variety of solid tumors as well as leukemias and lym phomas have been treated with antisera raised in sheep, horses, rabbits, and goats. Problems such as anaphylaxis, serum sick ness, and severe cytopenias have been encountered with these antisera. There are a number of potential mechanisms by which unconju gated antibodies might be cytotoxic to tumor cells. Antibodies bound to the cell surface membrane of tumor cells may lead to cell lysis by complement-dependent or antibody-dependent cellu lar cytotoxicity. Circulating tumor cells bound by antibody may be more susceptible to phagocytosis by the reticuloendothelial system. Antibody bound to the cell surface membrane of tumor cells may enhance immunogenicity of the tumor cell leading to activation of the host's immune system.

Author : Tod W. Speer
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 1451153260
Total Pages : 564 pages
Book Rating : 4.62/5 ( download)

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Download or read book Targeted Radionuclide Therapy written by Tod W. Speer and published by Lippincott Williams & Wilkins. This book was released on 2012-03-28 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: Radioimmunotherapy, also known as systemic targeted radiation therapy, uses antibodies, antibody fragments, or compounds as carriers to guide radiation to the targets. It is a topic rapidly increasing in importance and success in treatment of cancer patients. This book represents a comprehensive amalgamation of the radiation physics, chemistry, radiobiology, tumor models, and clinical data for targeted radionuclide therapy. It outlines the current challenges and provides a glimpse at future directions. With significant advances in cell biology and molecular engineering, many targeting constructs are now available that will safely deliver these highly cytotoxic radionuclides in a targeted fashion. A companion website includes the full text and an image bank.

Author : Richard P. Baum
Publisher : Springer Science & Business Media
ISBN 13 :
Total Pages : 208 pages
Book Rating : 4.82/5 ( download)

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Download or read book Clinical Use of Antibodies written by Richard P. Baum and published by Springer Science & Business Media. This book was released on 1991 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: 1. Advances in cancer imaging and therapy with radiolabelled antibodies.- 2. Evaluation of the diagnostic utility of immunoscintigraphy in oncology.- 3. The quality control and clinical testing of radiolabelled antibodies.- 4. Clinical utility of radiolabelled monoclonal antibodies in the management of gastrointestinal cancer.- 5. Use of 123-I radiolabelled F(AB')2 fragments of anti-CEA monoclonal antibody for the detection of primary and metastatic gastrointestinal carcinomas.- 6. Bispecific monoclonal antibodies for two phase radioimmunotherapy.- 7. Antimyosin antibody imaging in myocardial infarction.- 8. Antimyosin based radioimmunodetection of myocarditis cardiomyopathy and cardiac transplant rejection.- 9. Recent advances in the use of radiolabelled monoclonal antibodies in the management of ovarian cancer.- 10. Monoclonal antibodies for cell labelling with particular reference to thrombus imaging.- 11. The role of nuclear medicine in the evaluation of the patient with acquired immune deficiency syndrome (AIDS).- 12. Detection of inflammation/infection using radiolabelled anti-granulocyte antibodies: possibilities and limitations.- 13. A new marker for the detection of adenocardinomas by radioimmunoscintigraphy.- 14. New developments in the diagnosis of AIDS and strategies for therapy.