Radiation Sensitizers

Author : N. G. Huilgol
Publisher : CRC Press
ISBN 13 : 9780849310195
Total Pages : 102 pages
Book Rating : 4.99/5 ( download)

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Download or read book Radiation Sensitizers written by N. G. Huilgol and published by CRC Press. This book was released on 2001 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt: In spite of years of clinical research and trials of a variety of new and promising therapies, cancer remains as a major cause of morbidity and mortality. Use of ionizing radiation in treatment of cancer quickly followed the discovery of X-rays and radioactivity at the dawn of the last century. The limited success of radiotherapy has been attributed to several factors if which the intrinsic radioresistance of tumor cells, their fast reproduction, and tumor hypoxia are the major causes. Radiation Sensitizers: A Contemporary Audit presents data on newer hypoxic cell sensitizers like senazole and deal with old molecules such as chlorpromazine in a new role of sensitization. Bringing together information scattered throughout published and unpublished literature, the book contains contributions from an international panel that examines new therapies and new uses of old therapies. It contains tables and diagrams that illustrate the concepts and make the information easy to find.

Author : Luther W. Brady
Publisher :
ISBN 13 :
Total Pages : 552 pages
Book Rating : 4.49/5 ( download)

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Download or read book Radiation Sensitizers, Their Use in the Clinical Management of Cancer written by Luther W. Brady and published by . This book was released on 1980 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Shirley Lehnert
Publisher : CRC Press
ISBN 13 : 1439829020
Total Pages : 552 pages
Book Rating : 4.28/5 ( download)

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Download or read book Radiosensitizers and Radiochemotherapy in the Treatment of Cancer written by Shirley Lehnert and published by CRC Press. This book was released on 2014-12-08 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt: Radiosensitizers and Radiochemotherapy in the Treatment of Cancer catalogs and describes the mechanism of action for entities characterized as radiosensitizers. Developments in the biological and physical sciences have introduced new radiosensitizers and defined novel targets for radiosensitization. As a result, a book about radiosensitization must now address a huge range of topics, covering everything from molecular oxygen and high Z elements to monoclonal antibodies and complex phytochemicals. At the molecular level, the understanding of the molecular consequences of DNA damage and the DNA damage response have informed the development of targeted radiosensitizers and shed light on the mode of action of radiochemotherapy protocols of known clinical efficacy. In this book the mechanisms of action at the molecular and cellular level are described for documented radiosensitizers including, where applicable, a brief history of their clinical use and most recent clinical results. In addition, the clinical context is addressed including the importance of factors such as dose and dose rate, normal tissue toxicity, and drug delivery. Intuitively organized by topic and application, the book includes extensive illustrations, end-of-chapter summaries, and a wealth of references.

Author : A. Breccia
Publisher : Springer Science & Business Media
ISBN 13 : 1475703996
Total Pages : 285 pages
Book Rating : 4.93/5 ( download)

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Download or read book Advanced Topics on Radiosensitizers of Hypoxic Cells written by A. Breccia and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: In July 1979, the Faculty of Pharmacy of the University of Bologna received a proposal from Professor Breccia to hold an International Conference on "Nitroimidazoles: Chemistry, Pharmacology and Clinical Application." Because of the great interest in these drugs in various fields, I was very pleased to accept the proposal and to give the conference the sponsorship of the University of Bologna. It was an added pleasure to accept the chairmanship of the meeting, together with Professors Sensi and Adams. At the same time, the Minister of Education approved a proposal which also came from the Faculty of Pharmacy, to offer an advanced course on the topic "Radiosensitizers of Hypoxic Cells This course was subsequently approved by a special Committee of the NATO Scientific Programme as an Advanced Study Institute. Since the subject matter of both the conference and the course are closely inter-related, it was logical to plan the conference as part of the overall course. Bringing together specialists from quite different and apparently unrelated fields of research, but all with an interest in the study and application of one single group of drugs, is a novel idea with intriguing possibilities. The volumes of the proceedings include contributions from experts with such diverse interests as synthetic chemistry, mechanism of drug action, parasitology, anaerobic bacteria and protozoa, pharmacology and toxicology, radiation sensitizers for use in radiotherapy, and the development of drugs for use in cancer in general.

Author : Carsten Nieder
Publisher : Springer Science & Business Media
ISBN 13 : 3642556132
Total Pages : 308 pages
Book Rating : 4.35/5 ( download)

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Download or read book Modification of Radiation Response written by Carsten Nieder and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes and summarizes the radiation responses of both normal and neoplastic tissues with a focus on rational strategies for the modification of these responses. Emerging data from molecular oncology and radiobiology are reviewed in depth. The book covers not only general principles of radiation-induced reactions but also a large number of preclinical and clinical data that will guide the reader through this complex and dynamic field and will provide valuable information for the development of further research projects.

Author : Henning Willers
Publisher : Springer Nature
ISBN 13 : 3030497011
Total Pages : 370 pages
Book Rating : 4.19/5 ( download)

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Download or read book Molecular Targeted Radiosensitizers written by Henning Willers and published by Springer Nature. This book was released on 2020-08-10 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Targeted Radiosensitizers: Opportunities and Challenges provides the reader with a comprehensive review of key pre-clinical research components required to identify effective radiosensitizing drugs. The book features discussions on the mechanisms and markers of clinical radioresistance, pre-clinical screening of targeted radiosensitizers, 3D radiation biology for studying radiosensitizers, in vivo determinations of local tumor control, genetically engineered mouse models for studying radiosensitizers, targeting the DNA damage response for radiosensitization, targeting tumor metabolism to overcome radioresistance, radiosensitizers in the era of immuno-oncology, and more. Additionally, the book features discussions on high-throughput drug screening, predictive biomarkers, pre-clinical tumor models, and the influence of the tumor microenvironment and the immune system, with a specific focus on the challenges radiation oncologists and medical oncologists currently face in testing radiosensitizers in human cancers. Edited by two acclaimed experts in radiation biology and radiosensitizers, with thirteen chapters contributed by experts, this new volume presents an in-depth look at current developments within a rapidly moving field, with a look at where the field will be heading and providing comprehensive insight into the framework of targeted radiosensitzer development. Essential reading for investigators in cancer research and radiation biology.

Author : Edward C. Halperin
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 9780781763691
Total Pages : 2152 pages
Book Rating : 4.9X/5 ( download)

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Download or read book Perez and Brady's Principles and Practice of Radiation Oncology written by Edward C. Halperin and published by Lippincott Williams & Wilkins. This book was released on 2008 with total page 2152 pages. Available in PDF, EPUB and Kindle. Book excerpt: The thoroughly updated fifth edition of this landmark work has been extensively revised to better represent the rapidly changing field of radiation oncology and to provide an understanding of the many aspects of radiation oncology. This edition places greater emphasis on use of radiation treatment in palliative and supportive care as well as therapy.

Author : Alain Tressaud
Publisher : Elsevier
ISBN 13 : 0080558119
Total Pages : 821 pages
Book Rating : 4.10/5 ( download)

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Download or read book Fluorine and Health written by Alain Tressaud and published by Elsevier. This book was released on 2008-06-06 with total page 821 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fluorine and Health presents a critical multidisciplinary overview on the contribution of fluorinated compounds to resolve the important global issue of medicinal monitoring and health care. The involved subjects are organized in three thematic parts devoted to Molecular Imaging, Biomedical Materials and Pharmaceuticals. Initially the key-position of partially fluorinated low molecular weight compounds labelled either with the natural 19F-isotope for Magnetic Resonance Imaging (MRI) or labelled with the radioactive [18F]-isotope for Positron Emission Tomography (PET) is highlighted. Both non-invasive methods belong to the most challenging in vivo imaging techniques in oncology, neurology and in cardiology for the diagnosis of diseases having the highest mortality in the industrialized countries. The manifold facets of fluorinated biomaterials range from inorganic ceramics to perfluorinated organic molecules. Liquid perfluorocarbons are suitable for oxygen transport and as potential respiratory gas carriers, while fluorinated polymers are connected to the pathology of blood vessels. Another important issue concerns the application of highly fluorinated liquids in ophthalmology. Moreover, fluorine is an essential trace element in bone mineral, dentine and tooth enamel and is applied for the prophylaxis and treatment of dental caries. The various origins of human exposure to fluoride species is detailed to promote a better understanding of the effect of fluoride species on living organisms.Medicinally relevant fluorinated molecules and their interactions with native proteins are the main focus of the third part. New molecules fluorinated in strategic position are crucial for the development of pharmaceuticals with desired action and optimal pharmacological profile. Among the hundreds of marketed active drug components there are more than 150 fluorinated compounds. The chapters will illustrate how the presence of fluorine atoms alters properties of bioactive compounds at various biochemical steps, and possibly facilitate its emergence as pharmaceuticals. Finally the synthetic potential of a fluorinase, the first C-F bond forming enzyme, is summarized. New approach of topics involving chemistry, biology and medicinal techniques Transdisciplinar papers on fluoride products Importance of fluoride products in health Updated data on specific topics

Author : Tsutomu Sugahara
Publisher :
ISBN 13 :
Total Pages : 576 pages
Book Rating : 4.59/5 ( download)

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Download or read book Modification of Radiosensitivity in Cancer Treatment written by Tsutomu Sugahara and published by . This book was released on 1984 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author :
Publisher :
ISBN 13 : 9789201114747
Total Pages : 156 pages
Book Rating : 4.45/5 ( download)

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Download or read book Advances in Chemical Radiosensitization written by and published by . This book was released on 1974 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: