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Author : James Blanchard
Publisher :
ISBN 13 :
Total Pages : 356 pages
Book Rating : 4.61/5 ( download)
Download or read book Principles and Perspectives in Drug Bioavailability written by James Blanchard and published by . This book was released on 1979 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Xiaoling Li
Publisher : John Wiley & Sons
ISBN 13 : 1118067584
Total Pages : 875 pages
Book Rating : 4.81/5 ( download)
Download or read book Oral Bioavailability written by Xiaoling Li and published by John Wiley & Sons. This book was released on 2011-08-04 with total page 875 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understand and assess the design, delivery, and efficacy of orally administered drugs A practical guide to understanding oral bioavailability, one of the major hurdles in drug development and delivery, Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications is designed to help chemists, biologists, life science researchers, pharmaceutical scientists, pharmacologists, clinicians, and graduate and students become familiar with the fundamentals and practices of the science of oral bioavailability. The difference in rate and extent between a drug taken orally and the actual amount of a drug reaching the circulatory system, oral bioavailability is an essential parameter for determining the efficacy and adverse effects of new and developing medications, as well as finding an optimal dosing regimen. This book provides a much-needed one-stop resource to help readers better understand and appreciate the many facets and complex problems of oral bioavailability, including the basic barriers to oral bioavailability, the methods used to determine relevant parameters, and the challenges of drug delivery. In addition, this comprehensive book discusses biological and physicochemical methods for improving bioavailability, integrates physicochemistry with physiology and molecular biology, and includes several state-of-the-art technologies and approaches Caco-2 cell culture model, MDCK, and other related cell culture models which are used to study the science of oral bioavailability.
Author : Han van de Waterbeemd
Publisher : John Wiley & Sons
ISBN 13 : 3527605150
Total Pages : 602 pages
Book Rating : 4.56/5 ( download)
Download or read book Drug Bioavailability written by Han van de Waterbeemd and published by John Wiley & Sons. This book was released on 2006-03-06 with total page 602 pages. Available in PDF, EPUB and Kindle. Book excerpt: The peroral application (swallowing) of a medicine means that the body must first resorb the active substance before it can begin to take effect. The efficacy of drug uptake depends on the one hand on the chemical characteristics of the active substance, above all on its solubility and membrane permeability. On the other hand, it is determined by the organism's ability to absorb pharmaceuticals by way of specific transport proteins or to excrete them. Since many pharmacologically active substances are poorly suited for oral intake, a decisive criterion for the efficacy of a medicine is its so-called bioavailability. Written by an international team from academia and the pharmaceutical industry, this book covers all aspects of the oral bioavailability of medicines. The focus is placed on methods for determining the parameters relevant to bioavailability. These range from modern physicochemical techniques via biological studies in vitro and in vivo right up to computer-aided predictions. The authors specifically address possibilities for optimizing bioavailability during the early screening stage for the active substance. Its clear structure and comprehensive coverage make this book equally suitable for researchers and lecturers in industry and teaching.
Author : World Health Organization. Scientific Group on the Bioavailability of Drugs
Publisher :
ISBN 13 :
Total Pages : 24 pages
Book Rating : 4.63/5 ( download)
Download or read book Bioavailability of Drugs: Principles and Problems written by World Health Organization. Scientific Group on the Bioavailability of Drugs and published by . This book was released on 1974 with total page 24 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : World Health Organization. Scientific Group on the Bioavailability of Drugs - Principles and Problems
Publisher :
ISBN 13 : 9780119506389
Total Pages : 17 pages
Book Rating : 4.86/5 ( download)
Download or read book Bioavailability of Drugs, Principles and Problems written by World Health Organization. Scientific Group on the Bioavailability of Drugs - Principles and Problems and published by . This book was released on 1974 with total page 17 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Jan Gajdziok
Publisher :
ISBN 13 : 9783668810464
Total Pages : 176 pages
Book Rating : 4.6X/5 ( download)
Download or read book Drug Solubility and Bioavailability Improvement. Possible Methods with Emphasis on Liquisolid Systems Formulation written by Jan Gajdziok and published by . This book was released on 2018-10-09 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: Document from the year 2018 in the subject Pharmacology, grade: 1, course: Pharmaceutical Technology, language: English, abstract: The aim of this book is to provide a brief but comprehensive overview on the issue of drug bioavailability improvement by preparation of a perspective dosage form - liquisolid systems. The introduction chapter about drug solubility and bioavailability is followed by a description of the general methods which could be used to improve drug bioavailability using approaches of chemistry, physical modification, and primarily pharmaceutical technology. Benefits and practical use of each method are documented by examples. The main part of the book is aimed at characterization and description of liquisolid systems (LSS) - perspective dosage form for bioavailability improvement. Elementary principles of LSS formulation are described in detail, e.g. how to perform a preformulation study; how to choose the correct type and amount of excipients; how to evaluate the dosage forms, etc. All the above mentioned principles are documented with practical examples. The book could be used as a textbook for students of natural, medical and pharmaceutical sciences as well as by researchers in this field or industrial area. Contemporary pharmacotherapy is characterized by the increasing amount of active substances that are only poorly soluble in water. This may lead to the limitation of their systemic absorption on oral administration which is closely related to the bioavailability. This category is estimated to include more than forty percent of active substances that are in general use. So far, this poor aqueous solubility has been improved by physical or chemical modification of the active substance. In general, such changes are very expensive and troublesome, often leading to problems in stability, marketing authorization process, or administration comfort of the particular drug. This is one of the reasons why modern pharmaceutical technology has focus
Download or read book Bioavailability of drugs: principles and problems written by and published by . This book was released on 1975 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Han van de Waterbeemd
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.75/5 ( download)
Download or read book Drug Bioavailability written by Han van de Waterbeemd and published by . This book was released on 2003 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Shiew-Mei Huang
Publisher : Academic Press
ISBN 13 : 0128198842
Total Pages : 764 pages
Book Rating : 4.41/5 ( download)
Download or read book Atkinson's Principles of Clinical Pharmacology written by Shiew-Mei Huang and published by Academic Press. This book was released on 2021-10-16 with total page 764 pages. Available in PDF, EPUB and Kindle. Book excerpt: Atkinson’s Principles of Clinical Pharmacology, Fourth Edition is the essential reference on the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development. This well-regarded survey continues to focus on the basics of clinical pharmacology for the development, evaluation and clinical use of pharmaceutical products while also addressing the most recent advances in the field. Written by leading experts in academia, industry, clinical and regulatory settings, the fourth edition has been thoroughly updated to provide readers with an ideal reference on the wide range of important topics impacting clinical pharmacology. Presents the essential knowledge for effective practice of clinical pharmacology Includes a new chapter and extended discussion on the role of personalized and precision medicine in clinical pharmacology Offers an extensive regulatory section that addresses US and international issues and guidelines Provides extended coverage of earlier chapters on transporters, pharmacogenetics and biomarkers, along with further discussion on "Phase 0" studies (microdosing) and PBPK
Author : Li Di
Publisher : Elsevier
ISBN 13 : 0080557619
Total Pages : 549 pages
Book Rating : 4.18/5 ( download)
Download or read book Drug-like Properties: Concepts, Structure Design and Methods written by Li Di and published by Elsevier. This book was released on 2010-07-26 with total page 549 pages. Available in PDF, EPUB and Kindle. Book excerpt: Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be less desirable as a drug product. This book is a tool and resource for scientists engaged in, or preparing for, the selection and optimization process. The authors describe how properties affect in vivo pharmacological activity and impact in vitro assays. Individual drug-like properties are discussed from a practical point of view, such as solubility, permeability and metabolic stability, with regard to fundamental understanding, applications of property data in drug discovery and examples of structural modifications that have achieved improved property performance. The authors also review various methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties. Serves as an essential working handbook aimed at scientists and students in medicinal chemistry Provides practical, step-by-step guidance on property fundamentals, effects, structure-property relationships, and structure modification strategies Discusses improvements in pharmacokinetics from a practical chemist's standpoint
