Physiology Biochemistry And Pharmacology Of Transporters For Organic Cations

Author : Giuliano Ciarimboli
Publisher : MDPI
ISBN 13 : 3036505628
Total Pages : 248 pages
Book Rating : 4.26/5 ( download)

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Download or read book Physiology, Biochemistry, and Pharmacology of Transporters for Organic Cations written by Giuliano Ciarimboli and published by MDPI. This book was released on 2021-06-24 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Membrane transporters are of vital importance for cells. They mediate the flux of many substances through the plasma membrane. In this book, the transporters for organic cations, a special class of membrane transporters, are presented. Transporters belonging to this class are important because they allow many neurotransmitters (e.g., histamine and serotonin) and many drugs (e.g., trospium and tofacitinib) to permeate the plasma membrane. Therefore, transporters for organic cations can modulate the action of neurotransmitters and drugs, having in this way important physiological and pharmacological implications. These aspects are illustrated in original works and reviews presented in this book. Using a system biology approach, the global significance of different transporters working together has been illustrated. Regulation mechanisms determining their expression in specific organs and modulating their function are also described in this book, also concerning their role for special drug toxicities. Such an aspect is also discussed in relationship to mutations (single nucleotide polymorphisms) of transporters for organic cations. Finally, the translational value of studies performed in flies, mice, and rats is discussed. Therefore, this book offers integrative information on transporters for organic cations, which may be of interest to beginners and specialized scientists in this field.

Author : Giuliano Ciarimboli
Publisher :
ISBN 13 : 9783036505633
Total Pages : 248 pages
Book Rating : 4.36/5 ( download)

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Download or read book Physiology, Biochemistry, and Pharmacology of Transporters for Organic Cations written by Giuliano Ciarimboli and published by . This book was released on 2021 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Membrane transporters are of vital importance for cells. They mediate the flux of many substances through the plasma membrane. In this book, the transporters for organic cations, a special class of membrane transporters, are presented. Transporters belonging to this class are important because they allow many neurotransmitters (e.g., histamine and serotonin) and many drugs (e.g., trospium and tofacitinib) to permeate the plasma membrane. Therefore, transporters for organic cations can modulate the action of neurotransmitters and drugs, having in this way important physiological and pharmacological implications. These aspects are illustrated in original works and reviews presented in this book. Using a system biology approach, the global significance of different transporters working together has been illustrated. Regulation mechanisms determining their expression in specific organs and modulating their function are also described in this book, also concerning their role for special drug toxicities. Such an aspect is also discussed in relationship to mutations (single nucleotide polymorphisms) of transporters for organic cations. Finally, the translational value of studies performed in flies, mice, and rats is discussed. Therefore, this book offers integrative information on transporters for organic cations, which may be of interest to beginners and specialized scientists in this field.

Author : Giuliano Ciarimboli
Publisher : Springer
ISBN 13 : 3319237934
Total Pages : 276 pages
Book Rating : 4.30/5 ( download)

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Download or read book Organic Cation Transporters written by Giuliano Ciarimboli and published by Springer. This book was released on 2015-12-17 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: This innovative text explores the cellular transport of organic cations, from functional and structural properties to pharmacological implications and psychiatric developments. The authoritative chapters introduce organic cation transporters and then proceed to discuss their mechanisms such as binding of substrates and inhibitors; their drug dispositions and toxicity; their relationships to genetic and pathophysiological variability; and their roles in endocrine, metabolic, and neurological systems. The final chapters delve into the use of animal models for the study of organic cation transporter function and their possible use in environmental cycling of pharmaceutical residues. This comprehensive volume unites integrative transporter physiology with structural and molecular biology, genetics, pharmacology and pathophysiology, offering a holistic approach to utilizing this novel technique in physiological contexts. It will prove invaluable reading for researchers and students in various areas of integrative, organ, cell and molecular physiology as well as pharmacologists and neurologists.

Author : Lynette C. Daws
Publisher : Springer Nature
ISBN 13 : 3030829847
Total Pages : 333 pages
Book Rating : 4.41/5 ( download)

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Download or read book Organic Cation Transporters in the Central Nervous System written by Lynette C. Daws and published by Springer Nature. This book was released on 2021-10-27 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rapidly growing interest in the role of organic cation transporters (OCTs) and plasma membrane monoamine transporter (PMAT) in central monoamine homeostasis makes this book especially timely, given its thematic alignment with the role of OCTs and PMAT in CNS. This book discusses latest insights into the field laying an emphasis on health, disease and therapeutics. The chapter, “General Overview of Organic Cation Transporters in Brain”, of this book is available open access under a CC BY 4.0 license at link.springer.com

Author :
Publisher : Springer Science & Business Media
ISBN 13 : 3540452079
Total Pages : 168 pages
Book Rating : 4.72/5 ( download)

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Download or read book Reviews of Physiology, Biochemistry and Pharmacology written by and published by Springer Science & Business Media. This book was released on 2007-05-02 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: H. Wegele, L. Müller, and J. Buchner: Hsp70 and Hsp90 - A Relay Team for Protein Folding R. Schülein: The Early Stages of the Intracellular Transport of Membrane Proteins: Clinical and Pharmacological Implications L. Schild: The Epithelial Sodium Channel: From Molecule to Disease.

Author :
Publisher : Springer
ISBN 13 : 9783662310755
Total Pages : 162 pages
Book Rating : 4.59/5 ( download)

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Download or read book Reviews of Physiology, Biochemistry and Pharmacology written by and published by Springer. This book was released on 2014-08-23 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Ashim Mitra
Publisher : John Wiley & Sons
ISBN 13 : 1118662849
Total Pages : 844 pages
Book Rating : 4.47/5 ( download)

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Download or read book Advanced Drug Delivery written by Ashim Mitra and published by John Wiley & Sons. This book was released on 2013-08-26 with total page 844 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides both fundamentals and new and emerging applications Advanced Drug Delivery brings readers fully up to date with the state of the science, presenting the basics, formulation strategies, and therapeutic applications of advanced drug delivery. The book demonstrates how core concepts of pharmaceutical sciences, chemistry, and molecular biology can be combined and applied in order to spark novel ideas to design and develop advanced drug delivery systems for the treatment of a broad range of human diseases. Advanced Drug Delivery features contributions from an international team of pharmaceutical scientists. Chapters reflect a thorough review and analysis of the literature as well as the authors' firsthand experience developing drug delivery systems. The book is divided into four parts: Part I, Introduction and Basics of Advanced Drug Delivery, explores physiological barriers, stability, transporters, and biomaterials in drug delivery Part II, Strategies for Advanced Drug Delivery, offers tested and proven strategies for advanced delivery of both small molecules and macromolecules Part III, Translational Research of Advanced Drug Delivery, focuses on regulatory considerations and translational applications of advanced drug delivery systems for the treatment of cardiovascular diseases, cancer, sexually transmitted diseases, ophthalmic diseases, and brain diseases Part IV, Future Applications of Advanced Drug Delivery in Emerging Research Areas, examines stem cell research, cell-based therapeutics, tissue engineering, and molecular imaging Each chapter provides objectives and assessment questions to help readers grasp key concepts and assess their knowledge as they progress through the book. Advanced Drug Delivery is recommended for graduates and upper-level undergraduates in the pharmaceutical sciences who need a solid foundation in the basics. It is also recommended for pharmaceutical professionals who want to take advantage of new and emerging applications in advanced drug delivery systems.

Author :
Publisher : Academic Press
ISBN 13 : 0128003383
Total Pages : 512 pages
Book Rating : 4.81/5 ( download)

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Download or read book Pharmacology of the Blood Brain Barrier: Targeting CNS Disorders written by and published by Academic Press. This book was released on 2014-10-21 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume of Advances in Pharmacology presents pharmacology of the blood brain barrier, focusing on targeting CNS disorders. With a variety of chapters and the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike. Contributions from the best authors in the field An essential resource for pharmacologists, immunologists, and biochemists

Author : M.A. Jakupec
Publisher : Springer Science & Business Media
ISBN 13 : 3540002286
Total Pages : 223 pages
Book Rating : 4.84/5 ( download)

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Download or read book Reviews of Physiology, Biochemistry and Pharmacology 146 written by M.A. Jakupec and published by Springer Science & Business Media. This book was released on 2003-03-25 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this volume of Reviews of Physiology there are three outstanding contributions, the first on Selenium-containing proteins in mammals and other forms of life, and the second on constitutively active and G-protein coupled inward rectifier K+ channels: Kir2.0 and Kir3.0 and the third on Chloroplast quest: a journey from the cytosol into the chloroplast and beyond.

Author : Miles Hacker
Publisher : Academic Press
ISBN 13 : 9780080919225
Total Pages : 608 pages
Book Rating : 4.27/5 ( download)

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Download or read book Pharmacology written by Miles Hacker and published by Academic Press. This book was released on 2009-06-19 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacology meets the rapidly emerging needs of programs training pharmacologic scientists seeking careers in basic research and drug discovery rather than such applied fields as pharmacy and medicine. While the market is crowded with many clinical and therapeutic pharmacology textbooks, the field of pharmacology is booming with the prospects of discovering new drugs, and virtually no extant textbook meets this need at the student level. The market is so bereft of such approaches that many pharmaceutical companies will adopt Hacker et al. to help train new drug researchers. The boom in pharmacology is driven by the recent decryption of the human genome and enormous progress in controlling genes and synthesizing proteins, making new and even custom drug design possible. This book makes use of these discoveries in presenting its topics, moving logically from drug receptors to the target molecules drug researchers seek, covering such modern topics along the way as side effects, drug resistance, pharmacogenomics, and even nutriceuticals, one in a string of culminating chapters on the drug discovery process. The book is aimed at advanced undergraduates and beginning graduate students in medical, pharmacy, and graduate schools looking for a solid introduction to the basic science of pharmacology and envisioning careers in drug research. Uses individual drugs to explain molecular actions Full color art program explains molecular and chemical concepts graphically Logical structure reflecting the current state of pharmacology and translational research Covers such intricacies as drug resistance and cell death Consistent format across chapters and pedagogical strategies make this textbook a superior learning tool