Neoadjuvant Immunotherapy Treatment Of Localized Genitourinary Cancers

Author : Andrea Necchi
Publisher : Springer Nature
ISBN 13 : 3030805468
Total Pages : 312 pages
Book Rating : 4.63/5 ( download)

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Download or read book Neoadjuvant Immunotherapy Treatment of Localized Genitourinary Cancers written by Andrea Necchi and published by Springer Nature. This book was released on 2022-01-03 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims to provide readers with a current overview of enrolling trials with immune-checkpoint inhibitors in the preoperative setting of localized bladder cancer, renal cell carcinoma, and prostate cancer. The advent of immunotherapy has revolutionized treatments of genitourinary malignancy and evolved strategies for multidisciplinary management. This book explains neoadjuvant checkpoint inhibitors in localized genitourinary cancers, providing insights into the mechanisms of response and development of resistance of cancer cells to immunotherapy. It debates optimal trial design of preoperative checkpoint inhibitors in GU tumors, including optimal endpoints and the role of pathologic response as a surrogate endpoint of survival. It also illuminates clinical management of patients with organ-confined GU tumors, such as side effect management and perioperative safety, before providing an overview of biomarker use for patient selection across the early-stage GU malignancies. Lastly, the book provides the reader with the most up-to-date data emerging from clinical trials involving immunotherapy in early-stage GU malignancies. Neoadjuvant Immunotherapy Treatment of Localized Genitourinary Cancers: Multidisciplinary Management provides a comprehensive review of the field, serving as a valuable resource for urologists, medical oncologists, pathologists, fellows in urologic oncology, upper-level residents training in urology and medical oncology, as well as pharmacists interested in RCC clinicians.

Author : Edouard J. Trabulsi
Publisher : Springer Nature
ISBN 13 : 3030520218
Total Pages : 303 pages
Book Rating : 4.12/5 ( download)

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Download or read book Chemotherapy and Immunotherapy in Urologic Oncology written by Edouard J. Trabulsi and published by Springer Nature. This book was released on 2020-09-29 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is designed to familiarize clinical practitioners in systemic therapy options and medical management of urologic malignancies including prostate cancer, bladder and upper tract urothelial carcinoma, and renal cell carcinoma. Organized by organ system, the text highlights new therapies such as novel forms of androgen deprivation, cytotoxic chemotherapy, immune check point and immunomodulatory agents, and targeted therapies. Written by experts in the field, the book also reviews current chemotherapy and immunotherapy regimens for genitourinary malignancies and discusses indications, outcomes, and toxicities, as well as clinical trial concepts. Each of the book’s chapters offers a bulleted box of clinical pearls on the particular role of the APP. Chemotherapy and Immunotherapy in Urologic Oncology: A Guide for the Advanced Practice Provider is a resource for urologists, uro-radiologists, medical clinicians and family practitioners alike, familiarizing its audiences with systemic therapy regimens for urologic malignancies, as well as their expected outcomes and side effects.

Author : Siamak Daneshmand
Publisher : Springer
ISBN 13 : 3319933396
Total Pages : 308 pages
Book Rating : 4.99/5 ( download)

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Download or read book Genitourinary Cancers written by Siamak Daneshmand and published by Springer. This book was released on 2018-08-31 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses the most pressing current questions in the management of urologic malignancies. The rapid advances in imaging and molecular markers are placed into a clinical context, with explanation of their effects on prognosis and treatment planning. Similarly, progress in immunotherapy is carefully examined, focusing in particular on the role of immune checkpoint inhibitors in both early- and late-stage urologic malignancies. Looking beyond the improvements in minimally invasive techniques for urologic cancers, the impacts of care coordination pathways and enhanced recovery after surgery protocols are reviewed. Readers will also find enlightening discussion of the decision algorithm for the treatment of early-stage, high-grade bladder cancer, taking into account evidence on the most advanced treatment options and the circumstances in which surgery may need to be expedited. The penultimate chapter discusses the Cancer Genome Atlas project for bladder cancer, and the book closes by considering contemporary medical and surgical management of testicular cancer.

Author : Nicholas Vogelzang
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 0781749840
Total Pages : 936 pages
Book Rating : 4.48/5 ( download)

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Download or read book Comprehensive Textbook of Genitourinary Oncology written by Nicholas Vogelzang and published by Lippincott Williams & Wilkins. This book was released on 2006 with total page 936 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thoroughly revised for its Third Edition, this volume is the most comprehensive, multidisciplinary text on genitourinary cancers. This edition has two new editors—Frans M.J. Debruyne and W. Marston Linehan—and more than 50% new contributors. Seventeen new chapters cover familial prostate cancer, biology of bone metastases, molecular pathology and biologic determinants, PSA and related kallikreins, needle biopsy, laparoscopic surgical procedures, 3D conformal radiotherapy, hormones and radiotherapy, integration of chemotherapy and other modalities, quality of life after treatment of localized prostate cancer, management of rising PSA after local therapy, the role of surgery in advanced bladder cancer, post-chemotherapy node dissections and resection of metastatic disease, and stem cell transplantation.

Author : Sujit S Nair
Publisher : Elsevier Health Sciences
ISBN 13 : 0323754996
Total Pages : 145 pages
Book Rating : 4.96/5 ( download)

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Download or read book Cancer Immunotherapy in Urology, An Issue of Urologic Clinics, E-Book written by Sujit S Nair and published by Elsevier Health Sciences. This book was released on 2020-10-15 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Guest Editors of this issue of Urologic Clinics of North America have put together a comprehensive collection of articles that provides the current knowledge on urologic cancer immunotherapy. Expert authors have contributed clinical review articles on the following topics: Era of personalized vaccines for GU cancers; TCR and dendritic vaccine platforms for GU cancers; Neo-adjuvant platforms for GU cancer immunotherapy; Immune-editing in Cancer: Role of tumor microenvironment and immune-suppressive pathways in localized and aggressive disease; Clinical integration of neo-adjuvant platforms for prostate cancer immunotherapy; Immunotherapy for muscle and non-muscle invasive bladder cancer: BCG and beyond; Immunotherapy for metastatic bladder cancer; Immunotherapy options for metastatic castrate-resistant prostate cancer; Role of tissue infiltrating lymphocytes: Understanding TCR; Therapeutic platforms for IPSC-derived CAR-T; Immune-suppression in prostate cancer: Underlying causes and influence on response to immunotherapy; and Racial disparity in response to immunotherapy. Urologists will come away with the most current information they need to improve outcomes in the urologic cancer patient.

Author : Lance Pagliaro
Publisher : Springer
ISBN 13 : 3319300466
Total Pages : 372 pages
Book Rating : 4.67/5 ( download)

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Download or read book Rare Genitourinary Tumors written by Lance Pagliaro and published by Springer. This book was released on 2016-06-28 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rare Genitourinary Tumors offers the reader an up-to-date discussion of the less common neoplasms affecting the urinary tract and reproductive organs. Each authoritative chapter provides and in-depth discussion that is frequently not found in other urologic oncology textbooks. A valuable reference for urologists, oncologists, and those in specialty training, this volume provides ready access to information on etiology, incidence, risk factors, diagnosis, prognosis, insights from molecular pathology and, where applicable, data from clinical trials. The practical treatment guidelines included for each tumor type are written by experts and fully referenced.

Author : Aung Naing
Publisher : Springer Nature
ISBN 13 : 3030793087
Total Pages : 445 pages
Book Rating : 4.81/5 ( download)

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Download or read book Immunotherapy written by Aung Naing and published by Springer Nature. This book was released on 2022-01-01 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of immuno-oncology continues to rapidly evolve as new insights to fight and treat cancer emerge. The fourth edition of Immunotherapy provides the most current overview of immuno-oncology in different cancer types and toxicities associated with immunotherapy. While immunotherapy has revolutionized the treatment landscape of several solid malignancies, several challenges still exist. Only a subset of patients derive clinical benefits; some do not respond at all, and others respond initially, only for their disease to progress later. Because these drugs can activate a broad range of immune cells, patients suffer from a unique set of side effects known as immune-related adverse events. As more immunotherapeutic agents are used in the clinic, it is important to provide updates about current and ongoing developments in the field to further research efforts and inform treatment decisions. The fourth edition will have a new focus on strategies to overcome the challenges associated with immunotherapy. Chapters will discuss topics such as biomarkers of response, resistance mechanisms, role of imaging in predicting immune-related adverse events, and management of immune-related adverse events. Written by leading experts conducting cutting-edge research, readers will gain up-to-date knowledge on the current state and future of immunotherapy.

Author : Frans M.J. Debruyne
Publisher : Springer
ISBN 13 : 9783540528357
Total Pages : 0 pages
Book Rating : 4.50/5 ( download)

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Download or read book Immunotherapy of Renal Cell Carcinoma written by Frans M.J. Debruyne and published by Springer. This book was released on 1991-01-29 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: With contributions by numerous experts

Author : Daniel M. Trifiletti
Publisher : Springer
ISBN 13 : 3319968092
Total Pages : 492 pages
Book Rating : 4.94/5 ( download)

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Download or read book Absolute Clinical Radiation Oncology Review written by Daniel M. Trifiletti and published by Springer. This book was released on 2019-01-22 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a quick reference guide for clinicians in radiation oncology. It is designed to be an intuitive and easily reviewed study guide for board or maintenance of certification examinations, as well as a quick reference for residents and established radiation oncologists who need a refresher. The text begins with a general pearls chapter that radiation oncologists should consider in all aspects of their practice, including cancer visibility, dosing, counseling recommendations, and toxicity management. The subsequent chapters then delve into different cancer disease sites, including pediatrics, central nervous system, head and neck, thoracic, breast, gastrointestinal, gynecologic, genitourinary, hematologic, soft tissue, palliative, and radiophysics/radiobiology. Within each chapter, each disease and its recommended approach is then summarized in only a few pages, allowing a focus on the most essential information. Bullet points, figures, tables, and images make for an intuitive reader experience. Recommendations are taken from the American Society for Radiation Oncology (ASTRO), the European Society for Radiation Oncology (ESTRO), and the National Comprehensive Cancer Network (NCCN). Planning guides for imaging, diagnosis, and staging offer readers a starting point in approaching each patient based on disease origin, and dosing guidelines then detail consideration for treatment methods. Each chapter additionally includes disease-specific pearls and key points to test the knowledge reviewed in the chapters. Experts in the disease sites from the United States serve as senior authors on each chapter. The authors include all diseases associated with radiation oncology training to ensure a comprehensive resource for exam studying and clinical care. Residents, trainees, and established radiation oncologists find this an ideal study resource for both board and certification exams, as well as an easily accessible aid during practice.

Author : Hui Dai
Publisher : Frontiers Media SA
ISBN 13 : 2832547109
Total Pages : 374 pages
Book Rating : 4.06/5 ( download)

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Download or read book Biomarkers and Immunotherapy for Genitourinary Tumors written by Hui Dai and published by Frontiers Media SA. This book was released on 2024-04-02 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genitourinary tumors consist of a large variety of malignancies located in the urinary and the reproductive systems, mainly including prostate cancer, bladder cancer, and renal tumors. Apart from surgeries, various systemic treatments have been used for the whole-course management of genitourinary tumors, including radiation therapy, chemotherapy, and hormonal therapy. However, the characteristics of progression, metastasis, and drug resistance deriving from tumors require and breed novel treatments. Furthermore, exploring biomarkers of genitourinary tumors at the early stage is also beneficial to strengthen the management of patients with tumors. Additionally, the diagnostic and prognostic value of the potential biomarkers for immunotherapy and combined therapy of genitourinary tumors are underexplored. On the basis of precision treatments, the advent of immune-based therapies, including immune checkpoint inhibitors (ICIs, antibodies targeting PD-L1 /PD-1 and CTLA-4 pathways), tumor vaccines, and other therapies, has extended the scope of treatment modalities. FDA has until now approved the clinical application of immune checkpoint inhibitors in a wide range of diseases including some types of genitourinary tumors, whereas not all patients with genitourinary tumors are suitable for immune-based therapies, therefore, the understanding of its underlying mechanism is key to develop effective treatments based on current ICI-based immunotherapy.