Metabolic Engineering

Author : Jens Nielsen
Publisher : Springer
ISBN 13 : 3540453008
Total Pages : 193 pages
Book Rating : 4.00/5 ( download)

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Download or read book Metabolic Engineering written by Jens Nielsen and published by Springer. This book was released on 2003-07-03 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolic engineering is a rapidly evolving field that is being applied for the optimization of many different industrial processes. In this issue of Advances in Biochemical Engineering/Biotechnology, developments in different areas of metabolic engineering are reviewed. The contributions discuss the application of metabolic engineering in the improvement of yield and productivity - illustrated by amino acid production and the production of novel compounds - in the production of polyketides and extension of the substrate range - and in the engineering of S. cerevisiae for xylose metabolism, and the improvement of a complex biotransformation process.

Author : Vipin Chandra Kalia
Publisher : Springer
ISBN 13 : 9811055114
Total Pages : 412 pages
Book Rating : 4.19/5 ( download)

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Download or read book Metabolic Engineering for Bioactive Compounds written by Vipin Chandra Kalia and published by Springer. This book was released on 2017-10-07 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book comprehensively discusses the latest research in the area of metabolic engineering. Metabolic engineering solutions for bioactive compounds are now being derived by means of heterologous gene expression, in a wide range of organisms. The book provides an overview of the model systems being employed for metabolic manipulation to yield bioactive molecules, such as single-cell proteins, antibody generation, metabolites, proteases, chaperones, therapeutic proteins, nanomaterials, polymeric conjugates, dendrimers and nanoassemblies, Escherichia coli, Agrobacterium, Saccharomyces cerevisiae and cell lines, etc. In addition, it shares insights into the scope of these methods in the areas of prevention, diagnosis and treatment of diseases, e.g. immunotherapy for curing various diseases like cancer, allergies, autoimmune diseases, etc.

Author : Sang Yup Lee
Publisher : John Wiley & Sons
ISBN 13 : 352782345X
Total Pages : 1075 pages
Book Rating : 4.51/5 ( download)

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Download or read book Metabolic Engineering written by Sang Yup Lee and published by John Wiley & Sons. This book was released on 2021-06-02 with total page 1075 pages. Available in PDF, EPUB and Kindle. Book excerpt: Learn more about foundational and advanced topics in metabolic engineering in this comprehensive resource edited by leaders in the field Metabolic Engineering: Concepts and Applications delivers a one-stop resource for readers seeking a complete description of the concepts, models, and applications of metabolic engineering. This guide offers practical insights into the metabolic engineering of major cell lines, including E. Coli, Bacillus and Yarrowia Lipolytica, and organisms, including human, animal, and plant). The distinguished editors also offer readers resources on microbiome engineering and the use of metabolic engineering in bioremediation. Written in two parts, Metabolic Engineering begins with the essential models and strategies of the field, like Flux Balance Analysis, Quantitative Flux Analysis, and Proteome Constrained Models. It also provides an overview of topics like Pathway Design, Metabolomics, and Genome Editing of Bacteria and Eukarya. The second part contains insightful descriptions of the practical applications of metabolic engineering, including specific examples that shed light on the topics within. In addition to subjects like the metabolic engineering of animals, humans, and plants, you’ll learn more about: Metabolic engineering concepts and a historical perspective on their development The different modes of analysis, including flux balance analysis and quantitative flux analysis An illuminating and complete discussion of the thermodynamics of metabolic pathways The Genome architecture of E. coli, as well as genome editing of both bacteria and eukarya An in-depth treatment of the application of metabolic engineering techniques to organisms including corynebacterial, bacillus, and pseudomonas, and more Perfect for students of biotechnology, bioengineers, and biotechnologists, Metabolic Engineering: Concepts and Applications also has a place on the bookshelves of research institutes, biotechnological institutes and industry labs, and university libraries. It's comprehensive treatment of all relevant metabolic engineering concepts, models, and applications will be of use to practicing biotechnologists and bioengineers who wish to solidify their understanding of the field.

Author : S Cortassa
Publisher : World Scientific
ISBN 13 : 9814489514
Total Pages : 264 pages
Book Rating : 4.15/5 ( download)

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Download or read book An Introduction to Metabolic and Cellular Engineering written by S Cortassa and published by World Scientific. This book was released on 2002-03-07 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolic and cellular engineering, as presented in this book, is a powerful alliance of two technologies: genetics–molecular biology and fermentation technology. Both are driven by continuous refinement of the basic understanding of metabolism, physiology and cellular biology (growth, division, differentiation), as well as the development of new mathematical modeling techniques. The authors' approach is original in that it integrates several disciplines into a coordinated scheme, i.e. microbial physiology and bioenergetics, thermodynamics and enzyme kinetics, biomathematics and biochemistry, genetics and molecular biology. Thus, it is called a transdisciplinary approach (TDA). The TDA provides the basis for the rational design of microorganisms or cells in a way that has rarely been utilized to its full extent. Contents:Matter and Energy BalancesCell Growth and Metabolite Production. Basic ConceptsMethods of Quantitation of Cellular “Processes Performance”Dynamic Aspects of Bioprocess BehaviorBioprocess Development with Plant CellsCellular Engineering Readership: Undergraduates, graduates and researchers in biomedical engineering, biochemistry and biotechnology. Keywords:Reviews:“The book provides very well selected examples that permit an easy comprehension of the achievements expected from the different techniques. I consider the book suitable for both experimentalists and theoreticians … it also provides an excellent selection of key references on the main techniques available in the field which are very useful for students and research workers.”Marta Cascante Serratosa Professor of Biochemistry and Molecular Biology University of Barcelona “A worked example towards the end of the book of the use of such a scheme was most welcome. The book is aimed at final year undergraduates and postgraduate researchers and is suitable for personal purchase.”Microbiology Today

Author : R. Verpoorte
Publisher : Springer Science & Business Media
ISBN 13 : 9401594236
Total Pages : 288 pages
Book Rating : 4.33/5 ( download)

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Download or read book Metabolic Engineering of Plant Secondary Metabolism written by R. Verpoorte and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plant secondary metabolism is an economically important source of fine chemicals, such as drugs, insecticides, dyes, flavours, and fragrances. Moreover, important traits of plants such as taste, flavour, smell, colour, or resistance against pests and diseases are also related to secondary metabolites. The genetic modification of plants is feasible nowadays. What does the possibility of engineering plant secondary metabolite pathways mean? In this book, firstly a general introduction is given on plant secondary metabolism, followed by an overview of the possible approaches that could be used to alter secondary metabolite pathways. In a series of chapters from various authorities in the field, an overview is given of the state of the art for important groups of secondary metabolites. No books have been published on this topic so far. This book will thus be a unique source of information for all those involved with plants as chemical factories of fine chemicals and those involved with the quality of food and ornamental plants. It will be useful in teaching graduate courses in the field of metabolic engineering in plants.

Author : Stephen Van Dien
Publisher : Springer
ISBN 13 : 3319419668
Total Pages : 122 pages
Book Rating : 4.64/5 ( download)

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Download or read book Metabolic Engineering for Bioprocess Commercialization written by Stephen Van Dien and published by Springer. This book was released on 2016-07-16 with total page 122 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume reviews the current metabolic engineering tools and technologies from a practical point of view, and guides researchers as they overcome challenges at various stages of organism and bioprocess development. Microbes have been engineered to produce a variety of industrial products such as fuels, basic chemicals, fine chemicals, nutritional supplements, and pharmaceutical intermediates, and new tools such as gene synthesis, advanced cloning techniques, ‘omics’ analysis, and mathematical modeling have greatly accelerated the pace of innovation in the field. Written by leading experts in the field from both academia and industry, key topics include synthetic biology, pathway engineering, metabolic flux manipulation, adaptive evolution, and fermentation process scale-up. It is suitable for non-specialists, and is a valuable resource for anyone embarking on the exciting path to harnessing the metabolic potential of microorganisms.

Author : Christoph Wittmann
Publisher : Springer Science & Business Media
ISBN 13 : 9400745346
Total Pages : 391 pages
Book Rating : 4.46/5 ( download)

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Download or read book Systems Metabolic Engineering written by Christoph Wittmann and published by Springer Science & Business Media. This book was released on 2012-06-15 with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systems Metabolic Engineering is changing the way microbial cell factories are designed and optimized for industrial production. Integrating systems biology and biotechnology with new concepts from synthetic biology enables the global analysis and engineering of microorganisms and bioprocesses at super efficiency and versatility otherwise not accessible. Without doubt, systems metabolic engineering is a major driver towards bio-based production of chemicals, materials and fuels from renewables and thus one of the core technologies of global green growth. In this book, Christoph Wittmann and Sang-Yup Lee have assembled the world leaders on systems metabolic engineering and cover the full story – from genomes and networks via discovery and design to industrial implementation practises. This book is a comprehensive resource for students and researchers from academia and industry interested in systems metabolic engineering. It provides us with the fundaments to targeted engineering of microbial cells for sustainable bio-production and stimulates those who are interested to enter this exiting research field.

Author : Abhishek Sharma
Publisher :
ISBN 13 : 9781685073626
Total Pages : 372 pages
Book Rating : 4.2X/5 ( download)

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Download or read book The Future of Metabolic Engineering written by Abhishek Sharma and published by . This book was released on 2022-01-20 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: The last two decades of scientific research have progressed to the point where metabolic engineering, which involves the modifying of metabolic pathways of animals, plants, and bacterial cells at biochemical and molecular levels, is feasible. Conceptually, metabolic engineering takes into account the identification of major blocks or control points in a metabolic pathway at the molecular level followed by removal of these limitations with the help of various cellular engineering interventions. Understanding the metabolic pathways requires appropriate experiment setup, molecular biology and biochemistry methods, computational modelling, data analysis, and interpretation to allow the researchers to manipulate them as per their needs. This book comprises a total of 12 chapters from multiple contributors of different countries around the world, including Brazil, Egypt, India, Saudi Arabia, and Turkey. This book provides deep insight into the past, present, and future of metabolic engineering in the animal, microbial, and plant system, communicating interdisciplinary research and relevant results in biochemistry, molecular biology, applied microbiology, cellular physiology, cellular nutrition in health and disease, and biochemical engineering.

Author : Huimin Zhao
Publisher : Springer
ISBN 13 : 3319553186
Total Pages : 322 pages
Book Rating : 4.84/5 ( download)

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Download or read book Synthetic Biology – Metabolic Engineering written by Huimin Zhao and published by Springer. This book was released on 2017-10-27 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book review series presents current trends in modern biotechnology. The aim is to cover all aspects of this interdisciplinary technology where knowledge, methods and expertise are required from chemistry, biochemistry, microbiology, genetics, chemical engineering and computer science. Volumes are organized topically and provide a comprehensive discussion of developments in the respective field over the past 3-5 years. The series also discusses new discoveries and applications. Special volumes are dedicated to selected topics which focus on new biotechnological products and new processes for their synthesis and purification. In general, special volumes are edited by well-known guest editors. The series editor and publisher will however always be pleased to receive suggestions and supplementary information. Manuscripts are accepted in English.

Author : Christine Nicole S. Santos
Publisher : Humana Press
ISBN 13 : 9781493991419
Total Pages : 252 pages
Book Rating : 4.18/5 ( download)

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Download or read book Microbial Metabolic Engineering written by Christine Nicole S. Santos and published by Humana Press. This book was released on 2019-02-21 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume covers a wide array of topics that will aid researchers in the task of engineering complex biological systems. This book is divided into three parts: Part One discusses the discovery and identification of relevant biosynthetic pathways for engineering; Part Two looks at the development of genetic tools for manipulating enzymes, biosynthetic pathways, and whole genomes; and Part Three covers the characterization of engineered microbes using targeted and global systems biology tools, as well as in silico models. Chapters explore topics such as leveraging enzyme promiscuity to construct novel biosynthetic pathways; assembling combinatorial multigene pathways for rapid strain optimization; applying 'omics technologies for identifying bottlenecks; and engineering nontraditional host organisms like cyanobacterium and Yarrowia lipolytica. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting edge and authoritative, Microbial Metabolic Engineering: Methods and Protocols is a valuable resource for researchers and scientists interested in engineering and optimizing microbes for a variety of biotechnological applications.