Membranes To Molecular Machines

Author : Mathias Grote
Publisher : University of Chicago Press
ISBN 13 : 022662515X
Total Pages : 307 pages
Book Rating : 4.57/5 ( download)

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Download or read book Membranes to Molecular Machines written by Mathias Grote and published by University of Chicago Press. This book was released on 2019-07-09 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: Today's science tells us that our bodies are filled with molecular machinery that orchestrates all sorts of life processes. When we think, microscopic "channels" open and close in our brain cell membranes; when we run, tiny "motors" spin in our muscle cell membranes; and when we see, light operates "molecular switches" in our eyes and nerves. A molecular-mechanical vision of life has become commonplace in both the halls of philosophy and the offices of drug companies, where researchers are developing “proton pump inhibitors” or medicines similar to Prozac. Membranes to Molecular Machines explores just how late twentieth-century science came to think of our cells and bodies this way. This story is told through the lens of membrane research, an unwritten history at the crossroads of molecular biology, biochemistry, physiology, and the neurosciences, that directly feeds into today's synthetic biology as well as nano- and biotechnology. Mathias Grote shows how these sciences not only have made us think differently about life, they have, by reworking what membranes and proteins represent in laboratories, allowed us to manipulate life as "active matter" in new ways. Covering the science of biological membranes in the United States and Europe from the mid-1960s to the 1990s, this book connects that history to contemporary work with optogenetics, a method for stimulating individual neurons using light, and will enlighten and provoke anyone interested in the intersection of chemical research and the life sciences—from practitioner to historian to philosopher.

Author : Ron Milo
Publisher : Garland Science
ISBN 13 : 1317230698
Total Pages : 400 pages
Book Rating : 4.94/5 ( download)

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Download or read book Cell Biology by the Numbers written by Ron Milo and published by Garland Science. This book was released on 2015-12-07 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Top 25 CHOICE 2016 Title, and recipient of the CHOICE Outstanding Academic Title (OAT) Award. How much energy is released in ATP hydrolysis? How many mRNAs are in a cell? How genetically similar are two random people? What is faster, transcription or translation?Cell Biology by the Numbers explores these questions and dozens of others provid

Author : Peter M. Hoffmann
Publisher :
ISBN 13 : 0465022537
Total Pages : 290 pages
Book Rating : 4.33/5 ( download)

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Download or read book Life's Ratchet written by Peter M. Hoffmann and published by . This book was released on 2012-10-30 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: Life, Hoffman argues, emerges from the random motions of atoms filtered through the sophisticated structures of our evolved machinery. People are essentially giant assemblies of interacting nanoscale machines.

Author : Benoît Roux
Publisher : World Scientific
ISBN 13 : 9814343463
Total Pages : 288 pages
Book Rating : 4.66/5 ( download)

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Download or read book Molecular Machines written by Benoît Roux and published by World Scientific. This book was released on 2011 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ch. 1. Molecular behavior in biological cells : the bacterial cytoplasm as a model system / Adrian H. Elcock and Andrew S. Thomas -- ch. 2. The light-harvesting apparatus in purple photosynthetic bacteria : introduction to a quantum biological device / Johan Strumpfer [und weitere] -- ch. 3. DNA polymerases : structure, function, and modeling / Tamar Schlick -- ch. 4. Information processing by nanomachines : decoding by the ribosome / Karissa Y. Sanbonmatsu, Scott C. Blanchard and Paul C. Whitford -- ch. 5. Chaperonins : the machines which fold proteins / Del Lucent, Martin C Stumpe and Vijay S Pande -- ch. 6. Muscle and myosin / Ronald S. Rock -- ch. 7. Protein kinases : phosphorylation machines / Elaine E. Thompson, Susan S. Taylor and J. Andrew McCammon -- ch. 8. Computational studies of Na+/H+ antiporter : structure, dynamics and function / Assaf Ganoth, Raphael Alhadeff and Isaiah T. Arkin -- ch. 9. Membrane transporters : molecular machines coupling cellular energy to vectorial transport across the membrane / Zhijian Huang [und weitere] -- ch. 10. ABC transporters / E.P. Coll and D.P. Tieleman -- ch. 11. Sodium-coupled secondary transporters : insights from structure-based computations / Elia Zomot [und weitere] -- ch. 12. Voltage-gated ion channels : the machines responsible for the nerve impulse / Benoit Roux and Francisco Bezanilla -- ch. 13. Voltage-gated channels and the heart / Jonathan R. Silva and Yoram Rudy

Author :
Publisher : Elsevier
ISBN 13 : 0443136920
Total Pages : 318 pages
Book Rating : 4.24/5 ( download)

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Download or read book The Enzymes written by and published by Elsevier. This book was released on 2023-11-07 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Enzymes, Volume 54 highlights new advances in enzymes, with new chapters on a variety of topics, including the History of The Enzymes, Impact of The Enzymes in chronicling biochemical processes and pathways, Metabolism and Catalysis, Mitochondrial ATP synthase, The respiratory chain, A century of mitochondrial research, Five decades of metalloenzymology, Mechanisms of catalysis, Mitochondrial fatty acid synthesis and associated processes, Signaling, MAPK cascades: Origins, mechanisms and current status, Sphingolipids: From structural components to signaling hubs, Protein Homeostasis and Hydrolysis, Mitochondrial AAA+ proteases, Hsp70 and JDP proteins: structure-function perspective on molecular chaperone activity. Other sections cover DNA Replication and Repair, Structure-function studies of DNA replication proteins, and Helicases required for nucleotide excision repair. Provides the authority and expertise of leading contributors from an international board of authors Updated release includes the latest information on enzymes

Author : Bruce Alberts
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.81/5 ( download)

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Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Carmen Domene
Publisher : Royal Society of Chemistry
ISBN 13 : 1782626697
Total Pages : 264 pages
Book Rating : 4.95/5 ( download)

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Download or read book Computational Biophysics of Membrane Proteins written by Carmen Domene and published by Royal Society of Chemistry. This book was released on 2016-11-30 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Exploring current themes in modern computational and membrane protein biophysics, this book presents a comprehensive account of the fundamental principles underlying different methods and techniques used to describe the intriguing mechanisms by which membrane proteins function. The book discusses the experimental approaches employed to study these proteins, with chapters reviewing recent crucial structural advances that have allowed computational biophysicists to discern how these molecular machines work. The book then explores what computational methods are available to researchers and what these have taught us about three key families of membrane proteins: ion channels, transporters and receptors. The book is ideal for researchers in computational chemistry and computational biophysics.

Author : Mårten Wikström
Publisher : Royal Society of Chemistry
ISBN 13 : 1782628657
Total Pages : 396 pages
Book Rating : 4.51/5 ( download)

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Download or read book Mechanisms of Primary Energy Transduction in Biology written by Mårten Wikström and published by Royal Society of Chemistry. This book was released on 2017-11-28 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the events of primary energy transduction in life processes. Life as we know it depends on pumping protons across membranes. New tools to study the protein complexes involved has led to recent intensified progress in the field. Primary Energy Transduction in Biology focusses on recent structural results and new biophysical insights. These have been made possible by recent advances in high-resolution protein structures, in physical techniques to study reactions in real time, and in computational methods to study and refine both structures and their dynamics. Written and edited by leading experts, chapters discuss the latest key questions in cell respiration, photosynthesis, bioenergetics, proton transfer, electron transfer and membrane transport. Biochemists, biophysicists and chemical biologists will find this book an essential resource for a complete understanding of the molecular machines of bioenergetics.

Author : William Hoiles
Publisher : Cambridge University Press
ISBN 13 : 1108423507
Total Pages : 475 pages
Book Rating : 4.02/5 ( download)

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Download or read book Dynamics of Engineered Artificial Membranes and Biosensors written by William Hoiles and published by Cambridge University Press. This book was released on 2018-05-03 with total page 475 pages. Available in PDF, EPUB and Kindle. Book excerpt: A state-of-the-art guide to building synthetic membranes for biological devices, covering their construction, measurement, and modelling.

Author : Karl S. Matlin
Publisher : University of Chicago Press
ISBN 13 : 0226819345
Total Pages : 367 pages
Book Rating : 4.41/5 ( download)

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Download or read book Crossing the Boundaries of Life written by Karl S. Matlin and published by University of Chicago Press. This book was released on 2022-05-10 with total page 367 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The difficulty of reconciling chemical mechanisms with the functions of whole living systems has plagued biologists since the development of cell theory in the nineteenth century. As Karl Matlin argues in Crossing the Boundaries of Life, it is no coincidence that this longstanding knot of scientific inquiry was loosened most meaningfully by the work of a cytologist, the Nobel laureate Günter Blobel. In 1975, using an experimental setup that did not contain any cells at all, Blobel was able to synthesize proteins to theorize how proteins in the cell communicate spatially, an idea he called signal hypothesis. Over the next 20 years, Blobel and other scientists were able to dissect this process into its precise molecular details. For elaborating his signal concept into a process he termed membrane topogenesis-the idea that each protein in the cell is synthesized with an "address" that directs the protein to its correct destination within the cell-Blobel was awarded the Nobel Prize in Physiology or Medicine in 1999. Matlin argues that Blobel's investigative strategy and its subsequent application addressed the fundamental unresolved dilemma that had bedeviled biology from its very beginning, allowing biology to overcome the barrier that had long blocked progress toward mechanistic explanations of life. Crossing the Boundaries of Life thus uses Blobel's research and life story to shed light on the importance of cell biology for twentieth-century science, illustrating how it propelled the development of adjacent disciplines like biochemistry and molecular biology"--