Genetics And Pathophysiology Of Essential Hypertension

Author : Madhu Khullar
Publisher : BoD – Books on Demand
ISBN 13 : 9535102826
Total Pages : 250 pages
Book Rating : 4.23/5 ( download)

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Download or read book Genetics and Pathophysiology of Essential Hypertension written by Madhu Khullar and published by BoD – Books on Demand. This book was released on 2012-03-09 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, authored by renowned researchers in the field of Hypertension Research, details the state of the art knowledge in genetics, genomics and pathophysiology of Essential hypertension, specifically the genetic determinants of hypertension and role of gene variants in response to anti-hypertensive therapy. Two chapters describe mitochondrial mutations in Essential hypertension and in hypertension associated Left ventricular hypertrophy, one chapter reviews in detail the global gene expression in hypertension, and an up to date treatise on pathophysiology of resistant hypertension is detailed in another chapter. Other topics included in the book are end organ damage, baroreceptor sensitivity and role of music therapy in essential hypertension.

Author : Madhu Khullar
Publisher :
ISBN 13 : 9789535152347
Total Pages : 248 pages
Book Rating : 4.43/5 ( download)

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Download or read book Genetics and Pathophysiology of Essential Hypertension written by Madhu Khullar and published by . This book was released on 2012 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, authored by renowned researchers in the field of Hypertension Research, details the state of the art knowledge in genetics, genomics and pathophysiology of Essential hypertension, specifically the genetic determinants of hypertension and role of gene variants in response to anti-hypertensive therapy. Two chapters describe mitochondrial mutations in Essential hypertension and in hypertension associated Left ventricular hypertrophy, one chapter reviews in detail the global gene expression in hypertension, and an up to date treatise on pathophysiology of resistant hypertension is detailed in another chapter. Other topics included in the book are end organ damage, baroreceptor sensitivity and role of music therapy in essential hypertension.

Author : Anna F. Dominiczak
Publisher : Elsevier Health Sciences
ISBN 13 : 0444514562
Total Pages : 284 pages
Book Rating : 4.61/5 ( download)

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Download or read book Genetics of Hypertension written by Anna F. Dominiczak and published by Elsevier Health Sciences. This book was released on 2007-01-01 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Classic and modern tools of genetics have been applied to hypertension research for some 20 years. This volume in the Handbook of Hypertension series aims to go beyond a simple summary of discoveries and provides a critical commentary on many controversial issues. It will be particularly useful for clinician scientists at all stages of their careers, graduate students and post-doctoral scientists as well as all those interested in cardiovascular medicine and research throughout the entire spectrum from bench to bedside. As in every relatively young area of research, the initial excitement over the early positive observations has not always been confirmed by subsequent larger studies with greater statistical power. Issues related to current recommendations on design of studies and their analysis are therefore included. Pharmacogenetics and pharmacogenomics have been the subjects of many debates in recent years and are of particular importance in hypertension as life-long treatments, frequently with multiple drugs are given to millions of people world-wide. A critical appraisal of this controversial topic is provided. Several chapters on experimental genetics of hypertension with a special focus on physiological genomics are also included.

Author : George S. Stergiou
Publisher : Springer Nature
ISBN 13 : 3030230651
Total Pages : 174 pages
Book Rating : 4.54/5 ( download)

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Download or read book Home Blood Pressure Monitoring written by George S. Stergiou and published by Springer Nature. This book was released on 2019-10-31 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hypertension remains a leading cause of disability and death worldwide. Self-monitoring of blood pressure by patients at home is currently recommended as a valuable tool for the diagnosis and management of hypertension. Unfortunately, in clinical practice, home blood pressure monitoring is often inadequately implemented, mostly due to the use of inaccurate devices and inappropriate methodologies. Thus, the potential of the method to improve the management of hypertension and cardiovascular disease prevention has not yet been exhausted. This volume presents the available evidence on home blood pressure monitoring, discusses its strengths and limitations, and presents strategies for its optimal implementation in clinical practice. Written by distinguished international experts, it offers a complete source of information and guide for practitioners and researchers dealing with the management of hypertension.

Author : Duncan Milner
Publisher :
ISBN 13 : 9781632393197
Total Pages : 0 pages
Book Rating : 4.90/5 ( download)

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Download or read book Essential Hypertension written by Duncan Milner and published by . This book was released on 2015-02-16 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book deals with the field of hypertension study. The book offers a broad overview comprising the intricate aspects of the subject. It details the modern developments in genetics and pathophysiology of hypertension, specially the genetic determinants of hypertension and function of gene variants in response to anti-hypertensive treatment. It thoroughly analyzes mitochondrial alterations in vital hypertension and left ventricular hypertrophy. The book explains the universal gene appearance in hypertension. Furthermore, it presents the latest research on pathophysiology of defiant hypertension. Several other topics such as treating organ injuries and the purpose of music therapy in essential hypertension are explained in this book.

Author : Sunil Nadar
Publisher :
ISBN 13 : 0198701977
Total Pages : 209 pages
Book Rating : 4.72/5 ( download)

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Download or read book Hypertension written by Sunil Nadar and published by . This book was released on 2015 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: The management of hypertension varies considerably from clinician to clinician. This pocketbook is a concise and evidence-based summary of current understanding and practice, including the most up-to-date guidance from national bodies and their recommendations for hypertension care. An essential tool for everyday use in managing hypertension, this book covers the different phases of investigation and definitive management, and aids clinical decision-making by collating all the relevant information and guidance in one easily accessible place.

Author : Maria Dorobantu
Publisher : Springer
ISBN 13 : 3319933205
Total Pages : 408 pages
Book Rating : 4.07/5 ( download)

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Download or read book Hypertension and Heart Failure written by Maria Dorobantu and published by Springer. This book was released on 2019-03-30 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explains how hypertension affects 20-50% of the adult population in developed countries. Heart failure is the result of the hypertension's effects on the heart and it represents a growing public health problem. In this context the international scientific community is continuously struggling to develop better strategies in screening, diagnosing and treating hypertension and its deleterious effects. Thus, this field is continuously changing, with new important information being added constantly. This volume will offer both insights into the intimate mechanisms of transition from hypertension to heart failure and clinical practice advice on the prevention and treatment of heart failure in hypertensive population. The mechanisms which explain the progression from hypertension to heart failure will be also covered exhaustively by offering two chapters referring to the diagnosis of heart failure in hypertensive population and one regarding echocardiography which is the most frequently used imaging method in clinical practice. The reader will be also provided with information on cardiovascular magnetic resonance which has the unique advantage of differentiating hypertensive heart failure from other pathologies associated with increased myocardial thickness. This book is a useful tool for clinicians but also to the research community interested in heart failure and consequences of hypertension on heart who want to be up-to-date with the new developments in the field.

Author : Xi Cheng
Publisher : Biota Publishing
ISBN 13 : 161504695X
Total Pages : 67 pages
Book Rating : 4.59/5 ( download)

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Download or read book Genetics of Hypertension written by Xi Cheng and published by Biota Publishing. This book was released on 2015-08-01 with total page 67 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hypertension, or elevated blood pressure, is a major risk factor for various cardiovascular, renal diseases, and stroke. The form of hypertension with no identifiable cause is referred to as Essential Hypertension. Familial studies indicate that Essential Hypertension is heritable and, thereby, classical genetic approaches have been applied on both human and other mammalian models of hypertension to map the locations of the allelic variants within quantitative trait loci for blood pressure. The post genome era has further elevated this area of research into large-scale genome-wide association studies of hypertension in humans. Collectively, these studies have resulted in the prioritization and cataloging of several genomic regions containing allelic variants as candidates linked or associated with essential hypertension. Further, they are providing evidence to suggest that the inheritance of hypertension is rather complex, encompassing multiple variants both within protein-coding and non-coding annotations, each of which may act independently or interactively with other genes and/or environmental factors to differentially regulate blood pressure. This book provides an overview of the various methods employed to study the genetics of hypertension and discuss the progress and prospects of this area of research that may contribute towards individualized clinical management of hypertension in the future.

Author : Paul I. Korner
Publisher : Oxford University Press
ISBN 13 : 019535740X
Total Pages : 717 pages
Book Rating : 4.00/5 ( download)

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Download or read book Essential Hypertension and Its Causes written by Paul I. Korner and published by Oxford University Press. This book was released on 2007-05-11 with total page 717 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new account of the pathogenesis of essential hypertension (EH) represents a detailed analysis of the main components of the circulatory control system. The latter's properties resemble those of man-made adaptive control systems in which regulatory parameters are altered when operating conditions exceed certain limits, often through neural mechanisms. Inheritance of EH depends on both genes and environment. The high blood pressure (BP) genes have not yet been definitively identified, whilst the main environmental causes are mental stress, high dietary salt intake and obesity. EH occurs as two major syndromes, each initiated by chronic stress: 1) Stress-and-salt related EH, and 2) Hypertensive obesity. Stress is perceived by the cortex, from which increased dopaminergic (DA) neuron activity stimulates the hypothalamic defense area, raising sympathetic neural activity (SNA) and BP. Normally these subside quickly when the stress is over, but in those susceptible to EH the DA synapses become sensitized so that the defense response is evoked by ever lower levels of stress. Sensitization is common in memory circuits, but not in autonomic neurons, so that this property in EH may be genetically determined. Stress-related hypertension increases hypothalamic responsiveness to high salt, resulting in further rises in SNA and BP. Later, non-neural functional changes (e.g. reduction in nitric oxide) and the structural remodeling of resistance vessels further enhance the vasoconstriction. In contrast, in those developing hypertensive obesity food consumption is excessive, which transiently alleviates stress-related anxiety. The brain ignores the leptin-mediated signals that normally curb appetite, contrasting with normal energy regulation in SSR-EH. In hypertensive obesity, the SNA pattern is similar to that in SSR-EH, but vasoconstriction is masked by vasodilatation and fluid retention due to hyperinsulinemia. This syndrome is a volume overload hypertension, where high cardiac output, renal impairment and other non-neural factors contribute to the elevation of BP. Other topics include the role of various transmitters in autonomic regulation; the place of baroreflexes in the intact organism; why exercise training lowers resting BP; obstructive sleep apnea; non-pharmacological and drug treatment of EH; the role of the kidney in EH and in different types of renal hypertension and the pathogenesis of the Japanese spontaneously hypertensive rat, which provides a valuable animal model for EH. The work suggests that physiological systems analysis in a complex disorder like EH is a valuable tool for using the great advances in molecular biology to best advantage.

Author : Paolo Mulatero
Publisher : MDPI
ISBN 13 : 3039366270
Total Pages : 200 pages
Book Rating : 4.79/5 ( download)

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Download or read book Role of Genomics in the Management of Hypertension written by Paolo Mulatero and published by MDPI. This book was released on 2021-01-21 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: Arterial hypertension affects about 1 billion people worldwide and it is the strongest modifiable risk factor for cardiovascular disease and related disability. Since the initial discovery of rare monogenic disorders with large effects, the role of genomics has evolved into large genome-wide association studies detecting common variants with a modest effect size. Similarly, pharmacogenomics has emerged as a new tool for understanding variability in drug response, to maximize efficacy and reduce toxicity. This book presents the most recent advances in the field of genetics and genomics of arterial hypertension and their potential impact on clinical management. The book is a useful tool for clinicians but also to the research community and those who want to be updated in the field.