Evidence Biased Antidepressant Prescription

Author : Michael P. Hengartner
Publisher :
ISBN 13 : 9783030825881
Total Pages : 0 pages
Book Rating : 4.84/5 ( download)

DOWNLOAD NOW!

Download or read book Evidence-biased Antidepressant Prescription written by Michael P. Hengartner and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses the over-prescribing of antidepressants in people with mostly mild and subthreshold depression. It outlines the steep increase in antidepressant prescription and critically examines the current scientific evidence on the efficacy and safety of antidepressants in depression. The book is not only concerned with the conflicting views as to whether antidepressants are useful or ineffective in various forms of depression, but also aims at detailing how flaws in the conduct and reporting of antidepressant trials have led to an overestimation of benefits and underestimation of harms. The transformation of the diagnostic concept of depression from a rare but serious disorder to an over-inclusive, highly prevalent but predominantly mild and self-limiting disorder is central to the books argument. It maintains that biological reductionism in psychiatry and pharmaceutical marketing reframed depression as a brain disorder, corroborating the overemphasis on drug treatment in both research and practice. Finally, the author goes on to explore how pharmaceutical companies have distorted the scientific literature on the efficacy and safety of antidepressants and how patient advocacy groups, leading academics, and medical organisations with pervasive financial ties to the industry helped to promote systematically biased benefit-harm evaluations, affecting public attitudes towards antidepressants as well as medical education, training, and practice. Michael P. Hengartner is a senior researcher and lecturer at the Zurich University of Applied Sciences, Switzerland. He has published over 130 peer-reviewed journal articles and four book chapters. He was an expert evaluator for the European Research Council and the World Health Organization and currently is a member of the Swiss School of Public Health, the German Society for Social Psychiatry, and the European Public Health Association.

Author : Michael P. Hengartner
Publisher : Springer Nature
ISBN 13 : 3030825876
Total Pages : 355 pages
Book Rating : 4.74/5 ( download)

DOWNLOAD NOW!

Download or read book Evidence-biased Antidepressant Prescription written by Michael P. Hengartner and published by Springer Nature. This book was released on 2021-12-09 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses the over-prescribing of antidepressants in people with mostly mild and subthreshold depression. It outlines the steep increase in antidepressant prescription and critically examines the current scientific evidence on the efficacy and safety of antidepressants in depression. The book is not only concerned with the conflicting views as to whether antidepressants are useful or ineffective in various forms of depression, but also aims at detailing how flaws in the conduct and reporting of antidepressant trials have led to an overestimation of benefits and underestimation of harms. The transformation of the diagnostic concept of depression from a rare but serious disorder to an over-inclusive, highly prevalent but predominantly mild and self-limiting disorder is central to the books argument. It maintains that biological reductionism in psychiatry and pharmaceutical marketing reframed depression as a brain disorder, corroborating the overemphasis on drug treatment in both research and practice. Finally, the author goes on to explore how pharmaceutical companies have distorted the scientific literature on the efficacy and safety of antidepressants and how patient advocacy groups, leading academics, and medical organisations with pervasive financial ties to the industry helped to promote systematically biased benefit-harm evaluations, affecting public attitudes towards antidepressants as well as medical education, training, and practice.

Author : Irving Kirsch
Publisher : Basic Books
ISBN 13 : 0465021042
Total Pages : 240 pages
Book Rating : 4.48/5 ( download)

DOWNLOAD NOW!

Download or read book The Emperor's New Drugs written by Irving Kirsch and published by Basic Books. This book was released on 2010-01-26 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Do antidepressants work? Of course—everyone knows it. Like his colleagues, Irving Kirsch, a researcher and clinical psychologist, for years referred patients to psychiatrists to have their depression treated with drugs before deciding to investigate for himself just how effective the drugs actually were. Over the course of the past fifteen years, however, Kirsch's research—a thorough analysis of decades of Food and Drug Administration data—has demonstrated that what everyone knew about antidepressants was wrong. Instead of treating depression with drugs, we've been treating it with suggestion. The Emperor's New Drugs makes an overwhelming case that what had seemed a cornerstone of psychiatric treatment is little more than a faulty consensus. But Kirsch does more than just criticize: he offers a path society can follow so that we stop popping pills and start proper treatment for depression.

Author : Daniel Carlat
Publisher : Simon and Schuster
ISBN 13 : 9781416596356
Total Pages : 272 pages
Book Rating : 4.56/5 ( download)

DOWNLOAD NOW!

Download or read book Unhinged written by Daniel Carlat and published by Simon and Schuster. This book was released on 2010-05-18 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: IN THIS STIRRING AND BEAUTIFULLY WRITTEN WAKE-UP CALL, psychiatrist Daniel Carlat exposes deeply disturbing problems plaguing his profession, revealing the ways it has abandoned its essential purpose: to understand the mind, so that psychiatrists can heal mental illness and not just treat symptoms. As he did in his hard-hitting and widely read New York Times Magazine article "Dr. Drug Rep," and as he continues to do in his popular watchdog newsletter, The Carlat Psychiatry Report, he writes with bracing honesty about how psychiatry has so largely forsaken the practice of talk therapy for the seductive—and more lucrative—practice of simply prescribing drugs, with a host of deeply troubling consequences. Psychiatrists have settled for treating symptoms rather than causes, embracing the apparent medical rigor of DSM diagnoses and prescription in place of learning the more challenging craft of therapeutic counseling, gaining only limited understanding of their patients’ lives. Talk therapy takes time, whereas the fifteen-minute "med check" allows for more patients and more insurance company reimbursement. Yet DSM diagnoses, he shows, are premised on a good deal less science than we would think. Writing from an insider’s perspective, with refreshing forthrightness about his own daily struggles as a practitioner, Dr. Carlat shares a wealth of stories from his own practice and those of others that demonstrate the glaring shortcomings of the standard fifteen-minute patient visit. He also reveals the dangers of rampant diagnoses of bipolar disorder, ADHD, and other "popular" psychiatric disorders, and exposes the risks of the cocktails of medications so many patients are put on. Especially disturbing are the terrible consequences of overprescription of drugs to children of ever younger ages. Taking us on a tour of the world of pharmaceutical marketing, he also reveals the inner workings of collusion between psychiatrists and drug companies. Concluding with a road map for exactly how the profession should be reformed, Unhinged is vital reading for all those in treatment or considering it, as well as a stirring call to action for the large community of psychiatrists themselves. As physicians and drug companies continue to work together in disquieting and harmful ways, and as diagnoses—and misdiagnoses—of mental disorders skyrocket, it’s essential that Dr. Carlat’s bold call for reform is heeded.

Author : Peter D. Kramer
Publisher : Penguin
ISBN 13 : 0140266712
Total Pages : 481 pages
Book Rating : 4.19/5 ( download)

DOWNLOAD NOW!

Download or read book Listening to Prozac written by Peter D. Kramer and published by Penguin. This book was released on 1997-09-01 with total page 481 pages. Available in PDF, EPUB and Kindle. Book excerpt: The New York Times bestselling examination of the revolutionary antidepressant, with a new introduction and afterword reflecting on Prozac’s legacy and the latest medical research “Peter Kramer is an analyst of exceptional sensitivity and insight. To read his prose on virtually any subject is to be provoked, enthralled, illuminated.” —Joyce Carol Oates When antidepressants like Prozac first became available, Peter D. Kramer prescribed them, only to hear patients say that on medication, they felt different—less ill at ease, more like the person they had always imagined themselves to be. Referencing disciplines from cellular biology to animal ethology, Dr. Kramer worked to explain these reports. The result was Listening to Prozac, a revolutionary book that offered new perspectives on antidepressants, mood disorders, and our understanding of the self—and that became an instant national and international bestseller. In this thirtieth anniversary edition, Dr. Kramer looks back at the influence of his groundbreaking book, traces progress in the relevant sciences, follows trends in the use and public understanding of antidepressants, and assesses potential breakthroughs in the treatment of depression. The new introduction and afterword reinforce and reinvigorate a book that the New York Times called “originally insightful” and “intelligent and informative,” a window on a medicine that is “telling us new things about the chemistry of human character.”

Author : Johann Hari
Publisher : Bloomsbury Publishing
ISBN 13 : 1526634082
Total Pages : 417 pages
Book Rating : 4.85/5 ( download)

DOWNLOAD NOW!

Download or read book Lost Connections written by Johann Hari and published by Bloomsbury Publishing. This book was released on 2020-11-12 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: THE INTERNATIONAL BESTSELLER: A radically new way of thinking about depression and anxiety 'A book that could actually make us happy' SIMON AMSTELL 'This amazing book will change your life' ELTON JOHN 'One of the most important texts of recent years' BRITISH JOURNAL OF GENERAL PRACTICE 'Brilliant, stimulating, radical' MATT HAIG 'The more people read this book, the better off the world will be' NAOMI KLEIN 'Wonderful' HILLARY CLINTON 'Eye-opening' GUARDIAN 'Brilliant for anyone wanting a better understanding of mental health' ZOE BALL 'A game-changer' DAVINA MCCALL 'Extraordinary' DR MAX PEMBERTON Depression and anxiety are now at epidemic levels. Why? Across the world, scientists have uncovered evidence for nine different causes. Some are in our biology, but most are in the way we are living today. Lost Connections offers a radical new way of thinking about this crisis. It shows that once we understand the real causes, we can begin to turn to pioneering new solutions – ones that offer real hope.

Author : Swapnil Gupta
Publisher : Oxford University Press, USA
ISBN 13 : 0190654813
Total Pages : 265 pages
Book Rating : 4.18/5 ( download)

DOWNLOAD NOW!

Download or read book Deprescribing in Psychiatry written by Swapnil Gupta and published by Oxford University Press, USA. This book was released on 2019 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: The current state of medicine has witnessed the long-term adverse effects of certain medications, an increased rate of polypharmacy, and a cultural shift that emphasizes patient-centered practice. The term "deprescribing" refers to the optimization of the pharmacological regimen by reducing or cessing medications that incur more risks than benefits. Many people consider stopping their psychiatric medications, but prescribers may not know how to do this in a collaborative, systematic way. Deprescribing in Psychiatry presents a framework for deprescribing to guide the prescriber-patient dyad through the process of deciding if and when to reduce psychiatric medication, how to go about doing it, and at the same time, acknowledge the inherent risks in such an endeavour. As the first book on the subject, Deprescribing in Psychiatry stands to serve as a definitive text in this burgeoning field and as a 'rallying call' to raise crucial and topical questions in psychiatric practice, promote innovation, and act as a resource on the current state-of-the-art care. It describes the ins and outs of how clinicians can work closely with their patients to consider whether or not to try decreasing medications. It also discusses the anticipated future research directions, considerations for the field, and emphasizes collaboration with the patient, transparency, and the acknowledgement of uncertainty in psychiatric practice.

Author : Peter Nathan
Publisher : Oxford University Press
ISBN 13 : 0199760985
Total Pages : 705 pages
Book Rating : 4.85/5 ( download)

DOWNLOAD NOW!

Download or read book A Guide To Treatments that Work written by Peter Nathan and published by Oxford University Press. This book was released on 2002-01-18 with total page 705 pages. Available in PDF, EPUB and Kindle. Book excerpt: A fully revised and updated edition of this unique and authoritative reference The award-winning A Guide to Treatments that Work , published in 1998, was the first book to assemble the numerous advances in both clinical psychology and psychiatry into one accessible volume. It immediately established itself as an indispensable reference for all mental health practitioners. Now in a fully updated edition,A Guide to Treatments that Work, Second Edition brings together, once again, a distinguished group of psychiatrists and clinical psychologists to take stock of which treatments and interventions actually work, which don't, and what still remains beyond the scope of our current knowledge. The new edition has been extensively revised to take account of recent drug developments and advances in psychotherapeutic interventions. Incorporating a wealth of new information, these eminent researchers and clinicians thoroughly review all available outcome data and clinical trials and provide detailed specification of methods and procedures to ensure effective treatment for each major DSM-IV disorder. As an interdisciplinary work that integrates information from both clinical psychology and psychiatry, this new edition will continue to serve as an essential volume for practitioners of every kind: psychiatrists, psychologists, clinical social workers, counselors, and mental health consultants.

Author : Giovanni Fava
Publisher : Oxford University Press
ISBN 13 : 0192896644
Total Pages : 193 pages
Book Rating : 4.43/5 ( download)

DOWNLOAD NOW!

Download or read book Discontinuing Antidepressant Medications written by Giovanni Fava and published by Oxford University Press. This book was released on 2021-10-28 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt: "When I started my residency training program in psychiatry in Italy, more than four decades ago, depression was the psychiatric disorder that particularly attracted my attention. In 1980 I decided to move to United States to further pursue my interest, first in Albuquerque, New Mexico, and then in Buffalo, New York, where I was offered to establish a depression unit. I was convinced that depression was essentially an episodic disorder, that there were powerful remedies against it (antidepressant drugs) and chronicity was essentially a consequence of inadequate diagnosis and treatment. Today, if I think of my views then, I am surprised of my naivete and clinical blindness. We have become aware that depression is essentially a chronic disorder with multiple acute episodes along its course (1). But my view was then shared by almost any expert in the field"--

Author : Graziano Pinna
Publisher :
ISBN 13 : 9781634820769
Total Pages : 412 pages
Book Rating : 4.62/5 ( download)

DOWNLOAD NOW!

Download or read book Fluoxetine written by Graziano Pinna and published by . This book was released on 2015-04-01 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fluoxetine, best known by the trade name Prozac®, unlike other psychotropic drugs whose effects were serendipitously stumbled upon, was the first developed for a precise mechanism of action, that is, the ability to selectively inhibit serotonin reuptake, based upon the theory that increasing the availability of serotonin would treat major depression. Once approved by the FDA in 1987, fluoxetine quickly became the most prescribed psychotropic drug worldwide and its success in improving mood disorders has triggered the development of a large number of congener molecules, commonly known as SSRIs after their purported mechanism of action. However, a quarter of a century after its development, the idea that fluoxetine asserts its positive behavioral effect through inhibition of serotonergic reuptake is not firmly established. This book reviews several preclinical and clinical reports suggesting that the pharmacological effects of fluoxetine may be mediated by means other than the regulation of serotonin, including the regulation of gene expression, modifying epigenetic mechanisms as well as modifying microRNAs. One of the most prominent mechanisms for the therapeutic relevance of fluoxetine relates to influencing neuroplasticity by enhancing neurotropic factors, including BDNF signaling and altering adult neurogenesis. The ability of fluoxetine to rapidly increase neurosteroid levels accounts for the fast anxiolytic effects of this drug. Fluoxetine action at sigma-1 receptor or modulating glutamatergic neurotransmission as well as the combination of fluoxetine with other psychotropic drugs is discussed in relation to its therapeutic effects. While fluoxetine was primarily prescribed as an antidepressant, this drug currently represents a treatment of choice for a broad spectrum of psychiatric disorders, including post-traumatic stress disorder and a range of anxiety disorders. This drug even possesses analgesic actions and is a valuable therapy for stroke. This book also highlights emerging evidence on the gender-specific effects of fluoxetine, its potential adverse features, including its addiction liability in combination with psychostimulants, and the impact of perinatal fluoxetine exposure.