Drug Selectivity

Author : Norbert Handler
Publisher : John Wiley & Sons
ISBN 13 : 3527335382
Total Pages : 538 pages
Book Rating : 4.81/5 ( download)

DOWNLOAD NOW!

Download or read book Drug Selectivity written by Norbert Handler and published by John Wiley & Sons. This book was released on 2018-02-27 with total page 538 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book "Drug Selectivity - An Evolving Concept in Medicinal Chemistry" provides a current overview and comprehensive compilation for medicinal chemists that discusses the effects of aiming for multiple targets on the entire drug development process. The result is a broad survey of current and future strategies for drug selectivity in medicinal chemistry with theoretical but also practical aspects. Different strategies are presented and evaluated, such as various design approaches, merged multiple ligands, discovery technologies and a broad range of successful examples of unselective drugs taken from all major disease areas. With its wide-ranging view of an emerging new paradigm in drug development, this handbook is of prime importance for every medicinal and pharmaceutical chemist.

Author : Henri N. Doods
Publisher : Taylor & Francis Group
ISBN 13 :
Total Pages : 300 pages
Book Rating : 4.85/5 ( download)

DOWNLOAD NOW!

Download or read book Receptor Data for Biological Experiments written by Henri N. Doods and published by Taylor & Francis Group. This book was released on 1991 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides comprehensive coverage of the most relevant knowledge on classification, localization and biological effects of receptor systems and/or enzymes.

Author : Adrien Albert
Publisher : Springer Science & Business Media
ISBN 13 : 9400957343
Total Pages : 65 pages
Book Rating : 4.43/5 ( download)

DOWNLOAD NOW!

Download or read book The Selectivity of Drugs written by Adrien Albert and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 65 pages. Available in PDF, EPUB and Kindle. Book excerpt: 1. 1 What is Selectivity? purpose, and crop protective agent for the A biologically-active substance is said to be second, but there is no fundamental difference selective if it strongly affects certain cells with of principle in their mode of action. out causing any change in others, even when the Drug therapy has two, fundamentally two kinds of cells are close neighbours. In living opposed divisions. The first of these strives to organisms, there are many substances, often improve the action of one of the cell's natural quite small molecules, which have been chosen agents by modifying the molecule in order to for their specificity. This choice has been made localize or intensify its action. For instance, under the strong pressure of natural selection, the solubility can be decreased to make it form unhurried by any consideration of time. Such a deposit, or a change is made so that it becomes chemical compounds operate the metabolism a poorer fit on the naturally-occurring destruc of the cells and tissues, and ensure their health, tive enzyme. Both of these devices have proved survival, and reproduction. Important among useful in therapy, e. g. with steroid hormones. the smaller of these selective molecules are Such drugs, which seek to improve on Nature vitamins, coenzymes, hormones, neurotrans by performing more desirably, are called mitters, inorganic ions, nutritional fragments, agonists.

Author : Kunal Roy
Publisher : Academic Press
ISBN 13 : 0128163771
Total Pages : 886 pages
Book Rating : 4.71/5 ( download)

DOWNLOAD NOW!

Download or read book In Silico Drug Design written by Kunal Roy and published by Academic Press. This book was released on 2019-02-12 with total page 886 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Silico Drug Design: Repurposing Techniques and Methodologies explores the application of computational tools that can be utilized for this approach. The book covers theoretical background and methodologies of chem-bioinformatic techniques and network modeling and discusses the various applied strategies to systematically retrieve, integrate and analyze datasets from diverse sources. Other topics include in silico drug design methods, computational workflows for drug repurposing, and network-based in silico screening for drug efficacy. With contributions from experts in the field and the inclusion of practical case studies, this book gives scientists, researchers and R&D professionals in the pharmaceutical industry valuable insights into drug design. Discusses the theoretical background and methodologies of useful techniques of cheminformatics and bioinformatics that can be applied for drug repurposing Offers case studies relating to the in silico modeling of FDA-approved drugs for the discovery of antifungal, anticancer, antiplatelet agents, and for drug therapies against diseases Covers tools and databases that can be utilized to facilitate in silico methods for drug repurposing

Author : Kim Neve
Publisher : Springer Science & Business Media
ISBN 13 : 1603273352
Total Pages : 290 pages
Book Rating : 4.50/5 ( download)

DOWNLOAD NOW!

Download or read book Functional Selectivity of G Protein-Coupled Receptor Ligands written by Kim Neve and published by Springer Science & Business Media. This book was released on 2009-02-27 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: Functional selectivity refers to the ability of different ligands acting at one receptor subtype to activate multiple signaling pathways in unique combinations; that is, one drug can be an agonist at pathway A and an antagonist or partial agonist at pathway B, and another drug can have the reverse profile. Functional selectivity has profound implications for drug development, for chemical biology, and for the design of experiments to characterize receptor function. In Functional Selectivity of G Protein-Coupled Receptors expert neuroscientists and pharmacologists review the work that demonstrated the existence of functional selectivity, placed it within a theoretical framework, and provided a mechanistic basis for the phenomenon. This exciting, comprehensive, and future-oriented volume includes chapters that focus on theoretical and mechanistic aspects of functional selectivity and that cut across subfamilies of GPCRs. Additional chapters focus on subfamilies of therapeutically relevant receptors where there is considerable evidence of ligand functional selectivity. Accessible and authoritative, Functional Selectivity of G Protein-Coupled Receptors is a valuable educational tool and reference source for students and scientists interested in drug development, chemical biology, and GPCR function.

Author : Gabriel Waksman
Publisher : Springer Science & Business Media
ISBN 13 : 0387245324
Total Pages : 325 pages
Book Rating : 4.24/5 ( download)

DOWNLOAD NOW!

Download or read book Proteomics and Protein-Protein Interactions written by Gabriel Waksman and published by Springer Science & Business Media. This book was released on 2006-12-22 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gabriel Waksman Institute of Structural Molecular Biology, Birkbeck and University College London, Malet Street, London WC1E 7HX, United Kingdom Address for correspondence: Professor Gabriel Waksman Institute of Structural Molecular Biology Birkbeck and University College London Malet Street London WC1E 7H United Kingdom Email: g. waksman@bbk. ac. uk and g. waksman@ucl. ac. uk Phone: (+44) (0) 207 631 6833 Fax: (+44) (0) 207 631 6833 URL: http://people. cryst. bbk. ac. uk/?ubcg54a Gabriel Waksman is Professor of Structural Molecular Biology at the Institute of Structural Molecular Biology at UCL/Birkbeck, of which he is also the director. Before joining the faculty of UCL and Birkbeck, he was the Roy and Diana Vagelos Professor of Biochemistry and Molecular Biophysics at the Washington University School of Medicine in St Louis (USA). The rapidly evolving ?eld of protein science has now come to realize the ubiquity and importance of protein–protein interactions. It had been known for some time that proteins may interact with each other to form functional complexes, but it was thought to be the property of only a handful of key proteins. However, with the advent of hi- throughput proteomics to monitor protein–protein interactions at an organism level, we can now safely state that protein–protein interactions are the norm and not the exception.

Author : Svein G. Dahl
Publisher : Springer Science & Business Media
ISBN 13 : 3642712886
Total Pages : 294 pages
Book Rating : 4.83/5 ( download)

DOWNLOAD NOW!

Download or read book Clinical Pharmacology in Psychiatry written by Svein G. Dahl and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Fourth International Meeting on Clinical Pharmacology in Psychiatry was held in Bethesda, Maryland on 5-8 September 1985 and was dedicated to the memory of Dr. Earl Usdin. Earl was one of the organizers of the three previous meetings held in Chicago (1979), Troms0 (1980), and Odense (1982). During the organization of the fourth meeting Earl became ill and had to relinquish his role as one of the principal organizers. It is safe to conclude that there was no better, or more professional, or more efficient an organizer of scientific meetings in the field of neuropharmacology and psychiatry than Earl U sdin, and it was quite a task for the remaining organizers to fill the void left when he withdrew from this one. Those of us who have organized previous meetings with Earl were struck by how much more difficult our work became without him. This obviously speaks well for his subtle (and at times not so subtle) organizational skills. Nevertheless, in Earl's memory the organizers proceeded to invite a group of internationally renowned neuropsychopharmacologists to address the problem of selectivity in psychotropic drug action and to try to reconcile the amazing advances in basic preclinical neuropsychopharmacology with the problem of clinical specificity encountered by the psychiatrist.

Author : Jordi Mestres
Publisher : Wiley-VCH
ISBN 13 : 9783527331062
Total Pages : 400 pages
Book Rating : 4.69/5 ( download)

DOWNLOAD NOW!

Download or read book Drug Selectivity written by Jordi Mestres and published by Wiley-VCH. This book was released on 2013-07-10 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Bertram G. Katzung
Publisher : McGraw Hill Professional
ISBN 13 : 1260452328
Total Pages : 1326 pages
Book Rating : 4.27/5 ( download)

DOWNLOAD NOW!

Download or read book Basic and Clinical Pharmacology 15e written by Bertram G. Katzung and published by McGraw Hill Professional. This book was released on 2020-11-22 with total page 1326 pages. Available in PDF, EPUB and Kindle. Book excerpt: Master key pharmacological concepts and practices with the most comprehensive, authoritative guide available Doody's Core Titles for 2023! Presented in full-color and packed with hundreds of illustrations, Basic and Clinical Pharmacology is the wide-ranging, engaging guide students have counted on for decades. Organized to reflect the course sequence in many pharmacology courses and in integrated curricula, the guide covers the important concepts students need to know about the science of pharmacology and its application to clinical practice. This edition has been extensively updated to provide expanded coverage of transporters, pharmacogenomics, and new drugs Delivers the knowledge and insight needed to excel in every facet of pharmacology!. Encompasses all aspects of medical pharmacology, including botanicals and over-the-counter drugs Major revisions of the chapters on immunopharmacology, antiseizure, antipsychotic, antidepressant, antidiabetic, anti-inflammatory, and antiviral drugs, prostaglandins, and central nervous system neurotransmitters New chapter on the increasingly relevant topic of cannabis pharmacology Each chapter opens with a case study, covers drug groups and prototypes, and closes with summary tables and diagrams that encapsulate important information Revised full-color illustrations provide more information about drug mechanisms and effects and help clarify important concepts Trade Name/Generic Name tables are provided at end of each chapter for easy reference when writing a chart order or prescription Includes descriptions of important new drugs released through May 2019 New and updated coverage of general concepts relating to recently discovered receptors, receptor mechanisms, and drug transporters

Author : Beverley Isherwood
Publisher : Royal Society of Chemistry
ISBN 13 : 1839160799
Total Pages : 273 pages
Book Rating : 4.90/5 ( download)

DOWNLOAD NOW!

Download or read book Phenotypic Drug Discovery written by Beverley Isherwood and published by Royal Society of Chemistry. This book was released on 2020-12-09 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phenotypic drug discovery has been highlighted in the past decade as an important strategy in the discovery of new medical entities. How many marketed drugs are derived from phenotypic screens? From the most recent examples, what were the factors enabling target identification and validation? This book answers these questions by elaborating on fundamental capabilities required for phenotypic drug discovery and using case studies to illustrate approaches and key success factors. Written and edited by experienced practitioners from both industry and academia, this publication will equip researchers with a thought-provoking guide to the application and future development of contemporary phenotypic drug discovery for clinical success.