Downstream Industrial Biotechnology

Author : Michael C. Flickinger
Publisher : John Wiley & Sons
ISBN 13 : 111861898X
Total Pages : 884 pages
Book Rating : 4.81/5 ( download)

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Download or read book Downstream Industrial Biotechnology written by Michael C. Flickinger and published by John Wiley & Sons. This book was released on 2013-07-17 with total page 884 pages. Available in PDF, EPUB and Kindle. Book excerpt: DOWNSTREAM INDUSTRIAL BIOTECHNOLOGY An affordable, easily accessible desk reference on biomanufacturing, focused on downstream recovery and purification Advances in the fundamental knowledge surrounding biotechnology, novel materials, and advanced engineering approaches continue to be translated into bioprocesses that bring new products to market at a significantly faster pace than most other industries. Industrial scale biotechnology and new manufacturing methods are revolutionizing medicine, environmental monitoring and remediation, consumer products, food production, agriculture, and forestry, and continue to be a major area of research. The downstream stage in industrial biotechnology refers to recovery, isolation, and purification of the microbial products from cell debris, processing medium and contaminating biomolecules from the upstream process into a finished product such as biopharmaceuticals and vaccines. Downstream process design has the greatest impact on overall biomanufacturing cost because not only does the biochemistry of different products ( e.g., peptides, proteins, hormones, antibiotics, and complex antigens) dictate different methods for the isolation and purification of these products, but contaminating byproducts can also reduce overall process yield, and may have serious consequences on clinical safety and efficacy. Therefore downstream separation scientists and engineers are continually seeking to eliminate, or combine, unit operations to minimize the number of process steps in order to maximize product recovery at a specified concentration and purity. Based on Wiley’s Encyclopedia of Industrial Biotechnology: Bioprocess, Bioseparation, and Cell Technology, this volume features fifty articles that provide information on down- stream recovery of cells and protein capture; process development and facility design; equipment; PAT in downstream processes; downstream cGMP operations; and regulatory compliance. It covers: Cell wall disruption and lysis Cell recovery by centrifugation and filtration Large-scale protein chromatography Scale down of biopharmaceutical purification operations Lipopolysaccharide removal Porous media in biotechnology Equipment used in industrial protein purification Affinity chromatography Antibody purification, monoclonal and polyclonal Protein aggregation, precipitation and crystallization Freeze-drying of biopharmaceuticals Biopharmaceutical facility design and validation Pharmaceutical bioburden testing Regulatory requirements Ideal for graduate and advanced undergraduate courses on biomanufacturing, biochemical engineering, biopharmaceutical facility design, biochemistry, industrial microbiology, gene expression technology, and cell culture technology, Downstream Industrial Biotechnology is also a highly recommended resource for industry professionals and libraries.

Author : Mohamed A. Desai
Publisher : Springer Science & Business Media
ISBN 13 : 1592590276
Total Pages : 233 pages
Book Rating : 4.78/5 ( download)

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Download or read book Downstream Processing of Proteins written by Mohamed A. Desai and published by Springer Science & Business Media. This book was released on 2008-02-05 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: Considerable effort and time is allocated to introducing cell culture and fermentation technology to undergraduate students in academia, generally through a range of courses in industrial biotechnology and related disciplines. Similarly, a large number of textbooks are available to describe the appli- tions of these technologies in industry. However, there has been a general lack of appreciation of the significant developments in downstream processing and isolation technology, the need for which is largely driven by the stringent re- latory requirements for purity and quality of injectable biopharmaceuticals. This is particularly reflected by the general absence of coverage of this s- ject in many biotechnology and related courses in educational institutions. For a considerable while I have felt that there is increasing need for an introductory text to various aspects of downstream processing, particularly with respect to the needs of the biopharmaceutical and biotechnology ind- try. Although there are numerous texts that cover various aspects of protein purification techniques in isolation, there is a need for a work that covers the broad range of isolation technology in an industrial setting. It is anticipated that Downstream Processing of Proteins: Methods and Protocols will play a small part in filling this gap and thus prove a useful contribution to the field. It is also designed to encourage educational strategists to broaden the coverage of these topics in industrial biotechnology courses by including accounts of this important and rapidly developing element of the industrial process.

Author : Michael C. Flickinger
Publisher : Wiley
ISBN 13 : 9781118131251
Total Pages : 0 pages
Book Rating : 4.58/5 ( download)

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Download or read book Upstream and Downstream Industrial Biotechnology, 3V Bundle written by Michael C. Flickinger and published by Wiley. This book was released on 2013-04-15 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Upstream and Downstream Industrial Biotechnology 3 Volume Bundle consists of the following two key references: • Upstream Industrial Biotechnology, 2 Volume Set, and • Downstream Industrial Biotechnology: Recovery and Purification. The title is based on the Encyclopedia of Industrial Biotechnology: Bioprocess, Bioseparation, and Cell Technology, which is available in print and online, and offers you all you a complete overview about Upstream and Downstream Industrial Biotechnology. The references are available for purchase individually, or you can SAVE by buying the comprehensive 3 Volume Bundle!

Author : Venko N. Beschkov
Publisher : Walter de Gruyter GmbH & Co KG
ISBN 13 : 3110574004
Total Pages : 211 pages
Book Rating : 4.05/5 ( download)

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Download or read book Downstream Processing in Biotechnology written by Venko N. Beschkov and published by Walter de Gruyter GmbH & Co KG. This book was released on 2021-06-21 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt: The current book gives an excellent insight into downstream processing technology and explains how to establish a successful strategy for an efficient recovery, isolation and purification of biosynthetic products. In addition to the overview of purification steps and unit operations, the authors provide practical information on capital and operating costs related to downstream processing.

Author : Wim Soetaert
Publisher : John Wiley & Sons
ISBN 13 : 3527630244
Total Pages : 522 pages
Book Rating : 4.40/5 ( download)

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Download or read book Industrial Biotechnology written by Wim Soetaert and published by John Wiley & Sons. This book was released on 2010-03-30 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt: Describing all topics of white biotechnology admitted to the 7th EU Frame Programme and new industrial production processes aiming towards the Kyoto objectives, this comprehensive overview covers the technology, applications, economic potential and implications for society. Directed at readers with a general interest in a specific technology, this is equally suitable as an introductory handbook to a wide range of industries, including chemicals, biotechnology and pharmaceuticals, food and feed, paper and pulp, personal care, energy and agriculture.

Author : E. Goldberg
Publisher : Springer Science & Business Media
ISBN 13 : 9400915632
Total Pages : 745 pages
Book Rating : 4.33/5 ( download)

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Download or read book Handbook of Downstream Processing written by E. Goldberg and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 745 pages. Available in PDF, EPUB and Kindle. Book excerpt: The last two decades have seen a phenomenal growth of the field of genetic or biochemical engineering and have witnessed the development and ultimately marketing of a variety of products-typically through the manipulation and growth of different types of microorganisms, followed by the recovery and purification of the associated products. The engineers and biotechnologists who are involved in the full-scale process design of such facilities must be familiar with the variety of unit operations and equipment and the applicable regulatory requirements. This book describes current commercial practice and will be useful to those engineers working in this field in the design, construction and operation of pharmaceutical and biotechnology plants. It will be of help to the chemical or pharmaceutical engineer who is developing a plant design and who faces issues such as: Should the process be batch or continuous or a combination of batch and continuous? How should the optimum process design be developed? Should one employ a new revolutionary separation which could be potentially difficult to validate or use accepted technology which involves less risk? Should the process be run with ingredients formulated from water for injection, deionized water, or even filtered tap water? Should any of the separations be run in cold rooms or in glycol jacketed lines to minimize microbial growth where sterilization is not possible? Should the process equipment and lines be designed to be sterilized in-place, cleaned-in-place, or should every piece be broken down, cleaned and autoclaved after every turn?

Author : Michael C. Flickinger
Publisher : John Wiley & Sons
ISBN 13 : 111813124X
Total Pages : 884 pages
Book Rating : 4.44/5 ( download)

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Download or read book Downstream Industrial Biotechnology written by Michael C. Flickinger and published by John Wiley & Sons. This book was released on 2013-03-12 with total page 884 pages. Available in PDF, EPUB and Kindle. Book excerpt: DOWNSTREAM INDUSTRIAL BIOTECHNOLOGY An affordable, easily accessible desk reference on biomanufacturing, focused on downstream recovery and purification Advances in the fundamental knowledge surrounding biotechnology, novel materials, and advanced engineering approaches continue to be translated into bioprocesses that bring new products to market at a significantly faster pace than most other industries. Industrial scale biotechnology and new manufacturing methods are revolutionizing medicine, environmental monitoring and remediation, consumer products, food production, agriculture, and forestry, and continue to be a major area of research. The downstream stage in industrial biotechnology refers to recovery, isolation, and purification of the microbial products from cell debris, processing medium and contaminating biomolecules from the upstream process into a finished product such as biopharmaceuticals and vaccines. Downstream process design has the greatest impact on overall biomanufacturing cost because not only does the biochemistry of different products ( e.g., peptides, proteins, hormones, antibiotics, and complex antigens) dictate different methods for the isolation and purification of these products, but contaminating byproducts can also reduce overall process yield, and may have serious consequences on clinical safety and efficacy. Therefore downstream separation scientists and engineers are continually seeking to eliminate, or combine, unit operations to minimize the number of process steps in order to maximize product recovery at a specified concentration and purity. Based on Wiley’s Encyclopedia of Industrial Biotechnology: Bioprocess, Bioseparation, and Cell Technology, this volume features fifty articles that provide information on down- stream recovery of cells and protein capture; process development and facility design; equipment; PAT in downstream processes; downstream cGMP operations; and regulatory compliance. It covers: Cell wall disruption and lysis Cell recovery by centrifugation and filtration Large-scale protein chromatography Scale down of biopharmaceutical purification operations Lipopolysaccharide removal Porous media in biotechnology Equipment used in industrial protein purification Affinity chromatography Antibody purification, monoclonal and polyclonal Protein aggregation, precipitation and crystallization Freeze-drying of biopharmaceuticals Biopharmaceutical facility design and validation Pharmaceutical bioburden testing Regulatory requirements Ideal for graduate and advanced undergraduate courses on biomanufacturing, biochemical engineering, biopharmaceutical facility design, biochemistry, industrial microbiology, gene expression technology, and cell culture technology, Downstream Industrial Biotechnology is also a highly recommended resource for industry professionals and libraries.

Author : NIIR Board
Publisher : ASIA PACIFIC BUSINESS PRESS Inc.
ISBN 13 : 8178330709
Total Pages : 682 pages
Book Rating : 4.09/5 ( download)

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Download or read book Biotechnology Handbook written by NIIR Board and published by ASIA PACIFIC BUSINESS PRESS Inc.. This book was released on 2003-08-09 with total page 682 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biotechnology is a field of applied biology that involves the use of living organisms and bioprocesses in engineering, technology, medicine and other fields requiring bio products. Biotechnology also utilizes these products for manufacturing purpose. Modern use of similar terms includes genetic engineering as well as cell and tissue culture technologies. Biotechnology draws on the pure biological sciences and in many instances is also dependent on knowledge and methods from outside the sphere of biology. Conversely, modern biological sciences are intimately entwined and dependent on the methods developed through biotechnology and what is commonly thought of as the life sciences industry. It has a major application in modern brewing technology which includes the production of whisky, traditional fermented soybean foods bacterial biomass, cheese starters, cheese technology, L glutamic acid fermentation etc. Biotechnology and cell molecular biology have developed and emerged in to a major discipline during last two decades. Biotechnology is also used to recycle, treat waste, microbial treatment and utilization a waste. The growing global demand for biotechnology products, India has rich biodiversity that drives its clinical trials industry and forms a strong base for pharmaceutical research. In recent years, the worldwide biotechnology based products market has grown at an annual average rate of 15%. This book majorly deals with introduction to basic biotechnology, downstream processing in biotechnology, modern brewing technology, industrial chemicals, biochemical and fuels, microbial flavours and fragrances, biodegradation of non cellulosic wastes for environmental conservation and fuel production, landfills for treatment of solid wastes etc. This book also consists of addresses of machinery suppliers, addresses of chemical suppliers, list of universities, conducting Biotechnology courses in the directory section. This is a unique book, concise, up to date resource offering an innovative, adoptive and valuable presentation of the subject. It covers all important biotechnological topics of industrial and academic interests. This book will be very use full for industry people, students, and libraries and for those who want to venture in to manufacturing of biotechnological products. 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Author : Debabrata Das
Publisher : CRC Press
ISBN 13 : 100038229X
Total Pages : 501 pages
Book Rating : 4.97/5 ( download)

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Download or read book Industrial Biotechnology written by Debabrata Das and published by CRC Press. This book was released on 2021-05-06 with total page 501 pages. Available in PDF, EPUB and Kindle. Book excerpt: Exposes readers to various biochemical industries Analyzes problems within biochemical processes Discusses stoichiometry of bioprocesses Covers upstream and downstream processing Offers a wealth of case studies of different biochemical production processes, including those in development of food products, vaccines and medicines, single cell proteins, amino acids, cheese, biodiesel, biopesticides, and more

Author :
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.42/5 ( download)

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Download or read book Downstream Processing in Biotechnology written by and published by . This book was released on 1985 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: