Cytokine Ion Channel Interactions In Pulmonary Inflammation

Author : István Vadász
Publisher : Frontiers Media SA
ISBN 13 : 2889457036
Total Pages : 198 pages
Book Rating : 4.38/5 ( download)

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Download or read book Cytokine-Ion Channel Interactions in Pulmonary Inflammation written by István Vadász and published by Frontiers Media SA. This book was released on 2019-01-24 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Research Topic assembles original contributions and reviews from an international consortium of PIs related to interactions between pro-inflammatory cytokines and ion channels during acute lung injury and chronic heart failure.

Author : Anastasia P. Nesterova
Publisher : Elsevier
ISBN 13 : 0128170875
Total Pages : 732 pages
Book Rating : 4.78/5 ( download)

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Download or read book Disease Pathways written by Anastasia P. Nesterova and published by Elsevier. This book was released on 2019-10-18 with total page 732 pages. Available in PDF, EPUB and Kindle. Book excerpt: Disease Pathways: An Atlas of Human Disease Signaling Pathways is designed to fill a void of illustrated reviews about the cellular mechanisms of human diseases. It covers 42 of the most common non-oncologic diseases and illustrates the connections between the molecular causes of the disease and its symptoms. This resource provides readers with detailed information about the disease molecular pathways, while keeping the presentation simple. Pathway models that aggregate the knowledge about protein–protein interactions have become indispensable tools in many areas of molecular biology, pharmacology, and medicine. In addition to disease pathways, the book includes a comprehensive overview of molecular signaling biology and application of pathway models in the analysis of big data for drug discovery and personalized medicine. This is a must-have reference for general biologists, biochemists, students, medical workers, and everyone interested in the cellular and molecular mechanisms of human disease. Over 145 full-color illustrations of the molecular and cellular cascades underlying the disease pathology. Disease pathways are based on computational models from Elsevier’s Disease Pathway Collection, published for the first time outside of Pathway Studio® commercial software. Each relationship on the pathway models is supported by references to scientific articles and can be examined at freely available online resources.

Author : Gary Frank Nieman
Publisher : Frontiers Media SA
ISBN 13 : 2832502644
Total Pages : 241 pages
Book Rating : 4.48/5 ( download)

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Download or read book Protecting the Acutely Injured Lung: Physiologic, Mechanical, Inflammatory, and Translational Perspectives written by Gary Frank Nieman and published by Frontiers Media SA. This book was released on 2022-10-17 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Vera Regitz-Zagrosek
Publisher : Frontiers Media SA
ISBN 13 : 2889769771
Total Pages : 203 pages
Book Rating : 4.73/5 ( download)

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Download or read book Endocrinology and COVID-19: A Cross-Disciplinary Topic written by Vera Regitz-Zagrosek and published by Frontiers Media SA. This book was released on 2022-09-15 with total page 203 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author :
Publisher : Frontiers Media SA
ISBN 13 : 288974101X
Total Pages : 1671 pages
Book Rating : 4.14/5 ( download)

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Download or read book Coronavirus Disease (COVID-19): Pathophysiology, Epidemiology, Clinical Management and Public Health Response written by and published by Frontiers Media SA. This book was released on 2023-01-25 with total page 1671 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume I.A An outbreak of a respiratory disease first reported in Wuhan, China in December 2019 and the causative agent was discovered in January 2020 to be a novel betacoronovirus of the same subgenus as SARS-CoV and named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Coronavirus disease 2019 (COVID-19) has rapidly disseminated worldwide, with clinical manifestations ranging from mild respiratory symptoms to severe pneumonia and a fatality rate estimated around 2%. Person to person transmission is occurring both in the community and healthcare settings. The World Health Organization (WHO) has recently declared the COVID-19 epidemic a public health emergency of international concern. The ongoing outbreak presents many clinical and public health management challenges due to limited understanding of viral pathogenesis, risk factors for infection, natural history of disease including clinical presentation and outcomes, prognostic factors for severe illness, period of infectivity, modes and extent of virus inter-human transmission, as well as effective preventive measures and public health response and containment interventions. There are no antiviral treatment nor vaccine available but fast track research and development efforts including clinical therapeutic trials are ongoing across the world. Managing this serious epidemic requires the appropriate deployment of limited human resources across all cadres of health care and public health staff, including clinical, laboratory, managerial and epidemiological data analysis and risk assessment experts. It presents challenges around public communication and messaging around risk, with the potential for misinformation and disinformation. Therefore, integrated operational research and intervention, learning from experiences across different fields and settings should contribute towards better understanding and managing COVID-19. This Research Topic aims to highlight interdisciplinary research approaches deployed during the COVID-19 epidemic, addressing knowledge gaps and generating evidence for its improved management and control. It will incorporate critical, theoretically informed and empirically grounded original research contributions using diverse approaches, experimental, observational and intervention studies, conceptual framing, expert opinions and reviews from across the world. The Research Topic proposes a multi-dimensional approach to improving the management of COVID-19 with scientific contributions from all areas of virology, immunology, clinical microbiology, epidemiology, therapeutics, communications as well as infection prevention and public health risk assessment and management studies.

Author : Robert J. Mason
Publisher : Elsevier Health Sciences
ISBN 13 : 1437735533
Total Pages : 2457 pages
Book Rating : 4.36/5 ( download)

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Download or read book Murray and Nadel's Textbook of Respiratory Medicine E-Book written by Robert J. Mason and published by Elsevier Health Sciences. This book was released on 2010-06-09 with total page 2457 pages. Available in PDF, EPUB and Kindle. Book excerpt: Murray and Nadel’s Textbook of Respiratory Medicine has long been the definitive and comprehensive pulmonary disease reference. Robert J. Mason, MD now presents the fifth edition in full color with new images and highlighted clinical elements. The fully searchable text is also online at www.expertconsult.com, along with regular updates, video clips, additional images, and self-assessment questions. This new edition has been completely updated and remains the essential tool you need to care for patients with pulmonary disease. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Compatible with Kindle®, nook®, and other popular devices. Master the scientific principles of respiratory medicine and its clinical applications. Work through differential diagnosis using detailed explanations of each disease entity. Learn new subjects in Pulmonary Medicine including Genetics, Ultrasound, and other key topics. Grasp the Key Points in each chapter. Search the full text online at expertconsult.com, along with downloadable images, regular updates, more than 50 videos, case studies, and self-assessment questions. Consult new chapters covering Ultrasound, Innate Immunity, Adaptive Immunity, Deposition and Clearance, Ventilator-Associated Pneumonia. Find critical information easily using the new full-color design that enhances teaching points and highlights challenging concepts. Apply the expertise and fresh ideas of three new editors—Drs. Thomas R. Martin, Talmadge E. King, Jr., and Dean E. Schraufnagel. Review the latest developments in genetics with advice on how the data will affect patient care.

Author : Santiago Partida Sanchez
Publisher : Frontiers Media SA
ISBN 13 : 2889668479
Total Pages : 176 pages
Book Rating : 4.72/5 ( download)

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Download or read book TRP Channels in Inflammation and Immunity written by Santiago Partida Sanchez and published by Frontiers Media SA. This book was released on 2021-06-08 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Ioannis Zabetakis
Publisher : Frontiers Media SA
ISBN 13 : 2889715817
Total Pages : 296 pages
Book Rating : 4.17/5 ( download)

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Download or read book Coronavirus Disease (COVID-19): Diet, Inflammation and Nutritional Status written by Ioannis Zabetakis and published by Frontiers Media SA. This book was released on 2021-11-02 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Inka Sastalla
Publisher : Frontiers Media SA
ISBN 13 : 2889199916
Total Pages : 192 pages
Book Rating : 4.14/5 ( download)

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Download or read book Bacterial Exotoxins: How Bacteria Fight the Immune System written by Inka Sastalla and published by Frontiers Media SA. This book was released on 2016-10-07 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bacterial pathogenicity factors are functionally diverse. They may facilitate the adhesion and colonization of bacteria, influence the host immune response, assist spreading of the bacterium by e.g. evading recognition by immune cells, or allow bacteria to dwell within protected niches inside the eukaryotic cell. Exotoxins can be single polypeptides or heteromeric protein complexes that act on different parts of the cells. At the cell surface, they may insert into the membrane to cause damage; bind to receptors to initiate their uptake; or facilitate the interaction with other cell types. For example, bacterial superantigens specifically bind to major histocompatibility complex (MHC) II molecules on the surface of antigen presenting cells and the T cell receptor, while cytolysins cause pore formation. For intracellular activity, exotoxins need to be translocated across the eukaryotic membrane. Gram-negative bacteria can directly inject effector proteins in a receptor-independent manner by use of specialized needle apparatus such as bacterial type II, III, or type IV secretion systems. Other methods of translocation include the phagocytic uptake of bacteria followed by toxin secretion, or receptor-mediated endocytosis which allows the targeting of distinct cell types. Receptor-based uptake is initiated by the binding of heteromeric toxin complexes to the cell surface and completed by the translocation of the effector protein(s) across the endosomal membrane. In the cytosol, toxins interact with specific eukaryotic target proteins to cause post-translational modifications that often result in the manipulation of cellular signalling cascades and inflammatory responses. It has become evident that the actions of some bacterial toxins may exceed their originally assumed cytotoxic function. For example, pore-forming toxins do not only cause cytolysis, but may also induce autophagy, pyroptosis, or activation of the MAPK pathways, resulting in adjustment of the host immune response to infection and modification of inflammatory responses both locally and systemically. Other recently elucidated examples of the immunomodulatory function of cell death-inducing exotoxins include TcdB of Clostridium difficile which activates the inflammasome through modification of cellular Rho GTPases, or the Staphyloccocus d-toxin which activates mast cells. The goal of this research topic was to gather current knowledge on the interaction of bacterial exotoxins and effector proteins with the host immune system. The following 16 research and review articles in this special issue describe mechanisms of immune modification and evasion and provide an overview over the complexity of bacterial toxin interaction with different cells of the immune system.

Author : P. Gopalakrishnakone
Publisher : Springer
ISBN 13 : 9789400766471
Total Pages : 550 pages
Book Rating : 4.75/5 ( download)

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Download or read book Scorpion Venoms written by P. Gopalakrishnakone and published by Springer. This book was released on 2021-01-14 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, the field of Toxinology has expanded substantially. On the one hand it studies venomous animals, plants and micro organisms in detail to understand their mode of action on targets. While on the other, it explores the biochemical composition, genomics and proteomics of toxins and venoms to understand their three interaction with life forms (especially humans), development of antidotes and exploring their pharmacological potential. Therefore, Toxinology has deep linkages with biochemistry, molecular biology, anatomy and pharmacology. In addition, there is a fast developing applied subfield, clinical toxinology, which deals with understanding and managing medical effects of toxins on human body. Given the huge impact of toxin-based deaths globally, and the potential of venom in generation of drugs for so-far incurable diseases (for example, Diabetes, Chronic Pain), the continued research and growth of the field is imminent. This has led to the growth of research in the area and the consequent scholarly output by way of publications in journals and books. Despite this ever growing body of literature within biomedical sciences, there is still no all-inclusive reference work available that collects all of the important biochemical, biomedical and clinical insights relating to Toxinology. The Handbook of Toxinology aims to address this gap and cover the field of Toxinology comprehensively.