Cross Talk Between The Immune System And Metabolism

Author : Jixin Zhong
Publisher : Frontiers Media SA
ISBN 13 : 2889661709
Total Pages : 119 pages
Book Rating : 4.01/5 ( download)

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Download or read book Cross Talk Between the Immune System and Metabolism written by Jixin Zhong and published by Frontiers Media SA. This book was released on 2020-12-09 with total page 119 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Author : Anne Le
Publisher : Springer
ISBN 13 : 331977736X
Total Pages : 186 pages
Book Rating : 4.68/5 ( download)

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Download or read book The Heterogeneity of Cancer Metabolism written by Anne Le and published by Springer. This book was released on 2018-06-26 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.

Author : Alessandra Castegna
Publisher : Frontiers Media SA
ISBN 13 : 2889662624
Total Pages : 231 pages
Book Rating : 4.23/5 ( download)

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Download or read book Metabolism Meets Function: Untangling the Cross-Talk Between Signalling and Metabolism written by Alessandra Castegna and published by Frontiers Media SA. This book was released on 2020-12-18 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Author : Muzafar Ahmad Macha
Publisher : Springer Nature
ISBN 13 : 9811662266
Total Pages : 223 pages
Book Rating : 4.63/5 ( download)

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Download or read book Immuno-Oncology Crosstalk and Metabolism written by Muzafar Ahmad Macha and published by Springer Nature. This book was released on 2022-05-16 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the novel metabolic cross-talk between immune and tumor cells in the tumor microenvironment that promotes their growth and progression. It also describes deregulated metabolism in cancer cells that promotes suppressive and cancer cell-favourable microenvironment. Further, the book provides novel insights on the metabolic changes in immune cells that promote tumor cell growth and survival. In turn, it also reviews the involvement of immuno-onco metabolic cross-talk in the development of resistance to chemo-radiation therapy (CRT) in tumor cells. Lastly, it also explores the potential of immuno-oncology metabolism as a therapeutic approach against tumor cells.

Author : Claudio Mauro
Publisher : Frontiers Media SA
ISBN 13 : 2889196224
Total Pages : 82 pages
Book Rating : 4.27/5 ( download)

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Download or read book The Metabolic Challenges of Immune Cells in Health and Disease written by Claudio Mauro and published by Frontiers Media SA. This book was released on 2015-07-13 with total page 82 pages. Available in PDF, EPUB and Kindle. Book excerpt: Obesity and its co-morbidities, including atherosclerosis, insulin resistance and diabetes, are a world-wide epidemic. Inflammatory immune responses in metabolic tissues have emerged as a universal feature of these metabolic disorders. While initial work highlighted the contribution of macrophages to tissue inflammation and insulin resistance, recent studies demonstrate that cells of the adaptive immune compartment, including T and B lymphocytes and dendritic cells also participate in obesity-induced pathogenesis of these conditions. However, the molecular and cellular pathways by which the innate and adaptive branches of immunity control tissue and systemic metabolism remain poorly understood. To engage in growth and activation, cells need to increase their biomass and replicate their genome. This process presents a substantial bioenergetic challenge: growing and activated cells must increase ATP production and acquire or synthesize raw materials, including lipids, proteins and nucleic acids. To do so, they actively reprogram their intracellular metabolism from catabolic mitochondrial oxidative phosphorylation to glycolysis and other anabolic pathways. This metabolic reprogramming is under the control of specific signal transduction pathways whose underlying molecular mechanisms and relevance to physiology and disease are subject of considerable current interest and under intense study. Recent reports have elucidated the physiological role of metabolic reprogramming in macrophage and T cell activation and differentiation, B- and dendritic cell biology, as well as in the crosstalk of immune cells with endothelial and stem cells. It is also becoming increasingly evident that alterations of metabolic pathways play a major role in the pathogenesis of chronic inflammatory disorders. Due to the scientific distance between immunologists and experts in metabolism (e.g., clinicians and biochemists), however, there has been limited cross-talk between these communities. This collection of articles aims at promoting such cross-talk and accelerating discoveries in the emerging field of immunometabolism.

Author : Amir Ali Ghaffari
Publisher :
ISBN 13 :
Total Pages : 118 pages
Book Rating : 4.34/5 ( download)

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Download or read book Cross-talk Between Host Anti-viral Innate Immune Responses and Metabolism written by Amir Ali Ghaffari and published by . This book was released on 2013 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt: Viral infections can induce changes in host metabolism, either as a result of viral manipulations or host anti-viral responses. These metabolic changes in turn may result in various disorders. The liver, as the critical organ in maintaining metabolic homeostasis, is particularly susceptible to such changes during viral infections, and alterations in hepatic function can quickly result in severe metabolic imbalances. Viral infections can even contribute to liver failure by causing tissue damage through cytotoxicity and inflammation, as well as impaired drug metabolism. It is unclear to what extent these deleterious effects are due to viral manipulations or the host response. Here, we provide several mechanisms that illuminate the contribution of the host anti-viral responses to metabolic imbalances and tissue damage. First, we provide a mechanism by which activation of antiviral responses downregulates expression of nuclear hormone receptor retinoic X receptor- & alpha; (RXR & alpha;) and its heterodimeric partner pregnane X receptor (PXR) in mice, resulting in suppression of key downstream cytochrome P450 enzymes involved in metabolism of acetaminophen. Second, in addition to impairing drug metabolism, viral infections may result in liver damage by directly inducing cytopathic effects in infected cells, as well as by indirectly inducing host inflammatory responses that injure tissue. We have found that liver injury induced by mouse hepatitis virus is mediated by high-mobility group box 1 (HMGB1), a previously identified endogenous danger signal that can activate immune pathways. We further characterize an inhibitor of HMGB1, glycyrrhizic acid, as a hepatoprotective agent in both sterile and infectious challenges. Finally, in addition to effects on liver, we explore the cross-talk between anti-viral immune responses and cellular metabolism. Viruses rely on the metabolic network of the host cells for their replication, and while recent studies suggest that key genes in lipid metabolism are specifically modulated by viruses, it is unclear whether the host also modulates its own lipid metabolism to counter viral infection. We demonstrate that expression of fatty acid synthase (FASN), a critical gene in lipid metabolism, is regulated by the activation of innate immune pathways. Our findings offer novel mechanisms by which host-mediated downregulation of FASN can inhibit viral infections. Overall, these studies provide better understanding of the mechanisms underlying the cross-talk between innate immune pathways and metabolic imbalances.

Author : Peter M. Tiidus
Publisher : Human Kinetics
ISBN 13 : 9780736058674
Total Pages : 360 pages
Book Rating : 4.72/5 ( download)

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Download or read book Skeletal Muscle Damage and Repair written by Peter M. Tiidus and published by Human Kinetics. This book was released on 2008 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Attempts to cover a wide range of both basic research and applied clinical topics related to skeletal muscle damage and repair mechanisms and their application. This book examines muscle damage and repair mechanisms and issues in specific populations including older adults and special populations.

Author :
Publisher : BoD – Books on Demand
ISBN 13 : 1838801251
Total Pages : 140 pages
Book Rating : 4.50/5 ( download)

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Download or read book Glutathione System and Oxidative Stress in Health and Disease written by and published by BoD – Books on Demand. This book was released on 2020-08-26 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt: The imbalance between the production of reactive oxygen species (ROS) and antioxidant defenses determines a state known as oxidative stress. Higher levels of pro-oxidants compared to antioxidant defenses may generate oxidative damage, which, in turn, may lead to modifications in cellular proteins, lipids, and DNA, reducing functional capacity and increasing the risk of diseases. Nevertheless, the clearance of harmful reactive chemical species is achieved by the antioxidant defense systems. These protection systems are referred to as the first and second lines of defense and comprise the classic antioxidants, enzymatic and nonenzymatic defenses, including glutathione. This book presents and discusses the advancement of research on health and diseases and their underlying mechanisms, exploring mainly aspects related to the glutathione antioxidant system.

Author : Giacomina Brunetti
Publisher : Frontiers Media SA
ISBN 13 : 2889636135
Total Pages : 160 pages
Book Rating : 4.36/5 ( download)

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Download or read book Updates on Osteoimmunology: What’s New on the Crosstalk Between Bone and Immune Cells written by Giacomina Brunetti and published by Frontiers Media SA. This book was released on 2020-03-24 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Pallaval Veera Bramhachari
Publisher : Springer Nature
ISBN 13 : 9811631565
Total Pages : 306 pages
Book Rating : 4.66/5 ( download)

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Download or read book Microbiome in Human Health and Disease written by Pallaval Veera Bramhachari and published by Springer Nature. This book was released on 2021-10-18 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book provides an overview on how the microbiome contributes to human health and disease. The microbiome has also become a burgeoning field of research in medicine, agriculture & environment. The readers will obtain profound knowledge on the connection between intestinal microbiota and immune defense systems, medicine, agriculture & environment. The book may address several researchers, clinicians and scholars working in biomedicine, microbiology and immunology. The application of new technologies has no doubt revolutionized the research initiatives providing new insights into the dynamics of these complex microbial communities and their role in medicine, agriculture & environment shall be more emphasized. Drawing on broad range concepts of disciplines and model systems, this book primarily provides a conceptual framework for understanding these human-microbe, animal-microbe & plant-microbe, interactions while shedding critical light on the scientific challenges that lie ahead. Furthermore this book explains why microbiome research demands a creative and interdisciplinary thinking—the capacity to combine microbiology with human, animal and plant physiology, ecological theory with immunology, and evolutionary perspectives with metabolic science.This book provides an accessible and authoritative guide to the fundamental principles of microbiome science, an exciting and fast-emerging new discipline that is reshaping many aspects of the life sciences. These microbial partners can also drive ecologically important traits, from thermal tolerance to diet in a typical immune system, and have contributed to animal and plant diversification over long evolutionary timescales. Also this book explains why microbiome research presents a more complete picture of the biology of humans and other animals, and how it can deliver novel therapies for human health and new strategies.