Chiral Photochemical Scissors Targeting Proteins

Author : Kumar Challa
Publisher : World Scientific
ISBN 13 : 9813237635
Total Pages : 448 pages
Book Rating : 4.36/5 ( download)

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Download or read book Chiral Photochemical Scissors Targeting Proteins written by Kumar Challa and published by World Scientific. This book was released on 2018-10-26 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: The remarkable ability to target one or even a couple of sites on a large protein with a small molecule, under photochemical control, is a considerable challenge and this challenge has been addressed in some depth in this book. Systematic modification of the structure of the photoreagent provided valuable information on the binding site recognition as well as the mechanism of the photocleavage reaction. Some factors that impact the photocleavage reaction include the exact location of the probe binding site on the protein, conformations of the bound probe at the binding site, protein size, functional groups present on the probe that interact with the protein surroundings either in a favorable or unfavorable manner, overall charge on the photoreagent, and photophysical as well as photochemical properties of the probe. The protein photocleavage studies, in all case, were preceded by detailed binding studies by a variety of spectroscopic methods. Methods as simple as absorption and fluorescence spectroscopies or more sophisticated circular dichroism spectroscopy were used. Conclusions that are most consistent with the binding data indicated a single binding site on most proteins, irrespective of the probe or the protein, with only one exception noted so far. Photoactivation of the bound probe resulted in protein cleavage at a single site, in many instances. The specificity for the reaction has been investigated in detail and molecular modeling studies provided a firm ground to rationalize the observed cleavage sites. The reagents provide unique tools for sequencing large proteins by converting them into smaller fragments by non-biochemical transformations. Understanding of the rules for the above methodology are also investigated which provided rational methods for the design of small molecules that could bind at particular sites on large proteins, and this is a major breakthrough for a variety of fields including drug design, protein targeting, mass spectrometry, proteomics and other cutting-edge research areas.

Author : Lassaletta Jose M
Publisher : World Scientific
ISBN 13 : 1786346478
Total Pages : 676 pages
Book Rating : 4.76/5 ( download)

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Download or read book Atropisomerism And Axial Chirality written by Lassaletta Jose M and published by World Scientific. This book was released on 2019-05-23 with total page 676 pages. Available in PDF, EPUB and Kindle. Book excerpt: Atropisomerism and Axial Chirality provides a global survey of the chemistry of axially chiral compounds including biaryls, heterobiaryls, non-biaryl atropisomers, allenes and spyrocyclic derivatives. From the perspective of a synthetic organic chemist, this book provides a unique compilation of the available methodologies for their synthesis, with emphasis on the most efficient and modern strategies, a review of the huge amount of practical applications in the field of asymmetric catalysis, either as transition metal ligands or as organocatalysts, and an overview of their occurrence as bioactive compounds and natural products.The first of its kind, this book serves as a general introduction and a practical reference to advanced chemistry students and researchers, while also offering creative ideas for further developments in the field.

Author : Yoshihisa Inoue
Publisher : CRC Press
ISBN 13 : 0203026349
Total Pages : 704 pages
Book Rating : 4.42/5 ( download)

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Download or read book Chiral Photochemistry written by Yoshihisa Inoue and published by CRC Press. This book was released on 2004-08-30 with total page 704 pages. Available in PDF, EPUB and Kindle. Book excerpt: Control of molecular chirality is central to contemporary chemistry, biology, and materials-related areas. Chiral photochemistry employs molecular and supramolecular chiral interactions in the electronically excited state to induce molecular chirality, providing new and versatile strategies and surprising results unattainable by conventional therma

Author : Noel Timothy
Publisher : World Scientific
ISBN 13 : 1786342200
Total Pages : 284 pages
Book Rating : 4.01/5 ( download)

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Download or read book Photochemical Processes In Continuous-flow Reactors: From Engineering Principles To Chemical Applications written by Noel Timothy and published by World Scientific. This book was released on 2017-02-27 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Continuous-flow photochemistry is an expanding field within chemistry. It unites the mass transfer enhancement of flow chemistry with the high energy field density of microscale geometries. Moreover, it provides means to scale photochemical reactions efficiently. This book gives an overview of both technological and chemical aspects associated with photochemical processes in microreactors. It provides analysis, the first of its kind, of these new technologies developed within the field of photochemical processes, with a description and case studies of practical implementation. It specifically looks at: Design considerations of continuous-flow photoreactors;Detailed descriptions of photon and mass-transfer phenomena;Modeling approaches for photochemical transformations;Scale up strategies for photochemical transformations;Examples of continuous-flow photochemistry in organic synthetic chemistry and material science;Industrial examples of photochemical transformations. By providing a deeper understanding of underlying concepts, coupled with numerous examples, this book is an essential reference for chemistry students, researchers and professionals working on photochemistry, photoredox catalysis, flow chemistry, process chemistry and reactor engineering.

Author :
Publisher : Academic Press
ISBN 13 : 0123859050
Total Pages : 461 pages
Book Rating : 4.51/5 ( download)

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Download or read book Inorganic Photochemistry written by and published by Academic Press. This book was released on 2011-07-14 with total page 461 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Advances in Inorganic Chemistry series present timely and informative summaries of the current progress in a variety of subject areas within inorganic chemistry, ranging from bio-inorganic to solid state studies. This acclaimed serial features reviews written by experts in the field and serves as an indispensable reference to advanced researchers. Each volume contains an index, and each chapter is fully referenced. Features comprehensive reviews on the latest developments Includes contributions from leading experts in the field Serves as an indispensable reference to advanced researchers

Author : Rachel C. Evans
Publisher : Springer Science & Business Media
ISBN 13 : 9048138302
Total Pages : 619 pages
Book Rating : 4.02/5 ( download)

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Download or read book Applied Photochemistry written by Rachel C. Evans and published by Springer Science & Business Media. This book was released on 2014-07-08 with total page 619 pages. Available in PDF, EPUB and Kindle. Book excerpt: Applied Photochemistry encompasses the major applications of the chemical effects resulting from light absorption by atoms and molecules in chemistry, physics, medicine and engineering, and contains contributions from specialists in these key areas. Particular emphasis is placed both on how photochemistry contributes to these disciplines and on what the current developments are. The book starts with a general description of the interaction between light and matter, which provides the general background to photochemistry for non-specialists. The following chapters develop the general synthetic and mechanistic aspects of photochemistry as applied to both organic and inorganic materials, together with types of materials which are useful as light absorbers, emitters, sensitisers, etc. for a wide variety of applications. A detailed discussion is presented on the photochemical processes occurring in the Earth’s atmosphere, including discussion of important current aspects such as ozone depletion. Two important distinct, but interconnected, applications of photochemistry are in photocatalytic treatment of wastes and in solar energy conversion. Semiconductor photochemistry plays an important role in these and is discussed with reference to both of these areas. Free radicals and reactive oxygen species are of major importance in many chemical, biological and medical applications of photochemistry, and are discussed in depth. The following chapters discuss the relevance of using light in medicine, both with various types of phototherapy and in medical diagnostics. The development of optical sensors and probes is closely related to diagnostics, but is also relevant to many other applications, and is discussed separately. Important aspects of applied photochemistry in electronics and imaging, through processes such as photolithography, are discussed and it is shown how this is allowing the increasing miniaturisation of semiconductor devices for a wide variety of electronics applications and the development of nanometer scale devices. The final two chapters provide the basic ideas necessary to set up a photochemical laboratory and to characterise excited states. This book is aimed at those in science, engineering and medicine who are interested in applying photochemistry in a broad spectrum of areas. Each chapter has the basic theories and methods for its particular applications and directs the reader to the current, important literature in the field, making Applied Photochemistry suitable for both the novice and the experienced photochemist.

Author :
Publisher :
ISBN 13 :
Total Pages : 1956 pages
Book Rating : 4.5O/5 ( download)

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Download or read book Index Medicus written by and published by . This book was released on 2002-12 with total page 1956 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.

Author : Wolfgang Domcke
Publisher : World Scientific
ISBN 13 : 9814313440
Total Pages : 769 pages
Book Rating : 4.45/5 ( download)

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Download or read book Conical Intersections written by Wolfgang Domcke and published by World Scientific. This book was released on 2011 with total page 769 pages. Available in PDF, EPUB and Kindle. Book excerpt: The concept of adiabatic electronic potential-energy surfaces, defined by the Born?Oppenheimer approximation, is fundamental to our thinking about chemical processes. Recent computational as well as experimental studies have produced ample evidence that the so-called conical intersections of electronic energy surfaces, predicted by von Neumann and Wigner in 1929, are the rule rather than the exception in polyatomic molecules. It is nowadays increasingly recognized that conical intersections play a key mechanistic role in chemical reaction dynamics. This volume provides an up-to-date overview of the multi-faceted research on the role of conical intersections in photochemistry and photobiology, including basic theoretical concepts, novel computational strategies as well as innovative experiments. The contents and discussions will be of value to advanced students and researchers in photochemistry, molecular spectroscopy and related areas.

Author : Mary D. Archer
Publisher : World Scientific
ISBN 13 : 1860942555
Total Pages : 781 pages
Book Rating : 4.56/5 ( download)

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Download or read book Nanostructured and Photoelectrochemical Systems for Solar Photon Conversion written by Mary D. Archer and published by World Scientific. This book was released on 2008 with total page 781 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, expert authors describe advanced solar photon conversion approaches that promise highly efficient photovoltaic and photoelectrochemical cells with sophisticated architectures on the one hand, and plastic photovoltaic coatings that are inexpensive enough to be disposable on the other. Their leitmotifs include light-induced exciton generation, junction architectures that lead to efficient exciton dissociation, and charge collection by percolation through mesoscale phases. Photocatalysis is closely related to photoelectrochemistry, and the fundamentals of both disciplines are covered in this volume.

Author : Zhiyong Tang
Publisher : John Wiley & Sons
ISBN 13 : 3527337571
Total Pages : 300 pages
Book Rating : 4.76/5 ( download)

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Download or read book Chiral Nanomaterials written by Zhiyong Tang and published by John Wiley & Sons. This book was released on 2018-03-05 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thorough and up-to-date, this book presents recent developments in this exciting research field. To begin with, the text covers the fabrication of chiral nanomaterials via various synthesis methods, including electron beam lithography, ion beam etching, chemical synthesis and biological DNA directed assembly. This is followed by the relevant theory and reaction mechanisms, with a discussion of the characterization of chiral nanomaterials according to the optical properties of metal nanoparticles, semiconductor nanocrystals, and nanoclusters. The whole is rounded off by a summary of applications in the field of catalysis, sensors, and biomedicine. With its comprehensive yet concise coverage of the whole spectrum of research, this is invaluable reading for senior researchers and entrants to the field of nanoscience and materials science.