Cellular Osmolytes

Author : Laishram Rajendrakumar Singh
Publisher : Springer
ISBN 13 : 9811037078
Total Pages : 251 pages
Book Rating : 4.78/5 ( download)

DOWNLOAD NOW!

Download or read book Cellular Osmolytes written by Laishram Rajendrakumar Singh and published by Springer. This book was released on 2017-05-16 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides essential information on improving protein folding/stability, which is a result of the balance between the intra-molecular interactions of protein functional groups and their interactions with the solvent environment. The protein folding solvent environment mainly consists of salts, small molecule compounds, metabolites, molecular chaperones and other chemical species. Therefore, subtle change in the composition of the environment will alter the protein folding process. The importance of the solvent environment in protein folding is precisely due to the fact that various disease-causing proteopathies can be reversed by manipulating the solvent environment of the malfolded proteins. Hostile environmental stresses represent one of the basic causes of such challenges in protein folding or misfolding. Since cells commonly encounter extreme environmental fluctuations, it is crucial that they equip themselves with strategies to circumvent the hostile environmental conditions. Nature has developed many strategies to ensure that the complex and challenging protein folding reaction occurs with adequate efficiency and fidelity for the success of the organism. Among the strategies employed in a wide range of species and cell types is the elaboration of small organic molecules called osmolytes. Additionally, recent advances have also revealed that certain specific osmolytes might be key biomarkers of cancer, infectious diseases and vaccine flocculation. In fact, a large pool of data has been generated regarding their potential for the therapeutic intervention of neurodegenerative diseases and other metabolic disorders caused by protein aggregation or proteostasis failure. Reflecting the multiple applications of these small molecules in the health and other industries, this book combines contributions by respected leaders in the field and will help to inspire college students, basic researchers, and clinicians to translate these biological roles of osmolytes into clinical practice. It will also shed light on some important future prospects of osmolytes like their role as drug excipients and provide a deeper understanding of their mechanism of action in the prevention of neuro-degenerative diseases.

Author : George N. Somero
Publisher : Springer Science & Business Media
ISBN 13 : 364276682X
Total Pages : 374 pages
Book Rating : 4.24/5 ( download)

DOWNLOAD NOW!

Download or read book Water and Life written by George N. Somero and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presenting an analysis of the water relationships of the major groups of organisms: fungi, plants and animals, the text examines water stress at all levels of biological organization. Topics covered include: 1) organic osmotic agents: their distributions, modes of action, and mechanisms of regulation; 2) desiccation stress; mechanisms for preserving cellu lar integrity under conditions of low cellular water activity; 3) water stress and water compartmentation in plants; and 4) freezing stress: the prevention and regulation of ice formation in biological fluids, and mechanisms for overcoming the damaging effects of low temperatures on cellular integrity. Common adaptive strategies in diverse organisms are emphasized, as well as the fundamental physical-chemical properties of aqueous solutions that establish the nature of the interactions among water, low molecular weight solutes and macromolecules.

Author : Kevin Strange
Publisher : CRC Press
ISBN 13 : 1000714268
Total Pages : 415 pages
Book Rating : 4.65/5 ( download)

DOWNLOAD NOW!

Download or read book Cellular and Molecular Physiology of Cell Volume Regulation written by Kevin Strange and published by CRC Press. This book was released on 2020-01-16 with total page 415 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ability to regulate cell volume in the face of osmotic challenge is one of the most fundamental of cellular homeostatic mechanisms. Cellular and Molecular Physiology of Cell Volume Regulation is an integrated collection of articles describing key aspects of cell volume control. The book has been organized around concepts and cellular/molecular processes rather than around mechanisms of volume regulation in specific cell types in order to make it more accessible to a multidisciplinary audience of students, instructors, and researchers.

Author : Florian Lang
Publisher : S. Karger AG (Switzerland)
ISBN 13 :
Total Pages : 280 pages
Book Rating : 4.16/5 ( download)

DOWNLOAD NOW!

Download or read book Cell Volume Regulation written by Florian Lang and published by S. Karger AG (Switzerland). This book was released on 1998 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents a unique compilation of reviews on cell volume regulation in health and disease, with contributions from leading experts in the field. The topics covered include mechanisms and signaling of cell volume regulation and the effect of cell volume on cell function, with special emphasis on ion channels and transporters, kinases and gene expression. Several chapters elaborate on how cell volume regulatory mechanisms participate in the regulation of epithelial transport, urinary concentration, metabolism, migration, cell proliferation and apoptosis. Last but not least, this publication is an excellent guide to the role of cell volume in the pathophysiology of hypercatabolism, diabetes mellitus, brain edema, hemoglobinopathies, tumor growth and metastasis, to name just a few. Providing deeper insights into an exciting area of research which is also of clinical relevance, this publication is a valuable addition to the library of those interested in cell volume regulation.

Author :
Publisher : Elsevier
ISBN 13 : 0080552110
Total Pages : 630 pages
Book Rating : 4.18/5 ( download)

DOWNLOAD NOW!

Download or read book Osmosensing and Osmosignaling written by and published by Elsevier. This book was released on 2007-10-01 with total page 630 pages. Available in PDF, EPUB and Kindle. Book excerpt: For over fifty years the Methods in Enzymology series has been the critically acclaimed laboratory standard and one of the most respected publications in the field of biochemistry. The highly relevant material makes it an essential publication for researchers in all fields of life and related sciences. This volume features articles on the topic of osmosensing and osmosignaling written by experts in the field.

Author : Kevin Strange
Publisher : CRC Press
ISBN 13 : 1000722082
Total Pages : 442 pages
Book Rating : 4.86/5 ( download)

DOWNLOAD NOW!

Download or read book Cellular and Molecular Physiology of Cell Volume Regulation written by Kevin Strange and published by CRC Press. This book was released on 2020-01-16 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ability to regulate cell volume in the face of osmotic challenge is one of the most fundamental of cellular homeostatic mechanisms. Cellular and Molecular Physiology of Cell Volume Regulation is an integrated collection of articles describing key aspects of cell volume control. The book has been organized around concepts and cellular/molecular processes rather than around mechanisms of volume regulation in specific cell types in order to make it more accessible to a multidisciplinary audience of students, instructors, and researchers.

Author : Noushina Iqbal
Publisher : Springer
ISBN 13 : 813222616X
Total Pages : 178 pages
Book Rating : 4.61/5 ( download)

DOWNLOAD NOW!

Download or read book Osmolytes and Plants Acclimation to Changing Environment: Emerging Omics Technologies written by Noushina Iqbal and published by Springer. This book was released on 2015-12-16 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: The continual change in climatic conditions induces a series of adaptations in plants to suit the unfavorable conditions for sustainable agriculture. For sustainable agriculture, it is important to unravel the precise mechanism(s) that disturb the homeostatic equilibrium at cellular and molecular level and also to enhance understanding to build strategies for the tolerance of plants. Osmolytes have long been identified as pivotal abiotic stress busters because of their role in plants in overcoming extremely harsh environmental conditions. This edited compilation attempts to put forth the scattered knowledge on osmolytes and their role in abiotic stress tolerance together and disseminate as a package to deal with the problems of lower productivity under stressful environment. It will enhance the understanding on osmolytes function and bioengineering of plants for abiotic stress tolerance. The book covers very interesting topics dealing with various osmolytes and the mechanistic approach for abiotic stress tolerance to pave the path of agricultural scientists, breeders for developing high yielding sustainable transgenic crops.

Author : Robert J. Alpern
Publisher : Elsevier
ISBN 13 : 0080559506
Total Pages : 2922 pages
Book Rating : 4.06/5 ( download)

DOWNLOAD NOW!

Download or read book Seldin and Giebisch's The Kidney written by Robert J. Alpern and published by Elsevier. This book was released on 2007-10-10 with total page 2922 pages. Available in PDF, EPUB and Kindle. Book excerpt: A classic nephrology reference for over 20 years, Seldin & Giebisch’s The Kidney, is the acknowledged authority on renal physiology and pathophysiology. The fourth edition follows the changed focus of nephrology research to the study of how individual molecules work together to affect cellular and organ function, emphasizing the mechanisms of disease. With over 40 new chapters and over 1000 illustrations, this edition offers the most in-depth discussion anywhere of the physiologic and pathophysiologic processes of renal disease. Comprehensive, authoritative coverage progresses from molecular biology and cell physiology to clinical issues regarding renal function and dysfunction. If you research the development of normal renal function or the mechanisms underlying renal disease, Seldin & Giebisch’s The Kidney is your number one source for information. * Offers the most comprehensive coverage of fluid and electrolyte regulation and dysregulation in 51 completely revised chapters unlike Brenner & Rector's The Kidney which devotes only 7 chapters to this topic.* Includes 3 sections, 31 chapters, devoted to regulation and disorders of acid-base homeostasis, and epithelial and nonepithelial transport regulation. Brenner & Rector's only devotes 5 chapters to these topics.* Previous three editions edited by Donald Seldin and Gerhard Giebisch, world renowned names in nephrology. The title for the fourth edition has been changed to reflect their considerable work on previous editions and they have also written the forward for this edition. * Over 20 million adults over age 20 have chronic kidney disease with the number of people diagnosed doubling each decade making it America's ninth leading cause of death.

Author : Michael C. Flickinger
Publisher : John Wiley & Sons
ISBN 13 : 1118619277
Total Pages : 3600 pages
Book Rating : 4.78/5 ( download)

DOWNLOAD NOW!

Download or read book Upstream Industrial Biotechnology, 2 Volume Set written by Michael C. Flickinger and published by John Wiley & Sons. This book was released on 2013-07-22 with total page 3600 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biotechnology represents a major area of research focus, and many universities are developing academic programs in the field. This guide to biomanufacturing contains carefully selected articles from Wiley's Encyclopedia of Industrial Biotechnology, Bioprocess, Bioseparation, and Cell Technology as well as new articles (80 in all,) and features the same breadth and quality of coverage and clarity of presentation found in the original. For instructors, advanced students, and those involved in regulatory compliance, this two-volume desk reference offers an accessible and comprehensive resource.

Author : Ron J. Maughan
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3805596979
Total Pages : 170 pages
Book Rating : 4.78/5 ( download)

DOWNLOAD NOW!

Download or read book Sports Nutrition written by Ron J. Maughan and published by Karger Medical and Scientific Publishers. This book was released on 2011 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diet and athletic performance -- new aspects Diet significantly affects athletic performance, and adoption of a dietary strategy that meets an athlete's nutrition goals will maximize the possibility of competitive success. Over the years, the focus has shifted from a high intake of (animal) protein to the role of carbohydrate and water. Today, there is a growing recognition that the primary role of sports nutrition may be to promote the adaptations taking place in muscle and other tissues in response to the training stimulus. There is also much interest in the implications of manipulation of the fat and carbohydrate content of the diet. This publication contains the proceedings of the 69th Nestl Nutrition Institute Workshop held in Hawaii in October 2010. The aim of the workshop was to explore the effects of nutritional manipulations on the metabolic responses to acute and chronic exercise. Another goal was to further identify the possible role of these dietary interventions in promoting adaptive changes in muscle, adipose tissues and other potential sites of limitation to exercise performance. Papers cover the three macronutrients carbohydrate, fat and protein, plus an additional chapter on water, together with the accompanying discussions.