Cellular And Molecular Mechanisms Underlying The Pathogenesis Of Hepatic Fibrosis

Author : Ralf Weiskirchen
Publisher : MDPI
ISBN 13 : 3039361880
Total Pages : 276 pages
Book Rating : 4.85/5 ( download)

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Download or read book Cellular and Molecular Mechanisms Underlying the Pathogenesis of Hepatic Fibrosis written by Ralf Weiskirchen and published by MDPI. This book was released on 2020-12-29 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: Worldwide, liver fibrosis is a major cause of morbidity and mortality and is associated with a high medical and economic burden. It is the common consequence of chronic liver injury due to various etiologies. During fibrogenesis, there is a progressive substitution of the liver parenchyma by scar tissue. Recent advances in the understanding of the history of liver fibrosis have shown that the pathogenesis is driven by different cell types and a large variety of soluble mediators. At present, scientists working in this field aim to increase basic knowledge, improve diagnostics, and try to translate experimental findings into new treatment modalities. This book includes 12 selected contributions from the Special Issue “Cellular and Molecular Mechanisms Underlying the Pathogenesis of Hepatic Fibrosis” that was published in Cells. These articles summarize current perspectives and findings in hepatic fibrosis research showing how scientists try to use basic scientific research to create new therapies and diagnostics.

Author : Ralf Weiskirchen
Publisher :
ISBN 13 : 9783039361892
Total Pages : 276 pages
Book Rating : 4.99/5 ( download)

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Download or read book Cellular and Molecular Mechanisms Underlying the Pathogenesis of Hepatic Fibrosis written by Ralf Weiskirchen and published by . This book was released on 2020 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: Worldwide, liver fibrosis is a major cause of morbidity and mortality and is associated with a high medical and economic burden. It is the common consequence of chronic liver injury due to various etiologies. During fibrogenesis, there is a progressive substitution of the liver parenchyma by scar tissue. Recent advances in the understanding of the history of liver fibrosis have shown that the pathogenesis is driven by different cell types and a large variety of soluble mediators. At present, scientists working in this field aim to increase basic knowledge, improve diagnostics, and try to translate experimental findings into new treatment modalities. This book includes 12 selected contributions from the Special Issue “Cellular and Molecular Mechanisms Underlying the Pathogenesis of Hepatic Fibrosis” that was published in Cells. These articles summarize current perspectives and findings in hepatic fibrosis research showing how scientists try to use basic scientific research to create new therapies and diagnostics.

Author : Ralf Weiskirchen
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.39/5 ( download)

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Download or read book Special Issue "Cellular and Molecular Mechanisms Underlying the Pathogenesis of Hepatic Fibrosis 2020" written by Ralf Weiskirchen and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Pablo Muriel
Publisher : Academic Press
ISBN 13 : 0323952895
Total Pages : 276 pages
Book Rating : 4.97/5 ( download)

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Download or read book Hepatic Fibrosis written by Pablo Muriel and published by Academic Press. This book was released on 2022-04-23 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hepatic Fibrosis: Mechanisms and Targets is a complete volume of liver extracellular matrix biology, including molecular signaling pathways, cells and factors that modulate fibrogenesis and fibrosis. The book uses an integrated approach toward the molecular and cellular mechanisms involved in the synthesis and degradation of hepatic fibrotic tissue, emphasizing the possible molecular targets to fight fibrosis. This important reference describes, in detail and didactically, the cellular and molecular events that are conducive to fibrosis that leads to cirrhosis, hepatocellular carcinoma and death. The provided information allows readers to understand the molecular mechanisms of hepatic fibrogenesis to accelerate the development of new therapies. Presents progression from inflammation to fibrosis, with a special focus on the molecular mechanisms involved Didactically explains the participation of cells, cytokines and factors in profibrogenic pathways Illuminates the causative participation of free radicals in liver fibrogenesis Explains the role of gut dysbiosis in chronic liver diseases leading to fibrosis Provides experimental models to study liver fibrosis and describes available, noninvasive monitoring methods

Author : Jessica Llewellyn
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.27/5 ( download)

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Download or read book Understanding the Molecular Mechanisms Underlying Matrix Production in Liver Fibrosis written by Jessica Llewellyn and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : A.M. Gressner
Publisher : Springer
ISBN 13 :
Total Pages : 586 pages
Book Rating : 4.04/5 ( download)

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Download or read book Molecular and Cell Biology of Liver Fibrogenesis written by A.M. Gressner and published by Springer. This book was released on 1992-09-30 with total page 586 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume, the proceedings of the International Falk Symposium held in Marburg, Germany, in January 1992, summarizes the most recent advances in the study of cellular and molecular mechanisms of fibrosis provided by contributions from the leading scientists in this field. It updates our knowledge on the basic components of fibrosis, on the cellularorigin and degradation of matrix components, on peptide and non-peptide mediators, cellular cooperation and other mechanisms of fibrogenesis, on the role of the extracellular matrix as modulator of fibrogenesis, and on some aspects of antifibrotic trials and biochemical monitoring of the development of fibrosis. Since liver fibrogenesis has, to a certain extent, attained the status of a model for fibrotic tissue reactions that occur generally in various organs and tissues, the fundamental processes described here may be relevant for other sites of tissue repairs and fibrosis, for would healing and even for atherogenesis.

Author : Meike Knauel
Publisher :
ISBN 13 :
Total Pages : 143 pages
Book Rating : 4.52/5 ( download)

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Download or read book Molecular Mechanisms Underlying the Protective Effect of MIF in Experimental Liver Fibrosis written by Meike Knauel and published by . This book was released on 2013 with total page 143 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Chandrashekhar Gandhi
Publisher : Academic Press
ISBN 13 : 0128005440
Total Pages : 335 pages
Book Rating : 4.46/5 ( download)

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Download or read book Stellate Cells in Health and Disease written by Chandrashekhar Gandhi and published by Academic Press. This book was released on 2015-04-10 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stellate Cells in Health and Disease is a comprehensive reference providing the most up-to-date knowledge and perspectives on the function of stellate cells affecting the liver and other organs. The text presents comprehensive coverage of their already established role in hepatic fibrosis along with the newer emerging evidence for stellate cell participation in the liver cell (hepatocyte) survival and regeneration, hepatic immunobiology, transplant tolerance, and liver cancer. Chapters describe both animal and human research and the relevance of findings from animal research to human pathophysiology, and also contain sections on future directions which will be of special interest to basic and clinical researchers working on liver fibrosis, hepatic biology, and pathobiology. Presents coverage of the mechanisms of liver fibrosis with stellate cells as a target for therapy. Shows stellate cells as a major participant in hepatic immunobiology, including transplantation immunology. Key illustrations show the phenotypical changes in stellate cells in situ and tissue culture, their interactions with other cell types, signaling pathways and demonstrate the functions and roles of stellate cell in pathological processes.

Author : Satdarshan P. S. Monga
Publisher : Springer Science & Business Media
ISBN 13 : 1441971076
Total Pages : 920 pages
Book Rating : 4.74/5 ( download)

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Download or read book Molecular Pathology of Liver Diseases written by Satdarshan P. S. Monga and published by Springer Science & Business Media. This book was released on 2010-12-14 with total page 920 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cellular and Molecular Pathology of the Liver is extensive, complex and ranges from the understanding the basic molecular mechanisms that dictate everything from liver homeostasis to liver disease. Molecular Pathology of the liver is complicated due to some of the important functions inherent and unique to the Liver, including its innate ability to regenerate and the multitude of functions it plays for the wellbeing of an organism. With all this in mind, Molecular Pathology of Liver Diseases is organized in different sections, which will coherently and cohesively present the molecular basis of hepatic physiology and pathology. The first two sections are key to understanding the liver anatomy and physiology at a cellular level and go on to define the molecular mechanics in various liver cell types. These sections also cover the existing paradigms in liver development, regeneration and growth. The next section is key to understanding the Molecular Pathology unique to liver diseases and associated phenotypes. The final sections are geared towards the existing knowledge of the molecular basis of many common and uncommon liver diseases in both neoplastic and non-neoplastic areas including pathologies associated with intra-hepatic and extra-hepatic biliary tree. Thus, this textbook is a one-stop reference for comprehending the molecular mechanisms of hepatic pathobiology. It is clearly unique in its format, readability and information and thus will be an asset to many in the field of Pathology and other disciplines.

Author :
Publisher :
ISBN 13 : 9789176199190
Total Pages : pages
Book Rating : 4.93/5 ( download)

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Download or read book Cellular and Molecular Mechanisms in Immune Mediated Hepatic Fibros written by and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: