Biology Of Copper Complexes

Author : John R. J. Sorenson
Publisher : Springer Science & Business Media
ISBN 13 : 1461245842
Total Pages : 589 pages
Book Rating : 4.41/5 ( download)

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Download or read book Biology of Copper Complexes written by John R. J. Sorenson and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 589 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1928, it was discovered that copper was essential for normal human metabolism. Ten years later, 1938, it was observed that patients with rheumatoid arthritis had a higher than normal serum copper concentration, which returned to normal wi th remission of this disease. Thirteen years later, it was found that copper complexes were effective in treating arthritic diseaseS. The first report that copper complexes had antiinflammatory activity in an animal model of in flammation appeared twenty-two years after the discovery of essen tiality. In 1976, it was suggested that the active forms of the anti arthritic drugs are their copper complexes formed in vivo. This suggestion was confirmed and extended in the interim with over 1000 recent publications, and many of these were addressed in the proceed ings of our first symposium, published in 1982. The present symposium was organized to present new normal physiological, nutritional, and biochemical aspects of essential metal loelement metabolism as well as variations in metabolism associated with disease states. In addition new data concerning antimicrobial, antiinflammatory, antiulcer, anticancer, anticarcinogenic, analgesic, and radioprotectant activities of copper complexes were presented. These activities are consistent with the notion that they represent the facilitation of normal copper-dependent metabolic processes in dis ease states. The presentations and interactive discussions that fol lowed are contained in these proceedings. John R. J. Sorenson Dedication These proceedings are dedicated to those who made this truly memorable scientific and social Arkansas experience possible.

Author : John R. J. Sorenson
Publisher : Humana Press
ISBN 13 : 9780896031234
Total Pages : 598 pages
Book Rating : 4.33/5 ( download)

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Download or read book Biology of Copper Complexes written by John R. J. Sorenson and published by Humana Press. This book was released on 1987-10-01 with total page 598 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1928, it was discovered that copper was essential for normal human metabolism. Ten years later, 1938, it was observed that patients with rheumatoid arthritis had a higher than normal serum copper concentration, which returned to normal wi th remission of this disease. Thirteen years later, it was found that copper complexes were effective in treating arthritic diseaseS. The first report that copper complexes had antiinflammatory activity in an animal model of in flammation appeared twenty-two years after the discovery of essen tiality. In 1976, it was suggested that the active forms of the anti arthritic drugs are their copper complexes formed in vivo. This suggestion was confirmed and extended in the interim with over 1000 recent publications, and many of these were addressed in the proceed ings of our first symposium, published in 1982. The present symposium was organized to present new normal physiological, nutritional, and biochemical aspects of essential metal loelement metabolism as well as variations in metabolism associated with disease states. In addition new data concerning antimicrobial, antiinflammatory, antiulcer, anticancer, anticarcinogenic, analgesic, and radioprotectant activities of copper complexes were presented. These activities are consistent with the notion that they represent the facilitation of normal copper-dependent metabolic processes in dis ease states. The presentations and interactive discussions that fol lowed are contained in these proceedings. John R. J. Sorenson Dedication These proceedings are dedicated to those who made this truly memorable scientific and social Arkansas experience possible.

Author : Alan G. Lewis
Publisher : New York : International Copper Association
ISBN 13 :
Total Pages : 388 pages
Book Rating : 4.58/5 ( download)

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Download or read book The Biological Importance of Copper written by Alan G. Lewis and published by New York : International Copper Association. This book was released on 1991 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : K.D. Karlin
Publisher : Springer Science & Business Media
ISBN 13 : 940116875X
Total Pages : 510 pages
Book Rating : 4.55/5 ( download)

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Download or read book Bioinorganic Chemistry of Copper written by K.D. Karlin and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 510 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioinorganic Chemistry of Copper focuses on the vital role of copper ions in biology, especially as an essential metalloenzyme cofactor. The book is highly interdisciplinary in its approach--the outstanding list of contributors includes coordination chemists, biochemists, biophysicists, and molecular biologists. Chapters are grouped into major areas of research interest in inorganic copper chemistry, spectroscopy, oxygen chemistry, biochemistry, and molecular biology. The book also discusses basic research of great potential importance to pharmaceutical scientists. This book is based on the first Johns Hopkins University Copper Symposium, held in August 1992. Researchers in chemistry, biochemistry, molecular biology, and medicinal chemistry will find it to be an essential reference on its subject.

Author : John R. J. Sorenson
Publisher : Springer Science & Business Media
ISBN 13 : 1461258294
Total Pages : 614 pages
Book Rating : 4.92/5 ( download)

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Download or read book Inflammatory Diseases and Copper written by John R. J. Sorenson and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 614 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1928, it was discovered that copper was essential for normal human metabolism. A decade later, in 1938, it was observed that patients with rheu matoid arthritis exhibited a higher than normal serum copper concentration that returned to normal with remission of this disease. Thirteen years later, it was found that copper complexes were effective in treating arthritic dis eases. The first report that copper complexes had antiinflammatory activity in an animal model of inflammation appeared twenty-two years after the dis covery of essentiality. In 1976, it was suggested that the active forms of the antiarthritic drugs are their copper complexes formed in vivo. This sugges tion has been confirmed and extended in the interim in over 200 recent publications. Individual biomedical scientists from many countries who have published in these areas recently saw a need for a meeting to exchange current re supporting new hypotheses. We search results and discuss the evidence met on the University of Arkansas Medical Sciences campus in Little Rock, Arkansas, August 10-13, 1981. Participants came from Australia, England, France, Germany, Israel, Italy, The Netherlands, Norway, Poland, Scotland, Sweden, Switzerland, Wales, Zimbabwe, and over twenty of the United States.

Author : Charles Archibald Owen
Publisher : William Andrew
ISBN 13 :
Total Pages : 232 pages
Book Rating : 4.88/5 ( download)

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Download or read book Biochemical Aspects of Copper written by Charles Archibald Owen and published by William Andrew. This book was released on 1982 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: An authoritative reference text reviews the current body of knowledge concerning the isolation, characterization, and biochemical function of in vivo copper-containing species as related to copper metabolism and in vivo copper complexes for clinical biochemists and nutrition researchers. The material is organized among 3 principal categories: copper proteins and other copper-containing compounds (identified copper proteins (including enzymes) ill- defined copper proteins, possible copper enzymes, and copper porphyrins and other complexes), with references given for each of the 35 proteins and other compounds covered; the chemistry, isolation, function, assay, metabolism, and therapeutic use of ceruloplasmin, including deficiency and excess disorders; and the related topics of copper-protein binding and copper transport. (wz).

Author : Jalila Simaan
Publisher : World Scientific
ISBN 13 : 9811269505
Total Pages : 273 pages
Book Rating : 4.09/5 ( download)

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Download or read book Copper Bioinorganic Chemistry: From Health To Bioinspired Catalysis written by Jalila Simaan and published by World Scientific. This book was released on 2023-07-26 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioinorganic chemistry is an interdisciplinary research field which centers on metals in biology. Over the past few decades, advances in chemistry, biology as well as in spectroscopic methods have shed light on the role of copper in human pathologies and allowed the growing discovery of copper-containing biological systems. Following this trend, much effort is being constantly chanelled towards understanding these fundamental biological processes or enzymes. In addition, chemists are developing molecules to target copper or copper enzymes as therapeutic tools. On the other hand, inspired by the function of biological systems, small molecular weight complexes inspired by the active site of copper enzymes are being prepared and studied. These bioinspired complexes can function both as mechanistic tools and as functional catalysts for oxidative transformations.The seven chapters in this book, contributed by internationally recognized authors cover recent developments on these aspects illustrated by interdisciplinary fields from biology, chemistry, spectroscopy to bioinspired catalysis. It contains aspects ranging from human health issues (copper homeostasis in bacteria and the development of molecules as anticancer or antibacterial agents) to bioinspired catalysis.

Author : Maravanji S. Balakrishna
Publisher : Elsevier
ISBN 13 : 0128156945
Total Pages : 442 pages
Book Rating : 4.40/5 ( download)

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Download or read book Copper(I) Chemistry of Phosphines, Functionalized Phosphines and Phosphorus Heterocycles written by Maravanji S. Balakrishna and published by Elsevier. This book was released on 2019-04-25 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: Copper(I) Complexes of Phosphines, Functionalized Phosphines and Phosphorus Heterocycles is a comprehensive guide to one of the most widely used and extensively studied metals: copper. The numerous practical applications of copper compounds are discussed, including homogeneous and heterogeneous catalysis and their use as fungicides, pesticides, pigments for paints, resins and glasses, and in high-temperature superconductors. The remarkable structural flexibility of simple copper(I) complexes, such as cuprous halides is covered, including numerous structural motifs that, when combined with different ligand systems, exhibit linear, trigonal planar or tetrahedral geometries. This work is an essential reference for inorganic and coordination chemists, as well as researchers working on catalysis, anticancer reagents, luminescence, fluorescence and photophysical aspects. Discusses the properties of copper and similarities to noble metals, such as their corrosion resistance, high thermal and electrical conductivity and rich coordination chemistry Includes the copper(I) coordination chemistry of tertiary phosphines, bisphosphines and phosphines containing other donor atoms and their potential application in catalysis, biosystems and photochemical areas Features a discussion of the rich photochemistry exhibited by some mixed-ligand copper(I) complexes (phosphines with heteroaromatic ligands) which can exhibit coprophilic interactions, photoluminescence and thermochromic properties

Author : Rene Lontie
Publisher : CRC Press
ISBN 13 : 1351087797
Total Pages : 460 pages
Book Rating : 4.97/5 ( download)

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Download or read book Copper Proteins and Copper Enzymes written by Rene Lontie and published by CRC Press. This book was released on 2018-02-06 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: These volumes of Copper Proteins and Copper Enzymes are intended to describe the contemporary spectroscopy and other biophysical chemistry now being applied to copper proteins in order to determine the structures of their active sites. Several chapters of the treatise describe the functional understanding which is emerging from the new work. The authors are all major contributors to research progress on copper proteins and the volumes will be found to be definitive and authoritative.

Author :
Publisher : Academic Press
ISBN 13 : 0123965144
Total Pages : 338 pages
Book Rating : 4.41/5 ( download)

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Download or read book Inorganic/Bioinorganic Reaction Mechanisms written by and published by Academic Press. This book was released on 2012-10-11 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Advances in Inorganic Chemistry presents timely and informative summaries of the current progress in a variety of subject areas within inorganic chemistry, ranging from bio-inorganic to solid state studies. This acclaimed serial features reviews written by experts in the field and serves as an indispensable reference to advanced researchers. Each volume contains an index, and each chapter is fully referenced. The Advances in Inorganic Chemistry presents timely and informative summaries of the current progress in a variety of subject areas within inorganic chemistry, ranging from bio-inorganic to solid state studies