Animal Models For Retinal Diseases

Author : Iok-Hou Pang
Publisher : Humana
ISBN 13 : 9781493957507
Total Pages : 229 pages
Book Rating : 4.03/5 ( download)

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Download or read book Animal Models for Retinal Diseases written by Iok-Hou Pang and published by Humana. This book was released on 2016-08-23 with total page 229 pages. Available in PDF, EPUB and Kindle. Book excerpt: Affecting over a hundred million individuals worldwide, retinal diseases are among the leading causes of irreversible visual impairment and blindness, and appropriate study models, especially animal models, are essential to furthering our understanding of the etiology, pathology, and progression of these endemic diseases. In Animal Models for Retinal Diseases, recognized experts in the field highlight valuable techniques as well as animal models for the prominent retinal diseases in order to aid in the evaluation, development, and improvement of therapeutic strategies. Beginning with an overview of the morphology of the retina, visual behavior, and genetics and genomics approaches for retinal research, the book continues by covering animal models for the research of specific human retinal diseases, e.g., retinal degeneration, age-related macular degeneration, retinopathy of prematurity, diabetic retinopathy, glaucoma, retinal ischemia, and retinal inflammation. As a volume in the successful Neuromethods series, the chapters provide authoritative reviews of the most commonly used approaches in the field. Vital and easy to use, Animal Models for Retinal Diseases serves to support the important future research of ocular investigators, ophthalmologists, and neuroscientists currently delving into this fascinating field of study.

Author :
Publisher : Academic Press
ISBN 13 : 9780080921037
Total Pages : 232 pages
Book Rating : 4.35/5 ( download)

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Download or read book Animal Models in Eye Research written by and published by Academic Press. This book was released on 2011-04-28 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: The eye is a complex sensory organ, which enables visual perception of the world. Thus the eye has several tissues that do different tasks. One of the most basic aspects of eye function is the sensitivity of cells to light and its transduction though the optic nerve to the brain. Different organisms use different ways to achieve these tasks. In this sense, eye function becomes a very important evolutionary aspect as well. This book presents the different animal models that are commonly used for eye research and their uniqueness in evaluating different aspects of eye development, evolution, physiology and disease. * Presents information on the major animal models used in eye research including invertebrates and vertebrates * Provides researchers with information needed to choose between model organisms * Includes an introductory chapter on the different types of eyes, stressing possible common molecular machinery

Author : Chi-Chao Chan
Publisher : Springer
ISBN 13 : 3319194348
Total Pages : 152 pages
Book Rating : 4.49/5 ( download)

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Download or read book Animal Models of Ophthalmic Diseases written by Chi-Chao Chan and published by Springer. This book was released on 2015-12-01 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes experimental animal models that mimic common human ocular diseases: herpetic keratitis, cataract, glaucoma, age-related macular degeneration, diabetic retinopathy, uveitis, retinitis pigmentosa, Graves’ disease, and intraocular tumors. In conjunction, these models reflect the diversity and utility of tools used to study human disease. World expert clinicians discuss each model based on their clinical experience and the text is supported by numerous photos and diagrams. In describing the most pertinent animal models of ophthalmic diseases, this book will be of interest to ophthalmologists, vision researchers, fellows, residents and medical students.

Author : P. Michael Conn
Publisher : Springer Science & Business Media
ISBN 13 : 1597452858
Total Pages : 756 pages
Book Rating : 4.54/5 ( download)

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Download or read book Sourcebook of Models for Biomedical Research written by P. Michael Conn and published by Springer Science & Business Media. This book was released on 2008-03-07 with total page 756 pages. Available in PDF, EPUB and Kindle. Book excerpt: The collection of systems represented in this volume is a unique effort to reflect the diversity and utility of models used in biomedicine. That utility is based on the consideration that observations made in particular organisms will provide insight into the workings of other, more complex systems. This volume is therefore a comprehensive and extensive collection of these important medical parallels.

Author : Steven J. Pittler
Publisher : MDPI
ISBN 13 : 3039366548
Total Pages : 336 pages
Book Rating : 4.45/5 ( download)

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Download or read book The Molecular and Cellular Basis of Retinal Diseases written by Steven J. Pittler and published by MDPI. This book was released on 2020-12-29 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are more than 300 genes that have been identified which carry mutations that cause various forms of retinal dysfunction and degeneration, making the study of retinal diseases a subject of high relevance. In this compendium of original and review articles, many of the diseases and pathways associated with disorders of the retina are examined using animal models, to provide the reader with a good overview of current retinal research. Within this volume, you will find research reports on many of the most prominent retinal disorders, such as diabetic retinopathy (DR), age-related macular degeneration (AMD), choroidal neovascularization (CNV), and retinitis pigmentosa (RP). We hope that the work presented here will stimulate new ideas and lead to effective treatments for retinal diseases.

Author : Airo Tsubura
Publisher : Elsevier Inc. Chapters
ISBN 13 : 0128071966
Total Pages : 1108 pages
Book Rating : 4.60/5 ( download)

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Download or read book Animal Models for the Study of Human Disease written by Airo Tsubura and published by Elsevier Inc. Chapters. This book was released on 2013-05-29 with total page 1108 pages. Available in PDF, EPUB and Kindle. Book excerpt: Retinitis pigmentosa (RP) is a group of inherited neurodegenerative diseases in humans characterized by the loss of photoreceptor cells leading to reduction of the peripheral visual field (known as tunnel vision) and eventually to blindness. N-Methyl-N-nitrosourea (MNU) is an alkylating agent that exhibits its toxicity by transferring its methyl group to nucleobases in nucleic acids. A single systemic administration of MNU causes retinal degeneration in various animal species. The retinal degeneration is highly reproducible, and the photoreceptor cell loss occurs within a week when a suitable dose of MNU is administered. Photoreceptor cell loss occurs via apoptosis, which resembles human RP. Decreased levels of basal autophagy concomitantly occur during the course of apoptosis progression. The time-course progression of the disease, the molecular mechanisms of the disease, and the therapeutic trials against MNU-induced photoreceptor cell apoptosis are described.

Author : Michael R. Hamblin
Publisher : Academic Press
ISBN 13 : 0128153067
Total Pages : 656 pages
Book Rating : 4.62/5 ( download)

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Download or read book Photobiomodulation in the Brain written by Michael R. Hamblin and published by Academic Press. This book was released on 2019-07-13 with total page 656 pages. Available in PDF, EPUB and Kindle. Book excerpt: Photobiomodulation in the Brain: Low-Level Laser (Light) Therapy in Neurology and Neuroscience presents the fundamentals of photobiomodulation and the diversity of applications in which light can be implemented in the brain. It will serve as a reference for future research in the area, providing the basic foundations readers need to understand photobiomodulation’s science-based evidence, practical applications and related adaptations to specific therapeutic interventions. The book covers the mechanisms of action of photobiomodulation to the brain, and includes chapters describing the pre-clinical studies and clinical trials that have been undertaken for diverse brain disorders, including traumatic events, degenerative diseases and psychiatric disorders. Provides a much-needed reference on photobiomodulation with an unprecedented focus on the brain and its disorders Features a body of world-renowned editors and chapter authors that promote research, policy and funding Discusses the recent and rapid accumulation of literature in this area of research and the shift towards the use of non-invasive techniques in therapy

Author :
Publisher :
ISBN 13 : 9814470392
Total Pages : pages
Book Rating : 4.91/5 ( download)

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Download or read book Myopia written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Joyce Tombran-Tink
Publisher : Springer Science & Business Media
ISBN 13 : 159745186X
Total Pages : 465 pages
Book Rating : 4.64/5 ( download)

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Download or read book Retinal Degenerations written by Joyce Tombran-Tink and published by Springer Science & Business Media. This book was released on 2007-11-06 with total page 465 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents new and noteworthy research into retinal diseases. It focuses on what we currently know about the environment, genetics and mechanisms that lead to retinal degenerations, new diagnostics, and innovative therapeutic modalities to preserve vision. Written by renowned scientific investigators, this innovative collection of treatment strategies and technological discoveries allows for the realistic translation of research into practice.

Author : John D. Ash
Publisher : Springer
ISBN 13 : 3319754025
Total Pages : 669 pages
Book Rating : 4.24/5 ( download)

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Download or read book Retinal Degenerative Diseases written by John D. Ash and published by Springer. This book was released on 2018-05-02 with total page 669 pages. Available in PDF, EPUB and Kindle. Book excerpt: The blinding diseases of inherited retinal degenerations have no treatments, and age-related macular degeneration has no cures, despite the fact that it is an epidemic among the elderly, with 1 in 3-4 affected by the age of 70. The RD Symposium will focus on the exciting new developments aimed at understanding these diseases and providing therapies for them. Since most major scientists in the field of retinal degenerations attend the biennial RD Symposia, they are known by most as the “best” and “most important” meetings in the field. The volume will present representative state-of-the-art research in almost all areas of retinal degenerations, ranging from cytopathologic, physiologic, diagnostic and clinical aspects; animal models; mechanisms of cell death; candidate genes, cloning, mapping and other aspects of molecular genetics; and developing potential therapeutic measures such as gene therapy and neuroprotective agents for potential pharmaceutical therapy. While advances in these areas of retinal degenerations will be described, there will be many new topics that either were in their infancy or did not exist at the time of the last RD Symposium, RD2014. These include the role of inflammation and immunity, as well as other basic mechanisms, in age-related macular degeneration, several new aspects of gene therapy, and revolutionary new imaging and functional testing that will have a huge impact on the diagnosis and following the course of retinal degenerations, as well as to provide new quantitative endpoints for clinical trials. The retina is an approachable part of the central nervous system (CNS), and there is a major interest in neuroprotective and gene therapy for CNS diseases and neurodegenerations, in general. It should be noted that with successful and exciting initial clinical trials in neuroprotective and gene therapy, including the restoration of sight in blind children, the retinal degeneration therapies are leading the way towards new therapeutic measures for neurodegenerations of the CNS. Many of the successes recently reported in these areas of retinal degeneration sprang from collaborations established at previous RD Symposia, and many of those will be reported at the RD2018 meeting and included in the proposed volume. We anticipate the excitement of those working in the field and those afflicted with retinal degenerations will be reflected in the volume.