Animal Models For Microbiome Research

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309463882
Total Pages : 115 pages
Book Rating : 4.81/5 ( download)

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Download or read book Animal Models for Microbiome Research written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2018-05-23 with total page 115 pages. Available in PDF, EPUB and Kindle. Book excerpt: The surface of the human body and its mucous membranes are heavily colonized by microorganisms. Our understanding of the contributions that complex microbial communities make to health and disease is advancing rapidly. Most microbiome research to date has focused on the mouse as a model organism for delineating the mechanisms that shape the assembly and dynamic operations of microbial communities. However, the mouse is not a perfect surrogate for studying different aspects of the microbiome and how it responds to various environmental and host stimuli, and as a result, researchers have been conducting microbiome studies in other animals. To examine the different animal models researchers employ in microbiome studies and to better understand the strengths and weaknesses of each of these model organisms as they relate to human and nonhuman health and disease, the Roundtable on Science and Welfare in Laboratory Animal Use of the National Academies of Sciences, Engineering, and Medicine convened a workshop in December 2016. The workshop participants explored how to improve the depth and breadth of analysis of microbial communities using various model organisms, the challenges of standardization and biological variability that are inherent in gnotobiotic animal-based research, the predictability and translatability of preclinical studies to humans, and strategies for expanding the infrastructure and tools for conducting studies in these types of models. This publication summarizes the presentations and discussions from the workshop.

Author : Pallaval Veera Bramhachari
Publisher : Springer Nature
ISBN 13 : 9811631565
Total Pages : 306 pages
Book Rating : 4.66/5 ( download)

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Download or read book Microbiome in Human Health and Disease written by Pallaval Veera Bramhachari and published by Springer Nature. This book was released on 2021-10-18 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book provides an overview on how the microbiome contributes to human health and disease. The microbiome has also become a burgeoning field of research in medicine, agriculture & environment. The readers will obtain profound knowledge on the connection between intestinal microbiota and immune defense systems, medicine, agriculture & environment. The book may address several researchers, clinicians and scholars working in biomedicine, microbiology and immunology. The application of new technologies has no doubt revolutionized the research initiatives providing new insights into the dynamics of these complex microbial communities and their role in medicine, agriculture & environment shall be more emphasized. Drawing on broad range concepts of disciplines and model systems, this book primarily provides a conceptual framework for understanding these human-microbe, animal-microbe & plant-microbe, interactions while shedding critical light on the scientific challenges that lie ahead. Furthermore this book explains why microbiome research demands a creative and interdisciplinary thinking—the capacity to combine microbiology with human, animal and plant physiology, ecological theory with immunology, and evolutionary perspectives with metabolic science.This book provides an accessible and authoritative guide to the fundamental principles of microbiome science, an exciting and fast-emerging new discipline that is reshaping many aspects of the life sciences. These microbial partners can also drive ecologically important traits, from thermal tolerance to diet in a typical immune system, and have contributed to animal and plant diversification over long evolutionary timescales. Also this book explains why microbiome research presents a more complete picture of the biology of humans and other animals, and how it can deliver novel therapies for human health and new strategies.

Author : Trenton R Schoeb
Publisher : Academic Press
ISBN 13 : 0128045833
Total Pages : 428 pages
Book Rating : 4.31/5 ( download)

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Download or read book Gnotobiotics written by Trenton R Schoeb and published by Academic Press. This book was released on 2017-08-11 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gnotobiotics summarizes and analyzes the research conducted on the use of gnotobiotes, providing detailed information regarding actual facility operation and derivation of gnotobiotic animals. In response to the development of new tools for microbiota and microbiome analysis, the increasing recognition of the various roles of microbiota in health and disease, and the consequent expanding demand for gnotobiotic animals for microbiota/microbiome related research, this volume collates the research of this expanding field into one definitive resource. Reviews and defines gnotobiotic animal species Analyzes microbiota in numerous contexts Presents detailed coverage of the protocols and operation of a gnotobiotic facility

Author : Food Forum
Publisher : National Academies Press
ISBN 13 : 030926586X
Total Pages : 197 pages
Book Rating : 4.67/5 ( download)

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Download or read book The Human Microbiome, Diet, and Health written by Food Forum and published by National Academies Press. This book was released on 2013-02-27 with total page 197 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Food Forum convened a public workshop on February 22-23, 2012, to explore current and emerging knowledge of the human microbiome, its role in human health, its interaction with the diet, and the translation of new research findings into tools and products that improve the nutritional quality of the food supply. The Human Microbiome, Diet, and Health: Workshop Summary summarizes the presentations and discussions that took place during the workshop. Over the two day workshop, several themes covered included: The microbiome is integral to human physiology, health, and disease. The microbiome is arguably the most intimate connection that humans have with their external environment, mostly through diet. Given the emerging nature of research on the microbiome, some important methodology issues might still have to be resolved with respect to undersampling and a lack of causal and mechanistic studies. Dietary interventions intended to have an impact on host biology via their impact on the microbiome are being developed, and the market for these products is seeing tremendous success. However, the current regulatory framework poses challenges to industry interest and investment.

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309468698
Total Pages : 123 pages
Book Rating : 4.95/5 ( download)

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Download or read book Environmental Chemicals, the Human Microbiome, and Health Risk written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2018-03-01 with total page 123 pages. Available in PDF, EPUB and Kindle. Book excerpt: A great number of diverse microorganisms inhabit the human body and are collectively referred to as the human microbiome. Until recently, the role of the human microbiome in maintaining human health was not fully appreciated. Today, however, research is beginning to elucidate associations between perturbations in the human microbiome and human disease and the factors that might be responsible for the perturbations. Studies have indicated that the human microbiome could be affected by environmental chemicals or could modulate exposure to environmental chemicals. Environmental Chemicals, the Human Microbiome, and Health Risk presents a research strategy to improve our understanding of the interactions between environmental chemicals and the human microbiome and the implications of those interactions for human health risk. This report identifies barriers to such research and opportunities for collaboration, highlights key aspects of the human microbiome and its relation to health, describes potential interactions between environmental chemicals and the human microbiome, reviews the risk-assessment framework and reasons for incorporating chemicalâ€"microbiome interactions.

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309458390
Total Pages : 133 pages
Book Rating : 4.99/5 ( download)

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Download or read book The Chemistry of Microbiomes written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-07-19 with total page 133 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 21st century has witnessed a complete revolution in the understanding and description of bacteria in eco- systems and microbial assemblages, and how they are regulated by complex interactions among microbes, hosts, and environments. The human organism is no longer considered a monolithic assembly of tissues, but is instead a true ecosystem composed of human cells, bacteria, fungi, algae, and viruses. As such, humans are not unlike other complex ecosystems containing microbial assemblages observed in the marine and earth environments. They all share a basic functional principle: Chemical communication is the universal language that allows such groups to properly function together. These chemical networks regulate interactions like metabolic exchange, antibiosis and symbiosis, and communication. The National Academies of Sciences, Engineering, and Medicine's Chemical Sciences Roundtable organized a series of four seminars in the autumn of 2016 to explore the current advances, opportunities, and challenges toward unveiling this "chemical dark matter" and its role in the regulation and function of different ecosystems. The first three focused on specific ecosystemsâ€"earth, marine, and humanâ€"and the last on all microbiome systems. This publication summarizes the presentations and discussions from the seminars.

Author : Henning Seedorf
Publisher : Frontiers Media SA
ISBN 13 : 2832503179
Total Pages : 204 pages
Book Rating : 4.71/5 ( download)

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Download or read book Beyond Conventional Models: Expanding Experimental Systems for Animal-Microbiome Interaction Research written by Henning Seedorf and published by Frontiers Media SA. This book was released on 2022-10-21 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Aleksander Krag
Publisher : Springer
ISBN 13 : 3319988905
Total Pages : 294 pages
Book Rating : 4.00/5 ( download)

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Download or read book The Human Gut-Liver-Axis in Health and Disease written by Aleksander Krag and published by Springer. This book was released on 2018-11-09 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book brings together the current knowledge and future perspectives of the complex physiology and pathophysiology of gut-liver interactions in health and disease. It provides readers with a unique overview and access to knowledge that cannot be obtained elsewhere. The structure is logical and covers all aspect including the normal physiology, changes in various liver diseases, technology, sample collection and various interventions. Thus suitable for general reading, lookup for specific questions or as a reference book within the area. The book allows the reader to access all the knowledge that has been generated within the last 10 years in this field.

Author : Bernard S. Wostmann
Publisher : CRC Press
ISBN 13 : 0429605374
Total Pages : 206 pages
Book Rating : 4.76/5 ( download)

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Download or read book Germfree and Gnotobiotic Animal Models written by Bernard S. Wostmann and published by CRC Press. This book was released on 2020-03-25 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: The germfree animal is reared in the laboratory to be bacteria free; its counterpart, the gnotobiotic animal, is exposed to select microorganisms. The need for such an animal model for use in biomedical studies was first expressed by Pasteur in the late 1800s. Subsequent development of germfree and gnotobiotic animals led to an explosion of studies on the effects of microflora and its components on the physiology and metabolism of the host. Germfree and Gnotobiotic Animal Models brings together the most notable points of early and recent studies and gives reference to the most pertinent literature.

Author : Rachael E. Antwis
Publisher :
ISBN 13 : 9781108654418
Total Pages : pages
Book Rating : 4.1X/5 ( download)

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Download or read book Microbiomes of Soils, Plants and Animals written by Rachael E. Antwis and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: A comparative, holistic synthesis of microbiome research, spanning soil, plant, animal and human hosts.