Toxicology Biological Monitoring Of Metals In Humans

Author : Bonnie L. Carson
Publisher : CRC Press
ISBN 13 : 1351085832
Total Pages : 342 pages
Book Rating : 4.30/5 ( download)

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Download or read book Toxicology Biological Monitoring of Metals in Humans written by Bonnie L. Carson and published by CRC Press. This book was released on 2018-01-18 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: As one of many tasks of an analytical chemistry program sponsored by the office of Pesticides and Toxic Substances, Field Studies Branch, U.S. Environmental Protection Agency (EPA) (EPA Prime Contract No. 68-02-3938), Midwest Research Institute (MRI) prepared these summaries of the mammalian toxicology of 52 individual elements (metals and metalloids) and the lanthanides (rare earth elements). MRI is assisting the EPA in developing protocols for the monitoring of selected metals and organic compounds in the blood of the general U.S. population. The monitoring will enable evaluation of changes in the blood levels over time and any trends associated with instituted control measures. This review will help EPA select the metals to be included in the monitoring effort based on toxicity, relative exposure, and the ability of blood measurements to reflect exposure.

Author : Thomas W. Clarkson
Publisher : Springer Science & Business Media
ISBN 13 : 1461309611
Total Pages : 672 pages
Book Rating : 4.11/5 ( download)

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Download or read book Biological Monitoring of Toxic Metals written by Thomas W. Clarkson and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 672 pages. Available in PDF, EPUB and Kindle. Book excerpt: This document is the result of a conference on "Biological Monitoring of Metals" held in Rochester, June 2-6, 1986, organized jointly by the Environmental Health Sciences Center of the School of Medicine and Dentistry of the University of Rochester, NY, and the Scientific Committee on the Toxicology of Metals within the International Commission on Occupational Health (ICOH) at the Karolinska Institute and the National (Swedish) Institute of Environmental Medicine and the University of Umea, Sweden. The aim of the Conference was to define and evaluate the scientific basis for the biological monitoring of metals. The conference was co-sponsored by the World Health Organization through its International Program on Chemical Safety and received substantial encouragement and support from the Swedish Work Environmental Fund and the United States Environmental Protection Agency. This was the second conference organized jointly by the Scientific Committee on the Toxicology of Metals and The Toxicology Division of the University of Rochester. The previous joint conference was held in 1982 on the Reproductive and Developmental Toxicity of Metals. In addition, conferences have been organized by each group (see Appendices A and B). Several of these conferences are specially relevant to the topic of the current conference. These include the joint conference mentioned above and the conferences on dose-effect and dose-response relationship held in Tokyo in 1974 and on accumulation of metals held in Buenos Aires in 1972.

Author : H. K. Dillon
Publisher : Wiley-Interscience
ISBN 13 :
Total Pages : 312 pages
Book Rating : 4.73/5 ( download)

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Download or read book Biological Monitoring of Exposure to Chemicals written by H. K. Dillon and published by Wiley-Interscience. This book was released on 1991-01-16 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: This companion volume to Biological Monitoring of Exposure to Chemicals: Organic Compounds presents recent results from both field and laboratory studies investigating the presence of metals and organometallic compounds in biological media. A distinguished list of contributors describe studies which assess the extent of human exposure to metals, and recount fundamental studies at the molecular level, such as investigation of immunotoxicological effects of the interaction of metals during absorption and biological transformation. There is also a study of the biological monitoring of environmental contamination that demonstrates how biological samples determine the transport and fate of metals in the environment.

Author : Gunnar F. Nordberg
Publisher : Academic Press
ISBN 13 : 0128232935
Total Pages : 798 pages
Book Rating : 4.34/5 ( download)

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Download or read book Handbook on the Toxicology of Metals: Volume I: General Considerations written by Gunnar F. Nordberg and published by Academic Press. This book was released on 2021-11-30 with total page 798 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook on the Toxicology of Metals, Fifth Edition, Volume I: General Considerations is the first volume of a two-volume work that gives an overview and covers topics of general importance including reviews of various health effects of trace metals. The book emphasizes toxic effects in humans, along with discussions on the toxic effects of animals and biological systems in vitro when relevant. The book has been systematically updated with the latest studies and advances in technology and contains several new chapters. As a multidisciplinary resource that integrates both human and environmental toxicology, the book is a comprehensive and valuable reference for toxicologists, physicians, pharmacologists, and environmental scientists in the fields of environmental, occupational and public health. Contains peer-reviewed chapters that deal with the effects of metallic elements and their compounds on biological systems Includes information on sources, transport and the transformation of metals in the environment Covers the ecological effects of metals to provide a basis for better understanding of the potential for adverse effects on human health Provides critical information on the properties, use, biological monitoring, dose-response relationships, diagnosis, treatment and prevention of metallic elements and compounds

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309044375
Total Pages : 224 pages
Book Rating : 4.70/5 ( download)

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Download or read book Monitoring Human Tissues for Toxic Substances written by National Research Council and published by National Academies Press. This book was released on 1991-02-01 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: The National Human Monitoring Program (NHMP) identifies concentrations of specific chemicals in human tissues, including toxicologic testing and risk assessment determinations. This volume evaluates the current activities of the NHMP; identifies important scientific, technical, and programmatic issues; and makes recommendations regarding the design of the program and use of its products.

Author : Robert Ryan
Publisher : Routledge
ISBN 13 : 1351407562
Total Pages : 790 pages
Book Rating : 4.64/5 ( download)

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Download or read book Toxicology Desk Reference written by Robert Ryan and published by Routledge. This book was released on 2019-09-17 with total page 790 pages. Available in PDF, EPUB and Kindle. Book excerpt: A source of medical, legal and regulatory information on the toxicology of human exposure to metals and chemicals, this three-volume set is designed to be the first resource professionals turn to when formulating an opinion and developing a programme. It is annually updated to provide the latest information on over 150 chemical agents in a standar

Author : Philip L. Chambers
Publisher : Springer Science & Business Media
ISBN 13 : 3642741177
Total Pages : 457 pages
Book Rating : 4.73/5 ( download)

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Download or read book Biological Monitoring of Exposure and the Response at the Subcellular Level to Toxic Substances written by Philip L. Chambers and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 457 pages. Available in PDF, EPUB and Kindle. Book excerpt: This supplement contains the papers submitted at EUROTOX 88, the joint Congress of the European Society of Toxicology and the Federation of the European Societies of Toxicology. The theme was one of monitoring and examining the effects of toxic substances in the biological response at the subcellular level. Mechanisms of metal carcinogenicity are discussed as well as the biomonitoring of chemical exposure. Reports are provided on the role of individual differences in man and the effect of risk assessment. Papers appear dealing with the genetic control of drug metabolizing enzymes. The role of metabolism in organic specific toxicity is discussed. Information is included on the toxicological impact of chemicals interfering with the endocrine system as well as on the effects of toxicants on the immune system. Presentations deal with the current status of risk assessment in environmental toxicology.

Author : Peggy L. Carver
Publisher : Walter de Gruyter GmbH & Co KG
ISBN 13 : 3110526980
Total Pages : 640 pages
Book Rating : 4.81/5 ( download)

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Download or read book Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic written by Peggy L. Carver and published by Walter de Gruyter GmbH & Co KG. This book was released on 2019-01-14 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 19, entitled Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic of the series Metal Ions in Life Sciences centers on the role of metal ions in clinical medicine. Metal ions are tightly regulated in human health: while essential to life, they can be toxic as well. Following an introductory chapter briefly discussing several important metal-related drugs and diseases and a chapter about drug development, the focus is fi rst on iron: its essentiality for pathogens and humans as well as its toxicity. Chelation therapy is addressed in the context of thalassemia, its relationship to neurodegenerative diseases and also the risks connected with iron administration are pointed out. A subject of intense debate is the essentiality of chromium and vanadium. For example, chromium(III) compounds are taken as a nutritional supplement by athletes and bodybuilders; in contrast, chromate, Cr(VI), is toxic and a carcinogen for humans. The benefi cial and toxic effects of manganese, cobalt, and copper on humans are discussed. The need for antiparasitic agents is emphasized as well as the clinical aspects of metal-containing antidotes for cyanide poisoning. In addition to the essential and possibly essential ones, also other metal ions play important roles in human health, causing harm (like the metalloid arsenic, lead or cadmium) or being used in diagnosis or treatment of human diseases, like gadolinium, gallium, lithium, gold, silver or platinum. The impact of this vibrant research area on metals in the clinic is provided in 14 stimulating chapters, written by internationally recognized experts from the Americas, Europe and China, and is manifested by approximately 2000 references, and about 90 illustrations and tables. Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic is an essential resource for scientists working in the wide range from pharmacology, enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine ... not forgetting that it also provides excellent information for teaching.

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309133904
Total Pages : 316 pages
Book Rating : 4.06/5 ( download)

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Download or read book Human Biomonitoring for Environmental Chemicals written by National Research Council and published by National Academies Press. This book was released on 2006-10-30 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomonitoring—a method for measuring amounts of toxic chemicals in human tissues—is a valuable tool for studying potentially harmful environmental chemicals. Biomonitoring data have been used to confirm exposures to chemicals and validate public health policies. For example, population biomonitoring data showing high blood lead concentrations resulted in the U.S. Environmental Protection Agency's (EPA's) regulatory reduction of lead in gasoline; biomonitoring data confirmed a resultant drop in blood lead concentrations. Despite recent advances, the science needed to understand the implications of the biomonitoring data for human health is still in its nascent stages. Use of the data also raises communication and ethical challenges. In response to a congressional request, EPA asked the National Research Council to address those challenges in an independent study. Human Biomonitoring for Environmental Chemicals provides a framework for improving the use of biomonitoring data including developing and using biomarkers (measures of exposure), research to improve the interpretation of data, ways to communicate findings to the public, and a review of ethical issues.

Author : Desmond John Tobin
Publisher : Royal Society of Chemistry
ISBN 13 : 184755251X
Total Pages : 378 pages
Book Rating : 4.18/5 ( download)

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Download or read book Hair in Toxicology written by Desmond John Tobin and published by Royal Society of Chemistry. This book was released on 2007-10-31 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hair in Toxicology: An Important Biomonitor is the first book of its kind devoted exclusively to in-depth analysis of the hair shaft as an important tool for a diverse range of scientific investigations. This authoritative book combines contributions from experts in academic, governmental and industrial environments, to provide a unique, comprehensive look at: - Why hair can serve as an invaluable bio-resource in toxicology, with up-to-date reviews on hair growth, hair fibre formation and hair pigmentation - Information (including regulatory details) on the exposure of hair (and by extension the body) to drug and non-drug chemicals and pollutants - Toxicological issues relevant to the use of hair products (including colourants, shampoos and depilatories) - The ability of hair to capture information on personal identity, chemical exposure, and environmental interactions - How hair can provide an understanding of human life from archaeological and historical perspectives - Future direction in the use of hair in toxicology Hair in Toxicology: An Important Biomonitor is ideal as a reference and guide to investigations in the biomedical, biochemical and pharmaceutical sciences at the graduate and post graduate level.