The Virus Paradigm

Author : Roberto Marchesini
Publisher : Cambridge University Press
ISBN 13 : 1108967264
Total Pages : 127 pages
Book Rating : 4.66/5 ( download)

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Download or read book The Virus Paradigm written by Roberto Marchesini and published by Cambridge University Press. This book was released on 2021-02-18 with total page 127 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, the word 'virus' has lost its biological perimeter of reference to acquire a much broader – could say 'paradigmatic' – meaning. The term 'virus' can be seen as a key word or an explanatory model also for processes that go beyond the infectious sphere. Every event appears to have a viral character: from the way information is transmitted to the processes of cultural globalization, from the impact of human beings on the planet to the subversion of ecosystems, from pandemic risks to the demographic increase on the planet. This seems to be indeed the Age of the Virus. Its model can be applied to most of the phenomena that characterize the twenty-first. Its profile – its looming and invisible nature, its ability to use other people's resources to spread and to transform into a dangerous doppelganger – is perfect to represent the fears of the contemporary age.

Author : Joseph M. Valenzano
Publisher : Rowman & Littlefield
ISBN 13 : 1793652228
Total Pages : 295 pages
Book Rating : 4.25/5 ( download)

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Download or read book Post-Pandemic Pedagogy written by Joseph M. Valenzano and published by Rowman & Littlefield. This book was released on 2021-11-01 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt: Post-Pandemic Pedagogy: A Paradigm Shift discusses how the COVID-19 pandemic radically altered teaching and learning for faculty and students alike. The increased prevalence of video-conferencing software for conducting classes fundamentally changed the way in which we teach and seemingly upended many best practices for good pedagogy in the college classroom. Whether it was the reflection over surveillance software, or the increased mental health demands of the pandemic on teachers and students, or the completely reshaped ways in which classes and co-curricular experiences were delivered, the pandemic year represented an opportunity for one of the largest shifts in our understanding of good pedagogy unlike any experienced in the modern era. This edited collection explores what we thought we knew about a variety of teaching ideas, how the pandemic changed our approach to them, and proposes ways in which some of the adjustments made to accommodate the pandemic will remain for years to come. Scholars of communication, pedagogy, and education will find this book particularly interesting.

Author : Loureiro, Sandra Maria Correia
Publisher : IGI Global
ISBN 13 : 1799869652
Total Pages : 432 pages
Book Rating : 4.58/5 ( download)

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Download or read book Handbook of Research on Developing a Post-Pandemic Paradigm for Virtual Technologies in Higher Education written by Loureiro, Sandra Maria Correia and published by IGI Global. This book was released on 2021-06-25 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: The COVID-19 pandemic has forced companies, institutions, citizens, and students to rapidly change their behaviors and use virtual technologies to perform their usual working tasks. Though virtual technologies for learning were already present in most universities, the pandemic has forced virtual technologies to lead the way in order to continue teaching and learning for students and faculty around the world. Universities and teachers had to quickly adjust everything from their curriculum to their teaching styles in order to adapt to an online learning environment. Online learning is a complex issue and one that comes with both challenges and opportunities; there is plenty of room for growth, and further study is required to better understand how to improve online education. The Handbook of Research on Developing a Post-Pandemic Paradigm for Virtual Technologies in Higher Education is a comprehensive reference book that presents the testimonials of teachers and students with various degrees of experience with distance learning and their utilization of current virtual tools and applications for learning, as well as the impact of these technologies and their potential future use. With topics ranging from designing an online learning course to discussing group work in an online environment, this book is ideal for teachers, educational software developers, IT consultants, instructional designers, administrators, professors, researchers, lecturers, students, and all those who are interested in learning more about distance learning and all the positive and negative aspects that accompany it.

Author : Margaret Kielian
Publisher : Academic Press
ISBN 13 : 0128207612
Total Pages : 404 pages
Book Rating : 4.11/5 ( download)

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Download or read book Virus Assembly and Exit Pathways written by Margaret Kielian and published by Academic Press. This book was released on 2020-11-09 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Virus Research, Volume 108, in this ongoing series, highlights new advances in the field, with this new volume presenting interesting chapters on topics including Virus infections of the developing brain, Geminivirus assembly, Flavivirus assembly, Cell-cell transmission, Archael virus assembly, Potyvirus assembly, Poxvirus assembly and exit, Mycovirus assembly, Reo/orbivirus assembly and exit, Giant virus assembly, Quasi-enveloped virus assembly/exit, and Betaherpesvirus assembly and exit. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Advances in Virus Research series Includes the latest information on virus assembly and exit pathways

Author :
Publisher : Academic Press
ISBN 13 : 0128145161
Total Pages : 4109 pages
Book Rating : 4.66/5 ( download)

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Download or read book Encyclopedia of Virology written by and published by Academic Press. This book was released on 2021-02-24 with total page 4109 pages. Available in PDF, EPUB and Kindle. Book excerpt: Encyclopedia of Virology, Fourth Edition, Five Volume Set builds on the solid foundation laid by the previous editions, expanding its reach with new and timely topics. In five volumes, the work provides comprehensive coverage of the whole virosphere, making this a unique resource. Content explores viruses present in the environment and the pathogenic viruses of humans, animals, plants and microorganisms. Key areas and concepts concerning virus classification, structure, epidemiology, pathogenesis, diagnosis, treatment and prevention are discussed, guiding the reader through chapters that are presented at an accessible level, and include further readings for those needing more specific information. More than ever now, with the Covid19 pandemic, we are seeing the huge impact viruses have on our life and society. This encyclopedia is a must-have resource for scientists and practitioners, and a great source of information for the wider public. Offers students and researchers a one-stop shop for information on virology not easily available elsewhere Fills a critical gap of information in a field that has seen significant progress in recent years Authored and edited by recognized experts in the field, with a range of different expertise, thus ensuring a high-quality standard

Author : Paul Farmer
Publisher : Farrar, Straus and Giroux
ISBN 13 : 0374716986
Total Pages : 688 pages
Book Rating : 4.81/5 ( download)

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Download or read book Fevers, Feuds, and Diamonds written by Paul Farmer and published by Farrar, Straus and Giroux. This book was released on 2020-11-17 with total page 688 pages. Available in PDF, EPUB and Kindle. Book excerpt: “Paul Farmer brings his considerable intellect, empathy, and expertise to bear in this powerful and deeply researched account of the Ebola outbreak that struck West Africa in 2014. It is hard to imagine a more timely or important book.” —Bill and Melinda Gates "[The] history is as powerfully conveyed as it is tragic . . . Illuminating . . . Invaluable." —Steven Johnson, The New York Times Book Review In 2014, Sierra Leone, Liberia, and Guinea suffered the worst epidemic of Ebola in history. The brutal virus spread rapidly through a clinical desert where basic health-care facilities were few and far between. Causing severe loss of life and economic disruption, the Ebola crisis was a major tragedy of modern medicine. But why did it happen, and what can we learn from it? Paul Farmer, the internationally renowned doctor and anthropologist, experienced the Ebola outbreak firsthand—Partners in Health, the organization he founded, was among the international responders. In Fevers, Feuds, and Diamonds, he offers the first substantive account of this frightening, fast-moving episode and its implications. In vibrant prose, Farmer tells the harrowing stories of Ebola victims while showing why the medical response was slow and insufficient. Rebutting misleading claims about the origins of Ebola and why it spread so rapidly, he traces West Africa’s chronic health failures back to centuries of exploitation and injustice. Under formal colonial rule, disease containment was a priority but care was not – and the region’s health care woes worsened, with devastating consequences that Farmer traces up to the present. This thorough and hopeful narrative is a definitive work of reportage, history, and advocacy, and a crucial intervention in public-health discussions around the world.

Author : Marc H. V. Van Regenmortel
Publisher : Frontiers Media SA
ISBN 13 : 2889197271
Total Pages : 76 pages
Book Rating : 4.79/5 ( download)

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Download or read book Paradigm Changes Are Required in HIV Vaccine Research written by Marc H. V. Van Regenmortel and published by Frontiers Media SA. This book was released on 2015-12-08 with total page 76 pages. Available in PDF, EPUB and Kindle. Book excerpt: In his 1962 book "The Structure of Scientific Revolutions", Thomas Kuhn famously argued that researchers in every field of scientific enquiry always operate under a set of presuppositions known as paradigms that are rarely explicitly stated. In the field of HIV vaccine research, several prevailing paradigms led scientists for many years to pursue unfruitful lines of investigations that impeded significant progress. The uncritical acceptance of reigning paradigms makes scientists reluctant to abandon their mistaken assumptions even when they obtain results that are not consistent with the paradigms. The following five paradigms which disregard the degeneracy of the immune system were particularly harmful. 1) There is a primary and intrinsic epitope specific for each B cell receptor and for the corresponding monoclonal antibody. In reality, there is no single, intrinsic or "real" epitope for any antibody but only a diverse group of potential ligands. 2) Reactions with monoclonal antibodies are more specific than the combined reactivity of polyclonal antibodies. In reality, a polyclonal antiserum has greater specificity for a multiepitopic protein because different antibodies in the antiserum recognize separate epitopes on the same protein, giving rise to an additive specificity effect. By focusing vaccine design on single epitope-Mab pairs, the beneficial neutralizing synergy that occurs with polyclonal antibody responses is overlooked. 3) The HIV epitope identified by solving the crystallographic structure of a broadly neutralizing Mab – HIV Env complex should be able, when used as immunogen, to elicit antibodies endowed with the same neutralizing capacity as the Mab. Since every anti HIV bnMab is polyspecific, the single epitope identified in the complex is not necessarily the one that elicited the bnMab. Since hypermutated Mabs used in crystallographic studies differ from their germline-like receptor version present before somatic hypermutation, the identified epitope will not be an effective vaccine immunogen. 4) Effective vaccine immunogenicity can be predicted from the antigenic binding capacity of viral epitopes. Most fragments of a viral antigen can induce antibodies that react with the immunogen, but this is irrelevant for vaccination since these antibodies rarely recognize the cognate, intact antigen and even more rarely neutralize the infectivity of the viral pathogen that harbors the antigen. 5) The rational design of vaccine immunogens using reverse vaccinology is superior to the trial-and-error screening of vaccine candidates able to induce protective immunity. One epitope can be designed to increase its structural complementarity to one particular bnMab, but such antigen design is only masquerading as immunogen design because it is assumed that antigenic reactivity necessarily entails the immunogenic capacity to elicit neutralizing antibodies. When HIV Env epitopes, engineered to react with a bnMab are used to select from human donors rare memory B cells secreting bnAbs, this represents antigen design and not immunogen design. The aim of this Research Topic is to replace previous misleading paradigms by novel ones that better fit our current understanding of immunological specificity and will help HIV vaccine development.

Author : Sonia Shah
Publisher : Macmillan
ISBN 13 : 0374122881
Total Pages : 289 pages
Book Rating : 4.81/5 ( download)

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Download or read book Pandemic written by Sonia Shah and published by Macmillan. This book was released on 2016-02-16 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Interweaving history, original reportage, and personal narrative, Pandemic explores the origins of epidemics, drawing parallels between the story of cholera-- one of history's most disruptive and deadly pathogens-- and the new pathogens that stalk humankind today"--

Author : Daniel R. Brooks
Publisher : University of Chicago Press
ISBN 13 : 022663258X
Total Pages : 423 pages
Book Rating : 4.82/5 ( download)

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Download or read book The Stockholm Paradigm written by Daniel R. Brooks and published by University of Chicago Press. This book was released on 2019-07-19 with total page 423 pages. Available in PDF, EPUB and Kindle. Book excerpt: The contemporary crisis of emerging disease has been a century and a half in the making. Human, veterinary, and crop health practitioners convinced themselves that disease could be controlled by medicating the sick, vaccinating those at risk, and eradicating the parts of the biosphere responsible for disease transmission. Evolutionary biologists assured themselves that coevolution between pathogens and hosts provided a firewall against disease emergence in new hosts. Most climate scientists made no connection between climate changes and disease. None of these traditional perspectives anticipated the onslaught of emerging infectious diseases confronting humanity today. As this book reveals, a new understanding of the evolution of pathogen-host systems, called the Stockholm Paradigm, explains what is happening. The planet is a minefield of pathogens with preexisting capacities to infect susceptible but unexposed hosts, needing only the opportunity for contact. Climate change has always been the major catalyst for such new opportunities, because it disrupts local ecosystem structure and allows pathogens and hosts to move. Once pathogens expand to new hosts, novel variants may emerge, each with new infection capacities. Mathematical models and real-world examples uniformly support these ideas. Emerging disease is thus one of the greatest climate change–related threats confronting humanity. Even without deadly global catastrophes on the scale of the 1918 Spanish Influenza pandemic, emerging diseases cost humanity more than a trillion dollars per year in treatment and lost productivity. But while time is short, the danger is great, and we are largely unprepared, the Stockholm Paradigm offers hope for managing the crisis. By using the DAMA (document, assess, monitor, act) protocol, we can “anticipate to mitigate” emerging disease, buying time and saving money while we search for more effective ways to cope with this challenge.

Author : Nancy Turner Banks, MD
Publisher : Xlibris Corporation
ISBN 13 : 1524544213
Total Pages : 244 pages
Book Rating : 4.18/5 ( download)

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Download or read book The Slow Death of the Aids/Cancer Paradigm written by Nancy Turner Banks, MD and published by Xlibris Corporation. This book was released on 2016-10-14 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: AIDS and cancer are neither random nor infectious diseases. Both are characterized by a proton deficit and a reversal of the chimeric/energetic cooperative trend of the eukaryotic nucleus with the mitochondrial endosymbiont. This pattern is not random. It is consistent with the evolutionary heritage of the eukaryotic cell, which developed the foundational glycolytic pathways during the eon of the earths anaerobic-reducing atmosphere. It should no longer be a mystery that these primitive metabolic patterns dominate when bio-stressors cause deterioration in the quantum and electromagnetic wave forms that allow coherency. The Slow Death of the AIDS/Cancer Paradigm confronts these issues full on.