Author : Michael Fromm
Publisher : MDPI
ISBN 13 : 3039432249
Total Pages : 412 pages
Book Rating : 4.40/5 ( download)
Book Synopsis The Tight Junction and Its Proteins: More Than Just a Barrier by : Michael Fromm
Download or read book The Tight Junction and Its Proteins: More Than Just a Barrier written by Michael Fromm and published by MDPI. This book was released on 2020-11-20 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: For a long time, the tight junction (TJ) was known to form and regulate the paracellular barrier between epithelia and endothelial cell sheets. Starting shortly after the discovery of the proteins forming the TJ—mainly the two families of claudins and TAMPs—several other functions have been discovered, a striking one being the surprising finding that some claudins form paracellular channels for small ions and/or water. This Special Issue includes 43 articles covering numerous dedicated topics including pathogens affecting the TJ barrier, TJ regulation via immune cells, the TJ as a therapeutic target, TJ and cell polarity, function and regulation by proteins of the tricellular TJ, TJ as a regulator of cellular processes, organ- and tissue-specific functions, TJ as sensors and reacting to environmental conditions, and last but not least, TJ proteins and cancer.