The Philadelphia Chromosome A Genetic Mystery A Lethal Cancer And The Improbable Invention Of A Lifesaving Treatment

Author : Jessica Wapner
Publisher : The Experiment, LLC
ISBN 13 : 1615191658
Total Pages : 345 pages
Book Rating : 4.59/5 ( download)

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Download or read book The Philadelphia Chromosome: A Genetic Mystery, a Lethal Cancer, and the Improbable Invention of a Lifesaving Treatment written by Jessica Wapner and published by The Experiment, LLC. This book was released on 2014-04-08 with total page 345 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of The Wall Street Journal’s 10 Best Nonfiction Books of the Year Philadelphia, 1959: A scientist scrutinizing a single human cell under a microscope detects a missing piece of DNA. That scientist, David Hungerford, had no way of knowing that he had stumbled upon the starting point of modern cancer research— the Philadelphia chromosome. It would take doctors and researchers around the world more than three decades to unravel the implications of this landmark discovery. In 1990, the Philadelphia chromosome was recognized as the sole cause of a deadly blood cancer, chronic myeloid leukemia, or CML. Cancer research would never be the same. Science journalist Jessica Wapner reconstructs more than forty years of crucial breakthroughs, clearly explains the science behind them, and pays tribute—with extensive original reporting, including more than thirty-five interviews—to the dozens of researchers, doctors, and patients with a direct role in this inspirational story. Their curiosity and determination would ultimately lead to a lifesaving treatment unlike anything before it. The Philadelphia Chromosome chronicles the remarkable change of fortune for the more than 70,000 people worldwide who are diagnosed with CML each year. It is a celebration of a rare triumph in the battle against cancer and a blueprint for future research, as doctors and scientists race to uncover and treat the genetic roots of a wide range of cancers.

Author : Keiko Hiyama
Publisher : Springer Science & Business Media
ISBN 13 : 1603278796
Total Pages : 380 pages
Book Rating : 4.99/5 ( download)

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Download or read book Telomeres and Telomerase in Cancer written by Keiko Hiyama and published by Springer Science & Business Media. This book was released on 2009-03-18 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: Telomerase, an enzyme that maintains telomeres and endows eukaryotic cells with immortality, was first discovered in tetrahymena in 1985. In 1990s, it was proven that this enzyme also plays a key role in the infinite proliferation of human cancer cells. Now telomere and telomerase are widely accepted as important factors involved in cancer biology, and as promising diagnostic tools and therapeutic targets. Recently, role of telomerase in “cancer stem cells” has become another attractive story. Until now, there are several good books on telomere and telomerase focusing on biology in ciliates, yeasts, and mouse or basic sciences in human, providing basic scientists or students with updated knowledge.

Author : Ronald G. Walters
Publisher : JHU Press
ISBN 13 : 9780801863486
Total Pages : 214 pages
Book Rating : 4.81/5 ( download)

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Download or read book Primers for Prudery written by Ronald G. Walters and published by JHU Press. This book was released on 2000-06-16 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: He provides an updated bibliographical note.

Author : Michael Clinton Perry
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 9780781773287
Total Pages : 820 pages
Book Rating : 4.88/5 ( download)

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Download or read book The Chemotherapy Source Book written by Michael Clinton Perry and published by Lippincott Williams & Wilkins. This book was released on 2008 with total page 820 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Chemotherapy Source Book, Fourth Edition pulls together all the current information on the chemotherapeutic management of cancer patients, including choice of chemotherapeutic agents, use of combinations, and toxicity of individual drugs. Organized by disease site, the book brings together pharmacologic and patient management information in one source that clinicians can consult for any question encountered in the delivery of chemotherapy. This updated Fourth Edition includes new drugs as well as new indications for older drugs. Content has been streamlined to provide essential information more quickly for the busy practitioner. Plus, this edition is softcover for greater portability and convenience.

Author : Laurence Thomas
Publisher : Rowman & Littlefield
ISBN 13 : 0847687708
Total Pages : 192 pages
Book Rating : 4.01/5 ( download)

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Download or read book Sexual Orientation and Human Rights written by Laurence Thomas and published by Rowman & Littlefield. This book was released on 1999 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: 4 Reply to Thomas: Michael E. Levin

Author : J. Hoberman
Publisher : Univ of California Press
ISBN 13 : 0520274016
Total Pages : 304 pages
Book Rating : 4.13/5 ( download)

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Download or read book Black and Blue written by J. Hoberman and published by Univ of California Press. This book was released on 2012-04-03 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Black & Blue is the first systematic description of how American doctors think about racial differences and how this kind of thinking affects the treatment of their black patients. The standard studies of medical racism examine past medical abuses of black people and do not address the racially motivated thinking and behaviors of physicians practicing medicine today. Black & Blue penetrates the physician’s private sphere where racial fantasies and misinformation distort diagnoses and treatments. Doctors have always absorbed the racial stereotypes and folkloric beliefs about racial differences that permeate the general population. Within the world of medicine this racial folklore has infiltrated all of the medical sub-disciplines, from cardiology to gynecology to psychiatry. Doctors have thus imposed white or black racial identities upon every organ system of the human body, along with racial interpretations of black children, the black elderly, the black athlete, black musicality, black pain thresholds, and other aspects of black minds and bodies. The American medical establishment does not readily absorb either historical or current information about medical racism. For this reason, racial enlightenment will not reach medical schools until the current race-aversive curricula include new historical and sociological perspectives.

Author : Jessica Wapner
Publisher : The Experiment, LLC
ISBN 13 : 1615197354
Total Pages : 133 pages
Book Rating : 4.54/5 ( download)

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Download or read book Wall Disease: The Psychological Toll of Living Up Against a Border written by Jessica Wapner and published by The Experiment, LLC. This book was released on 2020-10-06 with total page 133 pages. Available in PDF, EPUB and Kindle. Book excerpt: We build border walls to keep danger out. But do we understand the danger posed by walls themselves? East Germans were the first to give the crisis a name: Mauerkrankheit, or “wall disease.” The afflicted—everyday citizens living on both sides of the Berlin wall—displayed some combination of depression, anxiety, excitability, suicidal ideation, and paranoia. The Berlin Wall is no more, but today there are at least seventy policed borders like it. What are they doing to our minds? Jessica Wapner investigates, following a trail of psychological harm around the world. In Brownsville, Texas, the hotly contested US-Mexico border wall instills more feelings of fear than of safety. And in eastern Europe, a Georgian grandfather pines for his homeland—cut off from his daughters, his baker, and his bank by the arbitrary path of a razor-wire fence built in 2013. Even in borderlands riven by conflict, the same walls that once offered relief become enduring reminders of trauma and helplessness. Our brains, Wapner writes, devote “border cells” to where we can and cannot go safely—so, a wall that goes up in our town also goes up in our minds. Weaving together interviews with those living up against walls and expert testimonies from geographers, scientists, psychologists, and other specialists, she explores the growing epidemic of wall disease—and illuminates how neither those “outside” nor “inside” are immune.

Author : Robert C. Gallo
Publisher : Basic Books
ISBN 13 : 9780465098156
Total Pages : 0 pages
Book Rating : 4.50/5 ( download)

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Download or read book Virus Hunting written by Robert C. Gallo and published by Basic Books. This book was released on 1993-08-18 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The renowned AIDS researcher Robert Gallo tells his story of scientific breakthrough in a riveting portrait of the people, the politics, and the pace of modern scientific discovery.

Author : Joshua Woods
Publisher : Lexington Books
ISBN 13 : 1498535224
Total Pages : 214 pages
Book Rating : 4.29/5 ( download)

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Download or read book Debating Immigration in the Age of Terrorism, Polarization, and Trump written by Joshua Woods and published by Lexington Books. This book was released on 2017-09-27 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: Debating Immigration utilizes a theoretically informed framework for analyzing the multifaceted immigration debate before and after 9/11 in the age of terrorism, political polarization, and authoritarianism.

Author : Robert Bazell
Publisher : Random House
ISBN 13 : 0307764982
Total Pages : 241 pages
Book Rating : 4.80/5 ( download)

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Download or read book Her-2 written by Robert Bazell and published by Random House. This book was released on 2011-04-27 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: Two years after she underwent a mastectomy and chemotherapy, Barbara Bradfield's aggressive breast cancer had recurred and spread to her lungs. The outlook was grim. Then she took part in Genentech's clinical trials for a new drug. Five years later she remains cancer-free. Her-2 is the biography of Herceptin, the drug that provoked dramatic responses in Barbara Bradfield and other women in the trials and that offers promise for hundreds of thousands of breast cancer patients. Unlike chemotherapy or radiation, Herceptin has no disabling side effects. It works by inactivating Her-2/neu--a protein that makes cancer cells grow especially quickly-- produced by a gene found in 25 to 30 percent of all breast tumors. Herceptin caused some patients' cancers to disappear completely; in others, it slowed the progression of the disease and gave the women months or years they wouldn't otherwise have had. Herceptin is the first treatment targeted at a gene defect that gives rise to cancer. It marks the beginning of a new era of treatment for all kinds of cancers. Robert Bazell presents a riveting account of how Herceptin was born. Her-2 is a story of dramatic discoveries and strong personalities, showing the combination of scientific investigation, money, politics, ego, corporate decisions, patient activism, and luck involved in moving this groundbreaking drug from the lab to a patient's bedside. Bazell's deft portraits introduce us to the remarkable people instrumental in Herceptin's history, including Dr. Dennis Slamon, the driven UCLA oncologist who played the primary role in developing the treatment; Lily Tartikoff, wife of television executive Brandon Tartikoff, who tapped into Hollywood money and glamour to help fund Slamon's research; and Marti Nelson, who inspired the activists who lobbied for a "compassionate use" program that would allow women outside the clinical trials to have access to the limited supplies of Herceptin prior to FDA approval of the drug. And throughout there are the stories of the heroic women with advanced breast cancer who volunteered for the trials, risking what time they had left on an unproven treatment. Meticulously researched, written with clarity and compassion, Her-2 is masterly reporting on cutting-edge science.