The Origins Of Genome Architecture

Author : Michael Lynch
Publisher : Sinauer
ISBN 13 :
Total Pages : 518 pages
Book Rating : 4.10/5 ( download)

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Download or read book The Origins of Genome Architecture written by Michael Lynch and published by Sinauer. This book was released on 2007-06 with total page 518 pages. Available in PDF, EPUB and Kindle. Book excerpt: The availability of genomic blueprints for hundreds of species has led to a transformation in biology, encouraging the proliferation of adaptive arguments for the evolution of genomic features. This text explains why the details matter and presents a framework for how the architectural diversity of eukaryotic genomes and genes came to arise.

Author : Michael Lynch
Publisher : Sinauer
ISBN 13 :
Total Pages : 518 pages
Book Rating : 4.10/5 ( download)

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Download or read book The Origins of Genome Architecture written by Michael Lynch and published by Sinauer. This book was released on 2007-06 with total page 518 pages. Available in PDF, EPUB and Kindle. Book excerpt: The availability of genomic blueprints for hundreds of species has led to a transformation in biology, encouraging the proliferation of adaptive arguments for the evolution of genomic features. This text explains why the details matter and presents a framework for how the architectural diversity of eukaryotic genomes and genes came to arise.

Author : Bruce Walsh
Publisher : Oxford University Press
ISBN 13 : 0192566644
Total Pages : 1504 pages
Book Rating : 4.45/5 ( download)

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Download or read book Evolution and Selection of Quantitative Traits written by Bruce Walsh and published by Oxford University Press. This book was released on 2018-06-21 with total page 1504 pages. Available in PDF, EPUB and Kindle. Book excerpt: Quantitative traits-be they morphological or physiological characters, aspects of behavior, or genome-level features such as the amount of RNA or protein expression for a specific gene-usually show considerable variation within and among populations. Quantitative genetics, also referred to as the genetics of complex traits, is the study of such characters and is based on mathematical models of evolution in which many genes influence the trait and in which non-genetic factors may also be important. Evolution and Selection of Quantitative Traits presents a holistic treatment of the subject, showing the interplay between theory and data with extensive discussions on statistical issues relating to the estimation of the biologically relevant parameters for these models. Quantitative genetics is viewed as the bridge between complex mathematical models of trait evolution and real-world data, and the authors have clearly framed their treatment as such. This is the second volume in a planned trilogy that summarizes the modern field of quantitative genetics, informed by empirical observations from wide-ranging fields (agriculture, evolution, ecology, and human biology) as well as population genetics, statistical theory, mathematical modeling, genetics, and genomics. Whilst volume 1 (1998) dealt with the genetics of such traits, the main focus of volume 2 is on their evolution, with a special emphasis on detecting selection (ranging from the use of genomic and historical data through to ecological field data) and examining its consequences.

Author : Aurora Ruiz-Herrera
Publisher : MDPI
ISBN 13 : 3036501568
Total Pages : 248 pages
Book Rating : 4.67/5 ( download)

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Download or read book Mechanisms Driving Karyotype Evolution and Genomic Architecture written by Aurora Ruiz-Herrera and published by MDPI. This book was released on 2021-08-31 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding of the origin of species and their adaptability to new environments is one of the main questions in biology. This is fueled by the ongoing debate on species concepts and facilitated by the availability of an unprecedented large number of genomic resources. Genomes are organized into chromosomes, where significant variations in number and morphology are observed among species due to large-scale structural variants such as inversions, translocations, fusions, and fissions. This genomic reshuffling provides, in the long term, new chromosomal forms on which natural selection can act upon, contributing to the origin of biodiversity. This book contains mainly articles, reviews, and an opinion piece that explore numerous aspects of genome plasticity among taxa that will help in understanding the dynamics of genome composition, the evolutionary relationships between species and, in the long run, speciation.

Author : Ann Arvin
Publisher : Cambridge University Press
ISBN 13 : 1139461648
Total Pages : 1325 pages
Book Rating : 4.41/5 ( download)

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Download or read book Human Herpesviruses written by Ann Arvin and published by Cambridge University Press. This book was released on 2007-08-16 with total page 1325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.

Author : Henry H. Heng
Publisher : Academic Press
ISBN 13 : 0128136367
Total Pages : 556 pages
Book Rating : 4.62/5 ( download)

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Download or read book Genome Chaos written by Henry H. Heng and published by Academic Press. This book was released on 2019-05-25 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genome Chaos: Rethinking Genetics, Evolution, and Molecular Medicine transports readers from Mendelian Genetics to 4D-genomics, building a case for genes and genomes as distinct biological entities, and positing that the genome, rather than individual genes, defines system inheritance and represents a clear unit of selection for macro-evolution. In authoring this thought-provoking text, Dr. Heng invigorates fresh discussions in genome theory and helps readers reevaluate their current understanding of human genetics, evolution, and new pathways for advancing molecular and precision medicine. Bridges basic research and clinical application and provides a foundation for re-examining the results of large-scale omics studies and advancing molecular medicine Gathers the most pressing questions in genomic and cytogenomic research Offers alternative explanations to timely puzzles in the field Contains eight evidence-based chapters that discuss 4d-genomics, genes and genomes as distinct biological entities, genome chaos and macro-cellular evolution, evolutionary cytogenetics and cancer, chromosomal coding and fuzzy inheritance, and more

Author : James Womack
Publisher : John Wiley & Sons
ISBN 13 : 1118301706
Total Pages : 285 pages
Book Rating : 4.08/5 ( download)

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Download or read book Bovine Genomics written by James Womack and published by John Wiley & Sons. This book was released on 2012-03-16 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: The genetic information being unlocked by advances in genomic and high throughput technologies is rapidly revolutionizing our understanding of developmental processes in bovine species. This information is allowing researchers unprecedented insight into the genetic basis of key traits. Bovine Genomics is the first book to bring together and synthesize the information learned through the bovine genome sequencing project and look at its practical application to cattle and dairy production. Bovine Genomics opens with foundational chapters on the domestication of cattle and traditional Mendelian genetics. Building on these chapters, coverage rapidly moves to quantitative genetics and the advances of whole genome technologies. Significant coverage is given to such topics as epigenetics, mapping quantitative trail loci, genome-wide association studies and genomic selection in cattle breeding. The book is a valuable synthesis of the field written by a global team of leading researchers. Providing wide-ranging coverage of the topic, Bovine Genomic, is an essential guide to the field. The basic and applied science will be of use to researchers, breeders, and advanced students.

Author : Dhavendra Kumar
Publisher : Oxford Monographs on Medical G
ISBN 13 : 019989602X
Total Pages : 853 pages
Book Rating : 4.28/5 ( download)

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Download or read book Genomic Medicine written by Dhavendra Kumar and published by Oxford Monographs on Medical G. This book was released on 2014-10-15 with total page 853 pages. Available in PDF, EPUB and Kindle. Book excerpt: Preceded by Genomics and clinical medicine / edited by Dhavendra Kumar. [First edition]. 2008.

Author : John H. Gillespie
Publisher : Oxford University Press
ISBN 13 : 0195357744
Total Pages : 351 pages
Book Rating : 4.45/5 ( download)

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Download or read book The Causes of Molecular Evolution written by John H. Gillespie and published by Oxford University Press. This book was released on 1994-05-26 with total page 351 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work provides a unified theory that addresses the important problem of the origin and maintenance of genetic variation in natural populations. With modern molecular techniques, variation is found in all species, sometimes at astonishingly high levels. Yet, despite these observations, the forces that maintain variation within and between species have been difficult subjects of study. Because they act very weakly and operate over vast time scales, scientists must rely on indirect inferences and speculative mathematical models. However, despite these obstacles, many advances have been made. The author's research in molecular genetics, evolution, and bio-mathematics has enabled him to draw on this work, and present a coherent and valuable view of the field. The book is divided into three parts. The first consists of three chapters on protein evolution, DNA evolution, and molecular mechanisms. This section reviews the experimental observations on genetic variation. The second part gives a unified treatment of the mathematical theory of selection in a fluctuating environment. The final two chapters combine the earlier assessments in a treatment of the scientific status of two competing theories for the maintenance of genetic variation. Steeped in the enormous advances population genetics has made over the past 25 years, this book has proven highly popular among human geneticists, biologists, evolutionary theorists, and bio-mathematicians.

Author : Esteban Domingo
Publisher : Elsevier
ISBN 13 : 0080564968
Total Pages : 573 pages
Book Rating : 4.68/5 ( download)

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Download or read book Origin and Evolution of Viruses written by Esteban Domingo and published by Elsevier. This book was released on 2008-06-23 with total page 573 pages. Available in PDF, EPUB and Kindle. Book excerpt: New viral diseases are emerging continuously. Viruses adapt to new environments at astounding rates. Genetic variability of viruses jeopardizes vaccine efficacy. For many viruses mutants resistant to antiviral agents or host immune responses arise readily, for example, with HIV and influenza. These variations are all of utmost importance for human and animal health as they have prevented us from controlling these epidemic pathogens. This book focuses on the mechanisms that viruses use to evolve, survive and cause disease in their hosts. Covering human, animal, plant and bacterial viruses, it provides both the basic foundations for the evolutionary dynamics of viruses and specific examples of emerging diseases. NEW - methods to establish relationships among viruses and the mechanisms that affect virus evolution UNIQUE - combines theoretical concepts in evolution with detailed analyses of the evolution of important virus groups SPECIFIC - Bacterial, plant, animal and human viruses are compared regarding their interation with their hosts