The Nucleolus And Ribosome Biogenesis

Author : A.A. Hadjiolov
Publisher : Springer Science & Business Media
ISBN 13 : 3709187427
Total Pages : 281 pages
Book Rating : 4.25/5 ( download)

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Download or read book The Nucleolus and Ribosome Biogenesis written by A.A. Hadjiolov and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: The nucleolus had consistently attracted the attention of investigators in the fields of cell biology and pathology. Because of its ubiquitous presence in the nucleus of eukaryotic cells, its rapid changes during their life cycle, and its rapid response to noxious agents, this organelle has been the subject of a large number of studies. Yet, the exact function and the very reason for the existence of the nucleolus (the only large cellular structure not delimited by a membrane) remain largely unknown. The ribosomes were discovered relatively late in the study of cells, but due to their crucial involvement in the protein synthesis machinery of all living organisms, the elucidation of their structure and function quickly became one of the major goals of molecular biology. The relatively simple structure of the ribosome strengthens the hope that a full understanding of the structure and function of this organelle in molecular terms is within the reach of contemporary research~ Since each of the rRNA and protein molecules embodied in the ribosome is the product of a distinct gene, studies on the biogenesis of ribosomes expanded rapidly to become a core topic in molecular genetics.

Author : Mark O. J. Olson
Publisher : Springer Science & Business Media
ISBN 13 : 1461405149
Total Pages : 434 pages
Book Rating : 4.46/5 ( download)

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Download or read book The Nucleolus written by Mark O. J. Olson and published by Springer Science & Business Media. This book was released on 2011-09-15 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: Within the past two decades, extraordinary new functions for the nucleolus have begun to appear, giving the field a new vitality and generating renewed excitement and interest. These new discoveries include both newly-discovered functions and aspects of its conventional role. The Nucleolus is divided into three parts: nucleolar structure and organization, the role of the nucleolus in ribosome biogenesis, and novel functions of the nucleolus.

Author : Irwin M. Arias
Publisher : John Wiley & Sons
ISBN 13 : 1119436826
Total Pages : 1156 pages
Book Rating : 4.29/5 ( download)

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Download or read book The Liver written by Irwin M. Arias and published by John Wiley & Sons. This book was released on 2020-03-09 with total page 1156 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bridging the gap between basic scientific advances and the understanding of liver disease — the extensively revised new edition of the premier text in the field. The latest edition of The Liver: Biology and Pathobiology remains a definitive volume in the field of hepatology, relating advances in biomedical sciences and engineering to understanding of liver structure, function, and disease pathology and treatment. Contributions from leading researchers examine the cell biology of the liver, the pathobiology of liver disease, the liver’s growth, regeneration, metabolic functions, and more. Now in its sixth edition, this classic text has been exhaustively revised to reflect new discoveries in biology and their influence on diagnosing, managing, and preventing liver disease. Seventy new chapters — including substantial original sections on liver cancer and groundbreaking advances that will have significant impact on hepatology — provide comprehensive, fully up-to-date coverage of both the current state and future direction of hepatology. Topics include liver RNA structure and function, gene editing, single-cell and single-molecule genomic analyses, the molecular biology of hepatitis, drug interactions and engineered drug design, and liver disease mechanisms and therapies. Edited by globally-recognized experts in the field, this authoritative volume: Relates molecular physiology to understanding disease pathology and treatment Links the science and pathology of the liver to practical clinical applications Features 16 new “Horizons” chapters that explore new and emerging science and technology Includes plentiful full-color illustrations and figures The Liver: Biology and Pathobiology, Sixth Edition is an indispensable resource for practicing and trainee hepatologists, gastroenterologists, hepatobiliary and liver transplant surgeons, and researchers and scientists in areas including hepatology, cell and molecular biology, virology, and drug metabolism.

Author :
Publisher : Academic Press
ISBN 13 : 0128171944
Total Pages : 444 pages
Book Rating : 4.43/5 ( download)

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Download or read book RNA-Based Regulation in Human Health and Disease written by and published by Academic Press. This book was released on 2020-08-19 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: RNA-based Regulation in Human Health and Disease offers an in-depth exploration of RNA mediated genome regulation at different hierarchies. Beginning with multitude of canonical and non-canonical RNA populations, especially noncoding RNA in human physiology and evolution, further sections examine the various classes of RNAs (from small to large noncoding and extracellular RNAs), functional categories of RNA regulation (RNA-binding proteins, alternative splicing, RNA editing, antisense transcripts and RNA G-quadruplexes), dynamic aspects of RNA regulation modulating physiological homeostasis (aging), role of RNA beyond humans, tools and technologies for RNA research (wet lab and computational) and future prospects for RNA-based diagnostics and therapeutics. One of the core strengths of the book includes spectrum of disease-specific chapters from experts in the field highlighting RNA-based regulation in metabolic & neurodegenerative disorders, cancer, inflammatory disease, viral and bacterial infections. We hope the book helps researchers, students and clinicians appreciate the role of RNA-based regulation in genome regulation, aiding the development of useful biomarkers for prognosis, diagnosis, and novel RNA-based therapeutics. Comprehensive information of non-canonical RNA-based genome regulation modulating human health and disease Defines RNA classes with special emphasis on unexplored world of noncoding RNA at different hierarchies Disease specific role of RNA - causal, prognostic, diagnostic and therapeutic Features contributions from leading experts in the field

Author : Mark O. J. Olson
Publisher : Springer
ISBN 13 : 9781461405153
Total Pages : 414 pages
Book Rating : 4.57/5 ( download)

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Download or read book The Nucleolus written by Mark O. J. Olson and published by Springer. This book was released on 2011-09-08 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt: Within the past two decades, extraordinary new functions for the nucleolus have begun to appear, giving the field a new vitality and generating renewed excitement and interest. These new discoveries include both newly-discovered functions and aspects of its conventional role. The Nucleolus is divided into three parts: nucleolar structure and organization, the role of the nucleolus in ribosome biogenesis, and novel functions of the nucleolus.

Author : E. G. Jordan
Publisher : Cambridge University Press
ISBN 13 : 9780521237345
Total Pages : 236 pages
Book Rating : 4.43/5 ( download)

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Download or read book The Nucleolus written by E. G. Jordan and published by Cambridge University Press. This book was released on 1982-06-24 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Vijay Kumar
Publisher : Elsevier
ISBN 13 : 012816364X
Total Pages : 296 pages
Book Rating : 4.41/5 ( download)

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Download or read book Emerging Concepts in Ribosome Structure, Biogenesis, and Function written by Vijay Kumar and published by Elsevier. This book was released on 2021-09-30 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Emerging Concepts in Ribosome Structure, Biogenesis, and Function provides a synthesized overview on all parts in this process. The book begins with an introduction to the ribosome factory, its origin and its evolution of translation. Sections discuss subunits, RNA, protein components, and its emergence as a frontier research area for translational potential in cancer and other diseases. In addition, the book explores current developments in ribosome research, including the emergence of ribosomopathies, how deregulation of ribosome biogenesis can impact disease mechanisms and aging, and the discovery of specialized ribosomes. This book provides the emerging research on ribosomes, their biogenesis, and other important topics on structure and function. Therefore, it will serve as a resourceful introduction for both new researchers and those engaged in interdisciplinary ribosomal research.

Author : Vijay Kumar
Publisher : Academic Press
ISBN 13 : 0128167343
Total Pages : 298 pages
Book Rating : 4.42/5 ( download)

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Download or read book Emerging Concepts in Ribosome Structure, Biogenesis, and Function written by Vijay Kumar and published by Academic Press. This book was released on 2021-09-25 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ribosome biogenesis is the process of making ribosomes which are responsible for mRNA translation into proteins. It is a tightly regulated process closely linked to nearly all biochemical and cellular processes, including cell division, growth, and development. Emerging Concepts in Ribosome Structure, Biogenesis, and Function provides a synthesized overview of all the parts engaged in this process. The book begins by providing an introduction to the ribosome factory, its origin, and its evolution of translation. It then goes on to describe ribosome structure including subunits, RNA, and protein components. Ribosome biogenesis and its emergence as a frontier research area for translational potential in cancer and other diseases are also discussed. In addition, the book explores current developments in ribosome research like the emergence of ribosomopathies, how deregulation of ribosome biogenesis can impact disease mechanisms and aging, and the discovery of specialized ribosomes that have specific functions that may translate differentially with consequences on normal and pathological processes. Emerging Concepts in Ribosome Structure, Biogenesis, and Function provides fundamental coverage and emerging research on ribosomes, biogenesis, and their structure and function and is a resourceful introduction for new researchers and those engaged in interdisciplinary ribosomal research. Provides an overview of ribosome biogenesis and examines its involvement in cell transformation and cancerous growth Covers disorders related to the ribosome (ribosomopathies) and explains the significance of ribosome dysfunction in human diseases Includes commonly used methods to study ribosomes, such as polysome preparation, RNA profiling and proteomics, CryoEM, and Cell-free assays along with proper illustrations

Author : Heinz Bielka
Publisher : Walter de Gruyter GmbH & Co KG
ISBN 13 : 3112729757
Total Pages : 340 pages
Book Rating : 4.55/5 ( download)

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Download or read book The Eukaryotic Ribosome written by Heinz Bielka and published by Walter de Gruyter GmbH & Co KG. This book was released on 1982-12-31 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: No detailed description available for "The Eukaryotic Ribosome".

Author : Robert Steinbauer
Publisher : Sudwestdeutscher Verlag Fur Hochschulschriften AG
ISBN 13 : 9783838126142
Total Pages : 148 pages
Book Rating : 4.49/5 ( download)

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Download or read book Regulation of Ribosome Biogenesis and Rna Polymerase I Transcription written by Robert Steinbauer and published by Sudwestdeutscher Verlag Fur Hochschulschriften AG. This book was released on 2011-06 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ribosome synthesis depends on nutrient availability sensed by the target of rapamycin (TOR) signaling pathway in eukaryotic cells. TOR inactivation affects ribosome biogenesis at the level of RNA polymerase I (Pol I)-dependent transcription of ribosomal RNA (rRNA) genes, expression of ribosomal proteins (r-proteins) and ribosome biogenesis factors, pre-ribosome processing, and transport. Detailed analysis shows that upon TOR inactivation the levels of newly synthesized ribosomal subunits drop drastically before the integrity of the Pol I apparatus is severely impaired but in good correlation with a sharp decrease in r-protein production. Inhibition of translation by cycloheximide mimics the rRNA maturation defect observed immediately after TOR inactivation. Both cycloheximide addition and the depletion of individual r-proteins also reproduce TOR-dependent nucleolar entrapment of specific ribosomal precursor complexes. The conclusion could be drawn that shortage of newly synthesized r-proteins after short-term TOR inactivation is sufficient to explain most of the observed effects on ribosome production.