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Author : Gregg G. Gundersen
Publisher :
ISBN 13 : 9781493986910
Total Pages : 338 pages
Book Rating : 4.10/5 ( download)
Download or read book The LINC Complex written by Gregg G. Gundersen and published by . This book was released on 2018 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Gregg G. Gundersen
Publisher : Humana
ISBN 13 : 9781493993673
Total Pages : 338 pages
Book Rating : 4.74/5 ( download)
Download or read book The LINC Complex written by Gregg G. Gundersen and published by Humana. This book was released on 2019-09-07 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume describes research methodologies and approaches used to study the Linker of Nucleoskeleton and Cytoskeleton (LINC) complex and its cellular functions. Chapters detail structural and biochemical analysis of LINC complexes, mechanical aspects of the LINC complex, analysis of the LINC complex in model systems and development, and LINC complex in mammalian tissue, organs, and disease. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, The LINC Complex: Methods and Protocols aims to ensure successful results in the further study of this vital field.
Author : Xuanzong Guo
Publisher :
ISBN 13 :
Total Pages : 38 pages
Book Rating : 4.19/5 ( download)
Download or read book Structural Studies on the LINC Complex and Fic-1 written by Xuanzong Guo and published by . This book was released on 2015 with total page 38 pages. Available in PDF, EPUB and Kindle. Book excerpt: LINC complexes span the nuclear envelope and connect the nucleoskeleton to the cytoskeleton. In 2012, our lab solved the first LINC complex structure, that of SUN domain of human SUN2 bound with KASH1 or KASH2 peptides. In this project testes-specific human SUN proteins (SUN3, SPAG4, and SUNS) were compared to ubiquitously-expressed SUN2. Secondly, fission and budding yeast LINC complexes differ from human ones and were analyzed as well. I was able to confirm SUN-KASH interaction in human and yeast. For structural analysis I explored various expression strategies. Fic-1 is a C. elegans Fic-domain protein with diverse cellular functions. As a subfamily III Fic enzyme, Fic-1 may reveal valuable insights into Fic enzyme mechanisms from its structure. After trying different knowledge-informed constructs and crystal optimization, small Fic-1 crystals were obtained, which diffracted X-rays to ~ 7 [angstroms]. With modest additional effort diffraction-quality crystals should be achievable.
Author : Davide Vigetti
Publisher : Humana Press
ISBN 13 : 9781493991327
Total Pages : 278 pages
Book Rating : 4.29/5 ( download)
Download or read book The Extracellular Matrix written by Davide Vigetti and published by Humana Press. This book was released on 2019-03-31 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume details established experimental protocols on the isolation, characterization, and detection of extracellular matrix (ECM) molecules as well as methods to study the activity and role of ECM components on various biological functions, the formation of exosomes, and tissue surrogates. Chapters display a variety of protocols ranging from biochemical, cell, and molecular biology assays to complex tissue imaging techniques and in vivo models to elucidate the role of the extracellular matrix. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, The Extracellular Matrix: Methods and Protocols aims to provide protocols and applications that can be used by both Ph.D. students and senior researchers to advance research in the field of extracellular matrix biology.
Author :
Publisher : Academic Press
ISBN 13 : 0123983274
Total Pages : 404 pages
Book Rating : 4.75/5 ( download)
Download or read book Mechanotransduction written by and published by Academic Press. This book was released on 2014-07-29 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Progress in Molecular Biology and Translational Science provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology. It contains contributions from leaders in their fields and abundant references. Volume 126 features in-depth reviews that focus on the tools required to investigate mechanotransduction. Additional chapters focus on how we can use these tools to answer fundamental questions about the interaction of physical forces with cell biology, morphogenesis, and function of mature structures. Chapters in the volume are authored by a unique combination of cell biologists and engineers, providing a range of perspectives on mechanotransduction. Provides a unique combination of perspectives from biologists and engineers Engaging to people of many training backgrounds
Author :
Publisher : Academic Press
ISBN 13 : 0123973473
Total Pages : 1081 pages
Book Rating : 4.74/5 ( download)
Download or read book Cellular Migration and Formation of Neuronal Connections written by and published by Academic Press. This book was released on 2013-05-06 with total page 1081 pages. Available in PDF, EPUB and Kindle. Book excerpt: The genetic, molecular, and cellular mechanisms of neural development are essential for understanding evolution and disorders of neural systems. Recent advances in genetic, molecular, and cell biological methods have generated a massive increase in new information, but there is a paucity of comprehensive and up-to-date syntheses, references, and historical perspectives on this important subject. The Comprehensive Developmental Neuroscience series is designed to fill this gap, offering the most thorough coverage of this field on the market today and addressing all aspects of how the nervous system and its components develop. Particular attention is paid to the effects of abnormal development and on new psychiatric/neurological treatments being developed based on our increased understanding of developmental mechanisms. Each volume in the series consists of review style articles that average 15-20pp and feature numerous illustrations and full references. Volume 2 offers 56 high level articles devoted mainly to Formation of Axons and Dendrites, Migration, Synaptogenesis, Developmental Sequences in the Maturation of Intrinsic and Synapse Driven Patterns. Series offers 144 articles for 2904 full color pages addressing ways in which the nervous system and its components develop Features leading experts in various subfields as Section Editors and article Authors All articles peer reviewed by Section Editors to ensure accuracy, thoroughness, and scholarship Volume 2 sections include coverage of mechanisms which regulate: the formation of axons and dendrites, cell migration, synapse formation and maintenance during development, and neural activity, from cell-intrinsic maturation to early correlated patterns of activity
Author : Peter Fantes
Publisher :
ISBN 13 : 9781383049756
Total Pages : 0 pages
Book Rating : 4.50/5 ( download)
Download or read book The Yeast Nucleus written by Peter Fantes and published by . This book was released on 2000 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher : Academic Press
ISBN 13 : 9780128034705
Total Pages : 0 pages
Book Rating : 4.0X/5 ( download)
Download or read book Intermediate Filament Proteins written by and published by Academic Press. This book was released on 2016-01-19 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intermediate Filament Proteins, the latest volume in the Methods in Enzymology series covers all the intermediate filaments in vertebrates and invertebrates, providing a unique understanding of the multiple different tissue-specific intermediate filaments. This volume also covers the latest methods that are currently being used to study intermediate filament protein function and dynamics. It will be an important companion for any experimentalist interesting in studying this protein family in their cell or organism model system.
Author : Loic Gazquez
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.96/5 ( download)
Download or read book Dynamics of the LINC Complex written by Loic Gazquez and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Mohammad Mofrad
Publisher :
ISBN 13 : 9781316140727
Total Pages : 496 pages
Book Rating : 4.25/5 ( download)
Download or read book Cellular Mechanotransduction written by Mohammad Mofrad and published by . This book was released on 2014-07-01 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the process of stress sensing and transducing mechanical force into biochemical signals.
