The Genetics Of Cancer

Author : B.A. Ponder
Publisher : Springer Science & Business Media
ISBN 13 : 9401106770
Total Pages : 222 pages
Book Rating : 4.71/5 ( download)

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Download or read book The Genetics of Cancer written by B.A. Ponder and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: It has been recognized for almost 200 years that certain families seem to inherit cancer. It is only in the past decade, however, that molecular genetics and epidemiology have combined to define the role of inheritance in cancer more clearly, and to identify some of the genes involved. The causative genes can be tracked through cancer-prone families via genetic linkage and positional cloning. Several of the genes discovered have subsequently been proved to play critical roles in normal growth and development. There are also implications for the families themselves in terms of genetic testing with its attendant dilemmas, if it is not clear that useful action will result. The chapters in The Genetics of Cancer illustrate what has already been achieved and take a critical look at the future directions of this research and its potential clinical applications.

Author : Fred Bunz
Publisher : Springer
ISBN 13 : 9401774846
Total Pages : 343 pages
Book Rating : 4.40/5 ( download)

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Download or read book Principles of Cancer Genetics written by Fred Bunz and published by Springer. This book was released on 2016-03-01 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the second edition of a widely used textbook that consolidates the basic concepts of the cancer gene theory and provides a framework for understanding the genetic basis of cancer. Particular attention is devoted to the origins of the mutations that cause cancer, and the application of evolutionary theory to explain how the cell clones that harbor cancer genes tend to expand. Focused on the altered genes and pathways that cause the growth of the most common tumors, Principles of Cancer Genetics is aimed at advanced undergraduates who have completed introductory coursework in genetics, biology and biochemistry, medical students and medical house staff. For students with a general interest in cancer, this book provides a highly accessible and readable overview. For more advanced students contemplating future study in the field of oncology and cancer research, this concise book will be useful as a primer.

Author : Suzanne M. Mahon
Publisher :
ISBN 13 : 9781635930498
Total Pages : 0 pages
Book Rating : 4.99/5 ( download)

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Download or read book Understanding Genomic and Hereditary Cancer Risk written by Suzanne M. Mahon and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Collecting a family medical history is a regular component of the nursing assessment process that often includes information on familial cancer diagnoses, and patients may fear that they or their loved ones might be at increased risk for developing cancer because of hereditary factors. Although true inherited risk for developing cancer is much less common than acquired risk for developing cancer, approximately 10% of cancer diagnoses can be attributed to inherited risk. The identification of families exhibiting hereditary cancer syndromes enables individuals at risk to engage in increased surveillance and, in some cases, risk-reducing surgery and other preventive measures, which ultimately lead to decreasing the morbidity and mortality associated with a cancer diagnosis. The role of the nurse in helping patients to understand and manage hereditary cancer risk requires specialized knowledge of genetics and genomics concepts. Understanding Genomic and Hereditary Cancer Risk: A Handbook for Oncology Nurses provides background on basic genetic and genomic concepts, particularly those related to hereditary risk for developing cancer, to aid nurses in knowing when and why to refer patients. It also provides reliable information about how and why genetic and genomic testing can both aid in treatment decisions and also guide recommendations for cancer prevention and early detection. The nurse's role in genetic testing and counseling are discussed, as are questions and answers about types of testing, including direct-to-consumer genetic testing. Following genetic testing, most genetics professionals provide detailed information about recommendations for care, including recommendations for ongoing prevention and early detection. For patients who are found to have a harmful mutation, these recommendations can be extensive and are based on the personal and family medical history, as well as the specific variant. This book provides quick overviews of many of the more common hereditary variants as well as resources for more information. This handbook provides nurses with the essentials to understand genomic and hereditary cancer risk, to assist in facilitating interprofessional care with genetics and other oncology professionals, and to provide their patients with accurate and reassuring information"--

Author : Gajanan V. Sherbet
Publisher :
ISBN 13 : 9780126398755
Total Pages : 338 pages
Book Rating : 4.55/5 ( download)

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Download or read book The Genetics of Cancer written by Gajanan V. Sherbet and published by . This book was released on 1997 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by internationally recognized experts, The Genetics of Cancer provides up-to-date information and insight into the genetic basis of cancer and the mechanisms involved in cancer invasion and its secondary spread. This volume presents the deregulation of the cell cycle in tumor development and integrates the function of tumor suppressor genes, oncogenes, and metastasis-associated genes in the pathogenesis and progression of cancer. The Genetics of Cancer will be useful to all graduate students, clinicians, and researchers working in the fields of cancer biology, genetics, and molecular biology. Key Features The contents include: * Clonal evolution of the metastasis phenotype * Cell Cycle regulation * Apoptosis in tumour growth and metastasis * Angiogenesis in cancer * Cell surface glycoproteins and their receptors * Proteinases and their inhibitors in cancer invasion * Oncogenes and cancer metastasis * Developmental genes * Tumour suppressor genes * Metastasis suppressor genes * Dominant metastasis-associated genes

Author : Bruce Alberts
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.81/5 ( download)

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Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Parvin Mehdipour
Publisher : Springer
ISBN 13 : 3319645501
Total Pages : 1170 pages
Book Rating : 4.06/5 ( download)

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Download or read book Cancer Genetics and Psychotherapy written by Parvin Mehdipour and published by Springer. This book was released on 2017-09-20 with total page 1170 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of this book is to provide the readers with the most comprehensive and latest accounts of research and development in this field by emphasizing on the manner of relation between doctors and cancer patients in direction of improving the patients’ style of life. This book, partly, will deal with psychotherapy by considering cancer patients, benefits, hazards and also social impacts including life style. The social supports as the key and influential paradigms will be challenged as a comparative insight by considering the global unity in order to provide a reasonable model to improve the interaction between cancer and psychological nest. In this book, the real stories of cancer patient will be also provided. The initial insight of sections includes: 1) Brief classifications and key points of clinical and histopatological aspects of each organ. 2) Brief view of genetic alterations in each organ. 3) Therapeutic aspects. 4) Brief classifications and key points of Psychology in cancer. 5) The interactions of clinical aspects with psychological field.

Author : Xavier Llor
Publisher : McGraw Hill Professional
ISBN 13 : 1260440281
Total Pages : 474 pages
Book Rating : 4.87/5 ( download)

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Download or read book Cancer Genetics: A Clinical Approach written by Xavier Llor and published by McGraw Hill Professional. This book was released on 2021-11-19 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ultimate guide to caring for and communicating with patients suffering with hereditary cancer syndromes Providing the essential tools needed to understand clinical cancer genetics, Cancer Genetics: A Clinical Approach builds your mastery of differential diagnosis formulation, all the available genetic testing options at your disposal, interpreting results logically and accurately, and educating patients and their families about effective cancer prevention methods. This unparalleled resource walks you through the process of effectively and thoughtfully counseling patients—from pre-test counseling and relaying test results to navigating the legal implications of hereditary conditions and coping with the resulting psychological challenges. Cancer Genetics: A Clinical Approach is ideal for both specialized cancer genetics clinics or any healthcare professional seeking to improve their skills in identifying patients with possible hereditary cancer syndromes and recognizing which ones should be referred to a high-risk/clinical genetics specialty program.

Author : Ramaswamy Govindan, MD
Publisher : Springer Publishing Company
ISBN 13 : 082616868X
Total Pages : 184 pages
Book Rating : 4.89/5 ( download)

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Download or read book Cancer Genomics for the Clinician written by Ramaswamy Govindan, MD and published by Springer Publishing Company. This book was released on 2019-01-28 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer Genomics for the Clinician is a practical guide to cancer genomics and its application to cancer diagnosis and care. The book begins with a brief overview of the various types of genetic alterations that are encountered in cancer, followed by accessible and applicable information on next generation sequencing technology and bioinformatics; tumor heterogeneity; whole genome, exome, and transcriptome sequencing; epigenomics; and data analysis and interpretation. Each chapter provides essential explanations of concepts, terminology, and methods. Also included are tips for interpreting and analyzing molecular data, as well as a discussion of molecular predictors for targeted therapies covering hematologic malignancies and solid tumors. The final chapter explains the use of FDA-approved genomic-based targeted therapies for breast cancer, lung cancer, sarcomas, gastrointestinal cancers, urologic cancers, head and neck cancer, thyroid cancer, and many more. Assembled in an accessible format specifically designed for the non-expert, this book provides the clinical oncologist, early career practitioner, and trainee with an essential understanding of the molecular and genetic basis of cancer and the clinical aspects that have led to advancements in diagnosis and treatment. With this resource, physicians and trainees will increase their breadth of knowledge and be better equipped to educate patients and families who want to know more about their genetic predispositions to cancer and the targeted therapies that could be considered and prescribed. Key Features: Describes how cancer genomics and next generation sequencing informs cancer screening, risk factors, therapeutic options, and clinical management across cancer types Explains what mutations are, what tests are needed, and how to interpret the results Provides information on FDA-approved targeted therapies that are being used in the clinic Covers different sequencing platforms and technologies and how they perform in research settings Includes access to the fully searchable eBook

Author : Joan H. Fujimura
Publisher : Harvard University Press
ISBN 13 : 9780674175532
Total Pages : 344 pages
Book Rating : 4.30/5 ( download)

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Download or read book Crafting Science written by Joan H. Fujimura and published by Harvard University Press. This book was released on 1996 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the late 1970s and 1980s, "cancer" underwent a remarkable transformation. In one short decade, what had long been a set of heterogeneous diseases marked by uncontrolled cell growth became a disease of our genes. How this happened and what it means is the story Joan Fujimura tells in a rare inside look at the way science works and knowledge is created. A dramatic study of a new species of scientific revolution, this book combines a detailed ethnography of scientific thought, an in-depth account of science practiced and produced, a history of one branch of science as it entered the limelight, and a view of the impact of new genetic technologies on science and society. The scientific enterprise that Fujimura unfolds for us is proto-oncogene cancer research--the study of those segments of DNA now thought to make normal cells cancerous. Within this framework, she describes the processes of knowledge construction as a social enterprise, an endless series of negotiations in which theories, material technologies, and practices are co-constructed, incorporated, and refashioned. Along the way, Fujimura addresses long-standing questions in the history and philosophy of science, culture theory, and sociology of science: How do scientists create "good" problems, experiments, and solutions? What are the cultural, institutional, and material technologies that have to be in place for new truths and new practices to succeed? Portraying the development of knowledge as a multidimensional process conducted through multiple cultures, institutions, actors, objects, and practices, this book disrupts divisions among sociology, history, anthropology, and the philosophy of science, technology, and medicine.

Author : S. V. Hodgson
Publisher : Cambridge University Press
ISBN 13 : 052168563X
Total Pages : 411 pages
Book Rating : 4.34/5 ( download)

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Download or read book A Practical Guide to Human Cancer Genetics written by S. V. Hodgson and published by Cambridge University Press. This book was released on 2007 with total page 411 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 2006 third edition of this very successful book provides a comprehensive and practical guide to the diagnosis and management of inherited disorders conferring susceptibility to cancer. Issues discussed include risk assessment, genetic counselling, predictive testing and organisation of a cancer genetics service. A full reference list gives access to background literature. With molecular information, screening guidelines and management advice, this new edition will provide geneticists and clinicians in all disciplines with an invaluable resource for screening, managing and advising patients.