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Author : A. I. Tauber
Publisher :
ISBN 13 : 9789400917873
Total Pages : 356 pages
Book Rating : 4.72/5 ( download)
Download or read book The Elusive Synthesis written by A. I. Tauber and published by . This book was released on 2014-01-15 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : A.I. Tauber
Publisher : Springer Science & Business Media
ISBN 13 : 9400917864
Total Pages : 348 pages
Book Rating : 4.66/5 ( download)
Download or read book The Elusive Synthesis: Aesthetics and Science written by A.I. Tauber and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: The tension between art and science may be traced back to the Greeks. What became "natural philosophy" and later "science" has traditionally been posed as a fundamental alternative to poetry and art. It is a theme that has commanded central attention in Western thought, as it captures the ancient conflict of Apollo and Dionysus over what deserves to order our thought and serve as the aspiration of our cultural efforts. The modern schi sm between art and science was again clearly articulated in the Romantic period and seemingly grew to a crescendo fifty years aga as a result of the debate concerning atomic power. The discussion has not abated in the physical sciences, and in fact has dramatically expanded most prominently into the domains of ecology and medicine. Issues concerning the role of science in modern society, although heavily political, must be regarded at heart as deeply embedded in our cultural values. Although each generation addresses them anew, the philosophical problems which lay at the foundation of these fundamental concerns always appear fresh and difficult. This anthology of original essays considers how science might have a greater commonality with art than was perhaps realized in a more positivist era. The contributors are concerned with how the aesthetic participates in science, both as a factor in constructing theory and influencing practice. The collec tion is thus no less than a spectrum of how Beauty and Science might be regarded through the same prism.
Author : Giora Shaviv
Publisher : Springer Science & Business Media
ISBN 13 : 3642283853
Total Pages : 700 pages
Book Rating : 4.57/5 ( download)
Download or read book The Synthesis of the Elements written by Giora Shaviv and published by Springer Science & Business Media. This book was released on 2012-04-13 with total page 700 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the origins and evolution of the chemical elements we and the cosmos are made of. The story starts with the discovery of the common elements on Earth and their subsequent discovery in space. How do we learn the composition of the distant stars? How did progress in quantum theory, nuclear physics, spectroscopy, stellar structure and evolution, together with observations of stars, converge to provide an incredibly detailed picture of the universe? How does research in the micro-world explain the macro-world? How does progress in one affect the other, or lack of knowledge in one inhibit progress in the other? In short, Shaviv describes how we discovered the various pieces of the jigsaw that form our present picture of the universe; and how we sometimes put these in the wrong place before finding in the right one. En route we meet some fascinating personalities and learn about heated controversies. Shaviv shows how science lurched from one dogma to the next, time and again shattering much of what had been considered solid knowledge, until eventually a stable understanding arose. Beginning with generally accepted science, the book ends in today’s terra incognita of nuclear physics, astrophysics and cosmology. A monumental work that will fascinate scientists, philosophers, historians and lay readers alike.
Author : Daniel Mendelsohn
Publisher : Vintage
ISBN 13 : 0307809870
Total Pages : 221 pages
Book Rating : 4.72/5 ( download)
Download or read book The Elusive Embrace written by Daniel Mendelsohn and published by Vintage. This book was released on 2012-01-04 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hailed for its searing emotional insights, and for the astonishing originality with which it weaves together personal history, cultural essay, and readings of classical texts by Sophocles, Ovid, Euripides, and Sappho, The Elusive Embrace is a profound exploration of the mysteries of identity. It is also a meditation in which the author uses his own divided life to investigate the "rich conflictedness of things," the double lives all of us lead. Daniel Mendelsohn recalls the deceptively quiet suburb where he grew up, torn between his mathematician father's pursuit of scientific truth and the exquisite lies spun by his Orthodox Jewish grandfather; the streets of manhattan's newest "gay ghetto," where "desire for love" competes with "love of desire;" and the quiet moonlit house where a close friend's small son teaches him the meaning of fatherhood. And, finally, in a neglected Jewish cemetery, the author uncovers a family secret that reveals the universal need for storytelling, for inventing myths of the self. The book that Hilton Als calls "equal to Whitman's 'Song of Myself,'" The Elusive Embrace marks a dazzling literary debut.
Author : Ashraf Brik
Publisher : John Wiley & Sons
ISBN 13 : 3527823581
Total Pages : 624 pages
Book Rating : 4.81/5 ( download)
Download or read book Total Chemical Synthesis of Proteins written by Ashraf Brik and published by John Wiley & Sons. This book was released on 2021-03-16 with total page 624 pages. Available in PDF, EPUB and Kindle. Book excerpt: How to synthesize native and modified proteins in the test tube With contributions from a panel of experts representing a range of disciplines, Total Chemical Synthesis of Proteins presents a carefully curated collection of synthetic approaches and strategies for the total synthesis of native and modified proteins. Comprehensive in scope, this important reference explores the three main chemoselective ligation methods for assembling unprotected peptide segments, including native chemical ligation (NCL). It includes information on synthetic strategies for the complex polypeptides that constitute glycoproteins, sulfoproteins, and membrane proteins, as well as their characterization. In addition, important areas of application for total protein synthesis are detailed, such as protein crystallography, protein engineering, and biomedical research. The authors also discuss the synthetic challenges that remain to be addressed. This unmatched resource: Contains valuable insights from the pioneers in the field of chemical protein synthesis Presents proven synthetic approaches for a range of protein families Explores key applications of precisely controlled protein synthesis, including novel diagnostics and therapeutics Written for organic chemists, biochemists, biotechnologists, and molecular biologists, Total Chemical Synthesis of Proteins provides key knowledge for everyone venturing into the burgeoning field of protein design and synthetic biology.
Author : Daniel Lednicer
Publisher : John Wiley & Sons
ISBN 13 : 9780471589594
Total Pages : 238 pages
Book Rating : 4.94/5 ( download)
Download or read book The Organic Chemistry of Drug Synthesis, Volume 5 written by Daniel Lednicer and published by John Wiley & Sons. This book was released on 1994-12-13 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: Updated every five years, the series represents the optimal compromise between currency and a sufficient body of material for cohesive and comprehensive treatment in a monograph. Provides a quick yet thorough overview of the synthetic routines that have been used to access specific classes of therapeutic agents. Materials are organized by chemical class, and syntheses are taken back to available starting materials. Discusses disease state, rational for method of drug therapy, biological activities of each compound and preparation. Coverage also includes those generic pharmaceutical compounds not accorded clinical status. A glossary defines biological terms.
Author : Michael Harmata
Publisher : Elsevier
ISBN 13 : 012821757X
Total Pages : 446 pages
Book Rating : 4.73/5 ( download)
Download or read book Strategies and Tactics in Organic Synthesis written by Michael Harmata and published by Elsevier. This book was released on 2021-11-11 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt: Strategies and Tactics in Organic Synthesis, Volume 15, provides a forum for investigators to discuss their approach to the science and art of organic synthesis. Rather than a simple presentation of data or a secondhand analysis, this classic provides stories that vividly demonstrate the power of the human endeavor known as organic synthesis and the creativity and tenacity of its practitioners. Firsthand accounts of each project present the excitement of conception, the frustration of failure and the joy experienced when either rational thought or good fortune gives rise to the successful completion of a project. Readers will be educated, challenged and inspired by these accounts, which portray the idea that triumphs do not come without challenges. This innovative approach also helps illustrate how challenges to further advance the science and art of organic synthesis can be overcome, driving the field forward to meet the demands of society by discovering new reactions, creating new designs and building molecules with atom and step economies that provide functional solutions to create a better world. Provides insight and offers new perspective to problem-solving Presents state-of-the-art developments in organic synthesis Written by leading experts in the field Uses firsthand narrative accounts to vividly illustrate the challenges and joys involved in advancing the science of organic synthesis
![Download Synthesis and application of ?-configured [18/19F]FDGs PDF Online Free](https://books.google.com/books/content/images/frontcover/iRZNDwAAQBAJ?fife=w200-h370)
Author : Mathias Elgland
Publisher : Linköping University Electronic Press
ISBN 13 : 9176853764
Total Pages : 100 pages
Book Rating : 4.64/5 ( download)
Download or read book Synthesis and application of ?-configured [18/19F]FDGs written by Mathias Elgland and published by Linköping University Electronic Press. This book was released on 2018-02-21 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt: Positron emission tomography (PET) is a non-invasive imaging method that renders three-dimensional images of tissue that selectively has taken up a radiolabelled organic compound, referred to as a radiotracer. This excellent technique provides clinicians with a tool to monitor disease progression and to evaluate how the patient respond to treatment. The by far most widely employed radiotracer in PET is called 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG), which is often referred to as the golden standard in PET. From a molecular perspective, [18F]FDG is an analogue of glucose where a hydroxyl group has been replaced with a radioactive fluorine atom (18F). It is well known that covalent attachment of carbohydrates (i.e., glycosylation) to biomolecules tend to improve their properties in the body, in terms of; improved pharmacokinetics, increased metabolic stability and faster clearance from blood and other non-specific tissue. It is therefore natural to pursuit the development of a [18F]fluoroglycosylation method where [18F]FDG is chemically conjugated to a ligand with high affinity for a given biological target (e.g., tumors or disease-associated protein aggregates). This thesis describes a novel [18F]fluoroglycosylation method that in a simple and general manner facilitate the conjugation of [18F]FDG to biological ligands using click chemistry. The utility of the developed [18F]fluoroglycosylation method is demonstrated by radiolabelling of curcumin, thus forming a tracer that may be employed for diagnosis of Alzheimer’s disease. Moreover, a set of oligothiophenes were fluoroglycosylated for potential diagnosis of Alzheimer’s disease but also for other much rarer protein misfolding diseases (e.g., Creutzfeldt-Jakob disease and systemic amyloidosis). In addition, the synthesis of a series of 19F-fluoroglycosylated porphyrins is described which exhibited promising properties not only to detect but also to treat melanoma cancer. Lastly, the synthesis of a set of 19F-fluorinated E-stilbenes, structurally based on the antioxidant resveratrol is presented. The E-stilbenes were evaluated for their capacity to spectrally distinguish between native and protofibrillar transthyretin in the pursuit of finding diagnostic markers for the rare but severe disease, transthyretin amyloidosis.
Author : Andrei K. Yudin
Publisher : John Wiley & Sons
ISBN 13 : 352760748X
Total Pages : 516 pages
Book Rating : 4.88/5 ( download)
Download or read book Aziridines and Epoxides in Organic Synthesis written by Andrei K. Yudin and published by John Wiley & Sons. This book was released on 2006-12-13 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aziridines and epoxides are among the most widely used intermediates in organic synthesis, acting as precursors to complex molecules due to the strains incorporated in their skeletons. Besides their importance as reactive intermediates, many biologically active compounds also contain these three-membered rings. Filling a gap in the literature, this clearly structured book presents the much needed information in a compact and concise way. The renowned editor has succeeded in gathering together excellent authors to cover synthesis, applications, and the biological aspects in equal depth. Divided roughly equally between aziridines and epoxides, the twelve chapters discuss: * Synthesis of aziridines * Nucleophilic ring-opening of aziridines and epoxides * Organic synthesis with aziridine building blocks * Vinyl aziridines in organic synthesis * Diastereoselective aziridination reagents * Synthetic aspects of aziridinomitocene chemistry * Biosynthesis of biologically important aziridines * Organic catalysis of epoxide and aziridine ring formation * Metal-mediated synthesis of epoxides * Asymmetric epoxide ring opening chemistry * Epoxides in complex molecule synthesis * Biological activity of epoxide-containing molecules A high-quality reference manual for academic and industrial chemists alike.
Author :
Publisher : Elsevier
ISBN 13 : 0081007620
Total Pages : 294 pages
Book Rating : 4.24/5 ( download)
Download or read book Strategies and Tactics in Organic Synthesis written by and published by Elsevier. This book was released on 2016-10-04 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Strategies and Tactics in Organic Synthesis provides a forum for investigators to discuss their approach to the science and art of organic synthesis. Rather than a simple presentation of data or a secondhand analysis, this classic provides stories that vividly demonstrate the power of the human endeavor known as organic synthesis and the creativity and tenacity of its practitioners. Firsthand accounts of each project present the excitement of conception, the frustration of failure, and the joy experienced when either rational thought or good fortune gives rise to the successful completion of a project. This book series shows how synthesis is really done. Readers will be educated, challenged, and inspired by these accounts, which portray the idea that triumphs do not come without challenges. This innovative approach also helps illustrate how challenges to further advance the science and art of organic synthesis can be overcome, driving the field forward to meet the demands of society by discovering new reactions, creating new designs, and building molecules with atom and step economies that provide functional solutions to create a better world. Presents state-of-the-art developments in organic synthesis Provides insight and offers new perspective to problem-solving Written by leading experts in the field Uses firsthand narrative accounts to vividly illustrate the challenges and joys involved in advancing the science of organic synthesis
