The Dose Response Relation In Pharmacology

Author : Ronald J. Tallarida
Publisher : Springer Science & Business Media
ISBN 13 : 1468462652
Total Pages : 218 pages
Book Rating : 4.54/5 ( download)

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Download or read book The Dose—Response Relation in Pharmacology written by Ronald J. Tallarida and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is designed to meet the modern need for a better understanding of drug-receptor interaction as applied to the gathering and interpretation of dose-response data. It is an introduction suitable for any student who has had a first course in pharmacology. This book is an extension of the pharmacology course into one area of what is now known as molecular pharmacology. The material included is an outgrowth of courses that we have given in recent years to health-science students in several professional schools and universities. The area of drug-receptor theory, although just a part of molecular phar macology, is already very broad. One major line of investigation is concerned with the chemical and structural nature of specific receptors and with efforts to isolate specific receptors. Another line of investigation is concerned with the kinetic theories of drug-receptor interaction, the effort there being to provide a general theory that is applicable to wide classes of drugs. We have chosen to deal with the latter. There are several reasons for our choice of topics. First, the information is very practical; that is, it permits one to use properly and consistently terms such as "efficacy," "partial agonist," "pure antagonist," "potency," "pA2'" etc., when describing drug action. Second, many students fail to appreciate the differences in and the limitations of the various theories, beginning with the classical theory of A. J. Clark, on up to the very recent allosteric theories.

Author : Adrian Kilcoyne
Publisher : OUP Oxford
ISBN 13 : 0191510394
Total Pages : 473 pages
Book Rating : 4.97/5 ( download)

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Download or read book Pharmaceutical Medicine written by Adrian Kilcoyne and published by OUP Oxford. This book was released on 2013-05-23 with total page 473 pages. Available in PDF, EPUB and Kindle. Book excerpt: The breadth of the pharmaceutical medicine can be daunting, but this book is designed to navigate a path through the speciality. Providing a broad overview of all topics relevant to the discipline of pharmaceutical medicine, it gives you the facts fast, in a user-friendly format, without having to dive through page upon page of dense text. With 136 chapters spread across 8 sections, the text offers a thorough grounding in issues ranging from medicines regulation to clinical trial design and data management. This makes it a useful revision aid for exams as well as giving you a taster of areas of pharmaceutical medicine adjacent to your current role. For healthcare professionals already working in the field, this book offers a guiding hand in difficult situations as well as supplying rapid access to the latest recommendations and guidelines. Written by authors with experience in the industry and drug regulation, this comprehensive and authoritative guide provides a shoulder to lean on throughout your pharmaceutical career.

Author : Ronald J Tallarida
Publisher :
ISBN 13 : 9781468462661
Total Pages : 224 pages
Book Rating : 4.60/5 ( download)

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Download or read book The Dose-Response Relation in Pharmacology written by Ronald J Tallarida and published by . This book was released on 1979-10-02 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Naitee Ting
Publisher : Springer Science & Business Media
ISBN 13 : 0387337067
Total Pages : 262 pages
Book Rating : 4.67/5 ( download)

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Download or read book Dose Finding in Drug Development written by Naitee Ting and published by Springer Science & Business Media. This book was released on 2006-12-29 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: If you have ever wondered when visiting the pharmacy how the dosage of your prescription is determined this book will answer your questions. Dosing information on drug labels is based on discussion between the pharmaceutical manufacturer and the drug regulatory agency, and the label is a summary of results obtained from many scientific experiments. The book introduces the drug development process, the design and the analysis of clinical trials. Many of the discussions are based on applications of statistical methods in the design and analysis of dose response studies. Important procedural steps from a pharmaceutical industry perspective are also examined.

Author : Ronald Tallarida
Publisher : Springer
ISBN 13 : 9780387905006
Total Pages : 0 pages
Book Rating : 4.06/5 ( download)

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Download or read book Manual of Pharmacologic Calculations written by Ronald Tallarida and published by Springer. This book was released on 1984-07-30 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a collection of quantitative procedures in common use in we selected may be pharmacology and related disciplines. The procedures considered" core" since it is likely that all scientists who work with drugs will use these procedures at some time or another. By excluding very specialized topics, we managed to keep the size of the book small. thus making it handy reference-a handbook in the true sense. for quick Since many scientists and students now have access to electronic computers, of lower cost microcomputers is likely to increase com and since the advent we also included a computer program for each puter availability even further, procedure. * The user need not know computer programming since all necessary information needed to run the programs is included here. The manual is divided into two parts. In the first, the pharmacologic basis for the calculation is briefly stated for each of the procedures (numbered 1 through 33). Then the appropriate equations (formulas) are given and an example of each calculation is provided. For each procedure, the discussion of theory and illustration of the calculation are brief and self-contained. With the tables in the Appendix and a pocket calculator, all of the calculations can be done without reference to any other source. It is recommended that the pro cedure and sample calculation be read and understood before going to the automated "magic" of the computer program in Part II.

Author : Matthew E. Cross
Publisher : Cambridge University Press
ISBN 13 : 1107615887
Total Pages : 439 pages
Book Rating : 4.85/5 ( download)

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Download or read book Physics, Pharmacology and Physiology for Anaesthetists written by Matthew E. Cross and published by Cambridge University Press. This book was released on 2014-03-06 with total page 439 pages. Available in PDF, EPUB and Kindle. Book excerpt: A quick reference to basic science for anaesthetists, containing all the key information needed for FRCA exams.

Author : Philippa D. Darbre
Publisher : Academic Press
ISBN 13 : 0128011203
Total Pages : 390 pages
Book Rating : 4.01/5 ( download)

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Download or read book Endocrine Disruption and Human Health written by Philippa D. Darbre and published by Academic Press. This book was released on 2015-03-21 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endocrine Disruption and Human Health starts with an overview of what endocrine disruptors are, the issues surrounding them, and the source of these chemicals in the ecosystem. This is followed by an overview of the mechanisms of action and assay systems. The third section includes chapters written by specialists on different aspects of concern for the effects of endocrine disruption on human health. Finally, the authors consider the risk assessment of endocrine disruptors and the pertinent regulation developed by the EU, the US FDA, as well as REACH and NGOs. The book has been written for researchers and research clinicians interested in learning about the actions of endocrine disruptors and current evidence justifying concerns for human health but is useful for those approaching the subject for the first time, graduate students, and advanced undergraduate students. Provides readers with access to a range of information from the basic mechanisms and assays to cutting-edge research investigating concerns for human health Presents a comprehensive, translational look at all aspects of endocrine disruption and its effects on human health Offers guidance on the risk assessment of endocrine disruptors and current relevant regulatory considerations

Author : Franz-Xaver Reichl
Publisher : Springer
ISBN 13 : 9783642353734
Total Pages : 0 pages
Book Rating : 4.38/5 ( download)

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Download or read book Regulatory Toxicology written by Franz-Xaver Reichl and published by Springer. This book was released on 2014-03-27 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will be written by experts for professionals, scientists and all those involved in toxicological data generation and decision-making. It is the updated and expanded version of a monograph published in German in 2004. Chemical safety is regulated on various levels including production, storage, transport, handling, disposal or labelling. This book deals comprehensively with the safety-ensuring methods and concepts employed by regulatory agencies, industry and academics. Toxicologists use experimental and scientific approaches for data collection, e.g. about chemical hazards, physicochemical features or toxicokinetics. The respective experimental methods are described in the book. Toxicologists also deal with much insecurity in the exposure and effect scenarios during risk assessment. To overcome these, they have different extrapolation methods and estimation procedures at their disposal. The book describes these methods in an accessible manner. Differing concepts from one regulation area to another are also covered. Reasons and consequences become evident when reading the book. Altogether, the book Regulatory Toxicology will serve as an excellent reference.

Author : Jochen Kuhlmann
Publisher : W. Zuckschwerdt
ISBN 13 : 9783886033669
Total Pages : 217 pages
Book Rating : 4.6X/5 ( download)

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Download or read book Dose-response Relationship of Drugs written by Jochen Kuhlmann and published by W. Zuckschwerdt. This book was released on 1990-01-01 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Yoo Kuen Chan
Publisher : Springer
ISBN 13 : 3319103865
Total Pages : 266 pages
Book Rating : 4.60/5 ( download)

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Download or read book Pharmacological Basis of Acute Care written by Yoo Kuen Chan and published by Springer. This book was released on 2014-11-19 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the 4th in a series of Acute Care books written with the aim to address the NEEDS of health care providers when handling the acutely ill patients. Globally it has become apparent that the study of pharmacology and subsequent clinical training has not always adequately equipped young doctors with the ability to administer drugs to their patients safely and confidently, particularly in the critically ill patient. Compounding this issue is the lack of resource material related to these pharmacological concepts contained in one book that can help health care providers to understand and manage drug therapy in the acute situation. In spite of progressively newer and more developed protocols, guidelines, algorithms and many other books addressing the technical aspects of what needs to be done, most health care providers still find it difficult to grasp the basic pharmacological knowledge and rationally deliver the CARE that is required in the acute phase of patient management. The editors/authors have therefore aimed for a book that highlights topics and pharmacological issues pertinent to management of patients in their hour of need. This is a multi-author book but the style has been guided by 3 editors. The editors have used a different perspective – that of normalizing abnormal physiological processes with pharmacological agents – to address the GAPS in a bedside to bench approach. The details are pared down but important principles/concepts are emphasized.