Systems Analysis Of Chromatin Related Protein Complexes In Cancer

Author : Andrew Emili
Publisher : Springer Science & Business Media
ISBN 13 : 1461479312
Total Pages : 320 pages
Book Rating : 4.14/5 ( download)

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Download or read book Systems Analysis of Chromatin-Related Protein Complexes in Cancer written by Andrew Emili and published by Springer Science & Business Media. This book was released on 2013-08-13 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: ​​​​​​​​​​​​​​​​​​​​​​​ Epigenetic modifications underlie all aspects of human physiology, including stem cell renewal, formation of cell types and tissues. They also underlie environmental impacts on human health, including aging and diseases like cancer. Consequently, cracking the epigenetic "code" is considered a key challenge in biomedical research. Chromatin structure and function are modified by protein complexes, causing genes to be turned “on” or “off” and controlling other aspects of DNA function. Yet while there has been explosive growth in the epigenetics field, human chromatin-modifying machines have only recently started to be characterized. To meet this challenge, our book explores complementary experimental tracks, pursued by expert international research groups, aimed at the physical and functional characterization of the diverse repertoire of chromatin protein machines - namely, the "readers, writers and erasers" of epigenomic marks. These studies include the identification of RNA molecules and drugs that interact selectively with components of the chromatin machinery. What makes this book distinctive is its emphasis on the systematic exploration of chromatin protein complexes in the context of human development and disease networks.

Author : Renato Paro
Publisher : Springer Nature
ISBN 13 : 3030686701
Total Pages : 215 pages
Book Rating : 4.03/5 ( download)

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Download or read book Introduction to Epigenetics written by Renato Paro and published by Springer Nature. This book was released on 2021-03-23 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access textbook leads the reader from basic concepts of chromatin structure and function and RNA mechanisms to the understanding of epigenetics, imprinting, regeneration and reprogramming. The textbook treats epigenetic phenomena in animals, as well as plants. Written by four internationally known experts and senior lecturers in this field, it provides a valuable tool for Master- and PhD- students who need to comprehend the principles of epigenetics, or wish to gain a deeper knowledge in this field. After reading this book, the student will: Have an understanding of the basic toolbox of epigenetic regulation Know how genetic and epigenetic information layers are interconnected Be able to explain complex epigenetic phenomena by understanding the structures and principles of the underlying molecular mechanisms Understand how misregulated epigenetic mechanisms can lead to disease

Author : Armen S. Asratian
Publisher : Cambridge University Press
ISBN 13 : 9780521593458
Total Pages : 283 pages
Book Rating : 4.5X/5 ( download)

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Download or read book Bipartite Graphs and Their Applications written by Armen S. Asratian and published by Cambridge University Press. This book was released on 1998-07-13 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first book which deals solely with bipartite graphs. Together with traditional material, the reader will also find many new and unusual results. Essentially all proofs are given in full; many of these have been streamlined specifically for this text. Numerous exercises of all standards have also been included. The theory is illustrated with many applications especially to problems in timetabling, Chemistry, Communication Networks and Computer Science. For the most part the material is accessible to any reader with a graduate understanding of mathematics. However, the book contains advanced sections requiring much more specialized knowledge, which will be of interest to specialists in combinatorics and graph theory.

Author : Jozef Šamaj
Publisher : Springer Science & Business Media
ISBN 13 : 3642324622
Total Pages : 337 pages
Book Rating : 4.28/5 ( download)

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Download or read book Endocytosis in Plants written by Jozef Šamaj and published by Springer Science & Business Media. This book was released on 2012-10-02 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endocytosis is a fundamental cellular process by means of which cells internalize extracellular and plasma membrane cargos for recycling or degradation. It is important for the establishment and maintenance of cell polarity, subcellular signaling and uptake of nutrients into specialized cells, but also for plant cell interactions with pathogenic and symbiotic microbes. Endocytosis starts by vesicle formation at the plasma membrane and progresses through early and late endosomal compartments. In these endosomes cargo is sorted and it is either recycled back to the plasma membrane, or degraded in the lytic vacuole. This book presents an overview of our current knowledge of endocytosis in plants with a main focus on the key molecules undergoing and regulating endocytosis. It also provides up to date methodological approaches as well as principles of protein, structural lipid, sugar and microbe internalization in plant cells. The individual chapters describe clathrin-mediated and fluid-phase endocytosis, as well as flotillin-mediated endocytosis and internalization of microbes. The book was written for a broad spectrum of readers including students, teachers and researchers.

Author : Sam Thiagalingam
Publisher : Cambridge University Press
ISBN 13 : 0521493390
Total Pages : 597 pages
Book Rating : 4.90/5 ( download)

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Download or read book Systems Biology of Cancer written by Sam Thiagalingam and published by Cambridge University Press. This book was released on 2015-04-09 with total page 597 pages. Available in PDF, EPUB and Kindle. Book excerpt: An overview of the current systems biology-based knowledge and the experimental approaches for deciphering the biological basis of cancer.

Author : Matthew Summers
Publisher : BoD – Books on Demand
ISBN 13 : 1838804900
Total Pages : 228 pages
Book Rating : 4.09/5 ( download)

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Download or read book Ubiquitin Proteasome System written by Matthew Summers and published by BoD – Books on Demand. This book was released on 2019-06-19 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: The human ubiquitin proteasome system (UPS) is comprised of nearly 1000 proteins. Although originally identified as a mechanism of protein destruction, the UPS has numerous additional functions and mediates central signaling events in myriad processes involved in both cellular and organismal health and homeostasis. Numerous pathways within the UPS are implicated in disease, ranging from cancer to neurodegenerative diseases such as Parkinson's. The goal of this book is to deliver a collection of synopses of current areas of UPS research that highlights the importance of understanding the biology of the UPS to identify disease-relevant pathways, and the need to elucidate the molecular machinations within the UPS to develop methods for therapeutic modulation of these pathways.

Author : Maurie Markman
Publisher : Current Medicine Group
ISBN 13 : 9781573402897
Total Pages : 0 pages
Book Rating : 4.93/5 ( download)

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Download or read book Atlas of Cancer written by Maurie Markman and published by Current Medicine Group. This book was released on 2008-06-13 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of the Atlas of Cancer highlights the major features of current cancer management, and clearly presents fundamental facts regarding our understanding of the etiology and pathophysiology of malignant disease.

Author : Wu-Min Deng
Publisher : Springer Nature
ISBN 13 : 3030236293
Total Pages : 251 pages
Book Rating : 4.98/5 ( download)

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Download or read book The Drosophila Model in Cancer written by Wu-Min Deng and published by Springer Nature. This book was released on 2019-09-13 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a series of review articles that capture the advances in using the fruit fly, Drosophila melanogaster, model system to address a wide range of cancer-related topics. Articles in this book provide case studies that shed light on the intricate cellular and molecular mechanisms underlying tumor formation and progression. Readers will discover the beauty of the fly model’s genetic simplicity and the vast arsenal of powerful genetic tools enabling its efficient and adaptable use. This model organism has provided a unique opportunity to address questions regarding cancer initiation and development that would be extremely challenging in other model systems. This book provides a useful resource for a researcher who wishes to learn about and apply the Drosophila model to tackle fundamental questions in cancer biology, and to find new ways to fight against this devastating disease.

Author : Jerry L. Workman
Publisher : Springer Science & Business Media
ISBN 13 : 1461486246
Total Pages : 594 pages
Book Rating : 4.44/5 ( download)

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Download or read book Fundamentals of Chromatin written by Jerry L. Workman and published by Springer Science & Business Media. This book was released on 2013-12-04 with total page 594 pages. Available in PDF, EPUB and Kindle. Book excerpt: ​​​​​​​​​​​​​While there has been an increasing number of books on various aspects of epigenetics, there has been a gap over the years in books that provide a comprehensive understanding of the fundamentals of chromatin. ​Chromatin is the combination of DNA and proteins that make up the genetic material of chromosomes. Its primary function is to package DNA to fit into the cell, to strengthen the DNA to prevent damage, to allow mitosis and meiosis, and to control the expression of genes and DNA replication. The audience for this book is mainly newly established scientists ​and graduate students. Rather than going into the more specific areas of recent research on chromatin the chapters in this book give a strong, updated groundwork about the topic. Some the fundamentals that this book will cover include the structure of chromatin and biochemistry and the enzyme complexes that manage it.

Author :
Publisher :
ISBN 13 :
Total Pages : 1828 pages
Book Rating : 4.97/5 ( download)

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Download or read book Cumulated Index Medicus written by and published by . This book was released on 2000 with total page 1828 pages. Available in PDF, EPUB and Kindle. Book excerpt: