Successes And Challenges Of Nk Immunotherapy

Author : Benjamin Bonavida
Publisher : Academic Press
ISBN 13 : 0128243961
Total Pages : 540 pages
Book Rating : 4.61/5 ( download)

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Download or read book Successes and Challenges of NK Immunotherapy written by Benjamin Bonavida and published by Academic Press. This book was released on 2021-06-23 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: Successes and Challenges of NK Immunotherapy: Increasing Anti-tumor Efficacy describes the unique therapeutic applications of NK cells to fight cancers and eliminate the bulk and subset of cancer stem cells responsible for metastasis, relapse and recurrences. The book provides information on the development, engineering, mechanisms of action, response to various preclinical models, and applications in various clinical trials. Sections cover the development of highly engineered cytotoxic NK cells, their mechanisms of action, preclinical and clinical applications, the development and application of CAR-NK cells, and new NK-drug conjugates, also emphasizing that activated NK cells can target and kill highly resistant cancer stem cells. Written by the leading experts on NK immunotherapy worldwide, this is a valuable resource for researchers, clinicians and members of the biomedical field who are interested in understanding novel and efficient therapies to fight cancers. Discusses the unique developmental applications of NK immunotherapy against cancers, which differs greatly from other types of immunotherapies Provides up-to-date and highly relevant information through chapters written by the leading researchers in the field Presents a significant number of schematic diagrams for easy understanding and reproducibility

Author : Anahid Jewett
Publisher : Academic Press
ISBN 13 : 0128226269
Total Pages : 496 pages
Book Rating : 4.61/5 ( download)

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Download or read book NK Cells in Cancer Immunotherapy: Successes and Challenges written by Anahid Jewett and published by Academic Press. This book was released on 2022-12-06 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: NK Cells in Cancer Immunotherapy: Successes and Challenges explains the latest immunotherapeutic strategies, focusing on NK cells to allow the best and precise combination treatments to cancer patients. The book provides existing background knowledge in the field of immunotherapy and discusses future areas of research required to carry out cutting-edge, validated therapies. Chapters cover advances in immunotherapeutic strategies, in particular, the use of NK cells with and without T-cell therapy in the treatment of cancer. The book is a valuable resource for cancer researchers, oncologists, graduate students and those interested in learning more about novel strategies to treat cancer patients. Immunotherapy is fast becoming the method of choice for cancer therapy. Although remarkable advances have been made in the field of immunotherapy, there are significant challenges and difficulties ahead since many of the current immunotherapeutic strategies do not provide long-lasting treatment strategies, and therefore are not very effective. Covers CAR/T and CAR/NK and adoptive NK cell therapy with and without T cell therapies Discusses basic biology of NK cells and mouse models of human cancers and the role of NK cells in metastatic cancer and in cancer stem cells Encompasses information on combination therapies using check point inhibition, adoptive transfer of cytotoxic effector cells, chemotherapeutic drugs and activating and inhibitory antibodies

Author : Maverick Davies
Publisher :
ISBN 13 : 9781639873982
Total Pages : 0 pages
Book Rating : 4.88/5 ( download)

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Download or read book NK Immunotherapy: Success and Challenges written by Maverick Davies and published by . This book was released on 2022-09-20 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Natural killer cells (NK cells) are the lymphocytes which belong to the same family as B and T cells, because they differentiate from a common progenitor. These cells detect and control early signs of cancer, and also recognize and kill virally infected cells. Specialized natural killer cells are found in placenta and are also known to play an important role in pregnancy. To enhance the immune system, natural killer cells secrete cytokines such as IFNγ and TNFα which act on other immune cells. Activating receptors recognize the molecules which are present on the surface of infected and cancer cells and switch on the natural killer cells. This book explores all the important aspects of natural killer cells. It brings forth the role of natural killer cells in disease response. In this book, using case studies and examples, constant effort has been made to make the understanding of the difficult concepts of this field as easy and informative as possible, for the readers.

Author : Francisco Borrego
Publisher : Frontiers Media SA
ISBN 13 : 2889199347
Total Pages : 224 pages
Book Rating : 4.41/5 ( download)

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Download or read book NK Cell-Based Cancer Immunotherapy written by Francisco Borrego and published by Frontiers Media SA. This book was released on 2016-09-08 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: Natural killer (NK) cells are innate lymphoid cells that have a significant role in regulating the defenses against cancer development and certain viral infections. They are equipped with an array of activating and inhibitory receptors that stimulate or diminish NK cell activity, respectively. Inhibitory receptors include, among others, the MHC class I ligands killer cell immunoglobulin-like receptors (KIR) in humans, and members of the Ly49 family of receptors in mice, and CD94/NKG2A. Activating receptors include cytokine and chemokine receptors, and those that interact with ligands expressed on target cells, such as the natural cytotoxicity receptors or NCRs (NKp30, NKp44 and NKp46), NKG2D, CD244 and DNAM-1. In addition, NK cells express Fc?RIIIA or CD16, the receptor that exerts antibody-dependent cell mediated cytotoxicity (ADCC). NK cells also express the death ligands FasL and TRAIL. The killing or sparing of target cells depends on the integration of distinct signals that originate from NK cell receptors. NK cells spare healthy cells that express normal levels of MHC class I molecules and low amounts of stress-induced self-molecules, whereas they kill target cells that down-regulate MHC class I molecules and/or up-regulate stress-induced self-molecules. The latter are common signatures of virus-infected cells and tumors. All the accumulated knowledge on NK cell biology, along with many clinical observations, is driving multiple efforts to improve the arsenal of NK cell-based therapeutic tools in the fight against malignant diseases. Indeed, NK cell-based immunotherapy is becoming a promising approach for the treatment of many cancers. It is well known that NK cells have a significant role in the anti-tumor effect of therapeutic antibodies that use ADCC as a mechanism of action. In addition to this, administration of autologous and allogeneic NK cells after activation and expansion ex vivo is used in the treatment of cancer. Moreover, adoptive transfer of NK cell lines has been tested in humans, and genetically modified NK cells expressing chimeric antigen receptors are being studied in preclinical models for potential use in the clinic.

Author : Loredana Cifaldi
Publisher : Frontiers Media SA
ISBN 13 : 2889638766
Total Pages : 146 pages
Book Rating : 4.65/5 ( download)

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Download or read book Molecular Strategies Aimed to Boost NK Cell-based Immunotherapy of Cancer written by Loredana Cifaldi and published by Frontiers Media SA. This book was released on 2020-07-31 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this Research Topic, we would like to honor the memory of Prof. Vito Pistoia and pay tribute to his scientific contributions to the field of Cancer Immunity and Immunotherapy. Topic Editor Daniel Olive is the co-founder and shareholder of company Imcheck Therapeutics. All other topic editors declare no competing interests with regards to the Research Topic subject.

Author : Jan B. Vermorken
Publisher : Springer Nature
ISBN 13 : 3031231759
Total Pages : 361 pages
Book Rating : 4.59/5 ( download)

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Download or read book Critical Issues in Head and Neck Oncology written by Jan B. Vermorken and published by Springer Nature. This book was released on 2023-03-27 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is an open access book. With a wealth of exciting data emerging in this rapidly evolving field this book will review the state-of-the-art knowledge with emphasis on multidisciplinary decision and management of head and neck cancer. The book provides significant detail on a wide range of topics including: the role of new targets for treatment, immunotherapy, resistance mechanisms, standardizing molecular profiling programs, and new methods to guide therapeutic approaches. In addition different disease situations are addressed including different treatment approaches in primary disease and in recurrent and/or metastatic disease as well as new developments in pathology, surgery and reconstruction techniques, new systemic therapies in salivary gland cancer, and supportive care and follow-up. All disciplines involved in the treatment of head & neck cancer are covered with a focus on translation into daily practice. The 8th-THNO is designed for medical oncologists, head and neck surgeons, radiation oncologists, otolaryngologists, and other medical professionals involved in the treatment of patients with head and neck cancer.

Author : Paulette Mehta
Publisher : Jones & Bartlett Learning
ISBN 13 : 9780763718558
Total Pages : 516 pages
Book Rating : 4.56/5 ( download)

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Download or read book Pediatric Stem Cell Transplantation written by Paulette Mehta and published by Jones & Bartlett Learning. This book was released on 2004 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook examines stem cell transplatation in pediatric patients.

Author : Tim F. Greten
Publisher : Springer
ISBN 13 : 9783319879116
Total Pages : 0 pages
Book Rating : 4.11/5 ( download)

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Download or read book Immunotherapy of Hepatocellular Carcinoma written by Tim F. Greten and published by Springer. This book was released on 2018-08-22 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book we provide insights into liver – cancer and immunology. Experts in the field provide an overview over fundamental immunological questions in liver cancer and tumorimmunology, which form the base for immune based approaches in HCC, which gain increasing interest in the community due to first promising results obtained in early clinical trials. Hepatocellular carcinoma (HCC) is the third most common cause of cancer related death in the United States. Treatment options are limited. Viral hepatitis is one of the major risk factors for HCC, which represents a typical “inflammation-induced” cancer. Immune-based treatment approaches have revolutionized oncology in recent years. Various treatment strategies have received FDA approval including dendritic cell vaccination, for prostate cancer as well as immune checkpoint inhibition targeting the CTLA4 or the PD1/PDL1 axis in melanoma, lung, and kidney cancer. Additionally, cell based therapies (adoptive T cell therapy, CAR T cells and TCR transduced T cells) have demonstrated significant efficacy in patients with B cell malignancies and melanoma. Immune checkpoint inhibitors in particular have generated enormous excitement across the entire field of oncology, providing a significant benefit to a minority of patients.

Author : Robert C. Rees
Publisher : Oxford University Press, USA
ISBN 13 : 0199676860
Total Pages : 469 pages
Book Rating : 4.66/5 ( download)

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Download or read book Tumor Immunology and Immunotherapy written by Robert C. Rees and published by Oxford University Press, USA. This book was released on 2014 with total page 469 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive account of cancer immunity and immunotherapy, examining recent results, current areas of interest and the specific issues that are affecting the research and development of vaccines. It provides insight into how these problems may be overcome as viewed by leaders in the field.

Author : Michael T. Lotze
Publisher : Academic Press
ISBN 13 : 9780080919294
Total Pages : 660 pages
Book Rating : 4.94/5 ( download)

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Download or read book Natural Killer Cells written by Michael T. Lotze and published by Academic Press. This book was released on 2009-11-12 with total page 660 pages. Available in PDF, EPUB and Kindle. Book excerpt: Natural Killer Cells explains the importance of killer cells and how they are produced. It mentions that the most likely explanation for killer cell production is that they serve as a complementary system for T cells as a primary defense against viruses. However, these cells defend against certain viruses only, such as herpes viruses and influenza viruses. The book also explains the primary functions of killer cells, and it discusses how these cells help recognize damaged tissues, limit further damage to tissues, and regenerate damaged tissues. It discusses how these cells mature and develop, and it covers the different isolation, culture, and propagation methods of these cells. Furthermore, it focuses on the different killer cells that are present in various parts of the human body. The book concludes by explaining that natural killer cells are utilized for clinical therapy of malignancies, and that they have led to positive outcomes in the field of biology and medicine. Provides a broad, detailed coverage of the biology and interactions of NK cells for students, fellows, scientists, and practitioners Includes figures, histologic sections, and illustrations of the ontogeny of NK cells