Studies Of The Heme Environment And Electron Flow In The Inducible Murine Macrophage Nitric Oxide Synthase

Author : Kimberly A. Mearman
Publisher :
ISBN 13 :
Total Pages : 270 pages
Book Rating : 4.17/5 ( download)

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Download or read book Studies of the Heme Environment and Electron Flow in the Inducible Murine Macrophage Nitric Oxide Synthase written by Kimberly A. Mearman and published by . This book was released on 1994 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt:

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ISBN 13 :
Total Pages : 778 pages
Book Rating : 4.10/5 ( download)

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Download or read book Dissertation Abstracts International written by and published by . This book was released on 1995 with total page 778 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Robert Allen Pufahl
Publisher :
ISBN 13 :
Total Pages : 358 pages
Book Rating : 4.34/5 ( download)

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Download or read book Characterization of the Mechanism of Oxidation of NG̲-Hydroxy-L-Arginine by Macrophage Nitric Oxide Synthase written by Robert Allen Pufahl and published by . This book was released on 1994 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Joan M. Hevel
Publisher :
ISBN 13 :
Total Pages : 3 pages
Book Rating : 4.26/5 ( download)

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Download or read book Purification of the Inducible Murine Macrophage Nitric Oxide Synthase written by Joan M. Hevel and published by . This book was released on 1991 with total page 3 pages. Available in PDF, EPUB and Kindle. Book excerpt:

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ISBN 13 :
Total Pages : pages
Book Rating : 4.09/5 ( download)

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Download or read book Molecular Regulation of Inducible Nitric Oxide Synthase Gene in Chicken Macrophages written by and published by . This book was released on 2002 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Inducible nitric oxide synthase serves as an important mediator of macrophage immunobiology by regulating the biosynthesis of nitric oxide that in turn mediates several immunological and physiological functions. Previous studies have demonstrated that macrophages from Cornell K-strain chickens (B15B15) were hyper-responsive to Escherichia coli LPS whereas macrophages from GB1 (B13B13) and GB2 (B6B6) chickens were hypo-responsive for inducible nitric oxide synthase (iNOS) expression and activity. Furthermore, this differential iNOS induction in response to LPS was transcriptionally regulated. The current study was conducted to explore the molecular basis of strain-based differential iNOS induction in chicken macrophages. In the first study, macrophages from K-strain, GB1, GB2 chickens and MQ-NCSU macrophage cell line were exposed to LPS from three sources other than E.coli and both iNOS activity and expression were studied. iNOS mRNA and nitrite data showed that these strain-based differences are intrinsic in nature and not limited to the bacterial source of LPS. In addition, when surface expression of LPS-related receptors was studied via flow cytometry, macrophages from the K-strain exhibited higher numbers of LPS signal transducing molecule TLR4 constitutively in comparison to GB2 macrophages. In the second study, inducible expression of LPS related receptors as well as NFkappaB activation and the involvement of these proteins in iNOS induction was studied. LPS exposure induced significantly higher numbers of inducible TLR4 and CD14 molecules on K-strain macrophages and a significantly higher corresponding increase in NFkappaB activation as compared with GB2 macrophages. Furthermore, blocking studies revealed that CD14, TLR4 and NFkappaB activation were all involved in LPS mediated iNOS induction in chicken macrophages. The objective of the third study was to examine the expression of IL-1beta and to explore if LPS-mediated induction of IL-1beta modulates iNOS ind.

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ISBN 13 :
Total Pages : 1860 pages
Book Rating : 4.4U/5 ( download)

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Download or read book Cumulated Index Medicus written by and published by . This book was released on 1999 with total page 1860 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : A. Maru
Publisher :
ISBN 13 :
Total Pages : 295 pages
Book Rating : 4.57/5 ( download)

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Download or read book Expression and Modulation of the Inducible Nitric Oxide Synthase (iNOS) in Murine Macrophages written by A. Maru and published by . This book was released on 1999 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt:

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ISBN 13 :
Total Pages : 2352 pages
Book Rating : 4.36/5 ( download)

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Download or read book Chemical Abstracts written by and published by . This book was released on 2002 with total page 2352 pages. Available in PDF, EPUB and Kindle. Book excerpt:

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ISBN 13 :
Total Pages : 1828 pages
Book Rating : 4.2S/5 ( download)

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Download or read book Index Medicus written by and published by . This book was released on 2001-05 with total page 1828 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.

Author : Michel Félétou
Publisher : Morgan & Claypool Publishers
ISBN 13 : 1615041230
Total Pages : 309 pages
Book Rating : 4.37/5 ( download)

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Download or read book The Endothelium written by Michel Félétou and published by Morgan & Claypool Publishers. This book was released on 2011 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References