Structural Studies Of Protein Nucleic Acid Interaction

Author : Thomas A. Steitz
Publisher : CUP Archive
ISBN 13 : 9780521414890
Total Pages : 108 pages
Book Rating : 4.9X/5 ( download)

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Download or read book Structural Studies of Protein-Nucleic Acid Interaction written by Thomas A. Steitz and published by CUP Archive. This book was released on 1993-09-16 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this 1993 text, Nobel Prize winner Professor Steitz reviews the wide-ranging research in structural studies of DNA-binding proteins and their complexes with DNA. The author clearly and concisely describes the uses of techniques in molecular genetics, DNA synthesis, protein crystallography and nuclear magnetic response.

Author : Wolfram Saenger
Publisher :
ISBN 13 :
Total Pages : 230 pages
Book Rating : 4.28/5 ( download)

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Download or read book Protein-nucleic Acid Interaction written by Wolfram Saenger and published by . This book was released on 1989 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains a series of essays which describe a range of problems in the field of nucleic-acid interactions, investigated by a variety of techniques. An introductory chapter on DNA-protein interactions in the regulation of gene expression is followed by papers on selected model systems.

Author : Phoebe A. Rice
Publisher : Royal Society of Chemistry
ISBN 13 : 0854042725
Total Pages : 417 pages
Book Rating : 4.22/5 ( download)

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Download or read book Protein-Nucleic Acid Interactions written by Phoebe A. Rice and published by Royal Society of Chemistry. This book was released on 2008-05-22 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides both in-depth background and up-to-date information in this area. The chapters are organized by general themes and principles, written by experts who illustrate topics with current findings. Topics covered include: - the role of ions and hydration in protein-nucleic acid interactions - transcription factors and combinatorial specificity - indirect readout of DNA sequence - single-stranded nucleic acid binding proteins - nucleic acid junctions and proteins, - RNA protein recognition - recognition of DNA damage. It will be a key reference for both advanced students and established scientists wishing to broaden their horizons.

Author : Bruce Alberts
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.81/5 ( download)

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Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Jost
Publisher : Birkhäuser
ISBN 13 : 3034875614
Total Pages : 319 pages
Book Rating : 4.15/5 ( download)

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Download or read book A Laboratory Guide to In Vitro Studies of Protein-DNA Interactions written by Jost and published by Birkhäuser. This book was released on 2013-03-13 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Safety Considerations Many techniques described here involve a number of hazards, such as high electrical current and voltage, radioactivity and highly toxic chemicals. It is absolutely essential that the instructions of equipment manufacturers be followed, and that particular attention be paid to the local and federal safety regulations. B Introduction The expression of prokaryotic and eukaryotic genes has been shown most often to be regulated at the level of mRNA synthesis. Thanks to the rapid development of methods for dissecting DNA sequences, cis-acting regulatory elements such as promoters and enhancers have been recognised. More recently, the widely expressed intuition that discrete sequences within these elements constitute binding sites for sequence-specific binding proteins has been confirmed, especially through the use of "footprinting" assays (for examples, Galas and Schmitz, 1978). This and similar assays have already resulted in the recognition, isolation and analysis of DNA-bind ing proteins for several genes. Excellent reviews exist of the structural studies on these transcription regulatory proteins and related DNA elements (for example, Glover, 1989 and Johnson and McKnight, 1989), to which the reader is referred for detailed information. To set the scene for applications of the techniques described in this volume, only the barest outline of previous studies is presented here. Protein-DNA interactions are dependent on very specific tertiary configurations of the binding protein which allow the closest contact with the DNA helix.

Author : Vaclav Brazda
Publisher : Mdpi AG
ISBN 13 : 9783036574455
Total Pages : 0 pages
Book Rating : 4.5X/5 ( download)

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Download or read book Impacts of Molecular Structure on Nucleic Acid-Protein Interactions written by Vaclav Brazda and published by Mdpi AG. This book was released on 2023-04-21 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interactions between nucleic acids and proteins are essential requirements for the viability of cellular life because they are indispensable for many basic biological processes. DNA is typically presented as a specific double-stranded helical structure, but nucleic acids have great structural flexibility. Current knowledge demonstrates that the structural conformations of nucleic acids play critical roles in protein-DNA interactions. This book presents a collection of research findings published in the Special Issue of the International Journal of Molecular Sciences, titled "Impacts of Molecular Structure on Nucleic Acid-Protein Interactions". The breadth of research findings reported here demonstrates that the structural flexibility of nucleic acids plays critical roles in their interactions with proteins, with important implications across a range of human diseases, including cancer and some infectious diseases. Prof. Richard Bowater University of East Anglia, Norwich, United Kingdom Prof. Václav Brázda Institute of Biophysics of the Czech Academy of Sciences, Brno, Czech Republic

Author : M Michael Gromiha
Publisher : World Scientific
ISBN 13 : 9811211884
Total Pages : 424 pages
Book Rating : 4.81/5 ( download)

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Download or read book Protein Interactions: Computational Methods, Analysis And Applications written by M Michael Gromiha and published by World Scientific. This book was released on 2020-03-05 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is indexed in Chemical Abstracts ServiceThe interactions of proteins with other molecules are important in many cellular activities. Investigations have been carried out to understand the recognition mechanism, identify the binding sites, analyze the the binding affinity of complexes, and study the influence of mutations on diseases. Protein interactions are also crucial in structure-based drug design.This book covers computational analysis of protein-protein, protein-nucleic acid and protein-ligand interactions and their applications. It provides up-to-date information and the latest developments from experts in the field, using illustrations to explain the key concepts and applications. This volume can serve as a single source on comparative studies of proteins interacting with proteins/DNAs/RNAs/carbohydrates and small molecules.

Author : W. Guschlbauer
Publisher : Springer Science & Business Media
ISBN 13 : 1468453831
Total Pages : 289 pages
Book Rating : 4.36/5 ( download)

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Download or read book DNA-Ligand Interactions written by W. Guschlbauer and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains the texts of the nineteen lectures presented at the NATO-ASI - FEBS Course on "DNA - ligand interactions: from drugs to proteins." The Advanced Study Institute (ASIl was held from August 30th to September 11th. 1986 in the Abbey of Fontevraud (France). The ASI was attended by 112 participants from a wide scientific horizon and from twentyone different countries. It was in some way a follow-up of the ASI held in Maratea. Italy in May 1981 and which was published in the NATO ASI Life Science series as volume 45. While much has been learned about the way the cellular machinery maintains and transmits the genetic heritage. as well as how these processes are regulated. little is Known about how the interactions between the various partners involved are taKing place. The interactions of drugs and proteins with nucleic acids are of evident importance in the understanding of these problems. The spectacular advances in recombinant DNA technology and the increased sophistication of biophysical techniques. in particular >:-ray diffraction and nuclear magnetic resonance. have created a scientific environment which is highly promising for the future of research in molecular biology. These advances permH the serious hope that biology on the molecular level may become a r-eality. Some of the contributions at the ASI presented the most recent advances in this e>:citing field.

Author : Stephen Neidle
Publisher : Academic Press
ISBN 13 : 0128196785
Total Pages : 456 pages
Book Rating : 4.86/5 ( download)

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Download or read book Principles of Nucleic Acid Structure written by Stephen Neidle and published by Academic Press. This book was released on 2021-10-15 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles of Nucleic Acid Structure, Second Edition, provides the most complete and concise summary of underlying principles and approaches to studying nucleic acid structure, including discussions of X-ray crystallography, NMR, molecular modelling and databases. The book's focus is on a survey of structures that are especially important for biomedical research and pharmacological applications. This updated edition includes the latest advances relevant to recognition of DNA and RNA by small molecules and proteins, including sections on RNA folding, ribosome structure and antibiotic interactions, DNA quadruplexes, DNA and RNA protein complexes and short interfering RNA (siRNA). This reference is a must-have for those seeking an authoritative, comprehensive and up-to-date source on all aspects of nucleic acid structure, from basic first principles to details of recent research results. Completely updated, with an expanded section on protein-nucleic acid interactions that reflects major increases in our knowledge Defines technical terms for novices Includes a complete list of resources, including relevant online databases and software, as well as useful websites

Author : David Malcolm James Lilley
Publisher : IRL Press
ISBN 13 :
Total Pages : 228 pages
Book Rating : 4.92/5 ( download)

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Download or read book DNA-protein written by David Malcolm James Lilley and published by IRL Press. This book was released on 1995 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many processes in the genetic life of the cell require the specific interaction between proteins and DNA. While DNA is normally thought of as a straight double helix, it can be distorted by bending and twisting. These alterations are critical to a number of cellular processes, including transcription, recombination, and the repair of DNA damage. An interesting group of proteins has the important role of recognizing and manipulating DNA structure. This book draws together findings from different areas in molecular biology to elucidate the importance of DNA structure in the interactions between proteins and DNA, and to generate a new perspective on these vital processes. The book is intended for researchers and graduate students in molecular biology, biochemistry, biophysics, and structural biology.