Streptomyces In Nature And Medicine

Author : D. A. Hopwood
Publisher : Oxford University Press
ISBN 13 : 019515066X
Total Pages : 261 pages
Book Rating : 4.67/5 ( download)

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Download or read book Streptomyces in Nature and Medicine written by D. A. Hopwood and published by Oxford University Press. This book was released on 2007-02-03 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights the lives of a group of soil microbes that make most of the antibiotics used in medicine today. Written by an insider, it describes how genetics tells us how these microscopic chemists compete in the soil and how their genes can be rearranged to make new antibiotics to fight re-emerging diseases.

Author : David A. Hopwood
Publisher : Oxford University Press
ISBN 13 : 0190287845
Total Pages : 272 pages
Book Rating : 4.49/5 ( download)

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Download or read book Streptomyces in Nature and Medicine written by David A. Hopwood and published by Oxford University Press. This book was released on 2007-02-03 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is an insiders account of 50 years of genetic studies of the soil-inhabiting microbes that produce most of the antibiotics used to treat infections, as well as anti-cancer, anti-parasitic and immunosuppressant drugs. The book begins by describing how these microbes the actinomycetes were discovered in the latter part of the nineteenth century, but remained a Cinderella group until, in the 1940s, they shot to prominence with the discovery of streptomycin, the first effective treatment for tuberculosis and only the second antibiotic, after penicillin, to become a medical marvel. There followed a massive effort over several decades to find further treatments for infectious diseases and cancer, tempered by the rise of antibiotic resistance consequent on antibiotic misuse and over-use. The book goes on to describe the discovery of gene exchange in the actinomycetes in the context of the rise of microbial genetics in the mid-20th century, leading to determination of the complete DNA sequence of a model member of the group at the turn of the millennium. There follow chapters in which the intricate molecular machinery that adapts the organisms metabolism and development to life in the soil, including antibiotic production, is illuminated by the DNA blueprint. Then come an up-to-the minute account of the use of genetic engineering to make novel, hybrid, antibiotics, and a topical description of techniques to learn the roles of the thousands of genes in a genome sequence, throwing a powerful light on the biology of the organisms and their harnessing for increasing antibiotic productivity. In the final chapter we return to the mycobacteria that cause tuberculosis and leprosy, the first actinomycetes to be discovered, and how methodology, in part derived from the study of the streptomycetes, is being applied to understand and control these still deadly pathogens.

Author : Dharumadurai Dhanasekaran
Publisher : BoD – Books on Demand
ISBN 13 : 9535122487
Total Pages : 401 pages
Book Rating : 4.87/5 ( download)

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Download or read book Actinobacteria written by Dharumadurai Dhanasekaran and published by BoD – Books on Demand. This book was released on 2016-02-11 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents an introductory overview of Actinobacteria with three main divisions: taxonomic principles, bioprospecting, and agriculture and industrial utility, which covers isolation, cultivation methods, and identification of Actinobacteria and production and biotechnological potential of antibacterial compounds and enzymes from Actinobacteria. Moreover, this book also provides a comprehensive account on plant growth-promoting (PGP) and pollutant degrading ability of Actinobacteria and the exploitation of Actinobacteria as ecofriendly nanofactories for biosynthesis of nanoparticles, such as gold and silver. This book will be beneficial for the graduate students, teachers, researchers, biotechnologists, and other professionals, who are interested to fortify and expand their knowledge about Actinobacteria in the field of Microbiology, Biotechnology, Biomedical Science, Plant Science, Agriculture, Plant pathology, Environmental Science, etc.

Author : Paul Dyson
Publisher :
ISBN 13 : 9781912530656
Total Pages : 271 pages
Book Rating : 4.51/5 ( download)

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Download or read book Streptomyces written by Paul Dyson and published by . This book was released on 2011 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: With contributions from some of the leading scientists in the field, this volume documents recent research and development in streptomycetes genomics, physiology and metabolism. With a focus on biotechnology and genomics, the book provides an excellent source of up-to-date information. Topics include: genome architecture, conjugative genetic elements, differentiation, protein secretion, central carbon metabolic pathways, regulation of nitrogen assimilation, phosphate control of metabolism, gamma-butyrolactones and their role in antibiotic regulation, clavulanic acid and clavams, genome-guided.

Author : Morton Meyers, M.D.
Publisher : St. Martin's Press
ISBN 13 : 1137000562
Total Pages : 273 pages
Book Rating : 4.69/5 ( download)

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Download or read book Prize Fight written by Morton Meyers, M.D. and published by St. Martin's Press. This book was released on 2012-06-05 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: We often think of scientists as dispassionate and detached, nobly laboring without any expectation of reward. But scientific research is much more complicated and messy than this ideal, and scientists can be torn by jealousy, impelled by a need for recognition, and subject to human vulnerability and fallibility. In Prize Fight , Emeritus Chair at SUNY School of Medicine Morton Meyers pulls back the curtain to reveal the dark side of scientific discovery. From allegations of stolen authorship to fabricated results and elaborate hoaxes, he shows us how too often brilliant minds are reduced to petty jealousies and promising careers cut short by disputes over authorship or fudged data. Prize Fight is a dramatic look at some of the most notable discoveries in science in recent years, from the discovery of insulin, which led to decades of infighting and even violence, to why the 2003 Nobel Prize in Medicine exposed how often scientific objectivity is imperiled.

Author : Shymaa Enany
Publisher : BoD – Books on Demand
ISBN 13 : 1789846145
Total Pages : 133 pages
Book Rating : 4.40/5 ( download)

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Download or read book Basic Biology and Applications of Actinobacteria written by Shymaa Enany and published by BoD – Books on Demand. This book was released on 2018-12-05 with total page 133 pages. Available in PDF, EPUB and Kindle. Book excerpt: Actinobacteria have an extensive bioactive secondary metabolism and produce a huge amount of naturally derived antibiotics, as well as many anticancer, anthelmintic, and antifungal compounds. These bacteria are of major importance for biotechnology, medicine, and agriculture. In this book, we present the experience of worldwide specialists in the field of Actinobacteria, exploring their current knowledge and future prospects.

Author : Evi Stegmann
Publisher :
ISBN 13 : 9783039369102
Total Pages : 362 pages
Book Rating : 4.05/5 ( download)

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Download or read book Actinomycetes written by Evi Stegmann and published by . This book was released on 2020-09-04 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: Beyond being the most important natural compound source, actinomycetes are the origin of up to two-thirds of all clinically used antibiotics. Currently, new antimicrobials are urgently needed, as infections caused by antibiotic-resistant pathogens are on the rise. In the identification of new antibiotics, many scientists are currently investigating biosynthetic aspects of antibiotic production in actinomycetes. Since the emergence of next-generation sequencing technologies, the field of antibiotics research has experienced a remarkable revival. These bacteria have the potential to produce more antibiotics than previously thought possible. Some antibiotics are produced in standard media, while others require the presence of a specific signaling molecule in the medium. Others, however, are only produced when the native regulation of the biosynthesis gene cluster is overruled. This book covers topics in the field of antibiotic-producing actinomycetes. The following tops are addressed: - Approaches to access novel antibiotic producers for novel natural compounds - Omics and genome mining approaches for the discovery of novel natural compounds - Analyses and genetic engineering of antibiotic biosynthesis - Regulation of the secondary metabolism in actinomycetes

Author : Nick J Westwood
Publisher : Royal Society of Chemistry
ISBN 13 : 178801507X
Total Pages : 339 pages
Book Rating : 4.73/5 ( download)

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Download or read book Chemical and Biological Synthesis written by Nick J Westwood and published by Royal Society of Chemistry. This book was released on 2018-08-16 with total page 339 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthetic chemistry plays a central role in many areas of chemical biology; utilising recent case studies, the goal of Chemical and Biological Synthesis is to highlight the full impact that the preparation of novel reagents can have in chemical biology. Covering the synthetic approaches that can be applied across the whole field of chemical biology, this book provides synthetic chemists with the broader context to which their work contributes and the biological questions that can be addressed through it. An ideal guide for postgraduate students and researchers in synthetic organic chemistry and chemical biology, Chemical and Biological Synthesis introduces synthetic techniques and methods to those who wish to incorporate synthesis for the first time in their biology-focused research programmes.

Author :
Publisher :
ISBN 13 :
Total Pages : 284 pages
Book Rating : 4.25/5 ( download)

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Download or read book The Southern Pine Beetle written by and published by . This book was released on 1981 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309180686
Total Pages : 102 pages
Book Rating : 4.89/5 ( download)

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Download or read book Treating Infectious Diseases in a Microbial World written by National Research Council and published by National Academies Press. This book was released on 2006-01-03 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt: Humans coexist with millions of harmless microorganisms, but emerging diseases, resistance to antibiotics, and the threat of bioterrorism are forcing scientists to look for new ways to confront the microbes that do pose a danger. This report identifies innovative approaches to the development of antimicrobial drugs and vaccines based on a greater understanding of how the human immune system interacts with both good and bad microbes. The report concludes that the development of a single superdrug to fight all infectious agents is unrealistic.