Statistical Physics Of Dna An Introduction To Melting Unzipping And Flexibility Of The Double Helix

Author : Nikos Theodorakopoulos
Publisher : World Scientific
ISBN 13 : 9811209553
Total Pages : 196 pages
Book Rating : 4.50/5 ( download)

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Download or read book Statistical Physics Of Dna: An Introduction To Melting, Unzipping And Flexibility Of The Double Helix written by Nikos Theodorakopoulos and published by World Scientific. This book was released on 2019-12-24 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: The stability of the DNA double helix is contingent on fine-tuning a number of physicochemical control parameters. Varying any one of them leads to separation of the two strands, in what constitutes a rare physical example of a thermodynamic phase transition in a one-dimensional system. The present book aims at providing a self-contained account of the statistical physics of cooperative processes in DNA, e.g. thermal and mechanical dissociation, force-induced melting, equilibria of hairpin-like secondary structures. In addition, the book presents some fundamental aspects of DNA elasticity, as observed in key experiments, old and new. The latter include some recently published scattering data on apparently soft, short DNA chains and their interpretation in terms of local structural defects (permanent bends, 'kinky DNA', after the original Crick-Klug hypothesis).The development of mathematical models used (Kratky-Porod polymer chain, Poland-Scheraga and Peyrard-Bishop-Dauxois models of DNA melting) emphasizes the use of realistic parameters and the relevance of practical numerical methods for comparing with experimental data. Accordingly, a large number of specially produced figures has been included.The presentation is at the level of an advanced undergraduate or introductory graduate course. An extra chapter provides the necessary mathematical background on elasticity of model polymer chains.

Author : Giovanni Zocchi
Publisher : Princeton University Press
ISBN 13 : 1400890063
Total Pages : 208 pages
Book Rating : 4.64/5 ( download)

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Download or read book Molecular Machines written by Giovanni Zocchi and published by Princeton University Press. This book was released on 2018-07-10 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Machines presents a dynamic new approach to the physics of enzymes and DNA from the perspective of materials science. Unified around the concept of molecular deformability—how proteins and DNA stretch, fold, and change shape—this book describes the complex molecules of life from the innovative perspective of materials properties and dynamics, in contrast to structural or purely chemical approaches. It covers a wealth of topics, including nonlinear deformability of enzymes and DNA; the chemo-dynamic cycle of enzymes; supra-molecular constructions with internal stress; nano-rheology and viscoelasticity; and chemical kinetics, Brownian motion, and barrier crossing. Essential reading for researchers in materials science, engineering, and nanotechnology, the book also describes the landmark experiments that have established the materials properties and energy landscape of large biological molecules. Molecular Machines is also ideal for the classroom. It gives graduate students a working knowledge of model building in statistical mechanics, making it an essential resource for tomorrow's experimentalists in this cutting-edge field. In addition, mathematical methods are introduced in the bio-molecular context—for example, DNA conformational transitions are used to illustrate the transfer matrix formalism. The result is a generalized approach to mathematical problem solving that enables students to apply their findings more broadly. Molecular Machines represents the next leap forward in nanoscience, as researchers strive to harness proteins, enzymes, and DNA as veritable machines in medicine, technology, and beyond.

Author : A. I?U. Grosberg
Publisher : World Scientific
ISBN 13 : 9812839224
Total Pages : 347 pages
Book Rating : 4.20/5 ( download)

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Download or read book Giant Molecules written by A. I?U. Grosberg and published by World Scientific. This book was released on 2011 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: ?? Giant molecules are important in our everyday life. But, as pointed out by the authors, they are also associated with a culture. What Bach did with the harpsichord, Kuhn and Flory did with polymers. We owe a lot of thanks to those who now make this music accessible ??Pierre-Gilles de GennesNobel Prize laureate in Physics(Foreword for the 1st Edition, March 1996)This book describes the basic facts, concepts and ideas of polymer physics in simple, yet scientifically accurate, terms. In both scientific and historic contexts, the book shows how the subject of polymers is fascinating, as it is behind most of the wonders of living cell machinery as well as most of the newly developed materials. No mathematics is used in the book beyond modest high school algebra and a bit of freshman calculus, yet very sophisticated concepts are introduced and explained, ranging from scaling and reptations to protein folding and evolution. The new edition includes an extended section on polymer preparation methods, discusses knots formed by molecular filaments, and presents new and updated materials on such contemporary topics as single molecule experiments with DNA or polymer properties of proteins and their roles in biological evolution.

Author : Kim Sneppen
Publisher : Cambridge University Press
ISBN 13 : 9780521844192
Total Pages : 328 pages
Book Rating : 4.93/5 ( download)

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Download or read book Physics in Molecular Biology written by Kim Sneppen and published by Cambridge University Press. This book was released on 2005-08-25 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, first published in 2005, is a discussion for advanced physics students of how to use physics to model biological systems.

Author : Chris R. Calladine
Publisher : Elsevier
ISBN 13 : 9780080474663
Total Pages : 352 pages
Book Rating : 4.67/5 ( download)

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Download or read book Understanding DNA written by Chris R. Calladine and published by Elsevier. This book was released on 2004-03-13 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: The functional properties of any molecule are directly related to, and affected by, its structure. This is especially true for DNA, the molecular that carries the code for all life on earth. The third edition of Understanding DNA has been entirely revised and updated, and expanded to cover new advances in our understanding. It explains, step by step, how DNA forms specific structures, the nature of these structures and how they fundamentally affect the biological processes of transcription and replication. Written in a clear, concise and lively fashion, Understanding DNA is essential reading for all molecular biology, biochemistry and genetics students, to newcomers to the field from other areas such as chemistry or physics, and even for seasoned researchers, who really want to understand DNA. Describes the basic units of DNA and how these form the double helix, and the various types of DNA double helix Outlines the methods used to study DNA structure Contains over 130 illustrations, some in full color, as well as exercises and further readings to stimulate student comprehension

Author : Leszek A. Utracki
Publisher : John Wiley & Sons
ISBN 13 : 0470193425
Total Pages : 805 pages
Book Rating : 4.26/5 ( download)

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Download or read book Polymer Physics written by Leszek A. Utracki and published by John Wiley & Sons. This book was released on 2010-09-14 with total page 805 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing a comprehensive review of the state-of-the-art advanced research in the field, Polymer Physics explores the interrelationships among polymer structure, morphology, and physical and mechanical behavior. Featuring contributions from renowned experts, the book covers the basics of important areas in polymer physics while projecting into the future, making it a valuable resource for students and chemists, chemical engineers, materials scientists, and polymer scientists as well as professionals in related industries.

Author : Ludmila V. Yakushevich
Publisher : John Wiley & Sons
ISBN 13 : 3527604731
Total Pages : 205 pages
Book Rating : 4.39/5 ( download)

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Download or read book Nonlinear Physics of DNA written by Ludmila V. Yakushevich and published by John Wiley & Sons. This book was released on 2006-01-24 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first edition of this book was the first on the physics of DNA to go beyond the simple (simplified) 'linear' approach, and it has since been found that the inclusion of nonlinear effects leads to a significantly improved interpretation of experimental data. This new edition naturally retains this approach, but has been completely revised, updated and expanded to cover recent developments. Beginning with introductory chapters on DNA structure and dynamics, the book also includes a comparison between linear and nonlinear approaches to the DNA molecule, a chapter devoted to the statistics of nonlinear excitations of DNA, and examples for the interpretation of experimental data on the dynamics of DNA in terms of nonlinear theory. Essential reading for researchers in biophysics and nonlinear physics, allowing biologists, chemists and physicists to continue developing new and improved techniques of investigating the DNA molecule.

Author : Cheng Dong
Publisher : Springer
ISBN 13 : 3319952943
Total Pages : 376 pages
Book Rating : 4.49/5 ( download)

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Download or read book Biomechanics in Oncology written by Cheng Dong and published by Springer. This book was released on 2018-10-27 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers multi-scale biomechanics for oncology, ranging from cells and tissues to whole organ. Topics covered include, but not limited to, biomaterials in mechano-oncology, non-invasive imaging techniques, mechanical models of cell migration, cancer cell mechanics, and platelet-based drug delivery for cancer applications. This is an ideal book for graduate students, biomedical engineers, and researchers in the field of mechanobiology and oncology. This book also: Describes how mechanical properties of cancer cells, the extracellular matrix, tumor microenvironment and immuno-editing, and fluid flow dynamics contribute to tumor progression and the metastatic process Provides the latest research on non-invasive imaging, including traction force microscopy and brillouin confocal microscopy Includes insight into NCIs’ role in supporting biomechanics in oncology research Details how biomaterials in mechano-oncology can be used as a means to tune materials to study cancer

Author : M. Mitchell Waldrop
Publisher : Open Road Media
ISBN 13 : 150405914X
Total Pages : 492 pages
Book Rating : 4.45/5 ( download)

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Download or read book Complexity written by M. Mitchell Waldrop and published by Open Road Media. This book was released on 2019-10-01 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: “If you liked Chaos, you’ll love Complexity. Waldrop creates the most exciting intellectual adventure story of the year” (The Washington Post). In a rarified world of scientific research, a revolution has been brewing. Its activists are not anarchists, but rather Nobel Laureates in physics and economics and pony-tailed graduates, mathematicians, and computer scientists from all over the world. They have formed an iconoclastic think-tank and their radical idea is to create a new science: complexity. They want to know how a primordial soup of simple molecules managed to turn itself into the first living cell—and what the origin of life some four billion years ago can tell us about the process of technological innovation today. This book is their story—the story of how they have tried to forge what they like to call the science of the twenty-first century. “Lucidly shows physicists, biologists, computer scientists and economists swapping metaphors and reveling in the sense that epochal discoveries are just around the corner . . . [Waldrop] has a special talent for relaying the exhilaration of moments of intellectual insight.” —The New York Times Book Review “Where I enjoyed the book was when it dove into the actual question of complexity, talking about complex systems in economics, biology, genetics, computer modeling, and so on. Snippets of rare beauty here and there almost took your breath away.” —Medium “[Waldrop] provides a good grounding of what may indeed be the first flowering of a new science.” —Publishers Weekly

Author : Nadrian C. Seeman
Publisher : Cambridge University Press
ISBN 13 : 0521764483
Total Pages : 269 pages
Book Rating : 4.83/5 ( download)

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Download or read book Structural DNA Nanotechnology written by Nadrian C. Seeman and published by Cambridge University Press. This book was released on 2015 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by the founder of the field, this is a comprehensive and accessible introduction to structural DNA nanotechnology.