Sickle Cell Simply Explained

Author : Dr. John Koramoa
Publisher : Author House
ISBN 13 : 1491897767
Total Pages : 195 pages
Book Rating : 4.68/5 ( download)

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Download or read book Sickle Cell Simply Explained written by Dr. John Koramoa and published by Author House. This book was released on 2014 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sickle cell disease is the most common genetic disease world-wide. For a person to suffer the disease, he or she has to inherit the faulty gene from each parent. It affects millions of people in the world. It is a chronic illness of serious proportions. Medical, psychological and socioeconomic consequences place a great burden on sufferers and their Carers. In the past sufferers of sickle cell anaemia survived for a few years only.When only one sickle cell gene is inherited by a person with normal haemoglobin, the condition is referred to as the carrier state or the trait. Individuals with the trait have no medical problems under normal conditions of life. This is how the gene has been able to survive and be passed on from generation to generation. The trait can thus have serious implications for marriage and childbearing. It is therefore, imperative for people intending to have children to know about it in order to help prevent the disease. Sickle cell disease which was once thought to be restricted to only a few areas, especially among Black people, is now known to be world-wide. It has been described as a world health problem.This book provides information in an easily readable format for everybody to understand sickle cell and its related conditions. There is the need for greater awareness and knowledge of the disease and the trait to avoid confusion, misunderstanding and myths, which hamper their proper management and prevention. At present there is no readily available cure for sickle cell disease. However, with proper management of the many ill-effects of the disease, sufferers can be assisted to live comfortable lives and for many years. Life-style measures are paramount and are referred to in some detail in the book. It is a great resource."

Author : Samir K. Ballas
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 1496331834
Total Pages : 1004 pages
Book Rating : 4.30/5 ( download)

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Download or read book Sickle Cell Pain written by Samir K. Ballas and published by Lippincott Williams & Wilkins. This book was released on 2015-06-01 with total page 1004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sickle Cell Pain is a panoramic, in-depth exploration of every scientific, human, and social dimension of this cruel disease. This comprehensive, definitive work is unique in that it is the only book devoted to sickle cell pain, as opposed to general aspects of the disease. The 752-page book links sickle cell pain to basic, clinical, and translational research, addressing various aspects of sickle pain from molecular biology to the psychosocial aspects of the disease. Supplemented with patient narratives, case studies, and visual art, Sickle Cell Pain’s scientific rigor extends through its discussion of analgesic pharmacology, including abuse-deterrent formulations. The book also addresses in great detail inequities in access to care, stereotyping and stigmatization of patients, the implications of rapidly evolving models of care, and recent legislation and litigation and their consequences.

Author : Miriam Bloom
Publisher : Univ. Press of Mississippi
ISBN 13 : 1604737573
Total Pages : 137 pages
Book Rating : 4.78/5 ( download)

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Download or read book Understanding Sickle Cell Disease written by Miriam Bloom and published by Univ. Press of Mississippi. This book was released on 2009-10-20 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although more is known about sickle cell disease than about any other inherited disease, no cure for it exists. In America alone, about one in 375 who are of African ancestry is born with sickle cell disease. A smaller number of Americans descended from families from the Mediterranean area, the Middle East, and India also are affected. In addition, about eight percent of black Americans who do not suffer from the disease itself carry the gene for it that can be transmitted to their children. Sickle cell disease is of enormous biological, social, and historic importance. It was first described in medical literature almost a century ago. Improvements during the past two decades in our understanding of the disease and in medical care are permitting those afflicted to live longer, more comfortable and more productive lives. This book was written for all who are interested in this disease--those who have it, their families, the carriers of the sickle cell gene, teachers, and those who wish to update their information about it. This overview of sickle cell disease explains what it is and how it is inherited, as well as the relationship between the sickle cell gene and its geographic origins, the way the gene has been spread throughout history, and the effect of sickle cell hemoglobin on red blood cells that carry it. Understanding Sickle Cell Disease describes the variety of symptoms in both children and adults and details the emotional aspects of the disease. Of particular interest is a chapter on the care, especially the home care, of those who are affected. This book explains how it is possible today for couples carrying the genes to raise families free of the disease. Although there is no known cure for sickle cell disease, there is little doubt that one will ultimately be devised. This volume surveys current research efforts and the promise they hold.

Author : Chaim Hershko
Publisher : Springer Science & Business Media
ISBN 13 : 1461505933
Total Pages : 275 pages
Book Rating : 4.38/5 ( download)

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Download or read book Iron Chelation Therapy written by Chaim Hershko and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: Within the last few years, iron research has yielded exciting new insights into the under standing of normal iron homeostasis. However, normal iron physiology offers little protec tion from the toxic effects of pathological iron accumulation, because nature did not equip us with effective mechanisms of iron excretion. Excess iron may be effectively removed by phlebotomy in hereditary hemochromatosis, but this method cannot be applied to chronic anemias associated with iron overload. In these diseases, iron chelating therapy is the only method available for preventing early death caused mainly by myocardial and hepatic iron toxicity. Iron chelating therapy has changed the quality of life and life expectancy of thalassemic patients. However, the high cost and rigorous requirements of deferoxamine therapy, and the significant toxicity of deferiprone underline the need for the continued development of new and improved orally effective iron chelators. Such development, and the evolution of improved strategies of iron chelating therapy require better understanding of the pathophysiology of iron toxicity and the mechanism of action of iron chelating drugs. The timeliness of the present volume is underlined by several significant develop ments in recent years. New insights have been gained into the molecular basis of aberrant iron handling in hereditary disorders and the pathophysiology of iron overload (Chapters 1-5).

Author : M D George R Buchanan
Publisher : Createspace Independent Publishing Platform
ISBN 13 : 9781502452788
Total Pages : 0 pages
Book Rating : 4.82/5 ( download)

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Download or read book Evidence-Based Management of Sickle Cell Disease written by M D George R Buchanan and published by Createspace Independent Publishing Platform. This book was released on 2014-09-09 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sickle cell disease can be severe and disabling. When properly treated, patients live longer and with better quality life. This is a US government publication intended to provide evidence-based guidelines for the care of these patients for the use of all concerned providers as well as patients and family members. This book is available in print here for convenience.

Author : U. S. Department of Health
Publisher : Createspace Independent Publishing Platform
ISBN 13 : 9781495279157
Total Pages : 0 pages
Book Rating : 4.54/5 ( download)

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Download or read book The Management of Sickle Cell Disease written by U. S. Department of Health and published by Createspace Independent Publishing Platform. This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: #1 Best Seller on Sickle Cell Disease (SCD). Sickle cell disease is a group of blood disorders passed down from parents to children. Sickle cell anemia shortens life expectancy by 30 years via bacterial infections, painful swellings, fever, arthritis, leg ulcers, eye, lung & heart damage. Over 100,000 people, mostly African-Americans, in the United States have sickle cell disease. Over 2 million people have sickle cell trait in America. It is estimated that more than 300,000 children are born each year with SCD around the world. This edition of The Management of Sickle Cell Disease (SCD) is organized into four parts: 1. Diagnosis and Counseling 2. Health Maintenance 3. Treatment of Acute and Chronic Complications 4. Special Topics. The original intent was to incorporate evidence-based medicine into each chapter, but there was variation among evidence-level scales, and some authors felt recommendations could be made, based on accepted practice, without formal trials in this rare disorder. The best evidence still is represented by randomized, controlled trials (RCTs), but variations exist in their design, conduct, endpoints, and analyses. It should be emphasized that selected people enter a trial, and results should apply in practice specifically to populations with the same characteristics as those in the trial. Randomization is used to reduce imbalances between groups, but unexpected factors sometimes may confound analysis or interpretation. In addition, a trial may last only a short period of time, but long-term clinical implications may exist. Another issue is treatment variation, for example, a new pneumococcal vaccine developed after the trial, which has not been tested formally in a sickle cell population. Earlier trial results may be accepted, based on the assumption that the change is small. In some cases, RCTs cannot be done satisfactorily (e.g., for ethical reasons, an insufficient number of patients, or a lack of objective measures for sickle cell "crises"). Thus the bulk of clinical experience in SCD still remains in the moderately strong and weaker categories of evidence. Not everyone has an efficacious outcome in a clinical trial, and the frequency of adverse events, such as with long-term transfusion programs or hematopoietic transplants, might not be considered. Thus, an assessment of benefit-to-risk ratio should enter into translation of evidence levels into practice recommendations. A final issue is that there may be two alternative approaches that are competitive (e.g., transfusions and hydroxyurea). In this case the pros and cons of each course of treatment should be discussed with the patient. This book is B&W copy of the government agency publication.

Author : Lisa Mullan
Publisher :
ISBN 13 : 9781916455061
Total Pages : 58 pages
Book Rating : 4.69/5 ( download)

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Download or read book My DNA Diary written by Lisa Mullan and published by . This book was released on 2019-10-31 with total page 58 pages. Available in PDF, EPUB and Kindle. Book excerpt: Have you heard of DNA? There's me, Alina and my three friends. Oh, and lots of cousins. How we live our life affects how you live yours. It's called genetics and this book will show you how it works. A gentle introduction to genes, chromosomes, inheritance, oxygen transport and sickle cell anaemia for 9-12 year-olds.

Author : Fernando Ferreira Costa
Publisher : Springer
ISBN 13 : 3319067133
Total Pages : 439 pages
Book Rating : 4.31/5 ( download)

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Download or read book Sickle Cell Anemia written by Fernando Ferreira Costa and published by Springer. This book was released on 2016-03-29 with total page 439 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although sickle cell anemia was the first molecular disease to be identified, its complex and fascinating pathophysiology is still not fully understood. A single mutation in the beta-globin gene incurs numerous molecular and cellular mechanisms that contribute to the plethora of symptoms associated with the disease. Our knowledge regarding sickle cell disease mechanisms, while still not complete, has broadened considerably over the last decades. Sickle Cell Anemia: From Basic Science to Clinical Practice aims to provide an update on our current understanding of the disease’s pathophysiology and use this information as a basis to discuss its manifestations in childhood and adulthood. Current therapies and prospects for the development of new approaches for the management of the disease are also covered.

Author : Deepak M. Kamat
Publisher : Springer Nature
ISBN 13 : 3030499804
Total Pages : 512 pages
Book Rating : 4.08/5 ( download)

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Download or read book Benign Hematologic Disorders in Children written by Deepak M. Kamat and published by Springer Nature. This book was released on 2020-08-18 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of benign hematologic disorders in children. Divided into nine sections, the text reviews common hematologic disorders or conditions that affect children, while providing state-of-the-art information on pathophysiology, diagnosis, treatment, and management strategies. The text begins with a section on hematopoiesis, and the next section covers red blood cell disorders. The following sections provide overviews of platelet disorders, white blood cell disorders, and coagulation disorders. The sixth and seventh sections discuss neonatal hematology and bone marrow failure syndrome. The eighth section reviews supportive care, while the final section covers miscellaneous subjects including pediatric vascular anomalies and complement dysregulation syndromes. Written by experts in the field, Benign Hematologic Disorders in Children: A Clinical Guide is a valuable resource for clinicians and practitioners who treat children afflicted with these disorders.

Author : Duana Fullwiley
Publisher : Princeton University Press
ISBN 13 : 1400840414
Total Pages : 369 pages
Book Rating : 4.10/5 ( download)

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Download or read book The Enculturated Gene written by Duana Fullwiley and published by Princeton University Press. This book was released on 2011-11-07 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the 1980s, a research team led by Parisian scientists identified several unique DNA sequences, or haplotypes, linked to sickle cell anemia in African populations. After casual observations of how patients managed this painful blood disorder, the researchers in question postulated that the Senegalese type was less severe. The Enculturated Gene traces how this genetic discourse has blotted from view the roles that Senegalese patients and doctors have played in making sickle cell "mild" in a social setting where public health priorities and economic austerity programs have forced people to improvise informal strategies of care. Duana Fullwiley shows how geneticists, who were fixated on population differences, never investigated the various modalities of self-care that people developed in this context of biomedical scarcity, and how local doctors, confronted with dire cuts in Senegal's health sector, wittingly accepted the genetic prognosis of better-than-expected health outcomes. Unlike most genetic determinisms that highlight the absoluteness of disease, DNA haplotypes for sickle cell in Senegal did the opposite. As Fullwiley demonstrates, they allowed the condition to remain officially invisible, never to materialize as a health priority. At the same time, scientists' attribution of a less severe form of Senegalese sickle cell to isolated DNA sequences closed off other explanations of this population's measured biological success. The Enculturated Gene reveals how the notion of an advantageous form of sickle cell in this part of West Africa has defined--and obscured--the nature of this illness in Senegal today. Some images inside the book are unavailable due to digital copyright restrictions.