Serine Proteases

Author : Barry W. Festoff
Publisher : Springer Science & Business Media
ISBN 13 : 1468483579
Total Pages : 359 pages
Book Rating : 4.74/5 ( download)

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Download or read book Serine Proteases and Their Serpin Inhibitors in the Nervous System written by Barry W. Festoff and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 359 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of a NATO ARW held in Maratea, Italy, July 2-8, 1989

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Publisher : Academic Press
ISBN 13 : 0080865968
Total Pages : 471 pages
Book Rating : 4.66/5 ( download)

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Download or read book Mechanisms of Catalysis written by and published by Academic Press. This book was released on 1991-01-28 with total page 471 pages. Available in PDF, EPUB and Kindle. Book excerpt: The remarkable expansion of information leading to a deeper understanding of enzymes on the molecular level necessitated the development of this volume which not only introduces new topics to The Enzymes series but presents new information on some covered in Volume I and II of this edition.

Author : Eva Böttcher-Friebertshäuser
Publisher : Springer
ISBN 13 : 3319754742
Total Pages : 335 pages
Book Rating : 4.41/5 ( download)

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Download or read book Activation of Viruses by Host Proteases written by Eva Böttcher-Friebertshäuser and published by Springer. This book was released on 2018-05-22 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will give an overview on viruses undergoing proteolytic activation through host proteases. The chapters will be organized in three themed parts, the first part describing respective viruses and their characteristics in detail. In the second part the molecular and cellular biology of the proteases involved as well as their physiological functions will be further explored. The third part will contain a chapter on protease inhibitors that are promising tools for antiviral therapy. This book will engage scholars in virology and medical microbiology as well as researchers with an interest in enzymology and protein structure and function relationship.

Author : Alan J. Barrett
Publisher : Elsevier
ISBN 13 : 0080984150
Total Pages : 1182 pages
Book Rating : 4.55/5 ( download)

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Download or read book Handbook of Proteolytic Enzymes, Volume 1 written by Alan J. Barrett and published by Elsevier. This book was released on 2012-12-02 with total page 1182 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Proteolytic Enzymes, Second Edition, Volume 1: Aspartic and Metallo Peptidases is a compilation of numerous progressive research studies on proteolytic enzymes. This edition is organized into two main sections encompassing 328 chapters. This handbook is organized around a system for the classification of peptidases, which is a hierarchical one built on the concepts of catalytic type, clan, family and peptidase. The concept of catalytic type of a peptidase depends upon the chemical nature of the groups responsible for catalysis. The recognized catalytic types are aspartic, cysteine, metallo, serine, threonine, and the unclassified enzymes, while clans and families are groups of homologous peptidases. Homology at the level of a family of peptidases is shown by statistically significant relationship in amino acid sequence to a representative member called the type example, or to another member of the family that has already been shown to be related to the type example. Each chapter discusses the history, activity, specificity, structural chemistry, preparation, and biological aspects of the enzyme. This book will prove useful to enzyme chemists and researchers.

Author : Sajal Chakraborti
Publisher : Springer Science & Business Media
ISBN 13 : 1461492335
Total Pages : 407 pages
Book Rating : 4.37/5 ( download)

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Download or read book Proteases in Health and Disease written by Sajal Chakraborti and published by Springer Science & Business Media. This book was released on 2013-12-04 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: In view of rapidly growing research in the deregulation of proteases and their impact in human health and diseases, this book will highlight existing and emerging research in this exciting area. In-depth critical state-of-the-art reviews will be written by established investigators on proteases dysfunctions associated with pathogenesis of different diseases that are known to occur due to deregulation of proteolytic systems. Multidisciplinary approaches demonstrating biochemical and signal transduction mechanisms associated with deregulation of proteases leading to manifestation of the diseases will be discussed. The book highlights the roles of both intracellular and extracellular proteases in health and disease.

Author : Anil K. Sharma
Publisher : Walter de Gruyter GmbH & Co KG
ISBN 13 : 3111325288
Total Pages : 221 pages
Book Rating : 4.86/5 ( download)

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Download or read book Serine Proteases written by Anil K. Sharma and published by Walter de Gruyter GmbH & Co KG. This book was released on 2023-10-23 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: Serine proteases play significant roles in healh and human disease. Abnormal expression and activities of serine proteases have been linked to the pathogenesis of many diseases. The book presents correlation between serine proteases and human diseases. It helps the reader understand classification, catalytic mechanism and types of serine proteases and their role in human disease pathogenesis at mechanistic level. The chapters explain the role of serine proteases in various diseases including respiratory disorders and cancer. It also covers the therapeutic importance of serine proteases as drug target and explains the mechanistic insights of serine proteases inhibitors. Serine protease are known to play crucial role in biological processes but disturbance in their equilibrium can result in serious health conditions. To maintain homeostasis, serine protease inhibitors come in action and inhibit proteases. Several serine protease inhibitors have been identified and many more are being designed as novel compounds for inhibitions of proteases that provide management of comorbidities. Therefore, this book will serve as a useful reference for students and researchers to understand physiological role of serine proteases and their association with initiation and progression of human diseases. It will also help to develop some strategies to develop serine proteases inhibitors as drug target of serine proteases at cellular and molecular level.

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Publisher : ScholarlyEditions
ISBN 13 : 1464926751
Total Pages : 160 pages
Book Rating : 4.54/5 ( download)

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Download or read book Serine Proteases: Advances in Research and Application: 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: Serine Proteases: Advances in Research and Application: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Serine Proteases in a concise format. The editors have built Serine Proteases: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Serine Proteases in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Serine Proteases: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Author : Laszlo Polgar
Publisher : CRC Press
ISBN 13 : 9780849369018
Total Pages : 236 pages
Book Rating : 4.10/5 ( download)

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Download or read book Mechanisms of Protease Action written by Laszlo Polgar and published by CRC Press. This book was released on 1989-01-31 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: A uniform treatment of the four protease groups and a discussion of the differences and similarities in their action is presented in this important new publication. Serine, cysteine, aspartate, and zinc proteases are systematically discussed by nomenclature, evolution, specificity and their regulatory role. The chemistry of the peptide bond, including the catalysis of ester and peptide hydrolyses, is explained. For each protease group the emphasis is placed on the structure and function. Kinetics, enzyme modifications, isotope effects, subzero temperature investigations, nuclear magnetic resonance measurements, X-ray diffraction data, binding of transition-state analogs, zymogen activation, and site-specific mutagenesis are combined to rationalize the action of proteases. Both natural and synthetic inhibitors are considered because of their importance in mechanistic studies and drug design.

Author : Sajal Chakraborti
Publisher : Springer
ISBN 13 : 9811025134
Total Pages : 619 pages
Book Rating : 4.36/5 ( download)

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Download or read book Proteases in Physiology and Pathology written by Sajal Chakraborti and published by Springer. This book was released on 2017-09-14 with total page 619 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using a multidisciplinary approach, this book describes the biochemical mechanisms associated with dysregulation of proteases and the resulting pathophysiological consequences. It highlights the role and regulation of different types of proteases as well as their synthetic and endogenous inhibitors. The role of proteases was initially thought to be limited to general metabolic digestion. However, we now know that the role of protein breakdown is much more complex, and proteases have multiple functions: they are coupled to turnover and can affect protein composition, function and synthesis. In addition to eliminating abnormal proteins, breakdown has many modulatory functions, including activating and inactivating enzymes, modulating membrane function, altering receptor channel properties, affecting transcription and cell cycles and forming active peptides. The ubiquity of proteases in nature makes them an important target for drug development. This in-depth, comprehensive is a valuable resource for researchers involved in identifying new targets for drug development. With its multidisciplinary scope, it bridges the gap between fundamental and translational research in the biomedical and pharmaceutical industries, making it thought-provoking reading for scientists in the field.

Author :
Publisher : ScholarlyEditions
ISBN 13 : 1481692305
Total Pages : 226 pages
Book Rating : 4.04/5 ( download)

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Download or read book Serine Proteases—Advances in Research and Application: 2013 Edition written by and published by ScholarlyEditions. This book was released on 2013-06-21 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Serine Proteases—Advances in Research and Application: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about ZZZAdditional Research in a concise format. The editors have built Serine Proteases—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about ZZZAdditional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Serine Proteases—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.