Reversal Of Multidrug Resistance In Cancer

Author : John A. Kellen
Publisher : CRC Press
ISBN 13 : 9780849347443
Total Pages : 164 pages
Book Rating : 4.40/5 ( download)

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Download or read book Reversal of Multidrug Resistance in Cancer written by John A. Kellen and published by CRC Press. This book was released on 1993-12-06 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: This critical, state-of-the-art review brings together the scattered and often controversial information on multidrug resistance reversal. Leading scientists in the field cover P-glycoprotein, the genetics of resistance, and its reversal by drugs. Resistance modifiers and modulators are tabulated and critically evaluated. Reversal of Multidrug Resistance in Cancer is important reading for oncologists, cancer chemotherapists, and other cancer researchers.

Author : John A. Kellen
Publisher : Springer Science & Business Media
ISBN 13 : 1461598524
Total Pages : 288 pages
Book Rating : 4.27/5 ( download)

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Download or read book Alternative Mechanisms of Multidrug Resistance in Cancer written by John A. Kellen and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nullius in verba. . . Truth will be tested not by words. Horace (Epistles) Few read introductions except for book reviewers, who want to take a shortcut and avoid reading the book itself. However, tradition requires that the preface make public why the book was written at all (this is not supposed to include powerful reasons such as augmenting the ego of the editor and authors). Frequently, the inflationary tendency to publish in verbose length is in conflict with market forces and interest. No doubt, multidrug resistance is a "fashionable" topic, but there are many fashions displayed on the cat-walk of scientific literature. One can rationalize that the forces driving our concern with multi drug resistance reflect the frustration of pharmaceutical companies and oncologists alike: as soon as a new anticancer drug enters clinical trials, cancer cells start eluding extinction with their elaborate and successful mechanisms. Many grants have been awarded and spent, only to confirm the futility of our efforts to defeat this cellular Darwinism. Our medical and scientific training makes it hard, if not impossible, to accept that the survival of a malignant cell, alone or as part of a tissue, is part of the continuance of life. Since exposure to noxious and lethal substances is unavoidable, cells have been forced to develop a multitude of mechanisms to prevent entry or accelerate exit of such materials from intracellular space.

Author : Jun Zhou
Publisher : Humana Press
ISBN 13 : 9781617796647
Total Pages : 492 pages
Book Rating : 4.46/5 ( download)

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Download or read book Multi-Drug Resistance in Cancer written by Jun Zhou and published by Humana Press. This book was released on 2012-08-09 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemotherapy is one of the major treatment options for cancer patients; however, the efficacy of chemotherapeutic management of cancer is severely limited by multidrug resistance, in that cancer cells become simultaneously resistant to many structurally and mechanistically unrelated drugs. In the past three decades, a number of mechanisms by which cancer cells acquire multidrug resistance have been discovered. In addition, the development of agents or strategies to overcome resistance has been the subject of intense study. This book contains comprehensive and up-to-date reviews of multidrug resistance mechanisms, from over-expression of ATP-binding cassette drug transporters such as P-glycoprotein, multidrug resistance-associated proteins, and breast cancer resistance p- tein to the drug ratio-dependent antagonism and the paradigm of cancer stem cells. The book also includes strategies to overcome multidrug resistance, from the development of compounds that inhibit drug transporter function to the modulation of transporter expression. In addition, this book contains techniques for the detection and imaging of drug transporters, methods for the investigation of drug resistance in animal models, and strategies to evaluate the efficacy of resistance reversal agents. The book intends to provide a state-of-the-art collection of reviews and methods for both basic and clinician investigators who are interested in cancer multidrug resistance mechanisms and reversal strategies. Tianjin, China Jun Zhou v Contents Preface. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . v Contributors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ix 1 Multidrug Resistance in Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Bruce C. Baguley 2 Multidrug Resistance in Oncology and Beyond: From Imaging of Drug Efflux Pumps to Cellular Drug Targets . . . . . . . . . . . . . . . . . . . . . . . . . .

Author :
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.06/5 ( download)

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Download or read book Reversal of Multidrug Resistance in Cancer written by and published by . This book was released on 1994 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Rishabha Malviya
Publisher : John Wiley & Sons
ISBN 13 : 1394209843
Total Pages : 228 pages
Book Rating : 4.42/5 ( download)

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Download or read book Multi-Drug Resistance in Cancer written by Rishabha Malviya and published by John Wiley & Sons. This book was released on 2023-07-18 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: MULTI-DRUG RESISTANCE IN CANCER The book details the mechanisms underlying multi-drug cellular resistance and the targets of novel chemotherapeutic agents. Cancer is a major killer all over the world. Even with all the progress made, chemotherapy is still the mainstay of modern cancer treatment. The progression of the cellular defeat of numerous independent anticancer drugs in terms of their chemical structure is a major barrier to successful chemotherapy. Multi-drug resistance (MDR) is a term for the fact that most cancer patients exhibit this phenomenon. According to the numbers, drug resistance carries the blame for 90% of cancer patient deaths. Refractory cancer and tumor recurrence are common outcomes of prolonged chemotherapy. Because of the prevalence of drug-resistance mutations, the difficulty of treating tumors increases and the therapeutic efficacy of drugs decreases. Multi-Drug Resistance in Cancer: Mechanism and Treatment Strategies contains nine chapters that cover topics such as: studying the mechanics of resistance to drugs by autophagy; studies to delineate the role of efflux transporters; expression of drug transporters; resistance to targeted therapies in breast cancer; advances in metallodrug driven combination treatment for cancer; and use of natural agents for the overcoming of cancer drug resistance. The book aims to provide the latest data on the mechanisms of cellular resistance to anticancer agents currently used in clinical treatment. It provides a better understanding of the mechanisms of MDR and targets of novel chemotherapy agents which should guide future research concerning new effective strategies in cancer treatment. Audience This book is written for pharmaceutical and biomedical scientists and researchers at both the bench and in the clinic who are interested in the mechanisms and strategies for overcoming cancer’s multi-drug resistance.

Author : Dihua Yu
Publisher : Springer Science & Business Media
ISBN 13 : 0387740392
Total Pages : 175 pages
Book Rating : 4.93/5 ( download)

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Download or read book Breast Cancer Chemosensitivity written by Dihua Yu and published by Springer Science & Business Media. This book was released on 2009-12-30 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Breast Cancer Chemosensitivity, a group of world leading experts review critical aspects of resistance to systemic therapy in breast cancer patients. Beginning with a clinical overview of the problem, the book then focuses on the latest findings of molecular mechanisms of drug resistance. Coverage provides an example of using novel approaches for chemosensitization of breast cancer cells that gives readers an idea about the future direction in breast cancer treatment. It allows those who are interested in breast cancer therapy to get a jump-start on critical issues in breast cancer therapeutic resistance.

Author : International Conference on Reversal of Multidrug Resistance in Cancer (1, 1994, Sankt Gallen)
Publisher :
ISBN 13 :
Total Pages : 79 pages
Book Rating : 4.24/5 ( download)

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Download or read book 1st International Conference on Reversal of Multidrug Resistance in Cancer, St Gallen, Switzerland, 1-3 September 1994 written by International Conference on Reversal of Multidrug Resistance in Cancer (1, 1994, Sankt Gallen) and published by . This book was released on 1994 with total page 79 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Borje Andersson
Publisher : Springer Science & Business Media
ISBN 13 : 1461511739
Total Pages : 391 pages
Book Rating : 4.31/5 ( download)

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Download or read book Clinically Relevant Resistance in Cancer Chemotherapy written by Borje Andersson and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last several decades, the introduction of new chemotherapeutic drugs and drug combinations has resulted in increased long term remission rates in several important tumor types. These include childhood leukemia, adult leukemias and lymphomas, as well as testicular and trophoblastic tumors. The addition of high-dose chemotherapy with growth factor and hemopoietic stem cell support has increased clinical remission rates even further. For the majority of patients with some of the more common malignancies, however, palliation (rather than cure) is still the most realistic goal of chemotherapy for metastatic disease. The failure of chemotherapy to cure metastatic cancer is commonly referred to among clinicians as "drug resistance". This phenomenon can, however, often be viewed as the survival of malignant cells that resulted from a failure to deliver an effective drug dose to the (cellular) target because of anyone of or combination of a multitude of individual factors. Clinically, this treatment failure is often viewed as the rapid occurrence of resistance at the single cell level. However, in experimental systems, stable drug resistance is usually relatively slow to emerge.

Author :
Publisher :
ISBN 13 :
Total Pages : 60 pages
Book Rating : 4.06/5 ( download)

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Download or read book Reversal of Multidrug Resistance in Breast Cancer written by and published by . This book was released on 1997 with total page 60 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our data show that MDR1 gene expression is important in breast cancer resistance. The role of the MDR1 gene in breast cancer treatment will be further defined by sequentially determining MDR1 gene expression pre and post treatment with doxorubicin in the context of three prospective clinical trials. In addition, this study will allow a correlation of MDR1 gene expression and clinical outcome. To determine what level of MDR1 gene expression is clinically significant, various molecular methods of determining MDR1 gene expression, including immunohistochemistry and quantitative reverse transcription followed by polymerase chain reaction, will be evaluated. MDR can be reversed in vitro and we will test this hypothesis in a Phase I study of Cyclosporine A and quinine as MDR reversers of Vinblastine resistance. Together these studies will address the major goal of circumventing drug resistance in breast cancer. When the data of the MDR1 gene expression in breast cancer specimens from this proposal are available, clinical trials incorporating the modulators of MDR, Cyclosporine and quinine, will be designed for breast cancer as well. An alteration in drug efflux potentially may have an impact on response to chemotherapy and may result in improved survival for breast cancer patients. During the period between March 15, 1993 and March 14, 1997, we have outfitted our laboratory with staff, equipment, supplies and reagents, have been performing control experiments and have been pursuing activation of the various clinical trials to support this project. We now have some preliminary data on the expression of MDR1 and MRP (Multidrug resistant associated protein) in breast cancer specimens and normal adjacent breast tissue. Further follow-up of these patients is needed to determine the clinical significance of expression of these drug resistance genes.

Author : Yue Du
Publisher : Frontiers Media SA
ISBN 13 : 283254844X
Total Pages : 148 pages
Book Rating : 4.48/5 ( download)

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Download or read book New Strategies for Reversing Cancer Therapy Resistance written by Yue Du and published by Frontiers Media SA. This book was released on 2024-04-26 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: Amazing anticancer therapy advancements have been made in the last decade due to tremendous innovations. Nonetheless, drug resistance remains a major challenge that limits the effectiveness of anticancer therapies, causing cancer recurrence and metastasis and being a major cause of cancer-related death. Drug resistance can be caused by complex molecular mechanisms such as gene mutations, epigenetic dysregulation, microenvironment alterations, etc. Many clinical strategies, including combination therapies and epigenetic drugs, have been used to avoid or reverse drug resistance effectively. However, the progression of cancers (in patients under treatment) or the lack of response of cancer patients indicate that current approaches to overcome resistance are far from sufficient, and more work is needed.