Retinal And Choroidal Angiogenesis

Author : John Penn
Publisher : Springer Science & Business Media
ISBN 13 : 1402067801
Total Pages : 567 pages
Book Rating : 4.08/5 ( download)

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Download or read book Retinal and Choroidal Angiogenesis written by John Penn and published by Springer Science & Business Media. This book was released on 2008-01-19 with total page 567 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive, in-depth review of our current understanding of the growth of blood vessels within the eye. Novel therapeutic strategies for the treatment of ocular angiogenesis are discussed, as are the unique challenges presented by delivery of drugs to the eye. The book emphasizes basic principles rather than specific experimental results, although recently acquired data is frequently cited to illustrate points of broader theoretical significance.

Author : Robert D. Stratton
Publisher : Springer Science & Business Media
ISBN 13 : 1617796069
Total Pages : 644 pages
Book Rating : 4.67/5 ( download)

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Download or read book Studies on Retinal and Choroidal Disorders written by Robert D. Stratton and published by Springer Science & Business Media. This book was released on 2012-02-17 with total page 644 pages. Available in PDF, EPUB and Kindle. Book excerpt: Studies on Retinal and Choroidal Disorders examines the role that oxidative and nitrosative stress plays in the complex physiology and pathophysiology of the retina and choroid. Both the basic science researcher and the clinical practitioner can use this book as a guide to the current understanding of retinal and choroidal cellular mechanisms involved in aging and disease. Beginning with a review of oxidative stress and inflammation in the pathoetiology of AMD and a review of the complement system in the retina, the book then takes a detailed look at oxidative stress in lipid metabolism and oxidized lipoproteins in the retina. It examines the anti-apoptotic activity of α-crystallins in the presence of glutathione, oxidative stress in the mitochondria and endoplasmic reticulum, the role of iron in retinal disease, the mechanisms of pathological VEGF expression, NAPDH oxidase mechanisms, and Hepatocyte Growth Factor in oxidative stress in the retina. A detailed look at the Ccl2-/-/Cx3cr1-/- mouse model of AMD follows. Then a detailed examination of the systemic changes in AMD is followed by a discussion of cerium oxide nanoparticle reduction of oxidative stress. Two chapters discuss progenitor cells in the cause and treatment of retinal diseases including AMD and diabetic retinopathy. Natural compounds in the prevention and treatment of retinal diseases are exhaustively presented, followed by a chapter on serotonin 5-HT1A receptor agonists in oxidative stress of the retina. The current anti-VEGF treatment strategies of neovascular AMD are then given. The volume continues with a detailed look at nitric oxide and inducible nitric oxide synthase in retinal vascular disease, an explanation of an in vivo technique of studying the effect of lipid hydroperoxides on circulating leucocytes in the retina, an excellent review of oxidative stress in retinopathy of prematurity, and a look at VEGF induced oxidative stress in the retinal ganglion cell. The book ends with a detail examination of the role of carotenoids in retinal health and disease. These 31 chapters summarize what is known about oxidative stress in retinal and choroidal disorders. All those involved with degenerative diseases of the eye will find Studies on Retinal and Choroidal Disorders to be illuminating and comprehensive.

Author : Joyce Tombran-Tink
Publisher : Springer Science & Business Media
ISBN 13 : 1597450472
Total Pages : 412 pages
Book Rating : 4.78/5 ( download)

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Download or read book Ocular Angiogenesis written by Joyce Tombran-Tink and published by Springer Science & Business Media. This book was released on 2007-11-06 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leading academic and pharmaceutical researchers and clinicians from many disciplines synthesize and summarize current clinical and basic knowledge concerning abnormal growth of blood vessels in the eye, the cause of major neovascular eye diseases. The authors also identify and assess the most promising approaches with potential for commercial exploitation and discuss the challenges encountered in developing therapeutics for ocular neovascular diseases. Highlights include illuminating chapters on gene therapy and novel drug delivery systems and excellent summaries of the newest therapeutic approaches.

Author : Arup Das
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 1451148313
Total Pages : 896 pages
Book Rating : 4.12/5 ( download)

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Download or read book Therapy for Ocular Angiogenesis written by Arup Das and published by Lippincott Williams & Wilkins. This book was released on 2012-03-28 with total page 896 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ocular angiogenesis, or the abnormal growth of blood vessels in the eye, is the cause of major neovascular eye diseases. With the new era of anti-angiogenic therapies, ophthalmologists have started treating many ocular diseases including macular degeneration, diabetic retinopathy, and retinal vascular occlusion using anti-angiogenic drugs. This book covers the basic pathophysiology of ocular angiogenesis and strategies for inhibition. The authors discuss the "Principles" of anti-angiogenic therapy, pre-clinical studies, future drugs on the horizon, drug delivery, and the "Practice" of the therapy in many ocular diseases. The book also includes chapters on diabetic macular edema, and various therapeutic options for this condition. A companion website includes the fully searchable text and an image bank.

Author : Andreas Stahl
Publisher : Springer
ISBN 13 : 3319240978
Total Pages : 193 pages
Book Rating : 4.78/5 ( download)

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Download or read book Anti-Angiogenic Therapy in Ophthalmology written by Andreas Stahl and published by Springer. This book was released on 2016-05-13 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a concise overview over the pathology of retinal angiogenic diseases and explains why anti-angiogenic therapy is effective in so many patients. The reader is guided through the various clinical indications for anti-angiogenic therapy and made aware of its merits as well as current challenges and limitations. It is explained how, since its introduction for the treatment of exudative age-related macular degeneration in 2006, anti-angiogenic therapy has revolutionized the way in which we treat a range of ocular diseases. All of the authors are established experts in their respective fields who share their extensive knowledge and clinical experience with the reader. This book is both a valuable introduction to anti-angiogenic therapy in ophthalmology and a day-to-day companion for all ophthalmologists seeing patients with some of the most prevalent retinal diseases.

Author : M. Battaglia Parodi
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3805595301
Total Pages : 155 pages
Book Rating : 4.08/5 ( download)

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Download or read book Anti-VEGF written by M. Battaglia Parodi and published by Karger Medical and Scientific Publishers. This book was released on 2010-08-13 with total page 155 pages. Available in PDF, EPUB and Kindle. Book excerpt: The development of therapy with anti-angiogenics or vascular endothelial growth factor inhibitors (anti-VEGF) has marked the beginning of a new era in neovascularization and macular edema treatment. Its main goals are the inhibition of growth and development of new vessels along with the reduction of vascular permeability. The advantages over conventional laser photocoagulation are evident as laser treatment always leaves scars and causes a retinal sensitivity deterioration.Starting with an outline of treatment principles, this volume covers all aspects of anti-VEGF therapy for ophthalmological disorders. In particular, specific chapters are dedicated to age-related macular degeneration, degenerative myopia, angioid streaks, inflammatory diseases, hereditary dystrophies, retinal vein occlusion, diabetic retinopathy, ocular tumors, as well as anterior segment neovascularization.The book gives an update on the application of anti-VEGF in ocular diseases to general ophthalmologists as well as retina specialists.

Author : de la Rosa (Enrique J.)
Publisher : Royal Society of Chemistry
ISBN 13 : 1782629491
Total Pages : 276 pages
Book Rating : 4.98/5 ( download)

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Download or read book Therapies for Retinal Degeneration written by de la Rosa (Enrique J.) and published by Royal Society of Chemistry. This book was released on 2018 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses approaches to the treatment of retinal diseases, targeting common processes and components.

Author : D. Virgil Alfaro
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 1469889641
Total Pages : 828 pages
Book Rating : 4.41/5 ( download)

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Download or read book Age-Related Macular Degeneration written by D. Virgil Alfaro and published by Lippincott Williams & Wilkins. This book was released on 2014-09-04 with total page 828 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stay up to date with the latest developments in your field with the highly-anticipated second edition of Age-Related Macular Degeneration. This comprehensive text covers recent advances in pathophysiology, diagnosis, and treatment including promising new developments that will affect your patient care. Dr. Virgil Alfaro and his colleagues at Retina Consultants of Charleston bring you their expertise in the areas of basic science, imaging, prevention, treatment, and more. Features: Learn from a renowned group of retina surgeons who address all aspects of management, including anatomy, physiology, and pathophysiology; imaging of the macula in ARMD, prevention measures and treatment; and future directions in the field. Gain a solid foundation in intravenous fluorescein angiography, indocyanine green angiography, and optical coherence tomography, as well as antiVEGE therapy and related new drugs, optimizing your diagnosis and treatment options. Understand the significant change in the classification system of choroidal neovascular membranes in ARMD. Get up-to-date information on treating ARMD secondary to geographic atrophy through cell transplantation and pharmacologic therapies. Easily visualize key aspects of ARMD thanks to high-quality illustrations and photographs. Find the information you need quickly by referencing individual chapters that offer comprehensive and inclusive coverage of the topic at hand.

Author : Jay Chhablani
Publisher : Springer Nature
ISBN 13 : 9811522138
Total Pages : 428 pages
Book Rating : 4.30/5 ( download)

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Download or read book Choroidal Neovascularization written by Jay Chhablani and published by Springer Nature. This book was released on 2020-07-31 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book discusses all aspects of choroidal neovascularization (CNV), including the basics, clinical conditions associated with CNV, clinical trials related to CNV, future directions and rehabilitation. The first section covers the pathogenesis, proposed mechanisms, disease models, histopathology and electronmicroscopy. The next section explores CNV secondary to various clinical conditions, such as age-related macular degeneration (AMD), myopia, and less common conditions like choroidal osteoma. The book also covers clinical features, imaging characteristics, and treatment approaches, as well as clinical trials in CNV conditions with recent updates. Lastly, it features chapters on stem cell therapy, gene therapy, new molecules, and lasers, as well as a section on rehabilitation, which addresses home monitoring and low vision aids. This book is intended for retina specialists, retina fellows and general ophthalmologists.

Author : Richard F. Spaide
Publisher : Springer Nature
ISBN 13 : 3030743349
Total Pages : 461 pages
Book Rating : 4.45/5 ( download)

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Download or read book Pathologic Myopia written by Richard F. Spaide and published by Springer Nature. This book was released on 2021-07-28 with total page 461 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pathologic Myopia is a major cause of severe vision loss worldwide. The mechanisms for vision loss include cataract, glaucoma, retinal detachment, and above all, myopic maculopathy within the posterior staphyloma. The first edition of Pathologic Myopia is one of the only current books to specifically address this disease and discusses recent developments in imaging technologies and various approaches to treatments, such as laser photocoagulation, photodynamic therapy, pharmaco-therapeutic injections in the vitreous, and surgery. This new edition is a timely update to the standard reference in the field, with new chapters on advanced refractive error correction, genetics, developing a classification system, and special surgical approaches for pathologic myopia. Complete with even more high-quality color images and informative tables, this book is written and edited by leaders in the field and is geared towards ophthalmologists, including residents and fellows in training, glaucoma and cataract specialists, and vitreoretinal macula experts.