Regulatory Mechanisms In Breast Cancer

Author : Marc E. Lippman
Publisher : Springer Science & Business Media
ISBN 13 : 1461539404
Total Pages : 455 pages
Book Rating : 4.07/5 ( download)

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Download or read book Regulatory Mechanisms in Breast Cancer written by Marc E. Lippman and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Breast Cancer: Cellular and Molecular Biology [Kluwer Academic Pub lishers, 1988], we tried to present an introduction to the emerging basic studies on steroid receptors, oncogenes, and growth factors in the regulation of normal and malignant mammary epithelium. The response to this volume was superb, indicating a tremendous interest in basic growth regulatory mechanisms governing breast cancer and controlling its malignant progres sion. In the two years since its publication, much new and exciting in formation has been published and the full interplay of regulatory mechanisms is now beginning to emerge. We have divided this book into four sections that we hope will unify important concepts and help to crystallize areas of consensus and/or disagreement among a diverse group of basic and clinical scientists working on the disease. The first section is devoted to studies on oncogenes, antioncogenes, proliferation, and tumor prognosis. The first chapter, by Sunderland and McGuire, introduces the characteristics of breast cancer as studied by patho logists to establish prognostic outcome. Of particular interest is a new proto oncogene called HER-2 (or neu), which is rapidly becoming accepted as a valuable new tumor marker of poor prognosis. The second chapter, by Lee Bookstein and Lee, introduces the best known antioncogene, the retinoblas toma antioncogene, whose expression is sometimes lost in breast cancer. Malignant progression appears to be influenced by the balance of proto oncogene and antioncogene expression.

Author : Robert C. Bast, Jr.
Publisher : John Wiley & Sons
ISBN 13 : 111900084X
Total Pages : 2008 pages
Book Rating : 4.46/5 ( download)

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Download or read book Holland-Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2008 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Author : Louise Mary Kelly
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.56/5 ( download)

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Download or read book Regulatory Mechanisms in the Metastatic Potential of Breast Cancer written by Louise Mary Kelly and published by . This book was released on 2003 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Charles M. McGrath
Publisher :
ISBN 13 :
Total Pages : 544 pages
Book Rating : 4.74/5 ( download)

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Download or read book Cell Biology of Breast Cancer written by Charles M. McGrath and published by . This book was released on 1980 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Surinder K. Batra
Publisher : CRC Press
ISBN 13 : 1351778331
Total Pages : 322 pages
Book Rating : 4.36/5 ( download)

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Download or read book Gene Regulation and Therapeutics for Cancer written by Surinder K. Batra and published by CRC Press. This book was released on 2021-03-22 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Differential gene regulation and targeted therapy are the critical aspects of several cancers. This book covers specific gene regulation and targeted therapies in different malignancies. It offers a comprehensive assessment of the transcriptional dysregulation in cancer, and considers some examples of transcriptional regulators as definitive oncogenic drivers in solid tumors, followed by a brief discussion of transcriptional effectors of the programs they drive, and discusses its specific targets. Most targeted therapeutics developed to date have been directed against a limited set of oncogenic drivers, exemplified by those encoding cell surface or cytoplasmic kinases that function in intracellular signaling cascades.

Author : Catalina Simion
Publisher :
ISBN 13 : 9781124223469
Total Pages : pages
Book Rating : 4.60/5 ( download)

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Download or read book Regulation of LRIG1 Expression in Breast Cancer written by Catalina Simion and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: In the present study, we investigated the regulation of the leucine-rich repeats and immunoglobulin-like domains protein 1 (LRIG1 - a negative regulator of the ErbB family receptor tyrosine kinases) gene expression in human breast cancer cell lines and examined both its suppression and upregulation mechanisms. We first investigated the methylation status of the CpG islands in the LRIG1 promoter and determined if demethylation by the methylase inhibitor 5-aza-2'-deoxycytidine (5-aza-dC) could restore LRIG1 expression in the cell lines. The methylation status around the promoter region of the LRIG1 was detected by bisulfite modification and subsequent PCR amplification. The messenger RNA (mRNA) and protein levels of these genes were determined by quantitative PCR (qPCR) and western blotting, respectively. We next investigated the correlation of LRIG1 levels with the estrogen receptor-alpha (ER[alpha]) in the human breast cancer cell line ZR-75-1. Meta analysis of gene expression data sets showed that LRIG1 expression is positively correlated to ER[alpha] status. Upon estradiol stimulation, LRIG1 transcript accumulates, as seen by qPCR. Tamoxifen and fulvestrant, ER[alpha] antagonists, blocked estrogen-induced LRIG1 expression, demonstrating that this is an ER[alpha] dependent event. Following depletion of endogenous LRIG1 by small interfering RNA, estrogen-dependent proliferation of ER[alpha] positive breast cancer cells is augmented. These findings suggest that LRIG1 is an estrogen-induced gene product that suppresses ER-dependent cell growth. Taken together, these analyses provide insight into the regulatory mechanisms which dictate LRIG1 expression in breast cancer cells. A detailed understanding of the mechanism by which this negative regulator is silenced in human tumours will lead to new approaches of restoring pathway function in cancerous cells, and eventually to new treatments of patients with ErbB-positive tumours.

Author : Dihua Yu
Publisher : Springer Science & Business Media
ISBN 13 : 0387740392
Total Pages : 175 pages
Book Rating : 4.93/5 ( download)

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Download or read book Breast Cancer Chemosensitivity written by Dihua Yu and published by Springer Science & Business Media. This book was released on 2009-12-30 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Breast Cancer Chemosensitivity, a group of world leading experts review critical aspects of resistance to systemic therapy in breast cancer patients. Beginning with a clinical overview of the problem, the book then focuses on the latest findings of molecular mechanisms of drug resistance. Coverage provides an example of using novel approaches for chemosensitization of breast cancer cells that gives readers an idea about the future direction in breast cancer treatment. It allows those who are interested in breast cancer therapy to get a jump-start on critical issues in breast cancer therapeutic resistance.

Author : Cesar Lopez-Camarillo
Publisher : CRC Press
ISBN 13 : 1466576774
Total Pages : 426 pages
Book Rating : 4.73/5 ( download)

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Download or read book MicroRNAs in Cancer written by Cesar Lopez-Camarillo and published by CRC Press. This book was released on 2013-02-22 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: MicroRNA (miRNA) biology is a cutting-edge topic in basic as well as biomedical research. This is a specialized book focusing on the current understanding of the role of miRNAs in the development, progression, invasion, and metastasis of diverse types of cancer. It also reviews their potential for applications in cancer diagnosis, prognosis, and th

Author : Sam Thiagalingam
Publisher : Cambridge University Press
ISBN 13 : 0521493390
Total Pages : 597 pages
Book Rating : 4.90/5 ( download)

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Download or read book Systems Biology of Cancer written by Sam Thiagalingam and published by Cambridge University Press. This book was released on 2015-04-09 with total page 597 pages. Available in PDF, EPUB and Kindle. Book excerpt: An overview of the current systems biology-based knowledge and the experimental approaches for deciphering the biological basis of cancer.

Author : Anne Le
Publisher : Springer
ISBN 13 : 331977736X
Total Pages : 186 pages
Book Rating : 4.68/5 ( download)

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Download or read book The Heterogeneity of Cancer Metabolism written by Anne Le and published by Springer. This book was released on 2018-06-26 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.