Radicals For Life

Author : Ernst van Faassen
Publisher : Elsevier
ISBN 13 : 0080489591
Total Pages : 444 pages
Book Rating : 4.99/5 ( download)

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Download or read book Radicals for Life written by Ernst van Faassen and published by Elsevier. This book was released on 2011-10-13 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: Radicals for Life: the Various Forms of Nitric Oxide provides an up-to-date overview of the role of nitrosocompounds and nitrosyl-iron complexes in physiology. Nitrosocompounds can be considered as stabilised forms of nitric oxide, one of the most important regulatory molecules in physiology today. Many nitrosocompounds share some of the physiological functions of nitric oxide, and may be formed inside living organisms. This is the first book to be published that is dedicated to the role of such nitrosocompounds in physiology, with particular emphasis on the nitrosocompounds that are endogenously formed in higher organisms and humans. Points of discussion include: physical and chemical properties of the compounds, the main chemical pathways in vivo, as well as the physiological effects that have been recognised to date. Each of the nineteen chapters is written by distinguished specialists in the field, well known for their original and important contributions to the subject. Also included are results from a wide range of studies in vitro, in cell cultures, animal models and human volunteers. Examples of alternative forms of nitric oxide, with special emphasis on their protective role against widespread human diseases like atherosclerosis, Alzheimer's disease, diabetes, sexual dysfunction, and renal insufficiency to stroke and ischemia are also included. First monograph to consider and provide an overview of endogenous nitrosocompounds and nitrosyl-iron complexes Extensive bibliographic references, written by specialists of human physiology Providing high scientific quality with a focus on implications for human diseases

Author : Barry Halliwell
Publisher : Oxford University Press
ISBN 13 : 0198717474
Total Pages : 961 pages
Book Rating : 4.78/5 ( download)

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Download or read book Free Radicals in Biology and Medicine written by Barry Halliwell and published by Oxford University Press. This book was released on 2015 with total page 961 pages. Available in PDF, EPUB and Kindle. Book excerpt: Free Radicals in Biology and Medicine has become a classic text in the field of free radical and antioxidant research. Now in its fifth edition, the book has been comprehensively rewritten and updated whilst maintaining the clarity of its predecessors. Two new chapters discuss 'in vivo' and 'dietary' antioxidants, the first emphasising the role of peroxiredoxins and integrated defence mechanisms which allow useful roles for ROS, and the second containing new information on the role of fruits, vegetables, and vitamins in health and disease. This new edition also contains expanded coverage of the mechanisms of oxidative damage to lipids, DNA, and proteins (and the repair of such damage), and the roles played by reactive species in signal transduction, cell survival, death, human reproduction, defence mechanisms of animals and plants against pathogens, and other important biological events. The methodologies available to measure reactive species and oxidative damage (and their potential pitfalls) have been fully updated, as have the topics of phagocyte ROS production, NADPH oxidase enzymes, and toxicology. There is a detailed and critical evaluation of the role of free radicals and other reactive species in human diseases, especially cancer, cardiovascular, chronic inflammatory and neurodegenerative diseases. New aspects of ageing are discussed in the context of the free radical theory of ageing. This book is recommended as a comprehensive introduction to the field for students, educators, clinicians, and researchers. It will also be an invaluable companion to all those interested in the role of free radicals in the life and biomedical sciences.

Author : Michael Brooks
Publisher : ABRAMS
ISBN 13 : 1468301713
Total Pages : 148 pages
Book Rating : 4.17/5 ( download)

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Download or read book Free Radicals written by Michael Brooks and published by ABRAMS. This book was released on 2012-04-26 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: “An exuberant tour through the world of scientists behaving badly” (The New York Times). They may have a public image as cool, logical, levelheaded types. But in reality, scientists will do pretty much anything—take drugs, follow mystical visions, lie, and even cheat—to make a discovery. In Free Radicals, physicist and journalist Michael Brooks seamlessly weaves together true stories of the “mad, bad and dangerous” men and women who have revolutionized the scientific world, and offers a fast-paced and thrilling exploration of the real process behind discovery (The Times, London). Brooks also traces the cover-up back to its source: the scientific establishment’s reaction to the public fear of science after World War II. He argues that it its high time for science to come clean about just how bold and daring scientists really are. “Not all scientists are nerds. In Free Radicals, physicist Michael Brooks tries to dispel the notion that scientists are stuffy, pen-protector-polishing bookworms.” —The Washington Post “Insightful . . . A page-turning, unvarnished look at the all-too-human side of science.” —Kirkus Reviews

Author : Adam Greenfield
Publisher : Verso Books
ISBN 13 : 1784780464
Total Pages : 396 pages
Book Rating : 4.63/5 ( download)

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Download or read book Radical Technologies written by Adam Greenfield and published by Verso Books. This book was released on 2017-06-01 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: A field manual to the technologies that are transforming our lives Everywhere we turn, a startling new device promises to transfigure our lives. But at what cost? In this urgent and revelatory excavation of our Information Age, leading technology thinker Adam Greenfield forces us to reconsider our relationship with the networked objects, services and spaces that define us. It is time to re-evaluate the Silicon Valley consensus determining the future. We already depend on the smartphone to navigate every aspect of our existence. We’re told that innovations—from augmented-reality interfaces and virtual assistants to autonomous delivery drones and self-driving cars—will make life easier, more convenient and more productive. 3D printing promises unprecedented control over the form and distribution of matter, while the blockchain stands to revolutionize everything from the recording and exchange of value to the way we organize the mundane realities of the day to day. And, all the while, fiendishly complex algorithms are operating quietly in the background, reshaping the economy, transforming the fundamental terms of our politics and even redefining what it means to be human. Having successfully colonized everyday life, these radical technologies are now conditioning the choices available to us in the years to come. How do they work? What challenges do they present to us, as individuals and societies? Who benefits from their adoption? In answering these questions, Greenfield’s timely guide clarifies the scale and nature of the crisis we now confront —and offers ways to reclaim our stake in the future.

Author : Zsolt Radák
Publisher : Human Kinetics
ISBN 13 : 9780880118811
Total Pages : 286 pages
Book Rating : 4.14/5 ( download)

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Download or read book Free Radicals in Exercise and Aging written by Zsolt Radák and published by Human Kinetics. This book was released on 2000 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Explore the emerging field of free radical biology, exercise, and aging with this definitive reference. Free Radicals in Exercise and Agingaddresses the current debate regarding whether free radicals released during exercise accelerate the aging process. It explains how free radicals can serve as important regulators of aerobic processes, and it clarifies the importance of exercise in increasing the efficiency of the antioxidant and oxidative repair systems. Mounting research data indicate that free radicals are involved in a variety of physiological and pathophysiological processes. This book focuses on exercise-induced adaptation. In general, a person's ability to adapt to internal and external changes decreases during the aging process. However, by continually exposing the body to different challenges, regular exercise triggers an adaptation process that keeps the body and mind fit. Free Radicals in Exercise and Agingelucidates the role of free radical species in regulating this process. This text is also one of the first to provide an in-depth review of skeletal muscle oxidative stress and aging. This issue is pivotal because muscle serves such a critical role in mobility and normal life. Free Radicals in Exercise and Aging shares the most current understanding of how reactive oxygen species influence the biology of skeletal muscles. It explores some of the unique characteristics that skeletal muscle displays during aging, both in terms of free radical production and with regard to antioxidant systems. The implications of this research are far-reaching. Mutation of DNA is linked very closely to cancer, and if regular exercise improves the regulation of the antioxidant systems and the oxidative damage repair system, these mechanisms may be a very important tool against this deadly disease. This research-oriented text presents the latest information on the subject. It reviews and critiques current literature and provides critical information for exercise physiologists, sports medicine specialists, sport nutritionists, and gerontologists.

Author : Kerri K. Greenidge
Publisher : Liveright Publishing
ISBN 13 : 1631495356
Total Pages : 432 pages
Book Rating : 4.59/5 ( download)

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Download or read book Black Radical: The Life and Times of William Monroe Trotter written by Kerri K. Greenidge and published by Liveright Publishing. This book was released on 2019-11-19 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: New York Times • Times Critics Top Books of 2019 This long-overdue biography reestablishes William Monroe Trotter’s essential place next to Douglass, Du Bois, and King in the pantheon of American civil rights heroes. William Monroe Trotter (1872– 1934), though still virtually unknown to the wider public, was an unlikely American hero. With the stylistic verve of a newspaperman and the unwavering fearlessness of an emancipator, he galvanized black working- class citizens to wield their political power despite the violent racism of post- Reconstruction America. For more than thirty years, the Harvard-educated Trotter edited and published the Guardian, a weekly Boston newspaper that was read across the nation. Defining himself against the gradualist politics of Booker T. Washington and the elitism of W. E. B. Du Bois, Trotter advocated for a radical vision of black liberation that prefigured leaders such as Marcus Garvey, Malcolm X, and Martin Luther King Jr. Synthesizing years of archival research, historian Kerri Greenidge renders the drama of turn- of- the- century America and reclaims Trotter as a seminal figure, whose prophetic, yet ultimately tragic, life offers a link between the vision of Frederick Douglass and black radicalism in the modern era.

Author : Saul Alinsky
Publisher : Vintage
ISBN 13 : 0307756890
Total Pages : 226 pages
Book Rating : 4.93/5 ( download)

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Download or read book Rules for Radicals written by Saul Alinsky and published by Vintage. This book was released on 2010-06-30 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: “This country's leading hell-raiser" (The Nation) shares his impassioned counsel to young radicals on how to effect constructive social change and know “the difference between being a realistic radical and being a rhetorical one.” First published in 1971 and written in the midst of radical political developments whose direction Alinsky was one of the first to question, this volume exhibits his style at its best. Like Thomas Paine before him, Alinsky was able to combine, both in his person and his writing, the intensity of political engagement with an absolute insistence on rational political discourse and adherence to the American democratic tradition.

Author : Vibha Rani
Publisher : Springer
ISBN 13 : 8132220358
Total Pages : 427 pages
Book Rating : 4.50/5 ( download)

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Download or read book Free Radicals in Human Health and Disease written by Vibha Rani and published by Springer. This book was released on 2014-11-14 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: The role of oxidative stress in human disease has become an area of intense interest. Free radicals, a normal product of metabolism, exist in all aerobic cells in balance with biochemical antioxidants. Environmental stress increases the levels of free radicals drastically, thereby disturbing the equilibrium between free radical production and the antioxidant capability causing oxidative stress. Over the years, ROS has been implicated in the pathologies of various diseases like cancer, neurological disorder, cardiovascular diseases rheumatoid arthritis, diabetes etc. This book provides an in depth critical state-of-art reviews from established investigators on free radicals, ROS associated pathogenesis of human diseases, biomarkers of oxidative damage, antioxidants, phytonutrients and other related health concerns of modern society. The present book is aimed at graduate students, researchers in academia, industry and clinicians with the interest in redox biology. Special attention has been devoted to the topic of ROS signalling, oxidative stress induced human pathologies & antioxidative therapies. The book consists of four parts in specified topics based on the current literatures for the better understanding of the readers with respect to their subject-wise interests. The first section of the book provides an overview about the ROS production and their measuring tools and techniques followed by the mechanisms involved in the oxidative stress in the second section. The third section describes the involvement of oxidative stress in different human diseases and the last section focuses on the different strategies to ameliorate oxidative stress induced stress.

Author : Michael Simic
Publisher : Springer Science & Business Media
ISBN 13 : 1468455680
Total Pages : 1064 pages
Book Rating : 4.87/5 ( download)

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Download or read book Oxygen Radicals in Biology and Medicine written by Michael Simic and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 1064 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is based on the papers presented at the "Fourth International Congress on Oxygen Radicals (4-ICOR)," held June 27 - July 3, 1987, at the University of California, La Jolla. The chapters deal with the phenomena associated with highly reactive oxygen species (hydroxy, peroxy, alkoxy, aroxy, and superoxide radicals, as well as singlet oxygen) and their peroxidation products (hydrogen peroxide, hydroperoxides, peroxides, and epoxides) as they relate to the fields of chemistry, food technology, nutrition, biology, pharmacology, and medicine. The kinetics, energetics, and mechanistic aspects of the reactions of these species and the interrelationship of oxygen radicals (or any other free radicals) and peroxidized products have been emphasized. Special attention is focused on the mechanisms of the generation of free radicals and peroxy products in biosystems and on the adverse effects of these radicals and products in humans. The topics span the continuum from the simple chemistry of model systems to the complex considerations of clinical medicine. The book also explores the mechanisms of agents that protect against free radicals and peroxy products in vitro and in vivo. These agents include antioxidants used in materials, food antioxidants, physiological antioxidants, and antioxienzymes (SOD, glutathione peroxidase, and catalases). The use of these inhibitors to prevent damage to organs being prepared for transplantation, thereby maintaining the quality of transplanted organs and/or extending their "shelf-life," also is examined.

Author : A.T. Diplock
Publisher : Elsevier
ISBN 13 : 0080858910
Total Pages : 309 pages
Book Rating : 4.13/5 ( download)

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Download or read book Techniques in Free Radical Research written by A.T. Diplock and published by Elsevier. This book was released on 1991-12-11 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: Free radical species are generally short-lived due to their high reactivity and thus direct measurement and identification are often impossible. ESR is the only technique which has the potential for direct detection of radicals but in biological systems even these must be trapped by a spin-trapping agent. Thus most investigations involve recognition of indicators of the presence of radicals in vivo or "FOOTPRINTS" of radical-mediated damage. Techniques in Free Radical Research assembles and critically assesses the most relevant and reliable experimental approaches used towards the measurement of radicals and radical-mediated damage in chemical systems, in cells and in tissues under the following six headings: a) Footprints of DNA damage, b) Footprints of protein damage, c) Footprints of lipid peroxidation, d) Footprints of antioxidant consumption, e) Footprints via indirect radical assays, and f) Footprints via the availability of transition metal complexes.