Protein Misfolding and Spreading Pathology in Neurodegenerative Diseases

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Publisher : Frontiers Media SA
ISBN 13 : 2889635074
Total Pages : 158 pages
Book Rating : 4.78/5 ( download)

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Book Synopsis Protein Misfolding and Spreading Pathology in Neurodegenerative Diseases by : Diana Fernandes Lázaro

Download or read book Protein Misfolding and Spreading Pathology in Neurodegenerative Diseases written by Diana Fernandes Lázaro and published by Frontiers Media SA. This book was released on 2020-02-20 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Protein Misfolding and Spreading of Pathology in Neurodegenerative Diseases

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ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.44/5 ( download)

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Book Synopsis Protein Misfolding and Spreading of Pathology in Neurodegenerative Diseases by : Diana Fernandes Lázaro

Download or read book Protein Misfolding and Spreading of Pathology in Neurodegenerative Diseases written by Diana Fernandes Lázaro and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Protein folding and misfolding: neurodegenerative diseases

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Publisher : Springer Science & Business Media
ISBN 13 : 1402094345
Total Pages : 284 pages
Book Rating : 4.47/5 ( download)

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Book Synopsis Protein folding and misfolding: neurodegenerative diseases by : Judit Ovádi

Download or read book Protein folding and misfolding: neurodegenerative diseases written by Judit Ovádi and published by Springer Science & Business Media. This book was released on 2008-12-21 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offering all the latest in the study of neurodegenerative diseases, this book reviews the molecular events initiated by unfolded or misfolded proteins leading to conformational human diseases, especially those found in Parkinson’s and Alzheimer’s diseases.

Protein Misfolding in Neurodegenerative Diseases

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Publisher : CRC Press
ISBN 13 : 1420007149
Total Pages : 596 pages
Book Rating : 4.45/5 ( download)

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Book Synopsis Protein Misfolding in Neurodegenerative Diseases by : Robert D. E. Sewell

Download or read book Protein Misfolding in Neurodegenerative Diseases written by Robert D. E. Sewell and published by CRC Press. This book was released on 2007-12-03 with total page 596 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current research suggests that neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's, and Creutzfeldt-Jacob may be linked to disorders in protein shape referred to as protein misfolding. Continued study in this area could lead to promising advances in future treatment of these diseases. This groundbreaking text describes the latest findings regarding protein misfolding in the context of it being a marker, and perhaps a cause, in neurodegenerative diseases. Comprehensive coverage includes the diverse biochemical targets/markers for each disease, the currently limited success of drug therapies, and the cutting-edge research that could lead to more promising treatments.

Protein Misfolding and Disease

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Publisher : Springer Science & Business Media
ISBN 13 : 1592593941
Total Pages : 317 pages
Book Rating : 4.41/5 ( download)

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Book Synopsis Protein Misfolding and Disease by : Peter Bross

Download or read book Protein Misfolding and Disease written by Peter Bross and published by Springer Science & Business Media. This book was released on 2008-02-02 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: For decades it has been known that structured conformations are important for the proper functioning of most cellular proteins. However, appreciation that protein folding to the functional conformations as well as the structural maintenance of protein molecules are very complex processes has only emerged during the last ten years. The intimate interplay uncovered by this scientific development led us to realize that perturbations of the protein folding process and disturbances of conformational maintenance are major disease mechanisms. This development has given rise to the concept of conformational diseases and the broader signature of protein folding diseases, comprising diseases in which mutations or environmental stresses may result in a partial misfolding that leads then to alternative conformations capable of disturbing cellular processes. This may happen by self-association (aggregation), as in prion and Alzheimer’s diseases, or by incorporation of alternatively folded subunits into structural entities, as in collagen diseases. Another possibility is that folding to the native structure is impaired or abolished, resulting in decreased stea- state levels of the correctly folded protein, as is observed in cystic fibrosis and 1-antitrypsin deficiency, as well as in many enzyme deficiencies. In addition, deficiencies of proteins that are engaged in assisting and supervising protein folding (protein quality control) may impair the folding of many other proteins, resulting in pathological phenotypes. Examples of this are the spastic paraplegia attributable to mutations in mitochondrial protease/chaperone complexes.

Protein Misfolding and Proteostasis Impairment in Aging and Neurodegeneration: From Spreading Studies to Therapeutic Approaches

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Publisher : Frontiers Media SA
ISBN 13 : 2889746070
Total Pages : 265 pages
Book Rating : 4.71/5 ( download)

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Book Synopsis Protein Misfolding and Proteostasis Impairment in Aging and Neurodegeneration: From Spreading Studies to Therapeutic Approaches by : Claudia Duran-Aniotz

Download or read book Protein Misfolding and Proteostasis Impairment in Aging and Neurodegeneration: From Spreading Studies to Therapeutic Approaches written by Claudia Duran-Aniotz and published by Frontiers Media SA. This book was released on 2022-10-05 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Genotype - Proteotype - Phenotype Relationships in Neurodegenerative Diseases

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Publisher : Springer Science & Business Media
ISBN 13 : 9783540248354
Total Pages : 192 pages
Book Rating : 4.58/5 ( download)

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Book Synopsis Genotype - Proteotype - Phenotype Relationships in Neurodegenerative Diseases by : Jeffrey L. Cummings

Download or read book Genotype - Proteotype - Phenotype Relationships in Neurodegenerative Diseases written by Jeffrey L. Cummings and published by Springer Science & Business Media. This book was released on 2005-04 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurodegenerative Disorders as Proteinopathies: Phenotypic Relationships.- Towards a Molecular Classification of Neurodegenerative Disease.- Racial and Ethnic Influences on the Expression of the Genotype in Neurodegenerative Diseases.- Causes and Consequences of Oxidative Stress in Neurodegenerative Diseases.- Early Onset Familial Alzheimer's Disease: Is a Mutation Predictive of Pathology?.- Identification of Genes that Modify the Age of Onset in a Large Familial Alzheimer's Disease Kindred.- Variable Phenotype of Alzheimer's Disease with Spastic Paraparesis.- Presenilin Mutations: Variations in the Behavioral Phenotype with an Emphasis on the Frontotemporal Dementia Phenoytpe.- Frontotemporal Dementias: Genotypes and Phenotypes.- Chromosome 17-Linked Frontotemporal Dementia with Ubiquitin-Positive, tau-Negative Inclusions.- Variations of the Phenotype in Frontotemporal Dementias.- Phenotype/Genotype Correlations in Parkinson's Disease.- Subject Index

Protein Misfolding Diseases

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Publisher : John Wiley & Sons
ISBN 13 : 1118031814
Total Pages : 1311 pages
Book Rating : 4.10/5 ( download)

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Book Synopsis Protein Misfolding Diseases by : Marina Ramirez-Alvarado

Download or read book Protein Misfolding Diseases written by Marina Ramirez-Alvarado and published by John Wiley & Sons. This book was released on 2010-12-01 with total page 1311 pages. Available in PDF, EPUB and Kindle. Book excerpt: An increasingly aging population will add to the number of individuals suffering from amyloid. Protein Misfolding Diseases provides a systematic overview of the current and emerging therapies for these types of protein misfolding diseases, including Alzheimer's, Parkinson's, and Mad Cow. The book emphasizes therapeutics in an amyloid disease context to help students, faculty, scientific researchers, and doctors working with protein misfolding diseases bridge the gap between basic science and pharmaceutical applications to protein misfolding disease.

Protein Misfolding Disorders

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Publisher : Bentham Science Publishers
ISBN 13 : 1608050130
Total Pages : 156 pages
Book Rating : 4.30/5 ( download)

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Book Synopsis Protein Misfolding Disorders by : Claudio Hetz

Download or read book Protein Misfolding Disorders written by Claudio Hetz and published by Bentham Science Publishers. This book was released on 2009 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurodegenerative disorders such as Amyotrophic lateral sclerosis (ALS), Alzheimer’s disease (AD), Parkinson’s disease (PD), Prion-related disorders (PrD) and Huntington’s disease (HD) share a common neuropathology, primarily featuring the presence of abnormal protein inclusions containing specific misfolded proteins. These groups of diseases are now classified as Protein Misfolding Disorders. This book gives a comprehensive overview of the possible mechanisms involved in Protein Misfolding Disorders and possible therapeutic strategies to treat these diseases. The Ebook provides the most recent evidence addressing the role of cellular stress responses to neurological diseases, along with therapeutic strategies to alleviate ER stress in a disease context. -- Publisher.

Tau oligomers

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Publisher : Frontiers E-books
ISBN 13 : 288919261X
Total Pages : 114 pages
Book Rating : 4.18/5 ( download)

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Book Synopsis Tau oligomers by : Jesus Avila

Download or read book Tau oligomers written by Jesus Avila and published by Frontiers E-books. This book was released on 2014-08-18 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurofibrillary tangles (NFTs) composed of intracellular aggregates of tau protein are a key neuropathological feature of Alzheimer’s Disease (AD) and other neurodegenerative diseases, collectively termed tauopathies. The abundance of NFTs has been reported to correlate positively with the severity of cognitive impairment in AD. However, accumulating evidences derived from studies of experimental models have identified that NFTs themselves may not be neurotoxic. Now, many of tau researchers are seeking a “toxic” form of tau protein. Moreover, it was suggested that a “toxic” tau was capable to seed aggregation of native tau protein and to propagate in a prion-like manner. However, the exact neurotoxic tau species remain unclear. Because mature tangles seem to be non-toxic component, “tau oligomers” as the candidate of “toxic” tau have been investigated for more than one decade. In this topic, we will discuss our consensus of “tau oligomers” because the term of “tau oligomers” [e.g. dimer (disulfide bond-dependent or independent), multimer (more than dimer), granular (definition by EM or AFM) and maybe small filamentous aggregates] has been used by each researchers definition. From a biochemical point of view, tau protein has several unique characteristics such as natively unfolded conformation, thermo-stability, acid-stability, and capability of post-translational modifications. Although tau protein research has been continued for a long time, we are still missing the mechanisms of NFT formation. It is unclear how the conversion is occurred from natively unfolded protein to abnormally mis-folded protein. It remains unknown how tau protein can be formed filaments [e.g. paired helical filament (PHF), straight filament and twisted filament] in cells albeit in vitro studies confirmed tau self-assembly by several inducing factors. Researchers are still debating whether tau oligomerization is primary event rather than tau phosphorylation in the tau pathogenesis. Inhibition of either tau phosphorylation or aggregation has been investigated for the prevention of tauopathies, however, it will make an irrelevant result if we don’t know an exact target of neurotoxicity. It is a time to have a consensus of definition, terminology and methodology for the identification of “tau oligomers”.