Protein Kinase C

Author : Alexandra C. Newton
Publisher : Springer Science & Business Media
ISBN 13 : 1592593976
Total Pages : 565 pages
Book Rating : 4.72/5 ( download)

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Download or read book Protein Kinase C Protocols written by Alexandra C. Newton and published by Springer Science & Business Media. This book was released on 2008-02-03 with total page 565 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the discovery that protein kinase C (PKC) transduces the ab- dance of signals that result in phospholipid hydrolysis, this enzyme has been at the forefront of research in signal transduction. Protein Kinase C Protocols covers fundamental methods for studying the structure, function, regulation, subcellular localization, and macromolecular interactions of PKC. Protein Kinase C Protocols is divided into 11 sections representing the major aspects of PKC regulation and function. Part I contains an introduction and a historical perspective on the discovery of PKC by Drs. Yasutomi Nishizuka and Ushio Kikkawa. Part II describes methods to purify PKC. Part III describes the standard methods for measuring PKC activity: its enzymatic activity and its stimulus-dependent translocation from the cytosol to the membrane. Part IV describes methods for measuring the membrane interaction of PKC in vivo and in vitro. Part V provides methodologies and techniques for measuring the ph- phorylation state of PKC, including a protocol for measuring the activity of PKC’s upstream kinase, PDK-1. Novel methods for identifying substrates are described in Part VI. Part VII presents protocols for expressing and analyzing the membrane targeting domains of PKC. Part VIII provides a comprehensive c- pilation of methods used to identify binding partners for PKC. Part IX describes pharmacological probes used to study PKC. The book ends with a presentation of genetic approaches to study PKC (Part X) and a discussion of approaches used to study PKC in disease (Part XI).

Author : Lodewijk V. Dekker
Publisher : Springer Science & Business Media
ISBN 13 : 9780306478635
Total Pages : 212 pages
Book Rating : 4.33/5 ( download)

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Download or read book Protein Kinase C written by Lodewijk V. Dekker and published by Springer Science & Business Media. This book was released on 2004-06-17 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein Kinase C is a pivotal component of the mechanism that allows a cell to respond to its changing environment. In this book, the most significant advances in recent basic research on Protein Kinase C are explained by active researchers in the field. The first seven chapters provide a comprehensive account of the fundamental structural and biochemical properties of Protein Kinase C. The remaining chapters contain overviews of the function of Protein Kinase C, both in lower organisms and in mammalian cells, the latter with a focus on immune cells and nerve cells. This book is the only recent publication devoted entirely to Protein Kinase C and forms a major point of reference for those active in the field. In addition it will appeal to those with a general interest in biochemistry, cell biology, immunology and neurobiology.

Author : Ayse Basak Engin
Publisher : Springer Nature
ISBN 13 : 3030498441
Total Pages : 415 pages
Book Rating : 4.43/5 ( download)

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Download or read book Protein Kinase-mediated Decisions Between Life and Death written by Ayse Basak Engin and published by Springer Nature. This book was released on 2021-02-04 with total page 415 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein phosphorylation via protein kinases is an inevitable process that alters physiological and pathological functions of the cells. Thus, protein kinases play key roles in the regulation of cell life or death decisions. Protein kinases are frequently a driving factor in a variety of human diseases including aging and cellular senescence, immune system and endothelial dysfunctions, cancers, insulin resistance, cholestasis and neurodegenerative diseases, as well as bacterial resistance in persistent infections. Recent developments in quantitative proteomics provide important opinions on kinase inhibitor selectivity and their modes of action in the biological context. Protein Kinase-mediated Decisions Between Life and Death aims to have the reader catch insights about up-to-date opinions on “Protein Kinases” related pathways that threaten human health and life. As “Protein Kinases” are related to many health problems, clinicians, basic science researchers and students need this information. Chapter “Signal Transduction in Immune Cells and Protein Kinases” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Author :
Publisher : ScholarlyEditions
ISBN 13 : 1464942250
Total Pages : 45 pages
Book Rating : 4.59/5 ( download)

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Download or read book Advances in Protein Kinase C Research and Application: 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 45 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Protein Kinase C Research and Application: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Protein Kinase C in a concise format. The editors have built Advances in Protein Kinase C Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Protein Kinase C in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Protein Kinase C Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Author : James Olds
Publisher :
ISBN 13 :
Total Pages : 14 pages
Book Rating : 4.6G/5 ( download)

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Download or read book A Role for Protein Kinase C in Associative Learning written by James Olds and published by . This book was released on 1991 with total page 14 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : David Simon Lester
Publisher : Prentice Hall
ISBN 13 :
Total Pages : 392 pages
Book Rating : 4.40/5 ( download)

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Download or read book Protein Kinase C written by David Simon Lester and published by Prentice Hall. This book was released on 1992 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Attempts to provide a detailed study of a protein which plays an important role in the regulation of numerous cellular processes. The volume contains reviews of current research in the field and provides a background to the techniques and concepts necessary for future developments.

Author : Dean J. Pierce
Publisher :
ISBN 13 : 9781536132106
Total Pages : 0 pages
Book Rating : 4.01/5 ( download)

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Download or read book Protein Kinase C written by Dean J. Pierce and published by . This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this compilation, the authors review the structural basis of PKC isozymes and focus on the C1 domain, as well as the plausible binding mechanisms of its activators. Additionally, the recent molecular dynamics simulation studies of how phorbol esters or bryostatin bind to the activator pocket are described and some of the key amino acid residues recently identified as important for activator binding are investigated. The following chapter focuses on the expression pattern and function of PKCα in cancer cells, and newly emerging PKCα-targeted cancer therapies. PKCα acts directly and/or indirectly in various signaling mechanisms in cancer cells, including proliferation, survival, invasion, migration, apoptosis and drug resistance. A final review is provided which dissects the crosstalk between p53 and PKCδ in the context of apoptotic cell death and cancer therapy. PKCδ is implicated in a transcriptional regulation of the p53 tumor suppressor that is critical for cell cycle arrest and apoptosis in response to DNA damage.

Author : Peter J. Parker
Publisher :
ISBN 13 : 9783540614319
Total Pages : 240 pages
Book Rating : 4.11/5 ( download)

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Download or read book Protein Kinase C written by Peter J. Parker and published by . This book was released on 1997-01-01 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book information from the wide range of disciplines involved in the investigation of protein kinase C is juxtaposed to provide an integrated picture of current research activities. The contributors are active researchers with specific expertise in a particular area. The basic biochemistry of protein kinase C, its appearance as a heterogeneous gene family, its structure, activation and regulation as well as the biology of this enzyme, its relevance to processes like cellular differentiation or synaptic transmission, are described in considerable detail. Explaining the heterogeneity in functional terms is in fact one of the main challenges facing researchers.

Author : Marcelo G. Kazanietz
Publisher : Springer Science & Business Media
ISBN 13 : 1607615436
Total Pages : 492 pages
Book Rating : 4.39/5 ( download)

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Download or read book Protein Kinase C in Cancer Signaling and Therapy written by Marcelo G. Kazanietz and published by Springer Science & Business Media. This book was released on 2010-06-10 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein kinase C (PKC), a family of serine-threonine kinases, rocketed to the forefront of the cancer research field in the early 1980’s with its identification as an effector of phorbol esters, natural products with tumor promoting activity. Phorbol esters had long been of interest to the cancer research field due to early studies in the mouse skin carcinogenesis model, which showed that prolonged topical application of phorbol esters promoted the formation of skin tumors on mice previously treated with mutagenic agents. Research in the last years has established key roles for PKC isozymes in the control of cell proliferation, migration, adhesion, and malignant transformation. In addition, there is a large body of evidence linking PKC to invasion and cancer cell metastasis. Moreover, it is now well established that the expression of PKC isozymes is altered in various types of cancers. More importantly, small molecule inhibitors have been developed with significant anti-cancer activity. The relevance of PKC isozymes in cancer signaling is therefore remarkable. This book will have 4 sections. There will be 23 chapters. Each section will have a brief introduction by an expert in the field (~ 1-2 pages).

Author : Phillip S. Leventhal
Publisher :
ISBN 13 :
Total Pages : 508 pages
Book Rating : 4.44/5 ( download)

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Download or read book Mechanisms of Protein Kinase C Activation and Substrate Phosphorylation written by Phillip S. Leventhal and published by . This book was released on 1993 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt: